Best TWAS P=1.9e-12 · Best GWAS P=2.55e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | ZC3HAV1L | 0.16 | 0.12 | enet | 7 | 0.08 | 3.6e-06 | -5.9 | -5.9 | 4.1e-09 | -0.98 | 0.01 | 0.99 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | JHDM1D | 0.14 | 0.07 | bslmm | 490 | 0.12 | 3.6e-15 | 2.5 | -5.4 | 5.6e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | JHDM1D | 0.05 | 0.01 | blup | 58 | 0.01 | 5.9e-04 | -5.1 | -7.0 | 1.9e-12 | -0.01 | 0.01 | 0.04 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZC3HAV1L | 0.03 | 0.03 | enet | 4 | 0.02 | 4.2e-03 | 5.1 | 5.2 | 1.6e-07 | 0.96 | 0.02 | 0.94 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARP12 | 0.02 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | -6.3 | 6.1 | 1.3e-09 | -0.04 | 0.01 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZC3HAV1 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -5.9 | 5.1 | 2.8e-07 | 0.94 | 0.01 | 0.84 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZC3HAV1 | 0.04 | 0.01 | blup | 76 | 0.02 | 2.4e-03 | 6.3 | 5.2 | 1.9e-07 | 0.70 | 0.01 | 0.80 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZC3HAV1L | 0.02 | 0.01 | blup | 46 | 0.00 | 7.9e-02 | 4.6 | 5.2 | 2.3e-07 | 0.85 | 0.02 | 0.71 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PARP12 | 0.06 | 0.04 | lasso | 2 | 0.04 | 1.3e-04 | -6.2 | -6.4 | 1.3e-10 | 0.04 | 0.01 | 0.98 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | JHDM1D | 0.14 | 0.01 | blup | 58 | 0.04 | 6.2e-05 | 3.3 | -6.5 | 7.9e-11 | -0.04 | 0.05 | 0.03 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | PARP12 | 0.14 | 0.11 | enet | 10 | 0.12 | 9.4e-12 | -6.2 | 6.2 | 5.9e-10 | -0.04 | 0.01 | 0.99 | FALSE |