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chr6:46,757,276-48,294,046

Best TWAS P=1.39e-53 · Best GWAS P=1.82e-48 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cerebellum	RP11-385F7.1	0.35	0.32	lasso	4	0.30	1.5e-09	13.3	-13.3	1.4e-40	-0.75	0.54	0.46	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	RP11-385F7.1	0.22	0.06	enet	40	0.10	3.1e-04	2.6	-5.3	9.6e-08	-0.39	0.08	0.17	FALSE
3	GTEx	Cells Transformed fibroblasts	CD2AP	0.12	0.04	lasso	7	0.04	1.1e-03	13.3	13.6	4.7e-42	0.72	0.58	0.09	FALSE
4	GTEx	Colon Transverse	RP11-385F7.1	0.15	0.03	enet	7	0.05	2.1e-03	13.3	-11.7	1.1e-31	-0.69	0.15	0.70	TRUE
5	GTEx	Esophagus Mucosa	CD2AP	0.12	0.09	lasso	5	0.12	4.2e-08	-3.4	7.2	8.8e-13	0.63	0.86	0.12	FALSE
6	GTEx	Esophagus Mucosa	RP11-385F7.1	0.20	0.10	lasso	20	0.07	1.6e-05	13.3	-13.3	3.3e-40	-0.71	0.49	0.51	FALSE
7	GTEx	Esophagus Muscularis	RP11-385F7.1	0.13	0.06	lasso	4	0.06	2.1e-04	13.3	-13.9	3.6e-44	-0.83	0.02	0.97	TRUE
8	GTEx	Lung	RP11-385F7.1	0.11	0.04	lasso	5	0.03	1.8e-03	13.3	-11.3	9.4e-30	-0.72	0.69	0.19	TRUE
9	GTEx	Pituitary	RP11-385F7.1	0.26	0.21	lasso	5	0.16	7.7e-05	13.3	-13.3	1.5e-40	-0.75	0.05	0.80	FALSE
10	GTEx	Skin Sun Exposed Lower leg	RP11-385F7.1	0.09	0.05	enet	6	0.05	6.1e-05	13.3	-15.3	5.4e-53	-0.80	0.02	0.96	FALSE
11	GTEx	Thyroid	RP11-385F7.1	0.23	0.20	lasso	3	0.19	2.0e-14	13.3	-13.0	7.2e-39	-0.75	1.00	0.00	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CD2AP	0.05	0.00	blup	73	0.02	1.1e-02	-3.4	7.9	2.8e-15	0.54	0.03	0.30	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPR111	0.03	0.01	lasso	2	0.02	2.5e-05	-11.1	15.4	1.4e-53	0.78	0.01	0.98	TRUE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPR115	0.01	0.00	blup	90	0.01	7.2e-03	-6.5	8.9	6.8e-19	0.21	0.25	0.05	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	GPR111	0.13	0.08	blup	97	0.11	5.0e-07	-11.1	6.7	1.7e-11	0.03	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Esophageal Carcinoma	GPR111	0.19	0.14	lasso	2	0.14	3.9e-05	-11.2	10.7	1.6e-26	0.33	0.49	0.26	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CD2AP	0.06	0.02	enet	10	0.02	8.8e-04	-2.6	6.4	1.5e-10	0.48	0.12	0.36	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPR111	0.10	0.16	enet	17	0.16	9.4e-18	-11.1	9.4	5.9e-21	0.25	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPR115	0.06	0.11	lasso	8	0.13	2.5e-14	-11.2	10.0	1.7e-23	0.25	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GPR111	0.04	0.08	lasso	1	0.05	6.7e-04	-11.2	11.2	3.4e-29	0.35	0.26	0.15	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD2AP	0.09	0.04	enet	8	0.08	1.7e-09	-3.4	7.3	2.3e-13	0.52	0.70	0.27	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	GPR111	0.02	0.01	blup	94	0.02	1.1e-03	-9.7	7.2	6.0e-13	0.05	0.14	0.02	TRUE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	CD2AP	0.05	0.02	blup	73	0.02	1.2e-03	-3.4	8.5	2.3e-17	0.59	0.21	0.14	TRUE
24	The Cancer Genome Atlas	Rectum Adenocarcinoma	GPR111	0.22	0.09	blup	94	0.14	4.5e-04	-6.9	7.4	1.3e-13	0.12	0.39	0.04	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	GPR111	0.03	0.04	lasso	1	0.03	2.4e-03	-11.1	11.1	9.8e-29	0.36	0.34	0.03	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GPR115	0.08	0.09	blup	90	0.06	3.4e-03	-6.9	9.4	6.1e-21	0.24	0.24	0.06	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	CD2AP	0.10	0.10	lasso	2	0.09	4.4e-09	-3.4	6.2	7.4e-10	0.58	0.99	0.00	FALSE