Best TWAS P=8.2e-12 · Best GWAS P=7.38e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | JAK1 | 0.09 | 0.10 | lasso | 4 | 0.11 | 4.7e-13 | -6.8 | 6.6 | 5.4e-11 | -0.98 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Brain Cerebellum | JAK1 | 0.48 | 0.27 | enet | 22 | 0.39 | 1.6e-12 | -6.3 | 6.8 | 1.1e-11 | -0.93 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Cortex | JAK1 | 0.34 | 0.21 | lasso | 2 | 0.23 | 4.6e-07 | -6.8 | 6.8 | 8.2e-12 | -1.00 | 0.01 | 0.99 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | LEPR | 0.09 | 0.07 | blup | 505 | 0.06 | 4.6e-08 | 3.8 | -5.2 | 2.5e-07 | 0.09 | 1.00 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | JAK1 | 0.12 | 0.13 | bslmm | 478 | 0.12 | 3.6e-15 | -6.5 | 6.8 | 1.3e-11 | -0.96 | 0.02 | 0.98 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RAVER2 | 0.33 | 0.32 | bslmm | 466 | 0.38 | 1.0e-51 | -5.0 | 5.5 | 3.3e-08 | -0.62 | 0.99 | 0.01 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | JAK1 | 0.09 | 0.08 | lasso | 1 | 0.07 | 1.8e-04 | -5.3 | 5.2 | 1.5e-07 | -0.65 | 0.06 | 0.71 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JAK1 | 0.08 | 0.08 | blup | 91 | 0.08 | 5.2e-09 | -6.8 | 5.6 | 2.2e-08 | -0.84 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAVER2 | 0.04 | 0.03 | blup | 77 | 0.05 | 1.0e-06 | -6.5 | 6.5 | 9.5e-11 | -0.88 | 0.02 | 0.98 | FALSE |