TWAS hub - EIF2C2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0223	0.0129	9.1e-03	0.024	0.000	0.001	NA	0.012	7.7e-04	0.29000	0.21000	NA	0.01300
2	TCGA	Prostate Adenocarcinoma	0.1132	0.0662	2.4e-03	0.042	0.013	0.030	NA	0.034	3.0e-05	0.01400	0.00041	NA	0.00015
3	TCGA	Thyroid Carcinoma	0.0680	0.0300	5.4e-05	0.062	0.035	0.044	NA	0.047	1.2e-06	0.00022	0.00004	NA	0.00002

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Overall health rating	9.1	19.5	21.8	-4.7	-4.1	-4.4
Miserableness	8.1	14.1	16.8	-4.1	-3.5	-3.7
Frequency of depressed mood in last 2 weeks	7.4	10.4	12.8	-3.6	-3.1	-3.0
Qualifications: College or University degree	7.4	23.3	27.6	4.6	4.6	5.3
Depressed Affect (Nagel 2018)	7.0	14.6	18.0	-4.2	-3.5	-3.7
Mood swings	7.0	12.7	15.7	-4.0	-3.0	-3.7
Qualifications: None of the above	6.6	14.2	15.5	-3.7	-3.7	-3.9
Hearing difficulty/problems: Yes	5.8	8.8	10.4	-3.2	-2.7	-3.0
Qualifications: CSEs or equivalent	5.7	7.5	8.2	-2.7	-2.9	-2.7
Reaction Time	5.5	10.5	13.5	-3.7	-2.8	-3.2
Alcohol intake frequency.	5.5	12.8	14.2	-3.5	-3.5	-3.8
Depression (Nagel 2018)	5.4	8.1	8.3	-2.9	-2.9	-2.8
Guilty feelings	5.4	8.2	8.8	-3.0	-2.8	-2.9
Frequency of tenseness / restlessness in last 2 weeks	5.2	8.0	9.6	-2.8	-3.1	-2.6
Mother’s age at death	4.8	6.0	6.6	2.2	2.6	2.6
Chronic bronchitis/emphysema (father)	4.5	5.3	7.2	-2.7	-2.0	-2.2
Qualifications: A levels/AS levels or equivalent	4.5	9.9	12.4	2.9	3.0	3.5
Medication: Paracetamol	4.5	7.5	8.6	-2.9	-2.4	-2.9
Irritable Bowel Disease (IBD)	4.2	10.0	10.8	-3.0	-3.3	-3.2
Neuroticism (2016)	4.2	6.0	6.8	-2.6	-2.1	-2.6
Hypothyroidism (self reported)	4.2	9.6	12.2	3.2	2.5	3.5
Falls in the last year	4.2	5.7	6.6	-2.3	-2.2	-2.6
Allergy or Eczema	4.1	10.7	12.4	3.3	3.0	3.5
Unable to work because of sickness or disability	4.1	5.3	6.0	-2.4	-2.0	-2.4
Sitting height	4.0	28.7	36.8	5.3	4.5	6.1
Neuroticism score	4.0	8.4	10.2	-3.2	-2.5	-2.9
Depression (self-reported)	4.0	4.8	5.0	-2.2	-2.2	-2.1
Neuroticism (Nagel 2018)	3.8	8.9	11.8	-3.4	-2.6	-2.9
Mean time to correctly identify matches	3.8	7.3	9.4	-3.1	-2.1	-2.9
Qualifications: NVQ or HND or HNC or equivalent	3.8	4.6	6.3	-1.7	-2.1	-2.5
Neuroticism	3.7	8.8	10.9	-3.3	-2.6	-2.9
Fed-up feelings	3.7	6.8	7.1	-2.6	-2.7	-2.5
Tinnitus: Yes, now most or all of the time	3.5	4.1	4.8	-2.2	-1.8	-2.1
Number of live births	3.4	4.8	5.7	-1.9	-2.2	-2.4
Medication: Lansoprazole	3.3	3.7	5.6	-1.6	-2.4	-1.7
Medication: Seretide 50 evohaler	3.3	3.8	4.6	2.1	1.6	2.2
Age at last live birth	3.3	4.8	6.3	2.1	1.9	2.5
Back pain experienced in last month	3.3	4.8	6.2	-1.9	-2.5	-2.2
Medication: Paracetamol	3.2	4.9	5.7	-2.4	-1.9	-2.4
Hayfever, allergic rhinitis or eczema	3.1	6.8	8.3	2.5	2.4	2.9
Blood Platelet Count	3.0	34.7	38.9	-6.2	-5.2	-6.2
Hearing aid user	3.0	3.4	5.5	1.6	2.3	1.4
Current tobacco smoking	2.9	4.7	6.4	-1.7	-2.2	-2.5
Age at first live birth	2.9	5.1	6.7	2.2	1.9	2.6
Qualifications: nursing, teaching	2.9	4.5	5.4	1.8	2.2	2.3
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	6.0	-2.4	-2.0	-1.8
Worrier / anxious feelings	2.7	5.2	7.0	-2.6	-2.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.7	7.5	2.4	2.0	2.7
Osteoarthritis (self-reported)	2.7	3.4	4.3	-2.0	-1.5	-2.1
Ulcerative Colitis (UC)	2.6	4.9	5.4	-2.1	-2.2	-2.3
Father’s age at death	2.6	3.5	3.9	1.9	1.7	2.0
Health satisfaction	2.6	3.4	4.7	-2.2	-1.7	-1.6
Crohns Disease (2017)	2.5	5.4	5.7	-2.3	-2.4	-2.2
Hearing difficulty/problems with background noise	2.5	4.0	5.6	-2.4	-1.5	-2.0
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	4.5	1.3	2.1	1.9
Pulse rate	2.5	4.2	5.8	-2.4	-1.7	-1.9
Smoking status: Current	2.5	3.9	5.2	-1.5	-2.1	-2.3
Verbal and Numeric Reasoning (VNR)	2.4	5.8	7.4	2.4	2.1	2.7
Age at First Birth	2.4	3.5	3.8	1.9	1.8	1.8
Standing height	2.4	24.2	30.3	4.7	4.5	5.5
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	6.6	2.1	1.7	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	4.0	-1.4	-1.6	-2.0
Leg pain on walking	2.3	2.9	3.0	-1.6	-1.7	-1.7
Body Mass Index (BMI) (2010)	2.2	3.0	3.5	1.7	1.6	1.9
Mean Putamen Volume	2.1	2.4	3.2	-1.8	-1.3	-1.5
Angina	2.1	2.8	4.1	-1.4	-2.0	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	2.9	1.2	1.7	1.7
Height	2.0	38.5	46.5	6.1	5.7	6.8
Relative age voice broke	2.0	3.0	3.4	1.7	1.7	1.8
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	4.0	1.6	2.0	1.8
Shortness of breath walking on level ground	2.0	2.4	4.0	-2.0	-1.3	-1.2
Neck or shoulder pain in last month	2.0	2.9	3.1	-1.7	-1.7	-1.8
Alcohol drinker status: Previous	2.0	2.3	2.8	-1.4	-1.4	-1.7
Bipolar Disorder (2018)	1.9	3.0	3.3	1.6	1.8	1.8
Supplements: Glucosamine	1.9	2.4	3.0	-1.5	-1.4	-1.7
Waist Hip Ratio (WHR)	1.8	8.0	10.0	-3.2	-2.4	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	2.6	-1.5	-1.6	-1.6
Medication for pain relief, constipation, heartburn	1.8	3.1	4.2	1.4	1.7	2.1
Migraine (self-reported)	1.8	2.2	3.4	-1.8	-1.0	-1.5
Illnesses of siblings: Diabetes	1.8	2.2	3.1	-1.8	-1.3	-1.4
Asthma (self-reported)	1.8	3.5	4.5	1.7	1.8	2.1
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.1	-1.0	-1.1	-1.8
Trunk fat-free mass	1.7	10.0	12.0	3.5	2.5	3.5
Exposure to tobacco smoke at home	1.7	1.9	2.0	-1.4	-1.3	-1.4
Loneliness, isolation	1.7	2.4	2.7	-1.5	-1.6	-1.5
Relative age of first facial hair	1.6	3.2	3.7	1.8	1.6	1.9
Trunk predicted mass	1.6	9.2	11.3	3.4	2.3	3.3
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.3	-1.5	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	4.1	-1.5	-2.0	-2.0
Financial situation satisfaction	1.6	2.0	2.9	-1.7	-1.0	-1.4
Rheumatoid Arthritis	1.5	2.0	2.9	-1.7	-0.8	-1.6
Medication for hormone replacement therapy	1.5	1.7	2.4	1.5	1.3	1.0
Leg fat-free mass (left)	1.5	7.7	10.0	3.2	2.0	3.0
Taking other prescription medications	1.5	2.4	3.6	-1.4	-1.9	-1.2
Leg predicted mass (left)	1.5	7.9	10.4	3.2	2.0	3.1
Leg fat-free mass (right)	1.5	7.9	10.3	3.2	2.0	3.0
Whole body water mass	1.5	8.6	10.9	3.3	2.2	3.2
Intelligence (Savage-Jansen 2018)	1.4	4.4	5.6	2.1	1.7	2.4
Blood White Count	1.4	10.1	12.0	-3.0	-3.1	-3.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.4	-1.5	-0.8	-1.4
Alcohol usually taken with meals	1.4	2.3	3.5	1.2	1.9	1.4
Medication: Amlodipine	1.4	1.9	2.8	-1.1	-1.3	-1.7
Emphysema/chronic bronchitis	1.4	1.6	2.1	-1.1	-1.3	-1.5
Whole body fat-free mass	1.4	8.0	10.2	3.2	2.0	3.1
Friendships satisfaction	1.4	1.7	2.3	1.0	1.5	1.3
Leg predicted mass (right)	1.4	7.3	9.7	3.1	1.9	2.9
Maternal smoking around birth	1.3	1.9	3.0	-1.7	-1.4	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	3.4	1.8	1.6	1.8
Financial difficulties in last 2 years	1.3	1.8	1.8	-1.4	-1.3	-1.3
Hip circumference	1.3	5.8	6.9	2.6	1.9	2.6
Angina (self-reported)	1.3	1.7	2.7	-1.0	-1.7	-1.1
Mineral and other dietary supplements	1.3	1.8	2.9	1.1	1.1	1.7
Basal metabolic rate	1.3	7.4	9.2	3.0	2.0	3.0
Heart disease (siblings)	1.3	1.5	1.9	-1.3	-1.1	-1.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.4	1.6	0.7	1.3
Ever had hysterectomy (womb removed)	1.2	1.3	2.0	-1.4	-0.7	-1.2
Townsend deprivation index at recruitment	1.2	1.6	2.2	-1.0	-1.3	-1.5
Impedance of leg (left)	1.2	5.7	9.9	-3.1	-1.4	-2.3
Allergy	1.2	2.7	3.1	-1.4	-1.7	-1.8
Medication: Atorvastatin	1.2	1.5	1.7	-1.3	-1.2	-1.1
Arm predicted mass (left)	1.2	5.9	7.5	2.7	1.9	2.6
Blood Eosinophil Count	1.1	8.5	11.1	-2.9	-3.3	-2.4
Asthma	1.1	2.1	2.8	1.3	1.4	1.7
Suffer from ‘nerves’	1.1	1.8	2.2	-1.4	-1.1	-1.5
Medication: Blood pressure	1.1	2.1	2.7	-1.6	-1.3	-1.4
Myopia	1.1	1.5	2.6	1.6	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.3	-1.1	-1.5	-0.8
Medication: Co-codamol	1.0	1.1	1.4	-1.2	-0.8	-1.1
Illnesses of siblings	1.0	1.4	2.5	1.6	0.8	1.1
Alcohol intake versus 10 years previously	1.0	1.5	2.2	-1.5	-1.0	-1.1
Noisy workplace	1.0	1.3	2.0	-0.6	-1.4	-1.2
Arm fat-free mass (right)	1.0	5.4	7.1	2.7	1.7	2.5
Arm predicted mass (right)	1.0	5.1	6.8	2.6	1.6	2.5
Medication: Aspirin	1.0	1.4	2.0	1.4	1.0	1.1
Arm fat-free mass (left)	1.0	5.3	6.6	2.6	1.8	2.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.5	0.9	1.2	1.0
Cholesterol lowering medication	1.0	1.4	2.1	-1.5	-1.1	-0.9
Fasting Glucose	0.9	1.1	1.5	0.8	1.2	1.1
Primary Biliary Cirrhosis	0.9	1.2	1.4	-1.1	-1.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	-1.4	-0.6	-0.9
Fluid intelligence score	0.9	1.9	2.9	1.0	1.4	1.7
Prospective memory result	0.9	1.1	1.2	-1.1	-1.0	-1.1
Length of working week for main job	0.9	0.9	1.7	0.6	1.3	0.9
Ever depressed for a whole week	0.9	1.1	1.7	-1.3	-0.8	-1.0
Pain experienced in last month	0.9	1.5	2.4	0.9	1.6	1.2
Schizophrenia (2018)	0.8	1.7	2.9	-1.7	-0.7	-1.3
Worry (Nagel 2018)	0.8	1.7	3.2	-1.8	-1.0	-0.9
Triglycerides	0.8	1.3	2.1	-1.1	-0.6	-1.5
Sensitivity / hurt feelings	0.8	1.4	1.6	-1.3	-1.0	-1.2
Systolic blood pressure, automated reading	0.8	2.4	3.1	-1.4	-1.8	-1.4
Impedance of leg (right)	0.8	3.8	7.3	-2.7	-1.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.4	-0.5	-1.2	-1.1
Tense / ‘highly strung’	0.8	1.3	2.0	-1.4	-1.1	-0.8
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.5	0.3	1.2	1.1
Forced vital capacity (FVC), Best measure	0.8	2.9	3.6	1.9	1.2	1.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	1.4	0.7	0.7
Eye problems/disorders: Cataract	0.8	0.9	1.1	-0.7	-1.0	-1.1
Supplements: Calcium	0.8	0.9	1.6	-0.6	-0.9	-1.3
Basal cell carcinoma (self-reported)	0.8	1.0	2.0	1.4	0.8	0.6
Hand grip strength (left)	0.7	1.8	2.7	1.7	0.8	1.4
Diabetes (father)	0.7	0.8	1.3	1.1	0.9	0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.1	-0.8	-1.1	-0.8
Had other major operations	0.7	0.9	1.2	-0.9	-0.7	-1.1
Weight	0.7	3.6	4.4	2.0	1.5	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.3	-1.1	-1.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	0.5	1.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	-0.7	-1.3	-0.7
Medication: Ibuprofen	0.7	0.8	1.3	-0.4	-1.1	-1.0
Chest pain or discomfort	0.7	0.9	1.6	-0.9	-0.7	-1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	-1.0	-0.4	-1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.0	-0.6	-0.8	-1.0
Blood Red Count	0.6	6.0	6.7	-2.6	-2.3	-2.4
Systolic Blood Pressure	0.6	3.1	4.8	-1.4	-2.2	-1.6
Number of treatments/medications taken	0.6	1.0	1.2	-0.9	-1.1	-1.1
Stomach or abdominal pain in last month	0.6	0.7	1.0	-1.0	-1.0	-0.5
Medication: Levothyroxine sodium	0.6	1.1	2.0	0.8	0.7	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	1.7	1.3	1.0	1.2
Diabetes (self-reported)	0.6	0.9	1.5	1.2	0.7	0.9
Knee pain experienced in last month	0.6	0.9	1.0	-1.0	-0.9	-1.0
Average weekly red wine intake	0.6	0.9	1.3	0.8	1.1	0.9
Diabetes diagnosed by doctor	0.6	0.9	1.2	1.1	0.9	0.9
Medication: Lisinopril	0.6	0.7	1.3	0.4	0.9	1.1
Alcohol drinker status: Never	0.6	0.7	0.8	-0.9	-0.8	-0.9
HDL Cholesterol	0.5	0.8	1.3	1.2	0.5	0.8
Schizophrenia (2014)	0.5	1.2	2.6	-1.6	-0.4	-0.8
Cardiovascular Disease	0.5	1.6	2.4	-1.1	-1.6	-1.1
Average weekly spirits intake	0.5	0.6	1.2	-1.1	-0.3	-0.7
Age when periods started (menarche)	0.5	1.1	1.8	1.3	1.0	0.8
Trunk fat mass	0.5	1.9	2.3	1.4	1.3	1.5
Birth weight	0.5	1.1	1.4	-0.8	-1.2	-1.2
Pulse wave peak to peak time	0.5	0.5	1.0	0.5	0.5	1.0
Osteoporosis (self-reported)	0.5	0.6	1.1	-0.5	-1.0	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.1	0.6	0.8	1.0
Illnesses of father: High blood pressure	0.5	0.6	0.9	0.9	0.6	0.7
Average weekly beer plus cider intake	0.5	0.7	1.3	-0.2	-1.2	-0.9
Major Depression (MDD)	0.4	0.4	1.0	-0.3	1.0	0.5
Crohns Disease (2012)	0.4	0.7	0.9	-0.8	-1.0	-0.7
Lupus	0.4	0.5	0.7	-0.4	-0.8	-0.9
Smoking Status	0.4	1.0	1.6	-0.8	-0.8	-1.3
Had menopause	0.4	0.5	1.0	-1.0	0.6	-0.5
Forced vital capacity (FVC)	0.4	1.5	2.5	1.6	0.7	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	1.0	0.5	0.7
Breastfed as a baby	0.4	0.4	0.5	0.6	0.7	0.7
Hair/balding pattern: Pattern 4	0.4	0.9	1.2	0.6	1.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	-1.1	-0.5	-0.7
Long-standing illness, disability or infirmity	0.4	0.7	1.3	-0.3	-1.1	-0.8
Number of self-reported non-cancer illnesses	0.4	0.7	1.0	-0.7	-0.8	-1.0
Commuting to job workplace: Public transport	0.4	0.4	0.7	0.1	0.8	0.8
High cholesterol (Self-reported)	0.4	0.8	1.0	-1.0	-0.9	-0.7
Age started oral contraceptive pill	0.4	0.6	0.8	-0.3	0.9	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.2	1.1	1.1	0.8
Prostate Cancer	0.3	0.5	0.7	-0.6	-0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.9	0.3	0.5
Pack years adult smoking proportion	0.3	0.5	0.6	-0.8	-0.6	-0.7
Hand grip strength (right)	0.3	0.8	1.6	1.3	0.2	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.7	-0.4	-0.7
Happiness	0.3	0.4	1.2	-1.1	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	1.2	0.2	1.0
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.4	-0.5	-0.9
Arm fat mass (right)	0.3	1.2	1.4	1.2	0.9	1.2
Loud music exposure frequency	0.3	0.4	0.5	-0.5	-0.5	-0.7
Glaucoma (self-reported)	0.3	0.3	0.6	0.8	0.6	0.2
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.2	0.8	0.7
Medication: Allopurinol	0.3	0.3	0.4	0.6	0.7	0.4
Medication: Omeprazole	0.3	0.4	0.9	-0.3	-1.0	-0.3
Whole body fat mass	0.3	1.1	1.2	1.1	1.0	1.1
Family relationship satisfaction	0.3	0.3	0.5	-0.7	-0.3	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.4	0.3	0.7	0.7
Leg fat percentage (left)	0.3	1.1	1.3	-1.1	-0.8	-1.1
Irritability	0.3	0.5	0.9	-0.9	-0.4	-0.8
HbA1C	0.2	0.2	0.4	-0.2	-0.4	-0.6
LDL Cholesterol	0.2	0.3	0.5	-0.7	0.4	-0.2
Respiratory disease	0.2	0.5	0.7	0.6	0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.5	0.7	0.6	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.6	0.1	-0.7
Vitamin and mineral supplements	0.2	0.3	0.6	0.1	0.5	0.8
Supplements: Zinc	0.2	0.2	0.2	0.5	0.5	0.3
Medication: Metformin	0.2	0.3	0.4	0.6	0.5	0.5
Severe depression (siblings)	0.2	0.2	0.4	0.3	0.2	0.6
Nervous feelings	0.2	0.4	0.7	-0.8	-0.3	-0.7
Time employed in main current job	0.2	0.2	0.2	0.4	0.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	1.1	0.1	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	0.6	0.6	0.4
Illnesses of mother	0.2	0.2	0.5	-0.1	-0.4	-0.7
Birth weight of first child	0.2	0.3	0.5	-0.5	0.1	-0.7
Peak expiratory flow (PEF)	0.2	0.6	0.7	0.7	0.7	0.9
Leg fat percentage (right)	0.2	0.9	1.0	-1.0	-0.8	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.3	-0.6	-0.5	-0.6
Number of children fathered	0.2	0.2	0.4	0.4	0.6	0.4
Medication: Blood pressure	0.2	0.3	0.5	0.7	0.3	0.5
Had major operations	0.2	0.2	0.3	0.3	-0.5	-0.5
Supplements: Vitamin C	0.2	0.3	0.3	-0.3	-0.6	-0.6
Hypertension (Self-reported)	0.2	0.4	0.5	-0.6	-0.7	-0.6
Ever had bowel cancer screening	0.2	0.2	0.5	0.0	0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.7	-0.2	0.3
Medication for cholesterol	0.2	0.4	0.4	0.7	0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.7	-0.1	0.4
Breast cancer (self-reported)	0.2	0.2	0.5	-0.3	0.7	0.1
Medication: Aspirin	0.2	0.3	0.7	0.8	0.2	0.4
Arm fat mass (left)	0.2	0.9	1.1	1.0	0.7	1.0
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.4	0.2	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.3	-0.3	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.3	-0.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.6	-0.3	-0.5
Impedance of whole body	0.2	1.1	2.5	-1.6	-0.1	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.1	0.2	-0.3	0.5	0.1
Breast Cancer	0.1	0.3	0.4	0.6	-0.1	0.6
Ovarian Cancer	0.1	0.1	0.1	-0.3	0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.3	0.2	0.5
Ulcerative Colitis	0.1	0.2	0.5	0.7	0.1	0.4
Lung FEV1/FVC ratio	0.1	0.6	1.1	-0.1	-1.0	-0.9
Lung FVC	0.1	0.7	1.5	-0.1	-0.7	-1.2
Chronotype (morning person)	0.1	0.3	0.8	0.1	0.9	0.4
Diabetes (mother)	0.1	0.1	0.1	-0.3	0.1	-0.4
Trunk fat percentage	0.1	0.3	0.4	0.4	0.7	0.6
Average weekly fortified wine intake	0.1	0.2	0.3	-0.3	-0.6	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.3	-0.5	-0.4	-0.2
High blood pressure	0.1	0.3	0.5	-0.5	-0.7	-0.4
Medication: Atenolol	0.1	0.2	0.3	0.0	0.4	0.5
High blood pressure (mother)	0.1	0.1	0.3	-0.1	-0.6	0.0
Number of incorrect matches in round	0.1	0.2	0.3	-0.6	-0.4	-0.5
Pain all over the body in last month	0.1	0.1	0.2	0.5	0.2	0.3
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	-0.2	0.3
Lung cancer (father)	0.1	0.2	0.2	-0.5	-0.3	-0.4
Pulse wave reflection index	0.1	0.1	0.2	0.4	0.3	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.5	-0.2	-0.4
Comparative body size at age 10	0.1	0.3	0.4	-0.5	-0.6	-0.4
Heart disease (mother)	0.1	0.2	0.4	0.6	0.2	0.1
Comparative height size at age 10	0.1	0.5	0.7	0.7	0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.1	-0.5	0.2
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.4	-0.3	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.4	0.0	-0.5
Risk taking	0.1	0.1	0.2	0.3	0.3	0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.5	-0.7	-0.7	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.4	-0.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	0.3	0.4	0.5
Pack years of smoking	0.1	0.1	0.2	-0.5	-0.2	-0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.2	-0.0	0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.3	-0.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.1	-0.3	-0.2
Heel T-Score	0.0	0.1	0.1	0.4	0.2	0.1
BMI	0.0	0.1	0.2	0.3	-0.4	-0.1
Hair Pigment	0.0	0.7	1.1	0.5	1.0	1.0
Tanning	0.0	0.1	0.2	-0.3	-0.4	-0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.0	0.1	-0.1
Body mass index (BMI)	0.0	0.1	0.1	0.2	-0.4	-0.1
Waist circumference	0.0	0.0	0.1	-0.1	-0.3	-0.1
Past tobacco smoking	0.0	0.1	0.1	0.3	0.0	0.3
Mouth/teeth dental problems	0.0	0.0	0.1	-0.3	0.3	-0.0
Heart attack	0.0	0.0	0.0	0.1	0.1	0.2
Medication: Ramipril	0.0	0.1	0.1	-0.1	0.1	-0.4
Medication: Simvastatin	0.0	0.0	0.1	-0.0	-0.2	0.3
Impedance of arm (right)	0.0	0.2	0.4	-0.5	0.6	0.0
Arm fat percentage (right)	0.0	0.2	0.2	0.4	0.4	0.4
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.1	0.5	0.1
Impedance of arm (left)	0.0	0.2	0.3	-0.5	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	-0.2	-0.1
Headache pain in last month	0.0	0.1	0.1	-0.3	-0.1	0.2
Gout (self-reported)	0.0	0.0	0.0	0.1	0.2	-0.0
High blood pressure (siblings)	0.0	0.0	0.0	-0.2	0.0	-0.2
Body fat percentage	0.0	0.0	0.1	-0.0	0.3	0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.3	0.0	-0.1
Number of full brothers	0.0	0.0	0.0	0.1	-0.0	-0.0
Worry too long after embarrassment	0.0	0.0	0.1	-0.3	-0.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.3	0.0	-0.1
Leg fat mass (right)	0.0	0.1	0.1	0.3	0.1	0.3
Pulse rate, automated reading	0.0	0.1	0.2	-0.4	-0.4	-0.4
Number of full sisters	0.0	0.0	0.0	-0.2	-0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	-0.2	-0.2
Smoking status: Previous	0.0	0.0	0.1	0.0	0.4	0.0
Arm fat percentage (left)	0.0	0.0	0.1	0.2	0.2	0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.1	-0.2	0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.1	-0.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.1	-0.4	-0.1
Medication: Gliclazide	0.0	0.0	0.1	-0.1	-0.2	-0.2
Wears glasses or contact lenses	0.0	0.0	0.1	-0.0	0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.1	0.0	0.1
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.1	-0.1	-0.0
Ever smoked	0.0	0.0	0.1	-0.2	-0.0	-0.3
Number of operations (self-reported)	0.0	0.1	0.1	0.2	0.3	-0.2
Leg fat mass (left)	0.0	0.1	0.1	0.3	0.1	0.3

Hub : Genes

EIF2C2

Models

Trait associations