TWAS
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Usage
Models
Genes
Traits
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Traits
:
Blood Platelet Count
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chr1:56,260,814-57,805,550
Best TWAS P=6.83e-12 · Best GWAS P=6.74e-13 conditioned to 0.022
56.2M
56.4M
56.6M
56.8M
57M
57.2M
57.4M
57.6M
57.8M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
PPAP2B
0.10
0.05
enet
6
0.06
4.2e-08
-6.4
-6.9
6.8e-12
0.91
0.01
0.99
TRUE
1
CommonMind
Brain Pre-frontal Cortex
PPAP2B
0.07
0.05
lasso
4
0.04
2.5e-05
-6.4
-6.2
4.5e-10
0.84
0.07
0.91
FALSE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
PPAP2B
0.08
0.02
lasso
6
0.05
1.5e-06
-4.1
-5.5
4.8e-08
0.68
0.32
0.67
FALSE