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chr7:126,593,467-130,351,276

Best TWAS P=9.22e-13 · Best GWAS P=9.36e-33 conditioned to 1.05e-20

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	The Cancer Genome Atlas	Thyroid Carcinoma	ZC3HC1	0.04	0.01	blup	48	0.02	8.1e-03	-5.9	-7.1	9.2e-13	-0.59	0.02	0.19	TRUE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IRF5	0.17	0.09	enet	6	0.15	1.8e-07	7.2	-6.9	5.0e-12	0.00	0.00	1.00	TRUE
11	METSIM	Adipose	SND1	0.06	0.03	blup	602	0.04	1.5e-06	3.8	-5.5	4.4e-08	-0.03	0.04	0.94	TRUE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IRF5	0.09	0.06	blup	30	0.08	1.8e-07	6.2	-6.8	7.2e-12	-0.03	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Glioblastoma Multiforme	IRF5	0.18	0.02	enet	8	0.04	2.4e-02	6.6	-6.4	1.2e-10	-0.01	0.00	0.77	FALSE
9	GTEx	Whole Blood	IRF5	0.17	0.06	lasso	4	0.09	1.2e-08	6.2	-6.4	1.3e-10	0.00	0.08	0.92	FALSE
10	METSIM	Adipose	IRF5	0.05	0.04	lasso	7	0.04	2.2e-06	-5.5	-6.4	1.4e-10	-0.03	0.01	0.99	FALSE
5	GTEx	Esophagus Muscularis	IRF5	0.21	0.12	lasso	5	0.11	3.9e-07	-5.5	-6.3	2.1e-10	-0.01	0.02	0.98	FALSE
8	GTEx	Thyroid	IRF5	0.14	0.10	enet	6	0.11	1.2e-08	-5.5	-6.3	4.0e-10	-0.01	0.30	0.69	FALSE
6	GTEx	Nerve Tibial	IRF5	0.13	0.09	enet	10	0.07	1.2e-05	-5.5	-6.2	4.2e-10	0.00	0.29	0.67	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	IRF5	0.22	0.21	enet	9	0.26	4.6e-25	5.6	-6.2	6.9e-10	0.00	0.98	0.02	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IRF5	0.09	0.09	blup	30	0.13	3.1e-14	5.6	-6.2	7.5e-10	0.02	0.07	0.93	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	IRF5	0.27	0.25	bslmm	336	0.25	7.1e-32	6.2	-6.0	1.6e-09	0.01	0.50	0.50	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IRF5	0.09	0.10	lasso	3	0.08	4.6e-04	5.6	-5.8	5.8e-09	0.00	0.02	0.75	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	IRF5	0.23	0.26	lasso	3	0.26	3.6e-27	5.6	-5.8	5.8e-09	0.01	0.98	0.02	FALSE
14	YFS	Blood	KLHDC10	0.29	0.34	lasso	9	0.35	3.4e-119	5.6	-5.8	5.9e-09	-0.41	1.00	0.00	FALSE
3	GTEx	Colon Transverse	IRF5	0.21	0.22	lasso	4	0.22	8.0e-11	-5.5	-5.8	8.3e-09	-0.01	0.28	0.72	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	IRF5	0.29	0.26	enet	6	0.29	3.1e-17	5.6	-5.8	8.3e-09	0.00	0.98	0.02	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IRF5	0.09	0.04	lasso	4	0.06	2.3e-04	-5.5	-5.7	1.3e-08	0.01	0.05	0.89	FALSE
13	YFS	Blood	IRF5	0.65	0.75	lasso	4	0.80	0.0e+00	6.2	5.7	1.4e-08	-0.01	0.50	0.50	FALSE
2	GTEx	Adipose Visceral Omentum	IRF5	0.16	0.08	lasso	4	0.08	8.2e-05	-5.5	-5.7	1.6e-08	-0.02	0.07	0.82	FALSE
4	GTEx	Esophagus Mucosa	IRF5	0.13	0.14	lasso	4	0.13	4.6e-09	-5.5	-5.6	1.9e-08	-0.02	0.68	0.31	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	IRF5	0.18	0.11	enet	9	0.14	1.6e-15	-5.5	-5.6	2.0e-08	-0.01	0.92	0.08	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IRF5	0.14	0.12	enet	7	0.15	1.8e-16	-4.8	-5.6	2.6e-08	0.01	0.96	0.04	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	IRF5	0.10	0.09	lasso	4	0.08	1.6e-16	-5.5	-5.5	3.3e-08	-0.01	0.98	0.02	FALSE
7	GTEx	Skin Sun Exposed Lower leg	IRF5	0.10	0.14	lasso	2	0.12	1.9e-10	-5.5	-5.5	3.4e-08	-0.01	0.86	0.14	FALSE
28	The Cancer Genome Atlas	Rectum Adenocarcinoma	IRF5	0.41	0.13	blup	33	0.23	3.5e-06	5.6	-5.5	4.9e-08	0.02	0.05	0.80	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IRF5	0.11	0.05	blup	30	0.07	2.2e-08	-5.5	-5.5	5.0e-08	0.00	0.88	0.12	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IRF5	0.14	0.15	enet	6	0.14	7.0e-10	5.6	-5.3	1.0e-07	0.00	0.97	0.03	FALSE
1	GTEx	Adipose Subcutaneous	SND1	0.19	0.15	enet	22	0.14	9.8e-12	4.7	-5.2	1.7e-07	0.01	0.03	0.96	FALSE
31	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	IRF5	0.27	0.16	blup	30	0.22	9.7e-07	5.6	-5.2	2.3e-07	0.02	0.05	0.91	FALSE