Best TWAS P=5.36e-11 · Best GWAS P=2.67e-10 conditioned to 0.448
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | L3MBTL2 | 0.14 | 0.01 | lasso | 6 | 0.04 | 1.8e-03 | -4.5 | 5.7 | 1.5e-08 | 0.73 | 0.03 | 0.90 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SLC25A17 | 0.09 | 0.03 | enet | 10 | 0.06 | 4.2e-05 | 6.3 | 6.6 | 5.4e-11 | 0.92 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Esophagus Mucosa | RANGAP1 | 0.07 | 0.02 | lasso | 4 | 0.02 | 8.6e-03 | 6.0 | -5.6 | 2.1e-08 | -0.89 | 0.04 | 0.84 | FALSE |
| 4 | GTEx | Pituitary | L3MBTL2 | 0.19 | 0.15 | enet | 17 | 0.19 | 1.6e-05 | -5.5 | 5.2 | 2.6e-07 | 0.63 | 0.27 | 0.37 | FALSE |
| 5 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RANGAP1 | 0.19 | 0.04 | enet | 10 | 0.05 | 2.8e-04 | 6.2 | 5.4 | 5.5e-08 | 0.81 | 0.00 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | L3MBTL2 | 0.05 | 0.03 | enet | 9 | 0.04 | 1.8e-04 | 6.3 | 6.3 | 2.9e-10 | 0.89 | 0.01 | 0.98 | FALSE |