Best TWAS P=5.47e-26 · Best GWAS P=9.85e-21 conditioned to 0.000161
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CASC7 | 0.21 | 0.12 | enet | 21 | 0.09 | 1.6e-07 | -5.5 | 6.3 | 3.4e-10 | -0.04 | 0.03 | 0.97 | TRUE |
| 2 | YFS | Blood | PTK2 | 0.02 | 0.00 | blup | 538 | 0.01 | 8.6e-04 | -3.7 | 5.8 | 5.5e-09 | -0.01 | 0.11 | 0.03 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GPR20 | 0.05 | 0.00 | blup | 30 | 0.02 | 2.1e-02 | -6.4 | -10.5 | 5.5e-26 | 0.57 | 0.02 | 0.17 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | EIF2C2 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.3e-02 | -5.5 | -6.2 | 4.3e-10 | 0.00 | 0.02 | 0.68 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF2C2 | 0.11 | 0.04 | lasso | 4 | 0.03 | 1.5e-04 | -5.4 | -5.2 | 1.9e-07 | 0.04 | 0.04 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | EIF2C2 | 0.07 | 0.06 | lasso | 3 | 0.05 | 2.0e-05 | -5.4 | -6.2 | 7.1e-10 | 0.02 | 0.03 | 0.96 | FALSE |