TWAS hub - PPAP2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0250	1.9e-03	0.047	0.024	0.022	0.027	0.037	2.1e-06	5.5e-04	9.7e-04	0.00025	2.5e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.1044	0.0353	1.6e-03	0.050	0.014	0.059	0.038	0.052	4.3e-07	5.5e-03	4.2e-08	0.00001	2.7e-07
3	TCGA	Brain Lower Grade Glioma	0.0807	0.0316	4.4e-06	0.024	0.046	0.047	NA	0.052	8.6e-04	6.1e-06	4.9e-06	NA	1.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Coronary Artery Disease (CAD)	16.9	20.1	23.7	-4.7	-4.9	-3.8
Heart disease (mother)	16.0	19.5	23.3	-4.8	-4.2	-4.2
Angina (self-reported)	7.4	9.7	12.3	-3.2	-3.5	-2.5
Angina	6.2	8.2	10.6	-3.0	-3.2	-2.3
Ulcerative Colitis (UC)	6.1	11.5	12.7	3.6	3.1	3.5
Father’s age at death	6.1	8.2	12.0	2.9	3.5	2.1
Illnesses of mother	6.1	7.5	8.6	2.9	2.8	2.5
Ulcerative Colitis	6.0	8.6	9.7	3.0	2.7	3.1
Lung cancer (father)	5.6	6.5	8.6	2.5	2.2	2.9
Leg pain on walking	5.5	6.9	7.8	2.8	2.3	2.8
Illnesses of father: Heart disease	5.5	7.6	10.6	-2.7	-3.3	-2.3
Systolic Blood Pressure	5.1	25.4	48.4	-4.2	-7.0	-3.2
Falls in the last year	4.6	6.2	7.7	2.5	2.8	2.2
Heart attack/myocardial infarction (self-reported)	4.5	5.9	6.5	-2.5	-2.5	-2.2
Systolic blood pressure, automated reading	4.4	12.8	23.8	-3.0	-4.9	-2.4
Impedance of leg (right)	4.4	21.3	26.4	-4.9	-5.1	-3.7
Current tobacco smoking	4.1	6.7	8.2	2.9	2.4	2.5
Ever highly irritable/argumentative for 2 days	4.1	5.0	6.3	1.7	2.4	2.5
Irritable Bowel Disease (IBD)	4.0	9.5	11.4	3.4	2.5	3.3
Health satisfaction	4.0	5.2	6.6	2.4	2.6	1.9
Heart attack	3.9	5.0	5.5	-2.3	-2.3	-2.0
BMI	3.8	22.1	25.1	4.6	5.0	4.5
Impedance of leg (left)	3.8	18.5	22.7	-4.6	-4.8	-3.5
Medication: Ramipril	3.7	4.7	10.0	-1.8	-3.2	-0.9
Illnesses of siblings	3.6	5.1	6.0	2.5	2.3	2.0
Loneliness, isolation	3.5	4.8	5.9	2.2	2.4	1.9
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	4.7	-2.2	-2.0	-1.9
HDL Cholesterol	3.3	5.4	6.7	2.1	2.3	2.6
Blood Platelet Count	3.3	38.6	47.1	-6.2	-6.9	-5.5
Qualifications: A levels/AS levels or equivalent	3.3	7.3	10.8	-2.6	-2.0	-3.3
Hip circumference	3.2	13.6	16.0	3.3	3.7	4.0
Medication: Aspirin	3.2	4.3	5.3	-1.8	-2.1	-2.3
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	4.5	2.0	1.6	2.1
Pulse rate	3.1	5.3	6.0	2.4	2.4	2.0
Shortness of breath walking on level ground	3.1	3.7	5.4	1.8	1.6	2.3
Medication: Omeprazole	3.1	3.7	5.1	1.9	1.5	2.2
Arm fat percentage (left)	3.0	12.0	13.1	3.4	3.6	3.4
Glaucoma (self-reported)	2.9	3.4	4.5	-2.1	-1.4	-1.9
Medication: Blood pressure	2.9	5.1	7.8	-2.2	-2.8	-1.6
Body mass index (BMI)	2.8	12.0	14.4	3.2	3.8	3.3
Arm fat percentage (right)	2.7	10.6	11.7	3.1	3.4	3.2
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	6.9	2.0	2.6	1.5
Supplements: Vitamin C	2.7	3.1	4.1	-1.9	-1.4	-2.0
Qualifications: nursing, teaching	2.7	4.2	5.0	-2.2	-2.2	-1.6
Illnesses of father: High blood pressure	2.7	3.4	5.9	-1.8	-2.4	-1.0
Medication: Aspirin	2.6	3.4	4.7	-1.6	-1.7	-2.2
Vascular/heart problems diagnosed by doctor	2.6	7.2	14.2	2.3	3.8	1.4
Qualifications: None of the above	2.5	5.3	7.6	2.1	1.9	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	3.3	1.6	1.7	1.8
Smoking status: Current	2.5	3.9	4.9	2.2	1.8	2.0
Heart disease (siblings)	2.5	3.0	3.5	-1.9	-1.8	-1.5
Medication: Cholesterol lowering	2.4	3.7	6.5	-1.8	-2.5	-1.2
Rheumatoid Arthritis	2.3	3.2	3.4	1.7	1.8	1.8
Miserableness	2.3	4.1	6.1	2.2	2.5	1.1
Heel T-Score	2.2	17.4	22.7	-4.8	-3.5	-4.2
Waist Hip Ratio (WHR)	2.2	10.1	16.2	-2.9	-4.0	-2.5
High blood pressure (mother)	2.1	3.0	6.3	-1.3	-2.5	-1.0
Mouth/teeth dental problems	2.1	3.2	3.5	-1.9	-1.8	-1.7
Medication: Simvastatin	2.1	3.2	3.8	-1.7	-2.0	-1.7
Mouth/teeth dental problems: Dentures	2.1	3.5	4.1	2.0	1.8	1.8
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	4.9	-1.9	-1.2	-2.2
High blood pressure (siblings)	2.1	3.0	4.3	-1.8	-2.1	-1.2
Arm fat mass (left)	2.1	8.8	10.0	2.8	3.2	3.0
Mother’s age at death	2.1	2.6	4.2	1.4	1.2	2.0
Medication: Atorvastatin	2.1	2.6	3.9	-1.4	-2.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	4.8	-2.0	-1.9	-2.2
Medication: Atenolol	1.9	2.4	5.4	-1.3	-2.3	-0.5
Waist circumference	1.9	6.9	8.6	2.4	2.5	2.9
Hair/balding pattern: Pattern 2	1.9	2.4	2.8	1.4	1.7	1.5
Prospective memory result	1.9	2.4	4.6	-1.2	-1.0	-2.1
Leg fat mass (left)	1.9	7.5	9.5	2.3	2.8	3.1
Average weekly spirits intake	1.8	2.3	4.0	1.2	2.0	1.2
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	2.8	1.6	1.2	1.7
Happiness	1.8	2.2	2.8	1.7	1.3	1.4
Leg fat mass (right)	1.8	6.9	8.7	2.2	2.7	3.0
High cholesterol (Self-reported)	1.8	3.2	4.3	-1.5	-1.7	-2.1
Breast Cancer	1.7	4.1	5.1	-2.2	-1.5	-2.2
Fasting Glucose	1.7	2.0	3.1	-1.1	-1.8	-1.4
High blood pressure	1.7	4.6	9.9	-1.7	-3.1	-1.0
Arm fat mass (right)	1.7	6.9	7.8	2.4	2.8	2.6
Illnesses of father: None of the above (group 1)	1.7	2.1	4.4	1.3	2.1	0.6
Medication: Bendroflumethiazide	1.7	2.6	5.9	-1.3	-2.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.3	1.5	0.9	1.8
Headache pain in last month	1.6	2.8	3.5	1.6	1.9	1.6
Hypertension (Self-reported)	1.6	4.4	9.9	-1.7	-3.1	-0.8
Impedance of whole body	1.6	8.0	11.1	-2.9	-3.3	-2.2
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.0	1.3	1.7	0.8
Hearing difficulty/problems with background noise	1.5	2.4	3.0	-1.7	-1.5	-1.4
Had other major operations	1.5	1.9	3.2	0.8	1.4	1.8
Medication: Amlodipine	1.5	2.1	2.9	-1.2	-1.4	-1.7
Eye problems/disorders: Cataract	1.5	1.8	3.4	1.1	0.8	1.8
Back pain experienced in last month	1.5	2.2	2.6	-1.5	-1.6	-1.3
Alzheimer’s Disease (in mother)	1.4	1.7	3.0	1.2	1.7	0.7
Trunk fat percentage	1.4	5.5	6.9	2.0	2.3	2.6
Trunk fat mass	1.4	5.9	7.9	2.0	2.4	2.8
Body fat percentage	1.4	5.7	7.3	2.0	2.4	2.7
Wheeze or whistling in the chest in last year	1.4	2.5	3.9	1.2	2.0	1.4
Whole body fat mass	1.4	5.7	7.5	2.0	2.4	2.7
Hearing aid user	1.4	1.6	2.2	-0.9	-1.5	-1.4
HbA1C	1.3	1.5	2.7	-1.0	-0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.6	-1.2	-1.1	-1.3
Emphysema/chronic bronchitis	1.3	1.5	3.2	0.9	1.8	0.8
Asthma	1.2	2.3	5.6	0.6	1.0	2.4
Pulse rate, automated reading	1.2	3.8	5.3	2.2	2.3	1.2
Leg fat-free mass (right)	1.2	6.3	7.5	2.3	2.5	2.7
Asthma (self-reported)	1.2	2.5	5.9	0.7	1.1	2.4
Leg predicted mass (right)	1.2	6.4	7.5	2.3	2.5	2.7
Leg fat percentage (left)	1.2	4.5	5.8	1.7	2.2	2.4
Commuting to job workplace: Cycle	1.2	1.4	1.9	-1.3	-0.9	-1.4
Depression (Nagel 2018)	1.1	1.7	2.1	1.0	1.4	1.4
Alzheimer’s Disease (including proxy)	1.1	1.6	3.3	1.1	1.8	0.6
Leg fat-free mass (left)	1.1	5.8	7.2	2.1	2.3	2.7
Leg predicted mass (left)	1.1	5.8	7.2	2.1	2.4	2.7
Weight	1.1	5.7	7.3	2.0	2.3	2.7
Overall health rating	1.1	2.3	3.2	1.4	1.3	1.8
Average weekly champagne plus white wine intake	1.1	1.5	2.0	-1.1	-1.4	-1.1
Age started oral contraceptive pill	1.1	1.4	2.0	-1.4	-1.4	-0.4
Cardiovascular Disease	1.0	3.3	7.5	-1.4	-2.7	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	1.3	1.1	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	1.7	-1.3	-1.2	-1.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.5	-1.1	-1.6	-0.3
Medication: Allopurinol	1.0	1.3	3.1	-0.9	-1.8	-0.1
Age at last live birth	1.0	1.5	2.5	-1.2	-1.6	-0.8
Basal cell carcinoma (self-reported)	1.0	1.2	1.9	-1.1	-0.6	-1.4
Smoking Status	0.9	2.2	3.5	1.9	1.4	1.1
Average weekly fortified wine intake	0.9	1.1	1.6	-1.2	-0.9	-0.9
Peak expiratory flow (PEF)	0.9	2.0	3.0	-1.7	-1.2	-1.3
Loud music exposure frequency	0.9	1.0	1.4	-0.5	-1.1	-1.2
Leg fat percentage (right)	0.9	3.1	4.4	1.3	1.8	2.1
Breast cancer (self-reported)	0.9	1.1	1.7	-1.0	-0.8	-1.3
Myopia	0.9	1.2	2.9	-0.7	-0.6	-1.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	0.9	1.3	0.7
Alcohol usually taken with meals	0.8	1.2	1.5	1.1	1.2	0.9
Impedance of arm (right)	0.8	3.6	4.6	-1.9	-2.1	-1.6
Time employed in main current job	0.8	1.0	1.6	-0.6	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.1	-1.9	-2.0	-0.8
Length of working week for main job	0.8	0.9	1.3	1.0	0.6	1.1
Exposure to tobacco smoke outside home	0.8	1.1	2.0	-1.4	-0.6	-1.0
Comparative body size at age 10	0.8	2.3	3.4	1.2	1.9	1.4
Family relationship satisfaction	0.8	0.9	1.1	1.0	1.1	0.8
Risk taking	0.8	1.1	1.4	1.1	1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	0.9	-0.9	-0.8	-0.9
Sensitivity / hurt feelings	0.7	1.2	2.9	0.4	0.8	1.7
Hand grip strength (right)	0.7	1.9	4.5	0.9	0.5	2.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.1	-0.4	-1.5	-0.1
Number of incorrect matches in round	0.7	1.1	1.6	1.0	0.9	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.4	1.2	1.0	1.0
Forced vital capacity (FVC)	0.7	2.8	5.0	-1.9	-2.2	-0.1
Fluid intelligence score	0.7	1.4	1.6	1.1	1.1	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	3.6	-1.7	-1.9	-0.7
Standing height	0.7	6.5	10.0	-2.8	-3.2	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	4.3	-1.7	-2.1	-0.2
Alcohol intake frequency.	0.7	1.6	1.9	1.1	1.3	1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	0.1	-0.4	1.5
Primary Biliary Cirrhosis	0.6	0.8	1.6	1.3	0.5	0.7
Triglycerides	0.6	1.1	1.5	-0.9	-1.2	-1.0
Height	0.6	11.3	16.3	-4.0	-4.0	-1.2
Lung FEV1/FVC ratio	0.6	2.9	8.4	-0.5	0.3	-2.9
Supplements: Zinc	0.6	0.6	0.7	0.8	0.8	0.8
Medication: Co-codamol	0.6	0.7	1.6	0.5	1.3	0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.8	1.1	0.5
Multivitamins +/- minerals	0.6	0.7	2.1	0.3	0.2	1.4
Alcohol intake versus 10 years previously	0.6	0.9	2.1	-0.6	-0.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.6	1.0	0.6	1.3
Exposure to tobacco smoke at home	0.6	0.6	1.3	-0.6	-1.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	0.4	0.7	1.2
Qualifications: College or University degree	0.6	2.0	2.8	-1.4	-1.1	-1.7
Mean time to correctly identify matches	0.6	1.1	1.7	1.0	1.3	-0.8
Ever depressed for a whole week	0.6	0.7	1.1	1.0	1.1	0.3
Depressed Affect (Nagel 2018)	0.5	1.1	1.3	1.1	1.1	0.8
Prostate Cancer	0.5	0.7	1.6	0.6	-0.1	1.3
Allergy or Eczema	0.5	1.4	2.7	-1.0	-1.6	-0.6
Diabetes (mother)	0.5	0.6	1.2	0.8	1.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	0.7	1.1	0.5
Sitting height	0.5	3.6	7.2	-1.8	-2.7	-0.6
Nervous feelings	0.5	0.9	1.6	-0.9	-0.6	-1.3
Noisy workplace	0.5	0.6	1.6	0.0	-0.3	1.3
Depression (self-reported)	0.5	0.6	1.2	0.6	1.1	0.2
Gout (self-reported)	0.5	0.7	1.9	0.4	-0.2	1.4
Illnesses of siblings: Diabetes	0.5	0.6	0.6	0.7	0.8	0.8
Average weekly red wine intake	0.5	0.8	0.9	-1.0	-0.9	-0.9
Ever had bowel cancer screening	0.5	0.6	1.0	-0.4	-1.0	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.8	0.6	0.9	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	-0.9	-0.5	-0.8
Ever smoked	0.5	0.9	1.1	1.0	1.1	0.7
Irritability	0.5	0.8	1.5	-1.2	0.3	-1.0
Diastolic blood pressure, automated reading	0.5	1.4	2.3	1.4	0.0	1.5
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	-0.9	-0.8	-0.3
Crohns Disease (2017)	0.4	0.8	1.3	1.0	-0.0	1.1
Reaction Time	0.4	0.7	1.0	0.8	1.0	-0.7
Blood Eosinophil Count	0.4	3.4	6.7	1.5	1.2	2.6
Chronotype (morning person)	0.4	1.0	1.4	0.7	1.1	1.2
Impedance of arm (left)	0.4	1.8	2.7	-1.2	-1.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.3	0.5	1.1	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.2	0.0	1.1
Smoking status: Previous	0.4	0.5	1.2	-0.7	-0.1	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.6	-0.8	-0.7	-0.5
Medication: Blood pressure	0.4	0.7	2.2	-0.0	-1.5	0.2
Basal metabolic rate	0.4	2.0	3.3	1.0	1.2	1.8
Age at First Birth	0.3	0.4	0.7	0.6	-0.1	0.9
Crohns Disease (2012)	0.3	0.4	0.6	0.7	0.5	0.8
Blood White Count	0.3	1.9	5.2	0.4	-0.6	2.3
Respiratory disease	0.3	0.8	1.9	0.1	0.6	1.4
Vitamin and mineral supplements	0.3	0.4	0.7	0.6	0.8	-0.4
Stomach or abdominal pain in last month	0.3	0.4	0.8	-0.6	-0.2	-0.9
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.5	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.7	0.7	1.3	0.2
Medication: Lansoprazole	0.3	0.3	0.9	-0.0	1.0	-0.3
Tense / ‘highly strung’	0.3	0.5	0.8	0.8	0.9	-0.0
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.4	0.5	0.9
Birth weight	0.3	0.6	1.0	-0.8	0.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.3	0.9	-0.3
Pulse wave peak to peak time	0.3	0.3	0.5	-0.6	-0.7	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	0.2	0.6	1.1
Neck or shoulder pain in last month	0.3	0.4	1.1	0.2	-0.1	1.0
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.7	-0.2	-0.5
Mineral and other dietary supplements	0.3	0.4	0.6	0.8	0.8	0.3
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.0	0.3	-0.9
Medication: Lisinopril	0.3	0.4	0.4	-0.7	-0.6	-0.6
Cholesterol lowering medication	0.3	0.4	0.8	-0.6	-0.4	-0.9
Worry (Nagel 2018)	0.2	0.5	1.2	-0.4	-0.2	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.3	0.8	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.9	0.4	0.5
Mean Putamen Volume	0.2	0.2	0.6	0.3	0.8	0.0
LDL Cholesterol	0.2	0.3	0.4	-0.6	-0.4	-0.5
Lupus	0.2	0.3	0.5	-0.3	0.5	-0.7
Neuroticism (2016)	0.2	0.3	0.8	0.2	0.9	0.4
Schizophrenia (2014)	0.2	0.4	0.4	0.6	0.7	0.6
Severe depression (siblings)	0.2	0.2	0.3	0.4	0.3	0.6
Pack years adult smoking proportion	0.2	0.2	0.4	-0.6	-0.4	-0.3
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.6	0.7	-0.1
Maternal smoking around birth	0.2	0.4	0.4	0.6	0.6	0.6
Past tobacco smoking	0.2	0.3	0.6	-0.5	-0.8	-0.2
Financial difficulties in last 2 years	0.2	0.2	0.7	-0.1	-0.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.7	-0.5	-0.0
Neuroticism score	0.2	0.5	0.6	0.6	0.8	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.6	0.8	-0.1
Breastfed as a baby	0.2	0.2	0.6	-0.1	-0.1	-0.8
Birth weight of first child	0.2	0.4	0.7	0.4	0.8	-0.5
Pulse wave reflection index	0.2	0.2	0.4	0.5	0.2	0.6
Arm fat-free mass (right)	0.2	1.0	2.2	0.6	0.7	1.5
Worry too long after embarrassment	0.2	0.4	0.6	-0.5	-0.8	-0.5
Migraine (self-reported)	0.2	0.3	0.8	-0.1	0.9	-0.1
Arm predicted mass (right)	0.2	0.8	1.9	0.5	0.6	1.4
Suffer from ‘nerves’	0.2	0.3	0.6	0.6	0.8	0.0
Knee pain experienced in last month	0.2	0.3	0.7	-0.3	-0.9	0.2
Whole body fat-free mass	0.2	0.9	1.8	0.5	0.7	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.3	0.6	0.2
Friendships satisfaction	0.2	0.2	0.5	0.7	0.5	-0.1
Medication for cholesterol	0.2	0.2	0.6	-0.3	0.2	-0.7
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.1	0.1	-0.8
Whole body water mass	0.2	1.0	2.1	0.6	0.8	1.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.8	-0.3	-0.7
Financial situation satisfaction	0.2	0.2	0.5	-0.3	-0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.7	-0.4	0.1
Medication: Paracetamol	0.2	0.3	0.5	0.5	-0.1	0.7
Alcohol drinker status: Never	0.2	0.3	0.6	-0.3	-0.4	0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.5	-0.5	-0.7	-0.1
Pain experienced in last month	0.2	0.3	0.8	-0.3	-0.3	-0.9
Supplements: Calcium	0.2	0.2	0.2	0.5	0.3	0.5
Bipolar Disorder (2018)	0.1	0.1	0.2	0.5	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.6	0.8	0.2	0.8
Schizophrenia (2018)	0.1	0.1	0.2	-0.5	-0.2	-0.4
Major Depression (MDD)	0.1	0.2	0.4	0.6	0.1	0.4
Ovarian Cancer	0.1	0.1	0.1	0.1	0.4	0.3
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.0	-0.3	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	0.2	-0.3
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.4	-0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.5	-0.1
Lung FVC	0.1	0.6	1.3	-0.4	-0.7	1.1
Neuroticism	0.1	0.2	0.4	0.3	0.7	-0.3
Tanning	0.1	0.7	0.9	-0.6	-1.0	-0.9
Hand grip strength (left)	0.1	0.3	0.8	0.2	-0.0	0.9
Relative age of first facial hair	0.1	0.2	0.6	-0.8	0.1	0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.0	0.2	0.6
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	0.4	0.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	0.2	-0.3
Diabetes (father)	0.1	0.1	0.2	0.5	0.1	0.4
Fed-up feelings	0.1	0.2	0.5	-0.7	-0.1	-0.5
Relative age voice broke	0.1	0.2	0.6	0.0	0.8	-0.3
Age when periods started (menarche)	0.1	0.3	0.6	0.0	-0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.3	0.7	-0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.1	-0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.3	-0.5	-0.5	-0.5
Supplements: Glucosamine	0.1	0.1	0.2	-0.5	-0.1	-0.3
Had menopause	0.1	0.2	0.5	0.1	0.0	0.7
Allergy	0.1	0.2	0.4	0.6	0.4	-0.2
Pain all over the body in last month	0.1	0.1	0.3	-0.5	0.0	-0.4
Diabetes (self-reported)	0.1	0.1	0.1	-0.3	-0.4	-0.4
Worrier / anxious feelings	0.1	0.3	0.4	0.6	0.4	0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.3	0.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.4	0.3	0.4
Medication: Paracetamol	0.1	0.1	0.2	0.1	-0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.2	-0.5	-0.4
Number of full brothers	0.1	0.2	0.5	-0.1	0.1	-0.7
Number of children fathered	0.1	0.1	0.2	-0.3	-0.4	0.3
Age at first live birth	0.1	0.2	0.5	0.1	-0.7	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.2	-0.2	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.1	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.4	0.3	0.4
Number of full sisters	0.1	0.1	0.2	-0.2	-0.4	-0.2
Chest pain or discomfort	0.1	0.1	0.3	-0.1	0.4	0.5
Had major operations	0.1	0.1	0.2	0.4	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.4	-0.3	-0.6
Mood swings	0.1	0.2	0.3	0.4	0.5	0.5
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.0	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.5	-0.2	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.3	0.4	0.2
Medication: Gliclazide	0.1	0.1	0.2	-0.2	0.2	0.5
Guilty feelings	0.1	0.1	0.2	0.1	0.5	0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.1	0.3	0.3
Arm fat-free mass (left)	0.1	0.5	1.2	0.2	0.3	1.1
Number of operations (self-reported)	0.1	0.1	0.2	-0.5	0.3	0.4
Average weekly beer plus cider intake	0.1	0.2	0.5	0.7	-0.1	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.2	-0.4	0.3
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.4	0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	0.3	0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.2	-0.4	0.1
Pack years of smoking	0.1	0.1	0.2	-0.4	-0.3	0.2
Arm predicted mass (left)	0.1	0.6	1.5	0.2	0.4	1.2
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	-0.1	0.0	-0.2
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.1	0.5	-0.0
Blood Red Count	0.0	0.4	1.0	0.5	1.0	-0.0
Hair Pigment	0.0	0.4	0.6	0.6	0.8	0.5
Number of treatments/medications taken	0.0	0.0	0.0	-0.2	-0.1	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.1	0.2	0.3
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.3	0.1	-0.3
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.2	-0.0	0.3
Medication: Metformin	0.0	0.1	0.1	0.3	0.2	-0.2
Taking other prescription medications	0.0	0.1	0.1	-0.4	-0.0	0.1
Trunk fat-free mass	0.0	0.2	0.4	-0.3	-0.1	0.6
Number of live births	0.0	0.0	0.1	-0.2	0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	-0.2	-0.0
Trunk predicted mass	0.0	0.2	0.3	-0.4	-0.3	0.5
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.2	-0.3	0.3
Medication: Ibuprofen	0.0	0.0	0.0	0.2	0.2	0.0
Comparative height size at age 10	0.0	0.2	0.3	-0.5	0.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.2	0.2	-0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.0	0.3	0.0
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.1	-0.3	-0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.2	0.0	-0.3

Hub : Genes

PPAP2B

Models

Trait associations