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chr7:44,935-3,581,391

Best TWAS P=1.45e-49 · Best GWAS P=6.4e-47 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	14.231	14.8	1.4e-49	0.96	0.02	0.98	TRUE
60	YFS	Blood	PSMG3	0.01	0.00	blup	331	0.01	1.5e-03	4.340	-7.3	3.7e-13	-0.05	0.04	0.38	TRUE
6	GTEx	Adipose Subcutaneous	COX19	0.08	0.02	lasso	7	0.04	2.1e-04	6.286	-6.8	1.3e-11	-0.01	0.01	0.99	TRUE
19	GTEx	Cells Transformed fibroblasts	EIF3B	0.24	0.19	enet	12	0.21	1.3e-15	3.948	6.7	2.8e-11	0.05	1.00	0.00	TRUE
14	GTEx	Breast Mammary Tissue	EIF3B	0.19	0.07	enet	19	0.03	7.2e-03	-4.431	-6.4	1.4e-10	-0.07	0.23	0.03	TRUE
52	METSIM	Adipose	AC004840.9	0.26	0.19	enet	14	0.21	2.9e-31	3.886	6.0	1.7e-09	0.03	1.00	0.00	TRUE
23	GTEx	Colon Transverse	HEATR2	0.18	0.18	lasso	5	0.14	4.0e-07	-5.817	-5.9	3.7e-09	-0.02	0.98	0.01	TRUE
4	GTEx	Adipose Subcutaneous	AC004840.9	0.21	0.08	enet	18	0.10	1.8e-08	3.886	5.5	4.2e-08	0.04	0.87	0.00	TRUE
16	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	14.088	14.4	2.7e-47	0.94	0.13	0.87	FALSE
50	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	14.385	14.4	2.9e-47	0.97	0.01	0.95	FALSE
20	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	14.292	14.3	2.0e-46	0.88	0.02	0.98	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	11.920	14.0	1.3e-44	0.86	0.04	0.95	FALSE
25	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	13.942	14.0	1.3e-44	0.87	0.04	0.96	FALSE
38	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	12.266	14.0	1.4e-44	0.88	0.26	0.74	FALSE
31	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	11.951	13.7	1.2e-42	0.84	0.96	0.04	FALSE
29	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	13.843	13.4	8.5e-41	0.76	0.05	0.95	FALSE
3	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	11.920	13.0	8.3e-39	0.74	0.63	0.37	FALSE
21	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	11.663	13.0	1.4e-38	0.82	0.06	0.80	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	14.231	-12.8	2.8e-37	-0.92	0.02	0.98	FALSE
9	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	14.231	12.7	4.4e-37	0.85	0.03	0.97	FALSE
53	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	12.151	12.3	1.2e-34	0.75	0.15	0.85	FALSE
43	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	12.151	12.2	3.3e-34	0.73	0.12	0.62	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	-6.931	12.1	6.0e-34	0.78	0.06	0.76	FALSE
47	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	11.663	12.0	4.6e-33	0.66	0.77	0.22	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	11.920	11.9	9.3e-33	0.70	0.10	0.68	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	11.304	-11.5	1.1e-30	-0.55	0.14	0.86	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	-7.984	11.4	3.9e-30	0.72	0.01	0.71	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	-10.022	10.9	1.5e-27	0.53	0.53	0.44	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	11.920	-10.5	7.4e-26	-0.63	0.06	0.74	FALSE
28	GTEx	Liver	AC004840.9	0.27	0.01	enet	27	0.06	7.0e-03	-3.772	-10.2	1.5e-24	-0.38	0.06	0.34	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	GNA12	0.09	0.00	blup	103	0.03	9.3e-03	11.951	9.5	1.8e-21	0.51	0.04	0.11	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	-7.984	-9.4	7.1e-21	-0.62	0.03	0.91	FALSE
22	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	-7.338	9.3	8.9e-21	0.62	0.34	0.63	FALSE
56	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	11.304	8.7	4.5e-18	0.62	0.96	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GNA12	0.06	0.00	bslmm	603	0.02	3.7e-03	0.234	-8.5	1.6e-17	-0.44	0.12	0.12	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AMZ1	0.17	0.11	enet	9	0.10	5.0e-05	-4.219	-7.5	9.4e-14	-0.46	0.05	0.46	FALSE
41	GTEx	Skin Sun Exposed Lower leg	COX19	0.05	0.01	enet	7	0.03	1.2e-03	5.938	-6.8	1.3e-11	-0.02	0.00	0.98	FALSE
8	GTEx	Adrenal Gland	ZFAND2A	0.13	0.03	enet	20	0.07	1.8e-03	4.232	-6.7	2.2e-11	-0.07	0.11	0.30	FALSE
30	GTEx	Muscle Skeletal	EIF3B	0.07	0.02	enet	9	0.04	1.1e-04	-1.819	6.6	4.3e-11	-0.01	0.19	0.05	FALSE
58	YFS	Blood	CHST12	0.04	0.00	enet	25	0.02	1.0e-06	0.019	-6.4	1.9e-10	-0.18	0.04	0.04	FALSE
7	GTEx	Adipose Visceral Omentum	GNA12	0.28	0.06	enet	46	0.08	8.0e-05	-10.022	6.3	2.8e-10	0.38	0.14	0.67	FALSE
55	NTR	Blood	C7orf50	0.02	0.01	blup	380	0.01	1.2e-04	4.916	6.3	3.7e-10	-0.02	0.21	0.75	FALSE
34	GTEx	Nerve Tibial	RP11-449P15.1	0.07	0.06	lasso	3	0.03	4.6e-03	6.153	-6.2	4.9e-10	0.00	0.23	0.73	FALSE
32	GTEx	Nerve Tibial	GPR146	0.07	0.06	lasso	3	0.03	3.0e-03	6.153	-6.2	5.3e-10	0.00	0.26	0.71	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	CYP2W1	0.03	0.01	blup	51	0.02	3.8e-03	4.864	-6.2	6.1e-10	-0.01	0.05	0.72	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF3B	0.02	0.02	blup	45	0.02	2.1e-04	3.736	6.1	9.8e-10	0.01	0.08	0.76	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	GPR146	0.12	0.02	blup	72	0.03	5.3e-02	-4.857	-6.0	1.8e-09	0.00	0.02	0.55	FALSE
48	GTEx	Testis	GPER1	0.22	0.04	lasso	5	0.04	5.8e-03	-5.378	-5.9	3.4e-09	0.00	0.18	0.04	FALSE
33	GTEx	Nerve Tibial	GPER1	0.15	0.14	lasso	4	0.15	7.9e-11	5.803	-5.8	5.2e-09	0.00	0.55	0.45	FALSE
59	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	-1.645	5.8	7.4e-09	0.51	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	GPER	0.03	0.01	lasso	5	0.01	2.1e-02	-4.465	-5.8	8.3e-09	0.02	0.02	0.82	FALSE
40	GTEx	Skin Sun Exposed Lower leg	AC004840.9	0.18	0.01	enet	36	0.02	3.7e-03	-0.919	5.8	8.6e-09	0.14	0.20	0.11	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	ZFAND2A	0.17	0.05	lasso	3	0.04	1.6e-02	-4.393	-5.8	9.2e-09	-0.01	0.14	0.60	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	AC004840.9	0.17	0.08	lasso	4	0.09	1.1e-05	3.886	5.7	1.5e-08	0.03	0.56	0.02	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GPER1	0.05	0.04	lasso	2	0.05	4.3e-05	4.684	-5.7	1.6e-08	0.01	0.44	0.37	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF3B	0.04	0.00	blup	45	0.02	9.5e-03	3.724	5.6	2.2e-08	0.03	0.01	0.42	FALSE
45	GTEx	Spleen	HEATR2	0.20	-0.01	enet	20	0.04	4.1e-02	4.400	-5.5	4.2e-08	-0.01	0.09	0.13	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMZ1	0.14	0.06	enet	15	0.06	7.4e-08	-4.219	-5.5	4.2e-08	-0.32	0.84	0.04	FALSE
5	GTEx	Adipose Subcutaneous	ELFN1	0.06	0.04	lasso	3	0.02	9.5e-03	-5.098	-5.4	5.4e-08	-0.05	0.01	0.90	FALSE
54	METSIM	Adipose	PRKAR1B	0.04	0.00	blup	361	0.01	3.4e-03	-2.558	-5.4	5.4e-08	-0.03	0.06	0.15	FALSE
13	GTEx	Brain Cerebellum	RP11-449P15.1	0.20	0.07	lasso	4	0.05	1.3e-02	-5.041	-5.4	5.7e-08	0.00	0.21	0.24	FALSE
35	GTEx	Pancreas	ZFAND2A	0.36	0.47	enet	20	0.46	9.4e-22	-4.673	-5.4	6.3e-08	0.01	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	C7orf50	0.08	0.01	blup	144	0.03	4.7e-04	5.411	-5.4	7.0e-08	0.00	0.26	0.37	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EIF3B	0.07	0.03	enet	8	0.03	3.0e-04	3.736	5.4	7.8e-08	0.02	0.85	0.01	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPR146	0.03	0.04	lasso	4	0.04	5.8e-05	-5.101	5.3	9.3e-08	0.01	0.05	0.92	FALSE
79	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZFAND2A	0.25	0.22	blup	54	0.23	3.5e-07	-4.673	-5.3	9.7e-08	0.01	0.02	0.96	FALSE
12	GTEx	Brain Cerebellum	GPR146	0.22	0.08	lasso	6	0.06	6.0e-03	-5.041	-5.3	1.4e-07	-0.01	0.26	0.25	FALSE
10	GTEx	Artery Tibial	HEATR2	0.16	0.14	lasso	4	0.16	1.6e-12	4.278	-5.2	1.5e-07	-0.06	1.00	0.00	FALSE
11	GTEx	Artery Tibial	COX19	0.10	0.03	enet	35	0.05	1.2e-04	-4.824	-5.2	1.5e-07	0.01	0.18	0.81	FALSE
44	GTEx	Small Intestine Terminal Ileum	HEATR2	0.38	0.19	lasso	6	0.23	6.1e-06	-4.593	-5.2	1.6e-07	-0.01	0.56	0.03	FALSE
51	GTEx	Whole Blood	RP11-449P15.2	0.11	0.08	lasso	3	0.09	6.4e-09	-5.103	-5.2	1.6e-07	-0.03	1.00	0.00	FALSE
46	GTEx	Spleen	RP11-449P15.2	0.37	0.27	lasso	7	0.19	1.3e-05	-5.106	-5.2	2.4e-07	-0.02	0.83	0.03	FALSE
15	GTEx	Breast Mammary Tissue (Female)	EIF3B	0.24	-0.01	enet	45	0.03	5.7e-02	-0.503	-5.2	2.6e-07	-0.09	0.05	0.05	FALSE
49	GTEx	Vagina	HEATR2	0.17	0.16	enet	9	0.15	2.8e-04	-5.035	-5.2	2.6e-07	-0.04	0.08	0.10	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	HEATR2	0.15	0.17	enet	5	0.12	7.1e-05	-5.035	-5.1	2.7e-07	-0.03	0.23	0.09	FALSE
27	GTEx	Esophagus Muscularis	ZFAND2A	0.29	0.30	enet	20	0.36	1.5e-22	-4.393	-5.1	2.7e-07	0.00	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEATR2	0.06	0.05	blup	46	0.05	1.3e-06	-4.998	5.1	2.7e-07	0.03	0.09	0.90	FALSE
42	GTEx	Skin Sun Exposed Lower leg	RP11-449P15.2	0.07	0.05	lasso	4	0.04	5.5e-04	-5.035	-5.1	2.9e-07	0.00	0.21	0.17	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	ZFAND2A	0.28	0.23	lasso	6	0.27	5.5e-07	4.551	-5.1	2.9e-07	0.03	0.02	0.90	FALSE