Best TWAS P=6.36e-17 · Best GWAS P=9.48e-26 conditioned to 0.248
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Testis | ESYT2 | 0.50 | 0.43 | lasso | 4 | 0.38 | 5.9e-18 | 8.35 | 8.4 | 6.4e-17 | 0.66 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | VIPR2 | 0.12 | 0.01 | lasso | 4 | 0.00 | 2.8e-01 | 1.96 | 6.8 | 1.1e-11 | 0.41 | 0.03 | 0.48 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PTPRN2 | 0.28 | 0.08 | enet | 27 | 0.22 | 3.6e-27 | 2.10 | -5.2 | 2.1e-07 | -0.29 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Thyroid | NCAPG2 | 0.50 | 0.02 | lasso | 9 | 0.01 | 2.8e-02 | 9.52 | 7.3 | 4.0e-13 | 0.67 | 0.08 | 0.09 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | ESYT2 | 0.08 | 0.00 | lasso | 3 | 0.00 | 2.4e-01 | 8.35 | 7.0 | 2.3e-12 | 0.56 | 0.06 | 0.66 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | LINC00689 | 0.08 | 0.01 | bslmm | 327 | 0.03 | 1.3e-04 | -0.69 | 6.4 | 1.8e-10 | 0.59 | 0.06 | 0.70 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | WDR60 | 0.12 | 0.03 | blup | 70 | 0.07 | 7.3e-05 | 2.91 | -5.7 | 1.0e-08 | -0.38 | 0.49 | 0.10 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | ESYT2 | 0.11 | 0.03 | enet | 11 | 0.05 | 7.3e-06 | 7.64 | 5.2 | 1.7e-07 | 0.42 | 0.32 | 0.19 | FALSE |