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chr1:61,510,619-63,844,736

Best TWAS P=2.24e-11 · Best GWAS P=1.62e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	INADL	0.22	0.03	lasso	6	0.05	1.3e-03	6.1	-5.2	1.7e-07	-0.72	0.05	0.66	FALSE
2	GTEx	Artery Aorta	DOCK7	0.14	0.08	lasso	4	0.09	1.2e-05	6.2	-5.5	3.3e-08	-0.87	0.09	0.90	FALSE
3	GTEx	Artery Tibial	DOCK7	0.07	0.07	enet	20	0.07	3.5e-06	6.1	-6.7	2.2e-11	-0.97	0.03	0.97	TRUE
4	GTEx	Cells Transformed fibroblasts	DOCK7	0.23	0.21	lasso	5	0.28	4.9e-21	6.6	-6.4	1.2e-10	-0.94	0.03	0.97	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	DOCK7	0.17	0.01	lasso	2	0.00	2.5e-01	6.3	-6.3	2.8e-10	-0.94	0.05	0.67	FALSE
6	GTEx	Skin Sun Exposed Lower leg	DOCK7	0.09	0.10	lasso	3	0.10	2.7e-08	6.3	-6.2	4.0e-10	-0.94	0.13	0.87	FALSE
7	GTEx	Spleen	DOCK7	0.28	0.14	enet	33	0.22	2.1e-06	6.0	-5.5	3.3e-08	-0.66	0.15	0.66	FALSE
8	GTEx	Whole Blood	DOCK7	0.06	0.00	lasso	6	0.00	1.6e-01	6.6	-6.3	2.2e-10	-0.96	0.03	0.94	FALSE
9	GTEx	Whole Blood	USP1	0.05	0.02	lasso	1	0.02	1.0e-02	6.0	-6.0	1.8e-09	-0.94	0.16	0.69	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	DOCK7	0.06	0.06	lasso	6	0.06	3.7e-08	6.1	5.3	1.2e-07	0.87	0.08	0.92	FALSE
11	YFS	Blood	DOCK7	0.05	0.04	lasso	8	0.05	1.3e-14	6.3	-6.5	9.7e-11	-0.91	0.19	0.81	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	DOCK7	0.01	0.01	blup	85	0.01	1.1e-03	6.0	-6.3	3.3e-10	-0.95	0.06	0.90	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	DOCK7	0.07	0.06	blup	83	0.06	2.1e-04	6.1	-6.6	4.7e-11	-0.92	0.10	0.86	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DOCK7	0.12	0.05	lasso	8	0.07	9.2e-09	6.0	-6.1	8.3e-10	-0.85	0.05	0.95	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANGPTL3	0.04	0.04	lasso	2	0.04	3.0e-05	6.0	-5.5	4.2e-08	-0.89	0.02	0.97	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOCK7	0.04	0.01	enet	11	0.04	5.6e-05	6.0	-5.8	8.9e-09	-0.74	0.12	0.72	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DOCK7	0.06	0.07	blup	86	0.07	1.0e-04	6.1	-6.5	9.9e-11	-0.93	0.09	0.90	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	DOCK7	0.04	0.01	enet	3	0.02	3.0e-03	6.0	-6.2	7.8e-10	-0.95	0.04	0.73	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	DOCK7	0.05	0.03	blup	86	0.02	1.6e-03	5.6	-5.9	3.6e-09	-0.93	0.06	0.90	FALSE