Hub : Genes

KLHDC10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0740 0.0320 0.00430 -0.003 NA 0.005 NA -0.002 8.3e-01 NA 1.1e-01 NA 5.4e-01
2 GTEx Thyroid 0.1040 0.0410 0.00730 -0.001 NA -0.003 NA 0.001 3.6e-01 NA 8.2e-01 NA 2.4e-01
3 YFS Blood 0.2886 0.0324 0.00000 0.335 0.315 0.346 0.346 0.347 5.6e-114 6.5e-106 1.4e-118 7.6e-119 3.4e-119
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0551 0.0262 0.00013 0.052 0.044 0.028 NA 0.044 1.5e-06 9.3e-06 3.8e-04 NA 8.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 4.2 6.6 10.5 -1.6 -3.1 3.2 -2.0
Bipolar Disorder or Schizophrenia 5.2 12.6 20.4 -2.0 -4.2 4.5 -3.0
Depressed Affect (Nagel 2018) 2.0 4.2 7.4 0.6 -2.7 2.3 -1.9
Depression (Nagel 2018) 1.2 1.7 3.5 -0.9 -1.9 1.2 -1.1
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.8 -0.1 1.6 -1.7 1.0
Neuroticism (Nagel 2018) 1.4 3.2 5.8 0.8 -2.4 2.1 -1.5
Schizophrenia (2018) 3.0 6.3 10.3 -1.3 -2.9 3.2 -2.2
Schizophrenia vs Biploar Disorder 1.6 2.0 3.7 1.4 1.6 -1.9 0.2
Worry (Nagel 2018) 1.4 3.1 5.2 1.1 -2.3 1.8 -1.6
Alzheimer’s Disease (in mother) 1.7 1.9 4.1 2.0 0.6 0.4 1.8
Alzheimer’s Disease (in father) 0.7 0.8 2.9 1.7 -0.3 -0.1 0.3
Alzheimer’s Disease (including proxy) 1.1 1.6 3.9 2.0 0.4 0.3 1.5
Crohns Disease (2017) 0.0 0.1 0.1 -0.3 -0.2 0.1 -0.3
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.0 -0.2 -0.2 -0.5
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.3 -0.3 -0.3 -0.2
Major Depression (MDD) 0.2 0.2 0.4 -0.6 0.6 -0.1 0.5
Reaction Time 1.8 3.4 5.4 -0.5 -1.7 2.2 -2.3
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.3 1.2 0.6 -0.7 0.6
Breast Cancer 0.5 1.1 3.0 -0.6 1.0 -1.7 -0.2
Ovarian Cancer 0.4 0.6 0.8 0.8 -0.9 0.8 -0.2
Prostate Cancer 1.7 2.4 4.4 1.6 1.3 -1.0 2.1
Age at First Birth 0.2 0.2 0.5 0.7 0.5 -0.3 0.1
Bipolar Disorder (2011) 1.8 1.8 6.2 -0.9 0.0 2.5 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 -0.3 0.8 0.0 0.5
Coronary Artery Disease (CAD) 4.6 5.5 13.8 0.3 -2.9 3.7 0.0
Crohns Disease (2012) 0.6 1.0 1.5 0.8 -1.2 0.9 -0.9
Mean Putamen Volume 1.4 1.6 2.1 1.4 1.2 -1.0 1.4
Fasting Glucose 1.1 1.3 1.6 -1.1 1.2 -1.1 1.3
HbA1C 0.4 0.4 0.7 0.5 -0.8 0.8 -0.2
HDL Cholesterol 0.8 1.4 2.9 0.3 1.2 -1.7 1.1
LDL Cholesterol 0.3 0.5 1.1 0.7 -0.8 1.0 -0.1
Lupus 2.4 3.7 6.0 -0.9 -2.4 2.3 -1.6
Neuroticism (2016) 0.5 0.7 1.1 1.1 -0.3 0.8 0.9
Primary Biliary Cirrhosis 0.8 1.1 2.7 -1.6 -1.0 0.3 -0.8
Rheumatoid Arthritis 0.0 0.0 0.1 -0.1 -0.2 -0.3 0.1
Schizophrenia (2014) 1.3 2.9 5.7 -1.4 -1.9 2.4 -0.8
Triglycerides 0.3 0.4 0.8 -0.9 -0.4 0.7 -0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.2 -1.5 1.0 -0.7 0.4
Ulcerative Colitis 0.2 0.3 0.5 0.7 0.3 -0.7 0.1
Blood Eosinophil Count 0.9 6.9 11.8 3.4 2.0 -2.7 2.1
Blood Platelet Count 1.8 20.8 33.9 3.7 4.4 -5.8 4.0
Blood Red Count 0.4 3.6 4.2 -2.1 -1.9 2.0 -1.4
Blood White Count 0.3 1.9 4.8 -0.3 1.4 -2.2 0.9
Heel T-Score 2.3 18.2 31.1 2.1 4.7 -5.6 3.8
BMI 0.7 4.2 6.3 -2.5 -1.8 1.9 -2.0
Height 0.9 17.3 31.9 1.5 5.1 -5.7 3.0
Waist Hip Ratio (WHR) 0.8 3.5 13.2 3.6 0.2 -0.6 0.4
Systolic Blood Pressure 1.9 9.3 12.1 -2.1 -3.0 3.5 -3.5
Smoking Status 1.7 4.1 5.9 -1.7 -2.4 2.1 -1.8
Allergy or Eczema 0.1 0.3 0.4 0.5 -0.6 0.4 -0.6
Cardiovascular Disease 6.8 22.5 24.2 -4.7 -4.9 4.7 -4.7
Hypothyroidism (self reported) 0.8 1.8 3.5 0.6 1.9 -1.4 1.2
Respiratory disease 0.2 0.4 1.0 0.1 -1.0 0.7 -0.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.8 -0.8 0.7 -0.9 1.3
Lung FEV1/FVC ratio 0.5 2.5 7.1 2.7 0.5 -1.6 -0.4
Lung FVC 0.1 0.4 1.2 0.6 -0.3 1.1 0.1
Neuroticism 1.1 2.5 4.1 0.8 -2.0 1.6 -1.7
Chronotype (morning person) 0.0 0.0 0.1 0.2 -0.1 0.3 -0.2
Hair Pigment 0.0 0.3 0.7 -0.8 0.2 -0.3 0.4
Tanning 0.1 0.9 2.8 -1.7 -0.5 -0.4 -0.7
Hand grip strength (left) 1.2 3.2 5.9 0.3 2.0 -1.7 2.4
Number of treatments/medications taken 0.8 1.5 2.1 -1.1 -1.4 0.9 -1.4
Average weekly spirits intake 0.9 1.1 2.7 -1.6 0.9 -0.6 0.7
Sensitivity / hurt feelings 0.5 0.9 1.7 -1.3 -0.8 0.6 -1.0
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.1 0.6 -0.0 -0.8 1.0
Hearing difficulty/problems: Yes 1.4 2.1 3.3 0.8 -1.8 1.2 -1.8
Relative age of first facial hair 0.7 1.4 3.4 -0.5 1.3 -1.8 0.3
Other serious medical condition/disability diagnosed by doctor 3.2 4.1 8.2 -0.1 1.9 -2.1 2.9
Ever used hormone-replacement therapy (HRT) 1.8 2.3 5.4 0.4 1.5 -2.3 1.1
Ever had hysterectomy (womb removed) 1.0 1.2 3.7 -1.9 -0.9 0.3 -0.3
Systolic blood pressure, automated reading 1.5 4.3 6.1 -1.5 -2.1 2.0 -2.5
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.1 0.6 1.4 -1.4 1.1
Angina 2.0 2.7 8.6 -2.9 -0.8 0.6 -1.0
Medication for hormone replacement therapy 2.8 3.1 5.3 0.8 1.9 -1.8 2.3
Vitamin and mineral supplements 0.3 0.4 0.6 -0.8 0.0 -0.7 -0.6
Supplements: Zinc 0.6 0.7 1.3 -1.2 -0.7 -0.0 -1.0
Medication: Co-codamol 4.9 5.7 8.9 -0.1 -3.0 2.9 -2.3
Medication: Metformin 0.1 0.2 0.3 0.5 0.3 0.1 0.5
Diabetes (father) 0.6 0.7 2.7 -1.6 -0.2 -0.1 -0.1
Diabetes (mother) 0.2 0.3 0.6 -0.7 -0.8 0.2 -0.4
Severe depression (siblings) 0.7 0.8 2.2 -1.5 -0.6 0.8 -0.3
Pack years adult smoking proportion 0.7 1.1 2.1 -0.4 -1.4 1.1 -0.9
Impedance of leg (right) 0.6 3.0 7.2 0.6 1.9 -2.7 0.9
Leg fat-free mass (left) 0.1 0.3 1.3 -1.1 0.1 0.1 -0.3
Trunk fat percentage 0.1 0.5 1.0 -0.4 -0.8 0.0 -1.0
Hand grip strength (right) 1.1 2.9 4.7 1.8 1.6 -1.1 2.2
Townsend deprivation index at recruitment 0.8 1.1 1.7 -0.8 -1.3 1.0 -1.1
Current tobacco smoking 0.6 1.0 1.5 -0.6 -1.2 0.9 -1.2
Average weekly fortified wine intake 0.5 0.5 0.7 0.3 -0.8 0.8 -0.8
Maternal smoking around birth 1.0 1.5 5.5 -2.3 0.3 -0.2 0.5
Fed-up feelings 1.7 3.0 6.0 0.5 -2.4 1.8 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.4 -1.5 -1.1 0.3 -0.1
Relative age voice broke 1.2 1.8 3.9 0.3 1.8 -2.0 -0.1
Taking other prescription medications 0.2 0.3 0.6 -0.8 0.1 -0.6 0.4
Age when periods started (menarche) 2.6 6.3 11.2 -1.5 2.9 -3.3 1.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.3 0.0 0.5 -0.4 1.1
Heel bone mineral density (BMD) T-score, automated (left) 3.0 6.8 14.1 1.1 3.0 -3.8 1.7
Tinnitus: Yes, but not now, but have in the past 5.4 5.7 7.3 -1.9 -2.7 2.4 -2.5
Qualifications: CSEs or equivalent 0.9 1.2 4.3 -2.1 -0.5 0.2 -0.5
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.2 0.1 0.1 -0.2
High blood pressure 4.4 12.3 15.8 -3.3 -4.0 3.3 -3.4
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.1 0.6 -1.0 0.9 -0.7
Multivitamins +/- minerals 0.2 0.2 0.7 0.2 -0.2 0.9 0.3
Stomach or abdominal pain in last month 1.8 2.3 2.8 -1.7 -1.5 1.3 -1.5
Supplements: Glucosamine 0.0 0.0 0.1 -0.4 -0.2 -0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.2 0.2 -0.6 -0.4
Medication: Atenolol 0.1 0.1 0.1 0.4 0.3 -0.2 0.3
Medication: Levothyroxine sodium 1.2 2.1 3.7 -0.5 1.9 -1.9 0.9
Sitting height 0.2 1.2 3.5 0.2 1.0 -1.9 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 1.9 -0.5 -1.4 1.2 -0.8
High blood pressure (mother) 1.8 2.5 4.3 -1.8 -1.1 1.1 -2.1
Body mass index (BMI) 1.0 4.2 5.2 -1.9 -2.3 2.0 -1.9
Impedance of leg (left) 0.8 3.8 8.2 1.2 2.0 -2.9 1.1
Leg predicted mass (left) 0.1 0.3 1.1 -1.0 0.0 0.1 -0.3
Trunk fat mass 0.1 0.4 0.9 -0.7 -0.6 -0.1 -1.0
Waist circumference 0.1 0.5 0.8 -0.2 -0.9 0.5 -0.8
Number of incorrect matches in round 0.6 1.0 2.3 -0.4 -1.0 1.5 -0.8
Past tobacco smoking 0.9 1.6 2.6 1.6 1.4 -1.3 0.5
Alcohol usually taken with meals 2.9 4.8 8.6 1.4 2.9 -2.0 2.1
Nervous feelings 0.9 1.6 2.8 -0.1 -1.6 1.0 -1.7
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.2 -0.1 -1.8 1.6 -0.7
Hearing difficulty/problems with background noise 0.2 0.3 0.4 -0.5 -0.7 0.0 -0.7
Hair/balding pattern: Pattern 2 1.8 2.3 4.6 2.1 1.5 -1.2 0.8
Had menopause 0.7 0.9 2.1 1.4 0.8 -0.8 0.3
Had other major operations 0.1 0.2 0.3 0.6 -0.5 0.2 -0.4
Forced vital capacity (FVC) 0.4 1.7 2.2 1.4 1.5 -1.2 1.0
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 12.0 1.4 2.7 -3.5 1.6
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.5 -1.1 -1.6 1.0 -2.1
Qualifications: None of the above 2.7 5.8 8.2 0.6 -2.7 2.7 -2.9
Financial difficulties in last 2 years 2.8 3.8 6.3 -1.4 -2.5 1.8 -1.9
Mouth/teeth dental problems 1.8 2.7 4.9 0.3 2.2 -1.5 1.9
Heart attack 2.1 2.7 3.4 -1.8 -1.5 1.4 -1.8
Allergy 0.7 1.7 3.1 -0.5 1.7 -1.8 0.6
Pain all over the body in last month 0.5 0.5 0.7 -0.8 -0.8 0.6 -0.6
Diabetes (self-reported) 0.3 0.4 1.7 -1.3 -0.2 -0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.1 -0.6 -1.5 0.6 -1.3
Medication: Ramipril 1.3 1.6 2.8 -1.7 -0.9 0.2 -1.7
Medication: Simvastatin 2.2 3.3 6.1 -0.5 -2.2 2.5 -1.4
Fluid intelligence score 0.6 1.3 3.1 1.7 0.8 -1.1 0.4
Illnesses of siblings 0.5 0.8 1.2 1.0 0.5 -0.8 -1.1
Neuroticism score 1.8 3.8 7.0 0.5 -2.6 2.3 -1.7
Weight 0.1 0.7 1.9 -1.4 -0.6 0.2 -0.8
Impedance of arm (right) 1.0 4.8 5.6 2.3 2.3 -2.4 1.7
Arm fat percentage (right) 0.3 1.3 2.0 -1.4 -1.1 0.7 -1.2
Trunk fat-free mass 0.0 0.2 0.5 -0.7 0.5 -0.4 -0.0
Hip circumference 0.0 0.2 0.4 -0.6 -0.5 0.3 -0.3
Time employed in main current job 0.4 0.5 0.8 0.6 0.9 -0.5 0.8
Alcohol intake versus 10 years previously 0.0 0.1 0.1 -0.3 -0.3 0.3 -0.2
Father’s age at death 0.6 0.8 1.9 1.4 0.8 -0.6 -0.6
Worrier / anxious feelings 0.7 1.3 2.3 1.0 -1.5 1.2 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.7 5.0 -0.1 -2.2 1.8 -1.6
Falls in the last year 0.1 0.2 0.4 0.0 -0.5 0.7 0.3
Hair/balding pattern: Pattern 3 1.3 1.9 2.3 -1.1 -1.5 1.4 -1.4
Number of live births 0.1 0.2 0.5 -0.7 -0.2 -0.1 -0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 2.3 1.2 1.5 -1.4 0.6
Pulse rate 0.8 1.3 2.5 -0.4 -1.3 1.6 -0.9
Happiness 0.9 1.0 2.0 -1.2 -0.8 -0.5 -1.4
Noisy workplace 2.9 3.5 6.6 -1.2 -2.1 1.3 -2.6
Qualifications: A levels/AS levels or equivalent 3.0 6.6 7.9 2.1 2.8 -2.6 2.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.8 -0.6 0.1 -0.2
Mouth/teeth dental problems: Dentures 0.3 0.6 1.2 -1.1 -0.3 -0.9 -0.3
Asthma 0.8 1.5 2.9 0.7 -1.7 1.6 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 0.8 0.7 -0.5 0.3
Medication: Cholesterol lowering 1.8 2.9 4.6 -0.5 -2.1 2.0 -1.6
Depression (self-reported) 1.1 1.3 1.7 -1.3 -1.2 1.0 -1.0
Medication: Lansoprazole 1.4 1.6 2.4 -1.5 1.2 -1.1 1.0
Prospective memory result 3.8 4.6 7.7 -1.8 -2.0 1.9 -2.8
Lung cancer (father) 0.4 0.5 1.6 -1.3 -0.0 -0.6 0.2
Illnesses of mother 0.7 0.8 1.8 1.3 0.6 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 0.2 1.0 -0.7 0.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.1 -0.4 -0.7 1.1 -0.2
Impedance of arm (left) 1.3 5.8 8.4 2.9 2.4 -2.5 1.7
Arm fat mass (right) 0.2 1.0 2.3 -1.5 -0.8 0.5 -0.9
Trunk predicted mass 0.0 0.2 0.6 -0.7 0.4 -0.3 -0.0
Standing height 0.8 7.8 13.3 1.1 3.5 -3.6 2.1
Length of working week for main job 0.7 0.8 1.0 0.9 1.0 -0.5 1.0
Exposure to tobacco smoke at home 2.6 2.9 5.6 0.1 -2.4 1.4 -2.0
Breastfed as a baby 0.3 0.3 0.5 -0.5 0.5 -0.7 0.7
Tense / ‘highly strung’ 0.3 0.6 2.1 1.4 -0.4 0.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 0.6 0.4 -0.8 -0.2
Hair/balding pattern: Pattern 4 0.4 0.9 1.3 -0.8 1.1 -1.1 0.6
Birth weight of first child 2.4 4.3 7.7 0.7 2.3 -2.8 1.9
Peak expiratory flow (PEF) 0.3 0.7 1.1 0.8 1.1 -0.9 0.4
Pulse wave reflection index 0.2 0.2 0.4 0.2 0.5 0.0 0.7
Ever highly irritable/argumentative for 2 days 0.5 0.5 1.1 -0.6 0.1 -0.8 -1.1
Loud music exposure frequency 2.9 3.1 4.8 -1.6 -1.7 1.5 -2.2
Qualifications: O levels/GCSEs or equivalent 2.3 3.7 6.7 0.6 2.1 -1.8 2.6
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 1.8 -0.7 -1.4 1.2 -1.2
Blood clot in the leg (DVT) 0.3 0.4 0.6 0.7 -0.7 0.8 0.0
Medication: Paracetamol 1.2 2.0 2.5 -1.2 -1.4 1.6 -1.4
Headache pain in last month 1.6 2.7 5.6 -2.4 -1.3 1.1 -1.5
Medication for cholesterol, blood pressure or diabetes 3.1 5.1 7.2 1.8 2.7 -2.2 2.2
Glaucoma (self-reported) 0.3 0.4 1.2 0.6 -0.3 1.1 0.1
Gout (self-reported) 1.0 1.4 2.3 -0.6 -1.2 1.5 -1.2
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.5 -0.5 1.9 -1.7 1.1
Medication: Amlodipine 1.5 2.1 3.1 -1.6 -1.2 1.2 -1.8
Medication: Ventolin 100micrograms inhaler 1.2 1.5 2.7 1.6 -1.4 1.0 -0.5
Birth weight 1.8 4.0 5.8 1.9 2.4 -1.0 2.3
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.9 -2.0 -0.8 -0.4 -0.4
High blood pressure (siblings) 0.9 1.3 4.2 -2.0 -0.6 0.5 0.8
Forced vital capacity (FVC), Best measure 0.1 0.5 1.2 -0.0 1.1 -0.7 0.6
Body fat percentage 0.2 0.8 1.5 -0.8 -1.0 0.2 -1.2
Leg fat percentage (right) 0.5 1.7 2.4 -1.5 -1.3 0.5 -1.6
Arm fat-free mass (right) 0.1 0.3 1.0 -1.0 0.0 -0.3 -0.4
Exposure to tobacco smoke outside home 4.0 5.3 6.9 -2.5 -2.6 2.0 -2.0
Comparative body size at age 10 0.2 0.5 1.4 1.2 0.3 0.7 -0.2
Number of full brothers 1.0 1.3 3.5 -1.9 -0.1 -1.0 -0.9
Worry too long after embarrassment 0.5 0.8 1.8 -0.0 -1.4 0.9 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.7 1.2 0.8 -1.0 1.3
Wheeze or whistling in the chest in last year 0.9 1.6 3.3 -0.1 -1.8 1.3 -1.0
Number of children fathered 0.9 1.0 3.5 -1.9 -0.3 -0.1 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 0.2 0.2 -0.7 0.3
Age at first live birth 0.5 0.9 3.0 1.7 0.2 0.4 -0.5
Pulse wave peak to peak time 0.4 0.5 1.3 0.4 0.7 -1.1 0.2
Health satisfaction 0.3 0.4 1.0 -1.0 -0.7 0.1 -0.6
Shortness of breath walking on level ground 3.7 4.4 6.4 -2.2 -2.5 1.8 -1.8
Qualifications: College or University degree 0.5 1.7 3.1 0.8 1.3 -1.1 1.8
Eye problems/disorders: None of the above 0.2 0.2 0.7 0.8 -0.3 0.1 0.1
Mouth/teeth dental problems: Loose teeth 4.6 5.4 8.8 -1.0 -2.7 3.0 -2.1
Emphysema/chronic bronchitis 0.5 0.6 1.5 -1.2 0.5 -0.6 0.6
Medication for pain relief, constipation, heartburn 1.7 2.8 4.3 1.4 1.8 -1.4 2.1
Neck or shoulder pain in last month 2.6 3.7 4.5 -1.1 -2.1 2.1 -2.1
Medication: Blood pressure 2.3 4.1 6.6 -2.2 -1.9 1.0 -2.6
Angina (self-reported) 2.0 2.6 8.3 -2.9 -0.8 0.6 -1.1
Migraine (self-reported) 0.2 0.2 0.4 0.2 -0.6 0.6 -0.4
Medication: Ibuprofen 0.4 0.5 0.8 0.8 0.9 -0.8 0.3
Medication: Allopurinol 1.3 1.8 2.4 -0.6 -1.4 1.5 -1.5
Medication: Omeprazole 0.2 0.2 0.5 0.1 -0.7 0.3 -0.6
Medication: Seretide 50 evohaler 0.7 0.8 1.1 -0.7 0.9 -1.0 0.9
Mean time to correctly identify matches 0.9 1.7 3.0 0.6 -1.1 1.5 -1.7
Heart disease (mother) 0.8 0.9 1.8 -0.3 -1.2 0.5 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.2 -1.1 -0.2 0.1 -0.5
Whole body fat mass 0.2 0.8 1.5 -1.2 -0.6 0.0 -1.1
Leg fat mass (right) 0.4 1.6 3.5 -1.9 -0.9 0.4 -1.4
Arm predicted mass (right) 0.0 0.2 0.5 -0.7 0.0 -0.2 -0.3
Pulse rate, automated reading 1.4 4.7 7.5 -1.9 -2.2 1.6 -2.7
Alcohol intake frequency. 0.1 0.2 0.6 0.7 0.1 0.5 -0.0
Comparative height size at age 10 0.0 0.3 1.0 1.0 0.3 -0.2 -0.0
Number of full sisters 1.4 1.7 3.2 0.3 -1.8 1.0 -1.6
Suffer from ‘nerves’ 3.6 5.7 10.4 -0.9 -3.2 2.5 -2.3
Overall health rating 2.6 5.6 8.5 -2.0 -2.9 2.5 -1.9
Chest pain or discomfort 2.1 3.0 5.8 -1.4 -2.4 1.4 -1.5
Had major operations 4.1 4.7 7.8 -0.6 2.3 -2.8 2.3
Age at last live birth 0.4 0.6 1.5 -0.8 -0.4 0.5 -1.2
Family relationship satisfaction 3.2 3.9 5.3 -2.2 -2.3 1.4 -1.9
Leg pain on walking 2.3 2.9 7.0 -0.8 -1.8 0.9 -2.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.7 -1.6 -0.2 0.7 0.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.0 -1.0 -1.0 0.6 -0.5
Illness, injury, bereavement, stress in last 2 years 3.7 4.5 6.0 2.2 2.4 -1.7 2.1
Medication: Aspirin 1.9 2.5 3.6 -1.6 -1.7 1.2 -1.9
Supplements: Vitamin C 0.1 0.2 0.4 0.6 -0.2 -0.0 0.5
Knee pain experienced in last month 0.1 0.2 0.5 0.2 -0.7 0.3 -0.2
Hypertension (Self-reported) 3.3 9.1 10.9 -3.0 -3.3 2.8 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.7 -0.8 0.0 -0.4 0.4
Illnesses of father: Heart disease 2.7 3.8 6.6 -0.5 -2.4 2.6 -1.5
Illnesses of siblings: Diabetes 0.4 0.5 1.9 1.4 0.4 0.2 0.1
Smoking status: Previous 0.6 0.8 2.3 -1.5 -0.8 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.8 -0.8 -0.5 0.3 -0.9
Whole body fat-free mass 0.0 0.2 0.6 -0.8 0.4 -0.3 0.0
Leg fat-free mass (right) 0.0 0.1 0.6 -0.8 0.1 0.1 -0.1
Arm fat percentage (left) 0.2 0.9 1.4 -0.8 -1.1 0.7 -1.2
Average weekly red wine intake 0.3 0.5 1.3 -0.1 1.2 -0.7 0.2
Handedness (chirality/laterality): Left-handed 1.6 2.0 2.9 -1.7 -1.2 0.7 -1.7
Mood swings 2.3 4.1 7.7 0.6 -2.8 2.6 -1.4
Loneliness, isolation 0.2 0.2 0.4 0.6 -0.7 -0.1 -0.3
Long-standing illness, disability or infirmity 2.4 3.7 5.9 0.9 1.9 -2.2 2.4
Ever had bowel cancer screening 2.5 3.0 5.5 2.4 1.4 -0.8 1.9
Diabetes diagnosed by doctor 0.0 0.0 0.1 -0.2 -0.0 -0.1 0.2
Ever had stillbirth, spontaneous miscarriage or termination 2.2 2.3 3.4 -0.9 1.8 -1.6 1.6
Friendships satisfaction 0.1 0.1 0.3 -0.5 0.2 -0.5 0.3
Qualifications: nursing, teaching 0.5 0.7 1.4 1.2 0.6 -0.8 0.7
Commuting to job workplace: Walk 0.2 0.3 0.7 -0.5 0.0 0.4 0.8
Eye problems/disorders: Cataract 0.0 0.0 0.1 -0.1 -0.1 0.3 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.4 -1.2 -0.5 -0.0 -1.0
Medication for cholesterol 0.4 0.6 2.2 1.5 -0.3 0.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 -0.1 -0.2 -0.0 -0.7
Back pain experienced in last month 0.2 0.4 0.7 0.8 -0.0 -0.2 0.8
Mineral and other dietary supplements 1.5 2.1 5.0 0.1 1.7 -2.2 0.6
Breast cancer (self-reported) 4.6 5.5 8.4 -1.1 -2.8 2.2 -2.9
Asthma (self-reported) 0.9 1.8 3.5 0.7 -1.9 1.7 -0.5
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.0 -0.6 1.0 0.8
Osteoarthritis (self-reported) 1.1 1.5 4.0 -2.0 -1.0 -0.0 -0.9
Medication: Aspirin 2.1 2.7 4.1 -1.8 -1.6 1.0 -2.0
Medication: Gliclazide 1.8 2.1 4.5 0.3 1.6 -2.1 1.1
Illnesses of father: None of the above (group 1) 3.7 4.6 8.1 0.8 2.7 -2.8 1.5
Smoking status: Current 0.5 0.8 1.2 -0.6 -1.1 0.8 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 0.4 0.1 -0.3 0.2
Whole body water mass 0.0 0.2 0.6 -0.8 0.3 -0.2 -0.0
Leg predicted mass (right) 0.0 0.1 0.6 -0.7 0.1 0.1 -0.2
Arm fat mass (left) 0.3 1.1 1.5 -1.2 -1.0 0.7 -1.2
Number of self-reported non-cancer illnesses 2.4 4.1 7.5 -0.9 -2.7 2.2 -1.8
Average weekly champagne plus white wine intake 0.3 0.4 1.5 -1.2 0.1 0.1 0.4
Miserableness 2.8 4.9 10.2 -0.5 -2.7 3.2 -1.3
Guilty feelings 0.9 1.3 3.2 0.7 -1.2 1.8 0.1
Wears glasses or contact lenses 0.6 0.7 2.5 1.6 0.4 0.2 0.0
Ever taken oral contraceptive pill 1.7 1.9 4.1 -0.1 1.5 -2.0 1.1
Hearing aid user 0.8 0.9 2.2 0.1 -0.9 0.7 -1.5
Mother’s age at death 1.4 1.8 3.6 -0.3 1.5 -1.9 1.1
Financial situation satisfaction 1.6 2.0 3.3 -0.5 -1.8 1.3 -1.7
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 -0.9 0.3 -0.5 -0.4
Commuting to job workplace: Public transport 3.6 4.4 6.1 1.2 2.4 -2.5 2.0
Eye problems/disorders: Glaucoma 0.3 0.4 0.6 0.5 -0.5 0.8 -0.6
Medication: Blood pressure 0.8 1.5 2.6 -1.0 -1.0 1.3 -1.6
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 0.2 -0.2 0.9 0.4
Supplements: Fish oil (including cod liver oil) 1.4 1.8 4.5 0.7 -1.3 2.1 -0.7
High cholesterol (Self-reported) 4.2 7.5 12.7 -0.8 -3.2 3.6 -2.5
Medication: Bendroflumethiazide 2.5 3.8 6.8 -1.6 -1.8 1.6 -2.6
Medication: Paracetamol 0.9 1.3 3.4 -1.8 -0.8 0.7 -0.9
Medication: Lisinopril 3.1 4.0 5.3 -1.0 -2.3 2.2 -2.2
Medication: Atorvastatin 0.0 0.0 0.1 0.2 0.1 0.2 0.3
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.4 -0.3 0.2 -0.5
Alcohol drinker status: Never 0.5 0.6 1.0 -0.6 0.8 -0.5 1.0
Ever smoked 0.9 1.5 2.2 -1.3 -1.5 1.1 -1.0
Basal metabolic rate 0.1 0.3 1.3 -1.1 0.1 -0.2 -0.2
Leg fat percentage (left) 0.4 1.4 2.1 -1.2 -1.3 0.5 -1.5
Arm fat-free mass (left) 0.1 0.4 1.3 -1.1 -0.2 -0.0 -0.4
Number of operations (self-reported) 1.8 2.7 4.8 0.6 1.6 -2.2 1.8
Average weekly beer plus cider intake 0.1 0.2 0.3 0.2 -0.5 0.5 -0.3
Irritability 0.3 0.5 1.1 1.1 -0.7 0.2 0.7
Risk taking 0.3 0.4 1.0 -1.0 0.0 -0.8 0.1
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.5 -0.2 1.3 -1.6 0.8
Fractured/broken bones in last 5 years 0.3 0.3 1.2 1.1 -0.3 0.1 -0.2
Age started oral contraceptive pill 2.3 2.9 4.9 1.7 1.8 -2.2 0.7
Diastolic blood pressure, automated reading 4.1 12.7 16.5 -2.7 -4.1 3.9 -3.4
Ever depressed for a whole week 1.0 1.2 2.2 0.2 -1.4 0.7 -1.5
Unable to work because of sickness or disability 0.3 0.3 1.0 -0.2 0.1 -0.6 1.0
Commuting to job workplace: Cycle 3.0 3.6 6.2 0.8 2.5 -2.0 1.9
Myopia 1.0 1.4 3.0 0.5 -1.3 1.7 -0.9
Vascular/heart problems diagnosed by doctor 5.2 14.2 16.7 4.1 3.9 -3.4 3.6
Cholesterol lowering medication 0.1 0.1 0.3 0.0 0.2 0.5 0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 -0.6 -0.7 0.4 -1.0
Pain experienced in last month 1.6 2.6 4.0 0.4 2.0 -1.5 2.0
Supplements: Calcium 1.6 1.7 3.1 1.3 -1.4 1.8 -0.4
Basal cell carcinoma (self-reported) 3.3 3.9 5.7 1.3 2.4 -1.9 2.1
Heart attack/myocardial infarction (self-reported) 1.7 2.2 3.4 -1.9 -1.3 1.2 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 0.5 -0.8 0.9 -0.3
Heart disease (siblings) 0.9 1.1 2.2 -0.1 -1.5 1.5 -0.2
Alcohol drinker status: Previous 0.8 1.0 2.4 1.5 0.8 -0.4 0.8
Pack years of smoking 0.5 0.8 1.6 -0.1 -1.3 0.9 -0.8
Impedance of whole body 0.8 3.8 5.5 2.2 1.9 -2.3 1.2
Leg fat mass (left) 0.3 1.2 2.9 -1.7 -0.7 0.2 -1.2
Arm predicted mass (left) 0.2 1.0 3.0 -1.7 -0.5 0.2 -0.8