Hub : Genes

KLHDC10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0740	0.0320	0.00430	-0.003	NA	0.005	NA	-0.002	8.3e-01	NA	1.1e-01	NA	5.4e-01
2	GTEx	Thyroid	0.1040	0.0410	0.00730	-0.001	NA	-0.003	NA	0.001	3.6e-01	NA	8.2e-01	NA	2.4e-01
3	YFS	Blood	0.2886	0.0324	0.00000	0.335	0.315	0.346	0.346	0.347	5.6e-114	6.5e-106	1.4e-118	7.6e-119	3.4e-119
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0551	0.0262	0.00013	0.052	0.044	0.028	NA	0.044	1.5e-06	9.3e-06	3.8e-04	NA	8.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.2	6.6	10.5	-1.6	-3.1	3.2	-2.0
Bipolar Disorder or Schizophrenia	5.2	12.6	20.4	-2.0	-4.2	4.5	-3.0
Depressed Affect (Nagel 2018)	2.0	4.2	7.4	0.6	-2.7	2.3	-1.9
Depression (Nagel 2018)	1.2	1.7	3.5	-0.9	-1.9	1.2	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.8	-0.1	1.6	-1.7	1.0
Neuroticism (Nagel 2018)	1.4	3.2	5.8	0.8	-2.4	2.1	-1.5
Schizophrenia (2018)	3.0	6.3	10.3	-1.3	-2.9	3.2	-2.2
Schizophrenia vs Biploar Disorder	1.6	2.0	3.7	1.4	1.6	-1.9	0.2
Worry (Nagel 2018)	1.4	3.1	5.2	1.1	-2.3	1.8	-1.6
Alzheimer’s Disease (in mother)	1.7	1.9	4.1	2.0	0.6	0.4	1.8
Alzheimer’s Disease (in father)	0.7	0.8	2.9	1.7	-0.3	-0.1	0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	3.9	2.0	0.4	0.3	1.5
Crohns Disease (2017)	0.0	0.1	0.1	-0.3	-0.2	0.1	-0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.0	-0.2	-0.2	-0.5
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.2
Major Depression (MDD)	0.2	0.2	0.4	-0.6	0.6	-0.1	0.5
Reaction Time	1.8	3.4	5.4	-0.5	-1.7	2.2	-2.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.3	1.2	0.6	-0.7	0.6
Breast Cancer	0.5	1.1	3.0	-0.6	1.0	-1.7	-0.2
Ovarian Cancer	0.4	0.6	0.8	0.8	-0.9	0.8	-0.2
Prostate Cancer	1.7	2.4	4.4	1.6	1.3	-1.0	2.1
Age at First Birth	0.2	0.2	0.5	0.7	0.5	-0.3	0.1
Bipolar Disorder (2011)	1.8	1.8	6.2	-0.9	0.0	2.5	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.3	0.8	0.0	0.5
Coronary Artery Disease (CAD)	4.6	5.5	13.8	0.3	-2.9	3.7	0.0
Crohns Disease (2012)	0.6	1.0	1.5	0.8	-1.2	0.9	-0.9
Mean Putamen Volume	1.4	1.6	2.1	1.4	1.2	-1.0	1.4
Fasting Glucose	1.1	1.3	1.6	-1.1	1.2	-1.1	1.3
HbA1C	0.4	0.4	0.7	0.5	-0.8	0.8	-0.2
HDL Cholesterol	0.8	1.4	2.9	0.3	1.2	-1.7	1.1
LDL Cholesterol	0.3	0.5	1.1	0.7	-0.8	1.0	-0.1
Lupus	2.4	3.7	6.0	-0.9	-2.4	2.3	-1.6
Neuroticism (2016)	0.5	0.7	1.1	1.1	-0.3	0.8	0.9
Primary Biliary Cirrhosis	0.8	1.1	2.7	-1.6	-1.0	0.3	-0.8
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.1
Schizophrenia (2014)	1.3	2.9	5.7	-1.4	-1.9	2.4	-0.8
Triglycerides	0.3	0.4	0.8	-0.9	-0.4	0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	-1.5	1.0	-0.7	0.4
Ulcerative Colitis	0.2	0.3	0.5	0.7	0.3	-0.7	0.1
Blood Eosinophil Count	0.9	6.9	11.8	3.4	2.0	-2.7	2.1
Blood Platelet Count	1.8	20.8	33.9	3.7	4.4	-5.8	4.0
Blood Red Count	0.4	3.6	4.2	-2.1	-1.9	2.0	-1.4
Blood White Count	0.3	1.9	4.8	-0.3	1.4	-2.2	0.9
Heel T-Score	2.3	18.2	31.1	2.1	4.7	-5.6	3.8
BMI	0.7	4.2	6.3	-2.5	-1.8	1.9	-2.0
Height	0.9	17.3	31.9	1.5	5.1	-5.7	3.0
Waist Hip Ratio (WHR)	0.8	3.5	13.2	3.6	0.2	-0.6	0.4
Systolic Blood Pressure	1.9	9.3	12.1	-2.1	-3.0	3.5	-3.5
Smoking Status	1.7	4.1	5.9	-1.7	-2.4	2.1	-1.8
Allergy or Eczema	0.1	0.3	0.4	0.5	-0.6	0.4	-0.6
Cardiovascular Disease	6.8	22.5	24.2	-4.7	-4.9	4.7	-4.7
Hypothyroidism (self reported)	0.8	1.8	3.5	0.6	1.9	-1.4	1.2
Respiratory disease	0.2	0.4	1.0	0.1	-1.0	0.7	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.8	-0.8	0.7	-0.9	1.3
Lung FEV1/FVC ratio	0.5	2.5	7.1	2.7	0.5	-1.6	-0.4
Lung FVC	0.1	0.4	1.2	0.6	-0.3	1.1	0.1
Neuroticism	1.1	2.5	4.1	0.8	-2.0	1.6	-1.7
Chronotype (morning person)	0.0	0.0	0.1	0.2	-0.1	0.3	-0.2
Hair Pigment	0.0	0.3	0.7	-0.8	0.2	-0.3	0.4
Tanning	0.1	0.9	2.8	-1.7	-0.5	-0.4	-0.7
Hand grip strength (left)	1.2	3.2	5.9	0.3	2.0	-1.7	2.4
Number of treatments/medications taken	0.8	1.5	2.1	-1.1	-1.4	0.9	-1.4
Average weekly spirits intake	0.9	1.1	2.7	-1.6	0.9	-0.6	0.7
Sensitivity / hurt feelings	0.5	0.9	1.7	-1.3	-0.8	0.6	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	0.6	-0.0	-0.8	1.0
Hearing difficulty/problems: Yes	1.4	2.1	3.3	0.8	-1.8	1.2	-1.8
Relative age of first facial hair	0.7	1.4	3.4	-0.5	1.3	-1.8	0.3
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	8.2	-0.1	1.9	-2.1	2.9
Ever used hormone-replacement therapy (HRT)	1.8	2.3	5.4	0.4	1.5	-2.3	1.1
Ever had hysterectomy (womb removed)	1.0	1.2	3.7	-1.9	-0.9	0.3	-0.3
Systolic blood pressure, automated reading	1.5	4.3	6.1	-1.5	-2.1	2.0	-2.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.1	0.6	1.4	-1.4	1.1
Angina	2.0	2.7	8.6	-2.9	-0.8	0.6	-1.0
Medication for hormone replacement therapy	2.8	3.1	5.3	0.8	1.9	-1.8	2.3
Vitamin and mineral supplements	0.3	0.4	0.6	-0.8	0.0	-0.7	-0.6
Supplements: Zinc	0.6	0.7	1.3	-1.2	-0.7	-0.0	-1.0
Medication: Co-codamol	4.9	5.7	8.9	-0.1	-3.0	2.9	-2.3
Medication: Metformin	0.1	0.2	0.3	0.5	0.3	0.1	0.5
Diabetes (father)	0.6	0.7	2.7	-1.6	-0.2	-0.1	-0.1
Diabetes (mother)	0.2	0.3	0.6	-0.7	-0.8	0.2	-0.4
Severe depression (siblings)	0.7	0.8	2.2	-1.5	-0.6	0.8	-0.3
Pack years adult smoking proportion	0.7	1.1	2.1	-0.4	-1.4	1.1	-0.9
Impedance of leg (right)	0.6	3.0	7.2	0.6	1.9	-2.7	0.9
Leg fat-free mass (left)	0.1	0.3	1.3	-1.1	0.1	0.1	-0.3
Trunk fat percentage	0.1	0.5	1.0	-0.4	-0.8	0.0	-1.0
Hand grip strength (right)	1.1	2.9	4.7	1.8	1.6	-1.1	2.2
Townsend deprivation index at recruitment	0.8	1.1	1.7	-0.8	-1.3	1.0	-1.1
Current tobacco smoking	0.6	1.0	1.5	-0.6	-1.2	0.9	-1.2
Average weekly fortified wine intake	0.5	0.5	0.7	0.3	-0.8	0.8	-0.8
Maternal smoking around birth	1.0	1.5	5.5	-2.3	0.3	-0.2	0.5
Fed-up feelings	1.7	3.0	6.0	0.5	-2.4	1.8	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.4	-1.5	-1.1	0.3	-0.1
Relative age voice broke	1.2	1.8	3.9	0.3	1.8	-2.0	-0.1
Taking other prescription medications	0.2	0.3	0.6	-0.8	0.1	-0.6	0.4
Age when periods started (menarche)	2.6	6.3	11.2	-1.5	2.9	-3.3	1.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.3	0.0	0.5	-0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	14.1	1.1	3.0	-3.8	1.7
Tinnitus: Yes, but not now, but have in the past	5.4	5.7	7.3	-1.9	-2.7	2.4	-2.5
Qualifications: CSEs or equivalent	0.9	1.2	4.3	-2.1	-0.5	0.2	-0.5
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2
High blood pressure	4.4	12.3	15.8	-3.3	-4.0	3.3	-3.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	0.6	-1.0	0.9	-0.7
Multivitamins +/- minerals	0.2	0.2	0.7	0.2	-0.2	0.9	0.3
Stomach or abdominal pain in last month	1.8	2.3	2.8	-1.7	-1.5	1.3	-1.5
Supplements: Glucosamine	0.0	0.0	0.1	-0.4	-0.2	-0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.2	0.2	-0.6	-0.4
Medication: Atenolol	0.1	0.1	0.1	0.4	0.3	-0.2	0.3
Medication: Levothyroxine sodium	1.2	2.1	3.7	-0.5	1.9	-1.9	0.9
Sitting height	0.2	1.2	3.5	0.2	1.0	-1.9	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	1.9	-0.5	-1.4	1.2	-0.8
High blood pressure (mother)	1.8	2.5	4.3	-1.8	-1.1	1.1	-2.1
Body mass index (BMI)	1.0	4.2	5.2	-1.9	-2.3	2.0	-1.9
Impedance of leg (left)	0.8	3.8	8.2	1.2	2.0	-2.9	1.1
Leg predicted mass (left)	0.1	0.3	1.1	-1.0	0.0	0.1	-0.3
Trunk fat mass	0.1	0.4	0.9	-0.7	-0.6	-0.1	-1.0
Waist circumference	0.1	0.5	0.8	-0.2	-0.9	0.5	-0.8
Number of incorrect matches in round	0.6	1.0	2.3	-0.4	-1.0	1.5	-0.8
Past tobacco smoking	0.9	1.6	2.6	1.6	1.4	-1.3	0.5
Alcohol usually taken with meals	2.9	4.8	8.6	1.4	2.9	-2.0	2.1
Nervous feelings	0.9	1.6	2.8	-0.1	-1.6	1.0	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.2	-0.1	-1.8	1.6	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.4	-0.5	-0.7	0.0	-0.7
Hair/balding pattern: Pattern 2	1.8	2.3	4.6	2.1	1.5	-1.2	0.8
Had menopause	0.7	0.9	2.1	1.4	0.8	-0.8	0.3
Had other major operations	0.1	0.2	0.3	0.6	-0.5	0.2	-0.4
Forced vital capacity (FVC)	0.4	1.7	2.2	1.4	1.5	-1.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	12.0	1.4	2.7	-3.5	1.6
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.5	-1.1	-1.6	1.0	-2.1
Qualifications: None of the above	2.7	5.8	8.2	0.6	-2.7	2.7	-2.9
Financial difficulties in last 2 years	2.8	3.8	6.3	-1.4	-2.5	1.8	-1.9
Mouth/teeth dental problems	1.8	2.7	4.9	0.3	2.2	-1.5	1.9
Heart attack	2.1	2.7	3.4	-1.8	-1.5	1.4	-1.8
Allergy	0.7	1.7	3.1	-0.5	1.7	-1.8	0.6
Pain all over the body in last month	0.5	0.5	0.7	-0.8	-0.8	0.6	-0.6
Diabetes (self-reported)	0.3	0.4	1.7	-1.3	-0.2	-0.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.1	-0.6	-1.5	0.6	-1.3
Medication: Ramipril	1.3	1.6	2.8	-1.7	-0.9	0.2	-1.7
Medication: Simvastatin	2.2	3.3	6.1	-0.5	-2.2	2.5	-1.4
Fluid intelligence score	0.6	1.3	3.1	1.7	0.8	-1.1	0.4
Illnesses of siblings	0.5	0.8	1.2	1.0	0.5	-0.8	-1.1
Neuroticism score	1.8	3.8	7.0	0.5	-2.6	2.3	-1.7
Weight	0.1	0.7	1.9	-1.4	-0.6	0.2	-0.8
Impedance of arm (right)	1.0	4.8	5.6	2.3	2.3	-2.4	1.7
Arm fat percentage (right)	0.3	1.3	2.0	-1.4	-1.1	0.7	-1.2
Trunk fat-free mass	0.0	0.2	0.5	-0.7	0.5	-0.4	-0.0
Hip circumference	0.0	0.2	0.4	-0.6	-0.5	0.3	-0.3
Time employed in main current job	0.4	0.5	0.8	0.6	0.9	-0.5	0.8
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.2
Father’s age at death	0.6	0.8	1.9	1.4	0.8	-0.6	-0.6
Worrier / anxious feelings	0.7	1.3	2.3	1.0	-1.5	1.2	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	5.0	-0.1	-2.2	1.8	-1.6
Falls in the last year	0.1	0.2	0.4	0.0	-0.5	0.7	0.3
Hair/balding pattern: Pattern 3	1.3	1.9	2.3	-1.1	-1.5	1.4	-1.4
Number of live births	0.1	0.2	0.5	-0.7	-0.2	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.3	1.2	1.5	-1.4	0.6
Pulse rate	0.8	1.3	2.5	-0.4	-1.3	1.6	-0.9
Happiness	0.9	1.0	2.0	-1.2	-0.8	-0.5	-1.4
Noisy workplace	2.9	3.5	6.6	-1.2	-2.1	1.3	-2.6
Qualifications: A levels/AS levels or equivalent	3.0	6.6	7.9	2.1	2.8	-2.6	2.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.8	-0.6	0.1	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.6	1.2	-1.1	-0.3	-0.9	-0.3
Asthma	0.8	1.5	2.9	0.7	-1.7	1.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.6	0.8	0.7	-0.5	0.3
Medication: Cholesterol lowering	1.8	2.9	4.6	-0.5	-2.1	2.0	-1.6
Depression (self-reported)	1.1	1.3	1.7	-1.3	-1.2	1.0	-1.0
Medication: Lansoprazole	1.4	1.6	2.4	-1.5	1.2	-1.1	1.0
Prospective memory result	3.8	4.6	7.7	-1.8	-2.0	1.9	-2.8
Lung cancer (father)	0.4	0.5	1.6	-1.3	-0.0	-0.6	0.2
Illnesses of mother	0.7	0.8	1.8	1.3	0.6	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.2	1.0	-0.7	0.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.4	-0.7	1.1	-0.2
Impedance of arm (left)	1.3	5.8	8.4	2.9	2.4	-2.5	1.7
Arm fat mass (right)	0.2	1.0	2.3	-1.5	-0.8	0.5	-0.9
Trunk predicted mass	0.0	0.2	0.6	-0.7	0.4	-0.3	-0.0
Standing height	0.8	7.8	13.3	1.1	3.5	-3.6	2.1
Length of working week for main job	0.7	0.8	1.0	0.9	1.0	-0.5	1.0
Exposure to tobacco smoke at home	2.6	2.9	5.6	0.1	-2.4	1.4	-2.0
Breastfed as a baby	0.3	0.3	0.5	-0.5	0.5	-0.7	0.7
Tense / ‘highly strung’	0.3	0.6	2.1	1.4	-0.4	0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.6	0.4	-0.8	-0.2
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	-0.8	1.1	-1.1	0.6
Birth weight of first child	2.4	4.3	7.7	0.7	2.3	-2.8	1.9
Peak expiratory flow (PEF)	0.3	0.7	1.1	0.8	1.1	-0.9	0.4
Pulse wave reflection index	0.2	0.2	0.4	0.2	0.5	0.0	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.1	-0.6	0.1	-0.8	-1.1
Loud music exposure frequency	2.9	3.1	4.8	-1.6	-1.7	1.5	-2.2
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	6.7	0.6	2.1	-1.8	2.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.8	-0.7	-1.4	1.2	-1.2
Blood clot in the leg (DVT)	0.3	0.4	0.6	0.7	-0.7	0.8	0.0
Medication: Paracetamol	1.2	2.0	2.5	-1.2	-1.4	1.6	-1.4
Headache pain in last month	1.6	2.7	5.6	-2.4	-1.3	1.1	-1.5
Medication for cholesterol, blood pressure or diabetes	3.1	5.1	7.2	1.8	2.7	-2.2	2.2
Glaucoma (self-reported)	0.3	0.4	1.2	0.6	-0.3	1.1	0.1
Gout (self-reported)	1.0	1.4	2.3	-0.6	-1.2	1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.5	-0.5	1.9	-1.7	1.1
Medication: Amlodipine	1.5	2.1	3.1	-1.6	-1.2	1.2	-1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.7	1.6	-1.4	1.0	-0.5
Birth weight	1.8	4.0	5.8	1.9	2.4	-1.0	2.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.9	-2.0	-0.8	-0.4	-0.4
High blood pressure (siblings)	0.9	1.3	4.2	-2.0	-0.6	0.5	0.8
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	-0.0	1.1	-0.7	0.6
Body fat percentage	0.2	0.8	1.5	-0.8	-1.0	0.2	-1.2
Leg fat percentage (right)	0.5	1.7	2.4	-1.5	-1.3	0.5	-1.6
Arm fat-free mass (right)	0.1	0.3	1.0	-1.0	0.0	-0.3	-0.4
Exposure to tobacco smoke outside home	4.0	5.3	6.9	-2.5	-2.6	2.0	-2.0
Comparative body size at age 10	0.2	0.5	1.4	1.2	0.3	0.7	-0.2
Number of full brothers	1.0	1.3	3.5	-1.9	-0.1	-1.0	-0.9
Worry too long after embarrassment	0.5	0.8	1.8	-0.0	-1.4	0.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.7	1.2	0.8	-1.0	1.3
Wheeze or whistling in the chest in last year	0.9	1.6	3.3	-0.1	-1.8	1.3	-1.0
Number of children fathered	0.9	1.0	3.5	-1.9	-0.3	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.2	0.2	-0.7	0.3
Age at first live birth	0.5	0.9	3.0	1.7	0.2	0.4	-0.5
Pulse wave peak to peak time	0.4	0.5	1.3	0.4	0.7	-1.1	0.2
Health satisfaction	0.3	0.4	1.0	-1.0	-0.7	0.1	-0.6
Shortness of breath walking on level ground	3.7	4.4	6.4	-2.2	-2.5	1.8	-1.8
Qualifications: College or University degree	0.5	1.7	3.1	0.8	1.3	-1.1	1.8
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.8	-0.3	0.1	0.1
Mouth/teeth dental problems: Loose teeth	4.6	5.4	8.8	-1.0	-2.7	3.0	-2.1
Emphysema/chronic bronchitis	0.5	0.6	1.5	-1.2	0.5	-0.6	0.6
Medication for pain relief, constipation, heartburn	1.7	2.8	4.3	1.4	1.8	-1.4	2.1
Neck or shoulder pain in last month	2.6	3.7	4.5	-1.1	-2.1	2.1	-2.1
Medication: Blood pressure	2.3	4.1	6.6	-2.2	-1.9	1.0	-2.6
Angina (self-reported)	2.0	2.6	8.3	-2.9	-0.8	0.6	-1.1
Migraine (self-reported)	0.2	0.2	0.4	0.2	-0.6	0.6	-0.4
Medication: Ibuprofen	0.4	0.5	0.8	0.8	0.9	-0.8	0.3
Medication: Allopurinol	1.3	1.8	2.4	-0.6	-1.4	1.5	-1.5
Medication: Omeprazole	0.2	0.2	0.5	0.1	-0.7	0.3	-0.6
Medication: Seretide 50 evohaler	0.7	0.8	1.1	-0.7	0.9	-1.0	0.9
Mean time to correctly identify matches	0.9	1.7	3.0	0.6	-1.1	1.5	-1.7
Heart disease (mother)	0.8	0.9	1.8	-0.3	-1.2	0.5	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	-1.1	-0.2	0.1	-0.5
Whole body fat mass	0.2	0.8	1.5	-1.2	-0.6	0.0	-1.1
Leg fat mass (right)	0.4	1.6	3.5	-1.9	-0.9	0.4	-1.4
Arm predicted mass (right)	0.0	0.2	0.5	-0.7	0.0	-0.2	-0.3
Pulse rate, automated reading	1.4	4.7	7.5	-1.9	-2.2	1.6	-2.7
Alcohol intake frequency.	0.1	0.2	0.6	0.7	0.1	0.5	-0.0
Comparative height size at age 10	0.0	0.3	1.0	1.0	0.3	-0.2	-0.0
Number of full sisters	1.4	1.7	3.2	0.3	-1.8	1.0	-1.6
Suffer from ‘nerves’	3.6	5.7	10.4	-0.9	-3.2	2.5	-2.3
Overall health rating	2.6	5.6	8.5	-2.0	-2.9	2.5	-1.9
Chest pain or discomfort	2.1	3.0	5.8	-1.4	-2.4	1.4	-1.5
Had major operations	4.1	4.7	7.8	-0.6	2.3	-2.8	2.3
Age at last live birth	0.4	0.6	1.5	-0.8	-0.4	0.5	-1.2
Family relationship satisfaction	3.2	3.9	5.3	-2.2	-2.3	1.4	-1.9
Leg pain on walking	2.3	2.9	7.0	-0.8	-1.8	0.9	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.7	-1.6	-0.2	0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	-1.0	-1.0	0.6	-0.5
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	6.0	2.2	2.4	-1.7	2.1
Medication: Aspirin	1.9	2.5	3.6	-1.6	-1.7	1.2	-1.9
Supplements: Vitamin C	0.1	0.2	0.4	0.6	-0.2	-0.0	0.5
Knee pain experienced in last month	0.1	0.2	0.5	0.2	-0.7	0.3	-0.2
Hypertension (Self-reported)	3.3	9.1	10.9	-3.0	-3.3	2.8	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	-0.8	0.0	-0.4	0.4
Illnesses of father: Heart disease	2.7	3.8	6.6	-0.5	-2.4	2.6	-1.5
Illnesses of siblings: Diabetes	0.4	0.5	1.9	1.4	0.4	0.2	0.1
Smoking status: Previous	0.6	0.8	2.3	-1.5	-0.8	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.8	-0.8	-0.5	0.3	-0.9
Whole body fat-free mass	0.0	0.2	0.6	-0.8	0.4	-0.3	0.0
Leg fat-free mass (right)	0.0	0.1	0.6	-0.8	0.1	0.1	-0.1
Arm fat percentage (left)	0.2	0.9	1.4	-0.8	-1.1	0.7	-1.2
Average weekly red wine intake	0.3	0.5	1.3	-0.1	1.2	-0.7	0.2
Handedness (chirality/laterality): Left-handed	1.6	2.0	2.9	-1.7	-1.2	0.7	-1.7
Mood swings	2.3	4.1	7.7	0.6	-2.8	2.6	-1.4
Loneliness, isolation	0.2	0.2	0.4	0.6	-0.7	-0.1	-0.3
Long-standing illness, disability or infirmity	2.4	3.7	5.9	0.9	1.9	-2.2	2.4
Ever had bowel cancer screening	2.5	3.0	5.5	2.4	1.4	-0.8	1.9
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.4	-0.9	1.8	-1.6	1.6
Friendships satisfaction	0.1	0.1	0.3	-0.5	0.2	-0.5	0.3
Qualifications: nursing, teaching	0.5	0.7	1.4	1.2	0.6	-0.8	0.7
Commuting to job workplace: Walk	0.2	0.3	0.7	-0.5	0.0	0.4	0.8
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-1.2	-0.5	-0.0	-1.0
Medication for cholesterol	0.4	0.6	2.2	1.5	-0.3	0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	-0.1	-0.2	-0.0	-0.7
Back pain experienced in last month	0.2	0.4	0.7	0.8	-0.0	-0.2	0.8
Mineral and other dietary supplements	1.5	2.1	5.0	0.1	1.7	-2.2	0.6
Breast cancer (self-reported)	4.6	5.5	8.4	-1.1	-2.8	2.2	-2.9
Asthma (self-reported)	0.9	1.8	3.5	0.7	-1.9	1.7	-0.5
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.0	-0.6	1.0	0.8
Osteoarthritis (self-reported)	1.1	1.5	4.0	-2.0	-1.0	-0.0	-0.9
Medication: Aspirin	2.1	2.7	4.1	-1.8	-1.6	1.0	-2.0
Medication: Gliclazide	1.8	2.1	4.5	0.3	1.6	-2.1	1.1
Illnesses of father: None of the above (group 1)	3.7	4.6	8.1	0.8	2.7	-2.8	1.5
Smoking status: Current	0.5	0.8	1.2	-0.6	-1.1	0.8	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.4	0.1	-0.3	0.2
Whole body water mass	0.0	0.2	0.6	-0.8	0.3	-0.2	-0.0
Leg predicted mass (right)	0.0	0.1	0.6	-0.7	0.1	0.1	-0.2
Arm fat mass (left)	0.3	1.1	1.5	-1.2	-1.0	0.7	-1.2
Number of self-reported non-cancer illnesses	2.4	4.1	7.5	-0.9	-2.7	2.2	-1.8
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-1.2	0.1	0.1	0.4
Miserableness	2.8	4.9	10.2	-0.5	-2.7	3.2	-1.3
Guilty feelings	0.9	1.3	3.2	0.7	-1.2	1.8	0.1
Wears glasses or contact lenses	0.6	0.7	2.5	1.6	0.4	0.2	0.0
Ever taken oral contraceptive pill	1.7	1.9	4.1	-0.1	1.5	-2.0	1.1
Hearing aid user	0.8	0.9	2.2	0.1	-0.9	0.7	-1.5
Mother’s age at death	1.4	1.8	3.6	-0.3	1.5	-1.9	1.1
Financial situation satisfaction	1.6	2.0	3.3	-0.5	-1.8	1.3	-1.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.9	0.3	-0.5	-0.4
Commuting to job workplace: Public transport	3.6	4.4	6.1	1.2	2.4	-2.5	2.0
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.5	-0.5	0.8	-0.6
Medication: Blood pressure	0.8	1.5	2.6	-1.0	-1.0	1.3	-1.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.2	-0.2	0.9	0.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.5	0.7	-1.3	2.1	-0.7
High cholesterol (Self-reported)	4.2	7.5	12.7	-0.8	-3.2	3.6	-2.5
Medication: Bendroflumethiazide	2.5	3.8	6.8	-1.6	-1.8	1.6	-2.6
Medication: Paracetamol	0.9	1.3	3.4	-1.8	-0.8	0.7	-0.9
Medication: Lisinopril	3.1	4.0	5.3	-1.0	-2.3	2.2	-2.2
Medication: Atorvastatin	0.0	0.0	0.1	0.2	0.1	0.2	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.5
Alcohol drinker status: Never	0.5	0.6	1.0	-0.6	0.8	-0.5	1.0
Ever smoked	0.9	1.5	2.2	-1.3	-1.5	1.1	-1.0
Basal metabolic rate	0.1	0.3	1.3	-1.1	0.1	-0.2	-0.2
Leg fat percentage (left)	0.4	1.4	2.1	-1.2	-1.3	0.5	-1.5
Arm fat-free mass (left)	0.1	0.4	1.3	-1.1	-0.2	-0.0	-0.4
Number of operations (self-reported)	1.8	2.7	4.8	0.6	1.6	-2.2	1.8
Average weekly beer plus cider intake	0.1	0.2	0.3	0.2	-0.5	0.5	-0.3
Irritability	0.3	0.5	1.1	1.1	-0.7	0.2	0.7
Risk taking	0.3	0.4	1.0	-1.0	0.0	-0.8	0.1
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.5	-0.2	1.3	-1.6	0.8
Fractured/broken bones in last 5 years	0.3	0.3	1.2	1.1	-0.3	0.1	-0.2
Age started oral contraceptive pill	2.3	2.9	4.9	1.7	1.8	-2.2	0.7
Diastolic blood pressure, automated reading	4.1	12.7	16.5	-2.7	-4.1	3.9	-3.4
Ever depressed for a whole week	1.0	1.2	2.2	0.2	-1.4	0.7	-1.5
Unable to work because of sickness or disability	0.3	0.3	1.0	-0.2	0.1	-0.6	1.0
Commuting to job workplace: Cycle	3.0	3.6	6.2	0.8	2.5	-2.0	1.9
Myopia	1.0	1.4	3.0	0.5	-1.3	1.7	-0.9
Vascular/heart problems diagnosed by doctor	5.2	14.2	16.7	4.1	3.9	-3.4	3.6
Cholesterol lowering medication	0.1	0.1	0.3	0.0	0.2	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.6	-0.7	0.4	-1.0
Pain experienced in last month	1.6	2.6	4.0	0.4	2.0	-1.5	2.0
Supplements: Calcium	1.6	1.7	3.1	1.3	-1.4	1.8	-0.4
Basal cell carcinoma (self-reported)	3.3	3.9	5.7	1.3	2.4	-1.9	2.1
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.4	-1.9	-1.3	1.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.5	-0.8	0.9	-0.3
Heart disease (siblings)	0.9	1.1	2.2	-0.1	-1.5	1.5	-0.2
Alcohol drinker status: Previous	0.8	1.0	2.4	1.5	0.8	-0.4	0.8
Pack years of smoking	0.5	0.8	1.6	-0.1	-1.3	0.9	-0.8
Impedance of whole body	0.8	3.8	5.5	2.2	1.9	-2.3	1.2
Leg fat mass (left)	0.3	1.2	2.9	-1.7	-0.7	0.2	-1.2
Arm predicted mass (left)	0.2	1.0	3.0	-1.7	-0.5	0.2	-0.8