[Hub]/) : Traits : Blood Platelet Count :

chr7:149,314,270-150,768,849

Best TWAS P=1.41e-10 · Best GWAS P=8.06e-10 conditioned to 2.78e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRRC61 0.30 0.37 lasso 5 0.38 2.1e-49 5.7 5.8 6.1e-09 -0.04 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex REPIN1 0.23 0.24 lasso 7 0.25 2.7e-30 5.7 5.7 1.3e-08 0.01 0.04 0.96 FALSE
3 GTEx Adipose Subcutaneous LRRC61 0.27 0.25 enet 15 0.25 2.4e-20 5.8 6.1 9.9e-10 -0.03 0.02 0.98 FALSE
4 GTEx Adipose Subcutaneous REPIN1 0.15 0.12 lasso 2 0.10 2.0e-08 5.3 5.2 1.6e-07 0.00 0.30 0.70 FALSE
5 GTEx Adipose Visceral Omentum RARRES2 0.13 0.07 lasso 1 0.05 1.2e-03 6.0 6.0 2.1e-09 -0.03 0.01 0.98 FALSE
6 GTEx Adipose Visceral Omentum LRRC61 0.23 0.23 lasso 5 0.21 5.1e-11 5.7 5.8 8.9e-09 -0.04 0.02 0.98 FALSE
7 GTEx Adipose Visceral Omentum ZBED6CL 0.19 0.11 lasso 1 0.10 9.4e-06 5.7 -5.7 1.1e-08 0.03 0.03 0.97 FALSE
8 GTEx Artery Aorta RARRES2 0.17 0.12 lasso 1 0.10 2.2e-06 5.8 5.8 8.9e-09 -0.03 0.02 0.98 FALSE
9 GTEx Artery Aorta LRRC61 0.29 0.31 lasso 2 0.29 1.3e-16 5.7 5.7 1.1e-08 -0.03 0.02 0.98 FALSE
10 GTEx Artery Tibial LRRC61 0.22 0.19 enet 12 0.21 2.9e-16 5.7 6.0 2.1e-09 -0.03 0.02 0.98 FALSE
11 GTEx Brain Caudate basal ganglia LRRC61 0.43 0.32 enet 12 0.36 3.7e-11 5.8 6.0 1.5e-09 -0.02 0.02 0.98 FALSE
12 GTEx Brain Caudate basal ganglia ZBED6CL 0.26 0.15 lasso 3 0.09 1.4e-03 5.8 -5.5 3.5e-08 0.03 0.02 0.90 FALSE
13 GTEx Brain Cerebellar Hemisphere LRRC61 0.60 0.44 lasso 4 0.48 3.7e-14 5.9 6.0 1.5e-09 -0.03 0.02 0.98 FALSE
14 GTEx Brain Cerebellum LRRC61 0.48 0.38 lasso 7 0.41 2.4e-13 5.7 6.0 2.6e-09 -0.03 0.02 0.98 FALSE
15 GTEx Brain Cortex LRRC61 0.43 0.34 enet 9 0.31 3.4e-09 5.7 6.3 2.1e-10 -0.01 0.02 0.98 FALSE
16 GTEx Brain Cortex ZBED6CL 0.32 0.15 lasso 6 0.09 1.5e-03 5.7 -5.9 4.2e-09 0.03 0.02 0.90 FALSE
17 GTEx Brain Frontal Cortex BA9 LRRC61 0.52 0.43 lasso 7 0.44 6.7e-13 5.9 5.9 2.8e-09 -0.03 0.02 0.98 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia LRRC61 0.47 0.27 lasso 8 0.31 5.0e-09 5.9 6.2 7.9e-10 -0.03 0.02 0.98 FALSE
19 GTEx Brain Putamen basal ganglia LRRC61 0.37 0.35 lasso 1 0.30 6.8e-08 5.9 5.9 3.4e-09 -0.03 0.01 0.98 FALSE
20 GTEx Breast Mammary Tissue LRRC61 0.37 0.36 lasso 6 0.39 2.7e-21 5.9 6.0 1.7e-09 -0.04 0.01 0.99 FALSE
21 GTEx Breast Mammary Tissue ZBED6CL 0.26 0.18 lasso 2 0.16 9.2e-09 5.7 -5.8 8.1e-09 0.03 0.03 0.97 FALSE
22 GTEx Breast Mammary Tissue (Male) LRRC61 0.19 0.20 lasso 4 0.17 8.5e-05 5.9 6.0 1.7e-09 -0.04 0.01 0.92 FALSE
23 GTEx Breast Mammary Tissue (Female) RARRES2 0.04 -0.01 lasso 3 0.06 6.6e-03 5.7 5.6 1.9e-08 -0.01 0.02 0.32 FALSE
24 GTEx Breast Mammary Tissue (Female) LRRC61 0.43 0.30 lasso 3 0.26 1.8e-08 5.9 6.0 2.0e-09 -0.04 0.01 0.99 FALSE
25 GTEx Breast Mammary Tissue (Female) ZBED6CL 0.23 0.18 lasso 2 0.17 8.4e-06 5.7 -5.8 5.0e-09 0.04 0.02 0.80 FALSE
26 GTEx Cells EBV-transformed lymphocytes LRRC61 0.27 0.14 lasso 9 0.13 5.1e-05 5.9 5.2 2.5e-07 -0.03 0.02 0.94 FALSE
27 GTEx Cells Transformed fibroblasts RARRES2 0.08 0.09 lasso 3 0.08 2.2e-06 5.8 5.9 3.1e-09 -0.03 0.01 0.98 FALSE
28 GTEx Cells Transformed fibroblasts LRRC61 0.20 0.19 lasso 5 0.20 1.3e-14 5.7 6.0 2.2e-09 -0.04 0.02 0.98 FALSE
29 GTEx Colon Sigmoid LRRC61 0.21 0.07 lasso 5 0.06 3.1e-03 5.7 6.1 1.1e-09 -0.01 0.02 0.94 FALSE
30 GTEx Colon Sigmoid ZBED6CL 0.26 0.19 lasso 4 0.14 1.7e-05 5.9 -6.0 2.7e-09 0.04 0.01 0.99 FALSE
31 GTEx Colon Transverse LRRC61 0.54 0.36 enet 40 0.40 1.7e-20 5.7 5.9 3.5e-09 -0.05 0.02 0.98 FALSE
32 GTEx Colon Transverse ZBED6CL 0.36 0.28 lasso 4 0.27 2.6e-13 5.8 -5.8 5.7e-09 0.03 0.02 0.98 FALSE
33 GTEx Esophagus Gastroesophageal Junction ZBED6CL 0.31 0.22 enet 12 0.22 2.0e-08 5.8 -5.4 5.7e-08 0.02 0.02 0.98 FALSE
34 GTEx Esophagus Mucosa LRRC61 0.38 0.28 lasso 6 0.30 1.2e-20 5.7 6.0 1.6e-09 -0.03 0.02 0.98 FALSE
35 GTEx Esophagus Mucosa ZBED6CL 0.29 0.25 lasso 7 0.25 7.7e-17 5.8 -5.9 2.8e-09 0.03 0.01 0.99 FALSE
36 GTEx Esophagus Muscularis LRRC61 0.21 0.20 lasso 5 0.22 2.8e-13 5.9 6.1 9.7e-10 -0.03 0.01 0.99 FALSE
37 GTEx Esophagus Muscularis ZBED6CL 0.48 0.27 lasso 12 0.26 5.4e-16 5.7 -5.8 7.9e-09 0.03 0.02 0.98 FALSE
38 GTEx Esophagus Muscularis REPIN1 0.12 0.03 lasso 3 0.04 1.9e-03 4.3 5.2 2.0e-07 0.00 0.04 0.89 FALSE
39 GTEx Heart Atrial Appendage LRRC61 0.32 0.24 lasso 3 0.21 6.5e-10 5.9 6.0 1.8e-09 -0.03 0.01 0.99 FALSE
40 GTEx Heart Atrial Appendage ZBED6CL 0.16 0.03 lasso 2 0.02 4.4e-02 5.8 -5.7 1.4e-08 0.03 0.02 0.82 FALSE
41 GTEx Heart Left Ventricle REPIN1 0.13 0.08 lasso 6 0.05 1.0e-03 5.3 5.3 1.1e-07 0.00 0.13 0.80 FALSE
42 GTEx Liver LRRC61 0.50 0.28 lasso 4 0.34 3.1e-10 5.7 5.8 7.1e-09 -0.03 0.02 0.98 FALSE
43 GTEx Lung LRRC61 0.25 0.18 enet 15 0.22 1.4e-16 5.7 5.8 8.8e-09 -0.04 0.02 0.98 FALSE
44 GTEx Lung ZBED6CL 0.12 0.12 enet 6 0.12 1.7e-09 5.9 -5.9 3.0e-09 0.04 0.02 0.98 FALSE
45 GTEx Muscle Skeletal LRRC61 0.24 0.23 lasso 6 0.24 1.4e-23 5.7 6.0 2.6e-09 -0.04 0.03 0.97 FALSE
46 GTEx Muscle Skeletal REPIN1 0.30 0.33 lasso 4 0.32 2.0e-32 5.3 5.5 4.2e-08 0.00 0.32 0.68 FALSE
47 GTEx Muscle Skeletal RP4-584D14.5 0.12 0.13 lasso 1 0.12 7.5e-12 5.3 5.3 1.4e-07 0.00 0.32 0.68 FALSE
48 GTEx Nerve Tibial RARRES2 0.23 0.18 enet 10 0.19 2.6e-13 6.0 6.1 1.4e-09 -0.03 0.01 0.99 FALSE
49 GTEx Nerve Tibial LRRC61 0.35 0.34 enet 12 0.38 5.1e-28 5.7 5.6 2.4e-08 -0.04 0.04 0.96 FALSE
50 GTEx Ovary LRRC61 0.36 0.30 lasso 6 0.24 1.2e-06 5.9 6.0 2.4e-09 -0.03 0.02 0.97 FALSE
51 GTEx Ovary ZBED6CL 0.29 0.32 lasso 4 0.30 4.6e-08 5.7 -5.8 5.2e-09 0.03 0.02 0.98 FALSE
52 GTEx Pancreas RARRES2 0.21 0.11 enet 27 0.15 8.0e-07 6.0 -5.3 1.1e-07 -0.02 0.01 0.98 FALSE
53 GTEx Pancreas LRRC61 0.28 0.27 lasso 4 0.27 5.8e-12 6.0 6.0 2.6e-09 -0.03 0.01 0.99 FALSE
54 GTEx Pancreas ZBED6CL 0.32 0.26 lasso 6 0.24 1.5e-10 5.7 -5.9 4.1e-09 0.03 0.02 0.98 FALSE
55 GTEx Pituitary LRRC61 0.51 0.17 lasso 9 0.16 7.7e-05 5.3 5.7 1.4e-08 -0.01 0.05 0.94 FALSE
56 GTEx Prostate ZBED6CL 0.45 0.39 lasso 2 0.38 1.7e-10 5.7 -5.7 9.8e-09 0.03 0.02 0.97 FALSE
57 GTEx Skin Not Sun Exposed Suprapubic LRRC61 0.43 0.28 enet 24 0.34 2.6e-19 5.9 6.3 3.1e-10 -0.03 0.01 0.99 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic ZBED6CL 0.12 0.14 lasso 1 0.13 1.8e-07 5.8 -5.8 8.9e-09 0.03 0.03 0.97 FALSE
59 GTEx Skin Sun Exposed Lower leg LRRC61 0.35 0.40 lasso 3 0.37 3.2e-32 5.7 5.8 7.7e-09 -0.04 0.04 0.96 FALSE
60 GTEx Skin Sun Exposed Lower leg ZBED6CL 0.12 0.12 lasso 1 0.12 6.1e-10 5.7 -5.7 1.1e-08 0.03 0.03 0.97 FALSE
61 GTEx Small Intestine Terminal Ileum LRRC61 0.40 0.36 lasso 7 0.36 6.4e-09 6.0 6.4 1.4e-10 -0.03 0.01 0.99 TRUE
62 GTEx Spleen LRRC61 0.51 0.43 enet 10 0.44 1.2e-12 5.7 6.0 2.1e-09 -0.03 0.02 0.98 FALSE
63 GTEx Stomach LRRC61 0.36 0.32 lasso 5 0.34 3.8e-17 5.3 5.9 4.4e-09 0.00 0.08 0.92 FALSE
64 GTEx Stomach ZBED6CL 0.22 0.18 lasso 3 0.16 3.0e-08 6.0 -5.9 4.1e-09 0.03 0.01 0.99 FALSE
65 GTEx Testis LRRC61 0.51 0.58 lasso 3 0.57 3.0e-30 5.9 6.0 2.5e-09 -0.03 0.01 0.99 FALSE
66 GTEx Thyroid LRRC61 0.29 0.25 enet 14 0.28 4.9e-22 6.0 6.1 9.7e-10 -0.03 0.01 0.99 FALSE
67 GTEx Thyroid ZBED6CL 0.26 0.20 lasso 6 0.19 2.0e-14 5.9 -5.9 3.6e-09 0.04 0.02 0.98 FALSE
68 GTEx Vagina LRRC61 0.40 0.23 lasso 8 0.20 2.8e-05 5.8 5.9 3.0e-09 -0.04 0.02 0.96 FALSE
69 GTEx Whole Blood LRRC61 0.16 0.10 lasso 2 0.10 1.2e-09 6.0 6.0 2.4e-09 -0.03 0.01 0.99 FALSE
70 METSIM Adipose LRRC61 0.28 0.28 lasso 2 0.28 1.1e-41 5.8 5.8 8.9e-09 -0.03 0.03 0.97 FALSE
71 METSIM Adipose RARRES2 0.06 0.03 blup 352 0.04 4.2e-06 5.9 5.3 1.1e-07 -0.02 0.01 0.99 FALSE
72 METSIM Adipose REPIN1 0.20 0.17 lasso 14 0.21 2.0e-30 5.3 5.5 3.6e-08 -0.01 0.28 0.72 FALSE
73 METSIM Adipose ZBED6CL 0.22 0.19 lasso 9 0.22 7.3e-32 5.9 -5.5 3.2e-08 0.03 0.02 0.98 FALSE
74 ROSMAP Brain Pre-frontal Cortex LRRC61 0.28 0.31 lasso 6 0.32 6.5e-43 5.8 5.8 7.9e-09 -0.04 0.02 0.98 FALSE
75 ROSMAP Brain Pre-frontal Cortex ZBED6CL 0.18 0.17 enet 11 0.17 9.2e-21 5.9 -6.0 2.1e-09 0.04 0.01 0.99 FALSE
76 ROSMAP Brain Pre-frontal Cortex REPIN1 0.07 0.06 lasso 5 0.05 1.9e-07 5.7 5.8 7.7e-09 0.03 0.04 0.96 FALSE
77 The Cancer Genome Atlas Bladder Urothelial Carcinoma LRRC61 0.08 0.03 blup 31 0.05 8.4e-05 5.9 5.7 1.5e-08 -0.03 0.01 0.98 FALSE
78 The Cancer Genome Atlas Breast Invasive Carcinoma C7orf29 0.15 0.20 lasso 3 0.20 3.4e-39 5.8 -5.8 8.9e-09 0.03 0.02 0.98 FALSE
79 The Cancer Genome Atlas Breast Invasive Carcinoma LRRC61 0.07 0.14 lasso 3 0.14 6.0e-28 6.0 5.9 3.2e-09 -0.03 0.01 0.99 FALSE
80 The Cancer Genome Atlas Breast Invasive Carcinoma RARRES2 0.02 0.04 blup 30 0.04 5.7e-08 6.0 6.2 7.8e-10 -0.02 0.01 0.99 FALSE
81 The Cancer Genome Atlas Breast Invasive Carcinoma REPIN1 0.02 0.01 blup 39 0.02 2.1e-04 5.7 5.4 7.7e-08 0.00 0.02 0.92 FALSE
82 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma LRRC61 0.16 0.14 lasso 3 0.12 1.1e-06 6.0 6.1 1.4e-09 -0.03 0.01 0.99 FALSE
83 The Cancer Genome Atlas Colon Adenocarcinoma C7orf29 0.08 0.12 enet 7 0.11 4.1e-07 5.9 -6.0 1.6e-09 0.03 0.01 0.99 FALSE
84 The Cancer Genome Atlas Colon Adenocarcinoma LRRC61 0.26 0.31 lasso 7 0.31 3.0e-18 5.8 6.0 2.2e-09 -0.03 0.02 0.98 FALSE
85 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C7orf29 0.07 0.07 lasso 3 0.07 4.6e-08 5.8 -5.8 5.8e-09 0.03 0.01 0.99 FALSE
86 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma LRRC61 0.09 0.10 blup 31 0.12 6.7e-14 5.9 5.9 3.6e-09 -0.04 0.01 0.99 FALSE
87 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C7orf29 0.03 0.04 lasso 2 0.04 3.0e-05 5.8 -5.8 6.1e-09 0.03 0.01 0.98 FALSE
88 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LRRC61 0.15 0.25 enet 7 0.25 2.7e-28 5.9 6.0 1.8e-09 -0.03 0.01 0.99 FALSE
89 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RARRES2 0.02 0.03 enet 6 0.03 1.5e-04 5.9 6.1 1.1e-09 -0.03 0.01 0.96 FALSE
90 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma REPIN1 0.04 0.03 blup 38 0.04 4.2e-05 6.0 5.5 4.5e-08 -0.01 0.01 0.99 FALSE
91 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C7orf29 0.09 0.05 blup 26 0.06 2.4e-04 5.7 -6.1 1.1e-09 0.03 0.02 0.93 FALSE
92 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LRRC61 0.14 0.22 enet 10 0.22 6.7e-13 5.8 5.9 3.4e-09 -0.04 0.01 0.99 FALSE
93 The Cancer Genome Atlas Brain Lower Grade Glioma C7orf29 0.05 0.07 lasso 2 0.08 3.0e-09 5.8 -6.1 1.3e-09 0.03 0.01 0.99 FALSE
94 The Cancer Genome Atlas Brain Lower Grade Glioma LRRC61 0.09 0.14 lasso 3 0.13 7.6e-15 5.9 6.0 1.7e-09 -0.02 0.01 0.99 FALSE
95 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C7orf29 0.07 0.11 lasso 1 0.10 3.1e-05 5.9 -5.9 3.1e-09 0.04 0.01 0.97 FALSE
96 The Cancer Genome Atlas Liver Hepatocellular Carcinoma LRRC61 0.18 0.22 lasso 2 0.21 3.7e-10 5.8 5.9 4.6e-09 -0.03 0.01 0.99 FALSE
97 The Cancer Genome Atlas Lung Adenocarcinoma C7orf29 0.10 0.19 lasso 3 0.19 1.6e-21 6.0 -6.0 1.9e-09 0.03 0.01 0.99 FALSE
98 The Cancer Genome Atlas Lung Adenocarcinoma LRRC61 0.07 0.12 blup 31 0.12 5.2e-14 5.8 6.0 1.4e-09 -0.04 0.02 0.98 FALSE
99 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C7orf29 0.05 0.08 blup 26 0.07 9.1e-09 5.9 -5.9 3.0e-09 0.05 0.01 0.99 FALSE
100 The Cancer Genome Atlas Lung Squamous Cell Carcinoma LRRC61 0.03 0.04 enet 7 0.05 2.3e-06 5.9 6.1 1.2e-09 -0.01 0.02 0.98 FALSE
101 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C7orf29 0.06 0.08 lasso 2 0.06 6.1e-05 5.9 -5.9 3.5e-09 0.04 0.01 0.98 FALSE
102 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma LRRC61 0.04 0.04 lasso 4 0.04 1.3e-03 5.8 5.8 5.9e-09 -0.03 0.01 0.92 FALSE
103 The Cancer Genome Atlas Pancreatic Adenocarcinoma C7orf29 0.07 0.09 lasso 4 0.06 1.4e-03 5.8 -5.9 4.7e-09 0.03 0.01 0.96 FALSE
104 The Cancer Genome Atlas Pancreatic Adenocarcinoma LRRC61 0.20 0.16 blup 30 0.20 9.9e-09 5.9 5.5 3.2e-08 -0.02 0.01 0.99 FALSE
105 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C7orf29 0.10 0.09 blup 26 0.08 5.4e-04 4.3 -6.1 1.2e-09 0.01 0.02 0.85 FALSE
106 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LRRC61 0.10 0.10 enet 3 0.08 3.2e-04 5.8 5.9 3.1e-09 -0.03 0.01 0.95 FALSE
107 The Cancer Genome Atlas Prostate Adenocarcinoma C7orf29 0.25 0.43 enet 12 0.45 2.9e-51 5.8 -6.0 1.6e-09 0.03 0.01 0.99 FALSE
108 The Cancer Genome Atlas Prostate Adenocarcinoma LRRC61 0.12 0.19 lasso 3 0.17 1.4e-17 5.9 5.9 3.0e-09 -0.03 0.01 0.99 FALSE
109 The Cancer Genome Atlas Rectum Adenocarcinoma C7orf29 0.27 0.16 enet 4 0.16 1.8e-04 5.8 -5.7 1.6e-08 0.04 0.01 0.82 FALSE
110 The Cancer Genome Atlas Rectum Adenocarcinoma LRRC61 0.30 0.18 blup 31 0.25 1.4e-06 4.5 5.5 4.0e-08 -0.02 0.02 0.95 FALSE
111 The Cancer Genome Atlas Stomach Adenocarcinoma C7orf29 0.11 0.18 enet 8 0.21 2.9e-15 5.9 -6.0 1.5e-09 0.03 0.01 0.99 FALSE
112 The Cancer Genome Atlas Stomach Adenocarcinoma LOC728743 0.06 0.02 enet 12 0.04 3.7e-04 3.2 -5.4 5.7e-08 -0.02 0.04 0.51 FALSE
113 The Cancer Genome Atlas Stomach Adenocarcinoma LRRC61 0.05 0.05 lasso 2 0.07 1.7e-05 5.8 5.8 6.9e-09 -0.01 0.02 0.97 FALSE
114 The Cancer Genome Atlas Testicular Germ Cell Tumors C7orf29 0.06 0.09 lasso 2 0.09 4.0e-04 5.8 -5.8 8.8e-09 0.03 0.01 0.80 FALSE
115 The Cancer Genome Atlas Testicular Germ Cell Tumors LRRC61 0.08 0.06 blup 30 0.11 1.3e-04 5.9 6.0 1.5e-09 -0.02 0.01 0.96 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma C7orf29 0.32 0.45 lasso 3 0.45 3.4e-48 5.8 -5.9 3.5e-09 0.04 0.02 0.98 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma LRRC61 0.24 0.40 lasso 9 0.42 1.5e-43 5.8 6.0 1.7e-09 -0.03 0.01 0.99 FALSE
118 The Cancer Genome Atlas Thyroid Carcinoma REPIN1 0.05 0.04 blup 39 0.06 2.3e-06 6.0 6.0 1.7e-09 -0.02 0.01 0.98 FALSE