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chr6:41,320,227-44,034,691

Best TWAS P=2.25e-18 · Best GWAS P=4.84e-21 conditioned to 0.0684

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CUL7	0.15	0.01	lasso	7	0.07	1.4e-06	1.5	-5.2	2.2e-07	0.37	0.67	0.18	FALSE
2	GTEx	Adipose Visceral Omentum	PEX6	0.55	0.44	lasso	6	0.57	1.5e-35	-5.1	-5.2	2.6e-07	0.21	1.00	0.00	FALSE
3	GTEx	Adrenal Gland	PEX6	0.63	0.39	lasso	7	0.54	7.5e-23	5.4	-5.2	1.9e-07	0.21	1.00	0.00	FALSE
4	GTEx	Artery Aorta	PEX6	0.37	0.38	lasso	3	0.38	3.3e-22	-5.1	-5.2	2.2e-07	0.16	1.00	0.00	FALSE
5	GTEx	Artery Coronary	GNMT	0.28	0.21	enet	6	0.19	6.6e-07	-5.2	5.2	1.9e-07	-0.21	0.92	0.00	FALSE
6	GTEx	Artery Tibial	PEX6	0.42	0.46	enet	16	0.51	3.7e-46	-5.1	-5.2	2.3e-07	0.19	1.00	0.00	FALSE
7	GTEx	Brain Cortex	PEX6	0.36	0.34	lasso	6	0.34	2.4e-10	-5.2	-5.2	1.8e-07	0.15	0.99	0.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	PEX6	0.35	0.30	enet	10	0.28	3.4e-08	-5.2	-5.2	2.1e-07	0.18	0.80	0.01	FALSE
9	GTEx	Brain Frontal Cortex BA9	GNMT	0.39	0.24	lasso	4	0.29	2.3e-08	5.4	5.2	2.2e-07	-0.22	0.91	0.01	FALSE
10	GTEx	Breast Mammary Tissue	PEX6	0.56	0.54	lasso	8	0.58	6.9e-36	-5.2	-5.2	2.0e-07	0.18	1.00	0.00	FALSE
11	GTEx	Breast Mammary Tissue (Male)	PEX6	0.19	0.19	lasso	3	0.18	4.8e-05	-5.2	-5.2	2.0e-07	0.15	0.18	0.05	FALSE
12	GTEx	Cells Transformed fibroblasts	PEX6	0.58	0.60	enet	27	0.67	2.0e-67	-5.1	-5.2	1.7e-07	0.17	1.00	0.00	FALSE
13	GTEx	Colon Sigmoid	PEX6	0.51	0.56	enet	35	0.58	7.3e-25	-5.1	-5.3	9.9e-08	0.18	1.00	0.00	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	PEX6	0.56	0.53	lasso	6	0.56	9.5e-24	-5.1	-5.1	2.8e-07	0.17	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	PEX6	0.47	0.49	lasso	7	0.51	1.3e-35	-5.1	-5.4	6.2e-08	0.18	1.00	0.00	FALSE
16	GTEx	Esophagus Muscularis	GNMT	0.17	0.14	lasso	4	0.12	1.4e-07	5.4	5.3	1.3e-07	-0.23	1.00	0.00	FALSE
17	GTEx	Muscle Skeletal	PEX6	0.58	0.52	lasso	6	0.64	1.3e-80	-5.1	-5.2	2.3e-07	0.21	1.00	0.00	FALSE
18	GTEx	Ovary	PEX6	0.48	0.38	enet	13	0.42	2.1e-11	-5.1	-5.2	2.1e-07	0.14	0.98	0.00	FALSE
19	GTEx	Pituitary	PEX6	0.46	0.30	lasso	5	0.39	9.2e-11	-5.1	-5.4	5.4e-08	0.19	0.98	0.00	FALSE
20	GTEx	Prostate	CNPY3	0.25	0.01	lasso	6	0.02	8.8e-02	5.4	-5.5	3.5e-08	0.22	0.06	0.12	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	PEX6	0.64	0.57	lasso	7	0.63	1.1e-43	-5.1	-5.1	2.8e-07	0.20	1.00	0.00	FALSE
22	GTEx	Spleen	PEX6	0.55	0.51	lasso	7	0.54	1.7e-16	-5.0	-5.4	7.8e-08	0.18	1.00	0.00	FALSE
23	METSIM	Adipose	PEX6	0.37	0.40	lasso	7	0.42	1.4e-69	-5.2	-5.3	1.4e-07	0.18	1.00	0.00	FALSE
24	NTR	Blood	ZNF318	0.04	0.03	lasso	8	0.02	1.3e-08	-9.4	-8.7	4.6e-18	0.99	0.00	1.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	PPP2R5D	0.05	0.00	bslmm	366	0.03	1.1e-04	-8.9	5.9	3.0e-09	-0.68	0.02	0.92	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	PEX6	0.49	0.58	lasso	7	0.60	1.6e-96	-5.2	-5.3	1.1e-07	0.16	1.00	0.00	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	TAF8	0.19	0.03	bslmm	442	0.09	5.4e-12	6.1	5.4	6.4e-08	0.00	0.00	1.00	TRUE
28	YFS	Blood	CUL9	0.04	0.00	blup	360	0.01	9.8e-06	1.4	-5.8	6.8e-09	0.45	0.12	0.70	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PEX6	0.25	0.27	enet	10	0.33	9.7e-29	4.0	-5.2	1.6e-07	0.24	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CRIP3	0.08	0.08	blup	34	0.07	1.0e-04	-7.5	-7.0	2.8e-12	0.86	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	GNMT	0.18	0.13	blup	45	0.12	4.6e-14	5.3	5.6	2.1e-08	-0.22	0.01	0.99	TRUE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF318	0.05	0.06	lasso	3	0.05	1.1e-06	-8.9	8.7	2.2e-18	-0.83	0.17	0.81	TRUE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GNMT	0.16	0.17	enet	9	0.21	3.7e-14	-5.1	5.2	2.4e-07	-0.20	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PEX6	0.31	0.40	enet	10	0.45	2.5e-33	5.3	-5.2	2.0e-07	0.21	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PEX6	0.50	0.38	enet	10	0.45	6.8e-20	-5.2	-5.4	6.5e-08	0.20	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF318	0.04	0.02	blup	48	0.04	2.2e-03	-7.5	-7.0	2.1e-12	0.87	0.02	0.49	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	GNMT	0.05	0.05	enet	7	0.05	2.0e-04	5.3	5.5	2.9e-08	-0.20	0.01	0.97	FALSE