Hub : Genes

MTAP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0190	6.4e-04	0.007	0.030	0.012	0.028	0.010	4.2e-02	1.4e-04	1.0e-02	2.2e-04	1.9e-02
2	GTEx	Adipose Subcutaneous	0.1190	0.0330	3.8e-07	0.067	NA	0.104	NA	0.042	3.4e-06	NA	7.2e-09	NA	2.3e-04
3	GTEx	Adipose Visceral Omentum	0.2120	0.0670	1.5e-05	0.083	NA	0.047	NA	0.041	4.1e-05	NA	1.7e-03	NA	3.2e-03
4	GTEx	Artery Tibial	0.0869	0.0331	2.3e-03	0.014	NA	0.005	NA	0.013	2.8e-02	NA	1.1e-01	NA	3.2e-02
5	GTEx	Cells Transformed fibroblasts	0.1640	0.0400	2.1e-09	0.126	NA	0.154	NA	0.152	1.1e-09	NA	1.2e-11	NA	1.6e-11
6	GTEx	Esophagus Muscularis	0.2140	0.0670	3.6e-04	0.094	NA	0.101	NA	0.087	2.5e-06	NA	1.1e-06	NA	6.1e-06
7	GTEx	Muscle Skeletal	0.1318	0.0328	2.7e-11	0.118	NA	0.150	NA	0.162	1.2e-11	NA	1.6e-14	NA	1.3e-15
8	GTEx	Skin Sun Exposed Lower leg	0.1100	0.0340	2.5e-05	0.070	NA	0.029	NA	0.046	2.1e-06	NA	1.6e-03	NA	1.1e-04
9	METSIM	Adipose	0.1028	0.0260	3.9e-07	0.088	0.068	0.088	0.091	0.090	4.1e-13	1.8e-10	4.5e-13	1.8e-13	2.6e-13
10	YFS	Blood	0.0230	0.0091	5.1e-04	0.013	0.004	0.007	0.004	0.010	2.1e-05	1.1e-02	1.5e-03	1.2e-02	1.8e-04
11	TCGA	Thyroid Carcinoma	0.0720	0.0370	3.2e-03	0.036	0.014	0.020	NA	0.024	1.9e-04	1.3e-02	4.3e-03	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	4.5	-2.1	-1.0	-1.9	-0.3	-0.5	-1.0	-0.7	-1.1	-1.2	0.5	0.5
Bipolar Disorder or Schizophrenia	1.7	4.2	6.9	-2.4	-2.6	-1.4	-1.9	-0.8	-2.5	-1.4	-2.3	-2.6	-1.2	2.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	-0.9	-1.5	-1.4	-1.0	-1.5	-0.7	-1.1	-1.0	-0.6	-0.4	0.2
Depression (Nagel 2018)	1.2	1.8	3.6	-1.7	-1.6	-1.0	-1.0	-1.7	-0.2	-1.7	-1.5	-0.6	-0.5	1.9
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.4	1.6	0.4	1.5	-0.6	1.9	-1.6	1.5	0.3	-1.7	-0.1	-2.1
Neuroticism (Nagel 2018)	0.6	1.5	4.3	-1.2	-2.1	-1.2	-0.8	-1.7	-0.2	-2.0	-0.9	-0.1	-0.3	0.5
Schizophrenia (2018)	1.8	3.8	7.4	-1.4	-2.7	-0.3	-2.2	-0.7	-2.6	-1.3	-2.0	-2.3	-1.9	2.5
Schizophrenia vs Biploar Disorder	1.1	1.4	3.7	0.5	-1.9	0.5	0.4	-1.7	1.1	-1.9	0.3	1.3	0.1	1.5
Worry (Nagel 2018)	0.2	0.5	2.5	-0.7	-1.0	-0.3	-0.1	-0.9	0.2	-1.6	-0.4	0.0	0.3	0.5
Alzheimer’s Disease (in mother)	0.7	0.8	3.1	-0.2	-0.3	-0.6	1.8	-0.4	0.9	-0.4	0.8	1.4	1.3	0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.4	0.2	-0.8	-0.5	-0.4	-0.2	-0.5	-0.6	-0.6	-0.7	-1.2	-0.7
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	-0.8	-0.9	-1.4	1.1	-1.2	0.4	-1.2	-0.1	0.7	0.7	0.1
Crohns Disease (2017)	3.6	7.8	11.2	3.1	2.7	3.0	3.4	2.1	3.3	2.3	2.7	2.5	1.9	-3.3
Irritable Bowel Disease (IBD)	2.5	5.9	10.1	3.2	2.3	3.1	2.2	2.3	2.2	2.4	2.6	2.1	0.9	-2.7
Ulcerative Colitis (UC)	0.5	1.0	4.4	1.2	0.5	2.1	-0.1	1.5	-0.1	1.1	0.8	0.3	-0.4	-0.6
Major Depression (MDD)	1.7	2.1	5.8	0.7	1.3	0.1	1.7	1.0	1.5	1.2	2.3	2.4	1.5	-0.0
Reaction Time	1.8	3.4	9.2	-2.4	-2.8	-2.0	-0.5	-2.1	0.3	-2.1	-1.2	-0.4	-0.1	3.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.8	1.4	-0.8	0.3	-1.5	0.7	-2.6	0.4	-1.0	-2.2	-1.5	-0.2
Breast Cancer	1.5	3.5	14.1	-0.0	2.3	-1.2	2.0	1.3	-1.0	1.4	3.8	2.0	1.5	1.8
Ovarian Cancer	0.8	1.0	6.5	-1.0	-0.5	-2.5	-0.1	-0.7	0.1	-1.1	0.2	1.1	0.8	0.3
Prostate Cancer	0.2	0.3	0.8	0.1	-0.8	-0.3	-0.4	-0.9	-0.1	-0.5	-0.8	-0.4	-0.6	-0.3
Age at First Birth	1.4	2.0	6.9	1.7	-0.7	0.9	-2.1	1.2	-0.6	0.4	-0.5	-1.3	-2.6	-1.6
Bipolar Disorder (2011)	1.5	1.4	2.7	-1.6	-1.6	-1.1	-1.1	-0.7	-1.4	-0.7	-1.5	-1.2	-0.7	0.8
Body Mass Index (BMI) (2010)	0.7	0.9	2.2	-0.3	-1.3	0.9	-1.1	0.4	-1.4	-0.2	-0.9	-1.5	-0.9	0.5
Coronary Artery Disease (CAD)	1.4	1.6	5.5	-0.8	0.3	-2.3	0.2	1.9	-1.4	1.9	0.6	-1.1	0.7	-0.1
Crohns Disease (2012)	3.2	5.1	6.6	2.2	2.1	2.4	2.4	2.5	2.5	2.6	2.2	1.5	1.7	-2.6
Mean Putamen Volume	0.7	0.8	2.8	0.4	0.3	0.8	-0.0	1.7	-0.1	1.7	-0.5	-1.1	0.2	-0.8
Fasting Glucose	0.8	1.0	5.0	-0.6	-1.8	-2.2	-0.5	-0.6	0.7	-0.8	-0.4	0.1	0.5	0.0
HbA1C	0.2	0.2	1.6	-0.3	-0.3	-1.2	-0.3	-0.1	-0.2	-0.4	0.2	-0.2	0.2	0.6
HDL Cholesterol	0.4	0.6	2.9	0.4	-1.7	-0.1	-0.7	-0.5	0.1	-1.0	-0.4	-0.5	-1.1	0.4
LDL Cholesterol	0.7	1.0	4.2	-1.4	-1.2	-0.9	0.5	-1.0	0.6	-0.8	-0.2	0.4	0.6	2.0
Lupus	1.4	2.2	4.8	-0.7	-1.1	-2.2	-1.5	-1.0	-1.6	-1.2	-2.1	-1.9	-1.0	0.9
Neuroticism (2016)	0.7	1.0	4.0	-1.7	-1.2	-2.0	-0.6	-0.7	-0.1	-1.1	-0.8	-0.1	0.1	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.1	-0.4	0.2	-0.6	0.9	-0.9	-0.1	-0.1	-0.7	-0.6	0.4
Rheumatoid Arthritis	1.0	1.4	3.6	-0.8	-0.8	-1.1	-1.9	-0.5	-0.9	-1.4	-1.8	-1.4	-1.2	0.2
Schizophrenia (2014)	1.8	3.9	9.4	-1.9	-3.1	-0.9	-2.0	-1.3	-1.6	-2.0	-1.8	-1.6	-2.0	2.7
Triglycerides	0.5	0.8	4.2	-0.4	0.8	-0.1	-1.0	0.4	-2.0	0.5	-0.6	-1.2	-0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.5	-0.4	-0.2	-1.6	-0.7	0.7	-0.2	0.1	-0.7	-1.2	-0.7	-1.6
Ulcerative Colitis	0.5	0.8	2.5	0.1	-1.6	0.7	-1.1	-0.5	-0.6	-0.4	-0.3	-0.0	-1.2	1.3
Blood Eosinophil Count	0.1	0.7	1.9	-0.0	-1.2	-1.0	-0.8	-0.0	-0.6	0.1	0.9	-0.6	-0.9	1.4
Blood Platelet Count	0.7	8.3	28.8	-2.3	-5.2	-4.2	0.1	-1.0	-2.2	-1.6	0.1	-1.5	-1.4	5.4
Blood Red Count	0.1	0.8	3.5	0.3	1.9	1.6	-0.3	0.2	-0.6	0.1	-0.6	-1.2	0.0	-0.9
Blood White Count	0.3	2.2	7.1	1.4	-2.6	0.3	-0.1	0.3	-2.7	1.0	0.0	-1.7	-1.8	1.0
Heel T-Score	0.6	4.6	9.1	3.0	1.9	2.7	1.8	2.4	1.3	2.4	2.8	1.9	1.3	-1.0
BMI	0.7	4.0	9.1	-2.8	-1.6	-0.5	-1.8	-2.6	-1.2	-2.7	-1.6	-0.5	-1.7	3.0
Height	0.1	1.9	5.3	0.9	-1.7	-0.3	-2.0	-0.8	-1.4	-1.5	-1.3	-1.1	-2.3	-0.9
Waist Hip Ratio (WHR)	0.2	0.9	4.0	0.8	-0.1	-2.0	-0.0	0.5	0.4	-0.6	-0.2	-0.3	0.2	-1.9
Systolic Blood Pressure	0.6	2.8	8.8	-1.2	-2.3	-2.4	-0.7	-3.0	-0.1	-1.8	-1.8	-0.6	-1.4	-0.4
Smoking Status	0.1	0.2	0.8	0.8	0.3	0.8	-0.1	0.4	0.2	0.0	0.3	0.4	-0.9	0.2
Allergy or Eczema	0.4	1.0	3.5	-0.7	0.1	0.8	-1.2	-0.6	-0.8	-0.8	-1.4	-0.9	-1.9	0.7
Cardiovascular Disease	1.0	3.4	10.7	-2.1	-2.5	-1.8	-0.5	-3.3	0.3	-2.7	-0.8	1.0	-1.2	1.4
Hypothyroidism (self reported)	3.0	7.0	20.0	-4.2	-2.4	-4.5	-0.6	-3.5	0.4	-3.5	-1.2	0.4	-0.1	2.6
Respiratory disease	0.3	0.7	3.4	-0.1	-0.9	-0.1	-0.1	-1.8	-0.0	-1.1	-0.3	0.4	-0.5	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.8	-0.5	0.3	-1.6	-0.8	0.1	0.3	0.5	0.1	0.2	-0.6	-1.7
Lung FEV1/FVC ratio	0.4	1.8	7.3	0.1	2.2	2.7	-0.1	1.3	-0.6	2.0	0.2	-0.9	-0.3	-0.6
Lung FVC	0.4	2.1	4.7	-0.6	0.0	-2.1	1.7	-1.0	2.2	-0.6	1.3	1.6	1.6	1.4
Neuroticism	0.4	1.1	3.9	-0.7	-1.2	-0.4	-1.1	-1.1	-1.1	-2.0	-1.1	-0.5	-0.8	0.5
Chronotype (morning person)	1.1	2.5	6.6	-1.4	-1.5	-0.5	-2.6	-1.0	-1.6	-1.1	-1.9	-2.1	-1.9	-0.3
Hair Pigment	0.1	2.3	11.3	1.9	1.2	3.4	1.6	-0.7	1.3	-0.7	0.7	1.7	0.3	-0.5
Tanning	0.3	3.2	13.4	2.6	0.9	1.3	-0.0	3.7	-0.5	2.2	0.3	-1.3	0.0	-2.3
Hand grip strength (left)	0.2	0.5	1.9	0.4	-0.4	-0.2	-0.9	-0.7	-0.3	-0.9	-1.0	-0.3	-1.4	-0.6
Number of treatments/medications taken	0.8	1.5	5.2	-2.0	-1.6	-1.3	-0.1	-2.3	-0.2	-1.4	-0.5	0.2	-0.5	0.7
Average weekly spirits intake	0.6	0.8	1.7	-0.4	-0.4	-1.3	0.6	-1.0	1.0	-1.1	0.6	1.2	0.1	0.9
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.8	-0.1	-0.4	0.4	-0.9	0.9	-1.1	0.5	0.9	0.4	-0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	-1.1	-1.6	-0.6	-1.2	-0.4	-0.5	-1.0	-1.2	-0.9	-0.5	1.2
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.8	-0.4	-0.8	-0.5	-0.1	-0.2	-0.3	-0.5	-0.5	-1.1	-0.7
Relative age of first facial hair	0.8	1.6	3.6	-0.2	-1.9	-0.3	-1.9	-0.9	-0.9	-1.3	-1.8	-0.9	-1.7	0.6
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	7.5	-0.8	-1.9	-2.7	-0.0	-2.5	0.5	-2.6	-0.6	0.8	-0.6	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	-0.7	-0.4	-0.9	1.0	-0.9	0.3	-0.4	0.7	0.8	0.8	-0.0
Ever had hysterectomy (womb removed)	0.7	0.7	1.5	1.1	0.6	0.4	0.9	0.8	1.1	1.2	0.2	-0.1	1.2	-0.9
Systolic blood pressure, automated reading	0.2	0.5	1.5	0.3	-0.4	0.8	-0.2	-0.7	-0.7	-0.1	-0.7	-0.7	-1.2	-1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.9	-0.4	-0.3	-1.4	-0.1	-0.1	0.5	-0.5	0.5	0.3	-0.1	-0.2
Angina	1.7	2.2	5.4	-1.3	1.2	-1.0	1.3	1.8	-0.4	2.3	2.1	0.8	1.6	-1.4
Medication for hormone replacement therapy	0.4	0.5	1.7	-0.4	-0.5	-0.6	0.6	-1.3	0.8	-0.7	0.3	0.9	-0.1	-0.4
Vitamin and mineral supplements	2.4	3.2	8.7	1.9	3.0	1.9	1.4	2.1	0.0	2.6	1.5	-0.3	1.0	-1.9
Supplements: Zinc	0.6	0.6	2.2	0.3	-1.5	-0.4	0.1	-0.0	1.3	-0.7	0.4	0.8	1.0	0.9
Medication: Co-codamol	0.2	0.3	0.7	0.8	0.3	0.9	0.6	-0.5	0.2	0.5	-0.0	0.6	-0.6	0.0
Medication: Metformin	1.0	1.4	4.8	-1.5	-0.5	-2.2	0.8	-0.9	1.6	-0.1	1.0	1.5	1.0	-0.3
Diabetes (father)	2.3	2.9	4.8	-2.1	-1.0	-1.2	-2.2	-2.1	-1.0	-1.8	-2.2	-1.3	-2.1	0.7
Diabetes (mother)	1.0	1.3	3.0	-1.1	-0.9	-1.7	-1.4	-1.3	-0.3	-1.1	-1.3	-0.3	-1.5	0.4
Severe depression (siblings)	0.2	0.3	0.7	0.3	-0.4	-0.8	0.1	-0.7	0.5	-0.5	0.2	0.7	-0.3	-0.5
Pack years adult smoking proportion	0.3	0.5	2.6	-0.4	0.4	1.1	0.4	0.1	1.6	0.0	0.2	0.5	0.6	0.6
Impedance of leg (right)	0.2	0.9	4.2	0.8	1.2	0.5	0.6	1.0	0.4	1.1	0.7	0.2	0.9	-2.0
Leg fat-free mass (left)	0.6	2.9	4.9	-0.8	-1.9	-0.6	-2.0	-1.7	-1.3	-2.2	-2.0	-1.2	-2.2	2.1
Trunk fat percentage	0.4	1.5	4.0	-1.2	-0.9	0.3	-0.5	-2.0	-1.1	-1.7	-1.1	-0.4	-1.2	1.6
Hand grip strength (right)	0.3	0.9	4.8	0.7	-0.3	-0.1	-1.6	0.2	-0.4	-0.5	-0.9	-0.8	-2.2	-0.6
Townsend deprivation index at recruitment	0.4	0.6	2.8	0.1	0.6	0.1	0.7	0.8	0.1	0.8	0.5	0.9	0.0	-1.7
Current tobacco smoking	0.2	0.3	0.9	-0.8	0.6	0.2	0.4	0.3	-0.0	0.7	0.4	0.4	0.9	0.2
Average weekly fortified wine intake	0.7	0.8	1.5	-1.0	-1.2	-1.1	0.1	-1.0	0.8	-1.2	0.1	0.3	1.0	0.9
Maternal smoking around birth	0.3	0.4	1.4	0.3	-0.0	-1.0	0.1	0.2	1.2	-0.5	0.4	0.8	-0.4	-0.6
Fed-up feelings	0.8	1.5	3.3	-0.2	-1.1	-0.2	-1.5	-0.8	-1.7	-0.8	-1.8	-1.5	-1.8	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.9	-1.8	-1.1	-1.6	-0.5	-2.0	0.6	-1.9	-1.0	0.3	-1.0	2.2
Relative age voice broke	0.3	0.4	1.1	-0.4	-0.4	-0.9	-0.7	-0.4	-0.3	-1.0	-0.9	-0.3	-0.6	0.6
Taking other prescription medications	0.4	0.5	1.9	-0.2	-0.1	-1.4	1.0	-1.1	0.7	-0.3	0.6	0.8	0.3	-0.1
Age when periods started (menarche)	0.6	1.4	4.9	-1.2	-0.0	0.1	1.3	-1.0	1.8	-0.5	0.9	2.2	0.9	1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	-0.7	-1.7	-1.6	-0.1	-0.4	1.1	-0.7	-0.5	-0.4	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.0	0.9	0.3	0.8	1.3	0.7	0.7	1.6	1.7	1.6	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.0	-0.7	-0.7	0.8	-0.2	-1.4	0.2	-1.0	-0.6	0.1	-0.6	0.6
Qualifications: CSEs or equivalent	1.9	2.5	5.2	-1.5	-1.2	-1.8	0.8	-2.1	1.6	-1.8	0.4	2.3	0.4	2.0
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.4	-0.8	-0.3	-0.5	-0.8	-1.3	-0.9	-0.9	-0.5	-1.3	0.9
High blood pressure	1.5	4.1	14.8	-2.9	-2.7	-1.4	-0.7	-3.8	-0.2	-2.4	-1.2	0.0	-1.0	1.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-1.2	0.2	0.9	-0.9	-0.4	-0.4	-0.5	-1.3	-0.8	-0.9	0.4
Multivitamins +/- minerals	3.0	3.8	9.0	-2.2	-3.0	-1.9	-1.9	-2.3	-0.5	-2.6	-2.1	-0.2	-1.2	1.5
Stomach or abdominal pain in last month	0.6	0.7	2.1	-0.4	-1.2	-0.3	-1.0	-0.4	-1.5	-0.5	-0.2	-0.5	-1.0	1.1
Supplements: Glucosamine	1.7	2.2	4.2	-0.6	-1.4	-0.6	-1.5	-1.8	-1.5	-1.6	-2.0	-1.1	-1.7	1.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	1.2	1.3	0.6	0.5	1.3	-0.7	1.1	0.6	-0.2	0.1	-1.0
Medication: Atenolol	0.6	0.7	2.6	-1.1	-1.6	-0.8	0.3	-1.3	-0.4	-1.0	0.2	0.6	-0.2	0.3
Medication: Levothyroxine sodium	2.1	3.5	9.7	-2.6	-1.6	-3.1	0.5	-2.4	0.8	-2.5	-0.5	0.8	0.6	2.2
Sitting height	0.1	0.4	1.2	0.0	-0.9	0.1	-1.0	-0.5	-0.1	-1.0	-0.5	0.1	-0.7	1.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	-0.4	0.1	-0.6	-0.5	-1.6	0.7	-1.3	-1.0	-0.1	-1.5	1.0
High blood pressure (mother)	0.6	0.8	1.8	-1.0	-0.6	0.4	-1.2	-1.1	-0.5	-0.8	-0.6	-0.5	-1.4	1.3
Body mass index (BMI)	0.6	2.4	5.3	-2.1	-1.3	-0.8	-1.0	-1.9	-1.3	-2.0	-1.4	-0.7	-1.3	2.3
Impedance of leg (left)	0.2	0.9	2.8	0.4	0.7	0.0	1.1	0.4	0.6	0.9	1.1	1.0	1.5	-1.7
Leg predicted mass (left)	0.5	2.7	4.5	-0.8	-1.8	-0.6	-1.9	-1.6	-1.2	-2.1	-1.8	-1.1	-2.1	2.0
Trunk fat mass	0.7	3.0	6.1	-1.5	-1.8	-0.2	-1.3	-2.5	-1.5	-2.4	-1.7	-0.9	-1.9	2.1
Waist circumference	1.3	4.7	8.9	-1.9	-2.2	-1.3	-2.1	-2.5	-2.0	-3.0	-2.5	-1.7	-2.3	1.8
Number of incorrect matches in round	0.2	0.3	0.8	0.9	0.9	0.6	0.4	-0.0	0.9	0.1	0.2	0.7	-0.3	0.0
Past tobacco smoking	0.6	1.0	5.8	-1.2	0.2	-0.1	0.8	0.4	0.5	1.0	1.2	0.8	2.4	0.1
Alcohol usually taken with meals	0.5	0.8	3.1	-1.4	-0.0	-0.9	-1.1	0.7	-0.4	0.3	-0.7	-1.8	-0.3	-0.0
Nervous feelings	1.0	1.9	5.8	-1.0	-2.4	-1.7	-1.2	-1.5	-0.2	-2.2	-0.7	-0.2	-0.9	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	-0.8	-1.2	-0.8	-1.6	-0.5	-0.9	-0.7	-1.1	-1.0	-1.1	-0.6
Hearing difficulty/problems with background noise	1.9	3.0	5.5	-0.9	-1.7	-2.3	-2.1	-1.2	-1.6	-2.2	-2.1	-1.6	-1.7	-0.8
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.2	-0.7	-0.7	0.1	-0.6	0.2	-0.4	-0.2	0.4	-0.1	-0.0
Had menopause	0.2	0.2	0.8	-0.4	0.8	-0.9	0.0	-0.3	0.2	0.1	0.4	0.3	0.1	0.4
Had other major operations	0.3	0.3	1.5	1.1	0.4	-0.5	-0.4	0.2	-0.3	-0.1	-0.2	-0.6	-1.2	0.2
Forced vital capacity (FVC)	0.6	2.3	5.7	-1.2	-1.7	-2.1	-0.6	-1.9	1.3	-2.0	-0.2	1.0	-0.3	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.0	1.3	0.3	0.9	1.0	1.5	0.3	2.0	1.6	0.9	0.2	0.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.2	0.2	-1.0	-2.1	0.5	-1.1	2.0	-0.7	1.1	1.8	-0.6	1.8
Qualifications: None of the above	0.3	0.7	2.0	-0.4	0.1	-0.4	0.8	-0.8	1.3	-0.4	0.7	1.3	1.4	0.4
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.7	-0.5	-1.3	0.5	-0.4	1.3	-0.6	0.4	1.2	0.5	1.0
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	-0.5	0.3	0.2	0.7	-0.2	0.4	0.3	-0.2	0.7	0.9
Heart attack	1.9	2.4	7.2	0.3	0.9	-1.2	1.4	2.0	-0.4	2.7	1.9	0.7	1.2	-2.2
Allergy	0.3	0.6	1.6	0.4	-0.7	-0.6	1.0	-0.1	0.8	-0.2	0.9	1.2	1.3	0.3
Pain all over the body in last month	0.2	0.2	0.8	-0.5	-0.5	0.1	0.1	-0.7	-0.5	-0.3	0.1	0.3	-0.3	0.9
Diabetes (self-reported)	0.3	0.4	1.9	-0.3	0.5	-1.4	-0.2	0.1	0.6	0.3	0.4	0.3	-0.5	-1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.7	-0.3	1.3	1.1	-0.1	0.5	1.2	0.4	0.6	0.6	-0.3	0.4
Medication: Ramipril	0.3	0.4	1.4	0.1	-0.1	-1.2	0.5	-0.5	-0.8	0.2	0.5	0.9	-0.2	-0.3
Medication: Simvastatin	0.3	0.5	2.9	-1.0	0.3	-0.6	0.5	-0.2	-0.4	0.5	0.2	0.1	0.6	-1.7
Fluid intelligence score	1.0	2.0	7.1	1.2	-0.1	0.1	-1.2	1.7	-2.7	1.0	-0.6	-2.6	-0.6	-1.0
Illnesses of siblings	0.4	0.6	4.6	-0.3	-0.4	-0.6	-0.5	0.1	-0.2	-0.9	-0.4	-0.6	0.0	2.1
Neuroticism score	0.9	1.9	5.6	-1.0	-1.5	-1.3	-1.3	-1.9	-0.8	-2.4	-1.4	-0.6	-1.3	0.7
Weight	0.9	4.4	8.1	-1.9	-2.4	-0.9	-2.0	-2.6	-1.7	-2.8	-2.1	-1.1	-2.2	2.6
Impedance of arm (right)	0.3	1.6	3.1	1.8	1.0	1.7	1.2	0.7	1.2	1.0	0.9	1.1	0.7	-1.7
Arm fat percentage (right)	0.9	3.4	7.7	-1.9	-1.9	-0.5	-1.2	-2.7	-1.3	-2.8	-2.0	-0.9	-1.7	2.0
Trunk fat-free mass	1.1	6.1	10.1	-1.6	-3.2	-1.9	-3.1	-2.5	-1.8	-3.1	-2.7	-1.7	-2.6	2.3
Hip circumference	1.7	7.5	10.7	-2.9	-2.7	-0.8	-2.8	-3.0	-2.5	-3.2	-3.1	-2.1	-2.8	3.3
Time employed in main current job	0.6	0.7	4.2	0.2	0.1	-0.5	0.0	-1.3	0.6	-0.6	0.5	0.8	0.0	2.1
Alcohol intake versus 10 years previously	0.3	0.5	3.6	0.2	0.7	1.9	0.5	-0.1	-0.3	0.0	0.9	0.3	0.4	-0.1
Father’s age at death	1.6	2.2	6.2	2.5	-0.1	1.4	-1.8	0.5	-1.2	-1.0	-1.4	-1.3	-2.5	-0.3
Worrier / anxious feelings	0.1	0.1	0.7	-0.5	0.2	-0.1	0.1	-0.4	0.3	-0.8	-0.2	0.3	0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.5	-0.8	-0.8	-0.8	-1.3	-0.1	-1.6	-0.4	-0.8	-1.2	-1.1	0.6
Falls in the last year	0.9	1.2	3.0	-0.8	-0.8	-1.3	0.6	-1.7	1.3	-1.1	0.3	1.6	0.6	1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	1.0	0.9	0.7	0.4	-0.3	0.6	-0.1	0.8	0.6	0.1	-0.4
Number of live births	0.4	0.5	1.4	-1.2	0.5	-0.9	0.6	-0.8	0.4	-0.3	0.3	1.1	0.8	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	6.9	-1.8	-1.4	-2.1	-1.0	-1.7	0.7	-1.7	-0.7	0.2	-0.3	2.6
Pulse rate	0.2	0.3	1.0	-0.6	0.4	-1.0	-0.1	-0.1	0.2	-0.4	-1.0	-0.2	-0.4	-0.3
Happiness	0.2	0.2	0.4	-0.1	0.3	-0.0	0.5	0.2	0.4	0.6	0.3	0.6	0.5	0.6
Noisy workplace	0.7	0.9	5.3	1.0	0.4	0.9	0.3	0.4	0.4	0.7	0.6	0.7	-0.6	-2.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.4	-0.6	-0.5	0.1	-2.0	0.2	-1.7	-0.4	-1.3	-2.1	-1.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.0	-0.7	-1.6	-2.0	-1.6	-0.3	-1.1	-0.8	-1.1	-0.9	-1.0	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.2	0.5	1.5	0.8	1.2	0.1	1.4	0.8	0.5	0.8	1.0	-0.8
Asthma	0.1	0.1	0.5	-0.2	0.0	-0.2	-0.0	-0.7	0.1	-0.3	0.1	-0.2	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.8	-1.2	-0.8	-0.4	-1.3	-1.7	-0.9	-0.6	-1.4	-0.6	-1.5	1.0
Medication: Cholesterol lowering	0.3	0.4	1.4	-0.8	-0.2	0.6	0.6	-0.2	-0.6	0.4	1.0	0.3	0.3	-1.2
Depression (self-reported)	0.4	0.5	1.5	-0.6	-0.9	-0.2	-0.4	-1.1	-0.2	-1.2	-0.5	0.3	-0.4	0.8
Medication: Lansoprazole	0.8	0.9	1.8	0.5	1.4	0.3	1.2	1.0	0.3	1.1	1.3	0.7	1.0	-0.6
Prospective memory result	1.3	1.6	3.9	1.0	2.0	1.5	1.5	0.6	0.8	0.7	1.5	1.8	1.1	0.2
Lung cancer (father)	0.6	0.7	2.2	0.2	0.4	1.0	1.1	-0.1	1.1	0.6	1.0	0.8	1.5	0.1
Illnesses of mother	0.9	1.1	3.8	1.9	0.9	1.1	1.1	1.1	0.2	0.6	0.1	-0.3	0.8	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.6	-0.8	-0.9	-1.2	-0.3	-0.7	1.3	-0.7	-0.1	0.6	-0.3	1.9
Pulse wave Arterial Stiffness index	1.8	2.1	5.2	-2.2	-0.2	-2.3	-1.5	-2.0	-0.0	-1.6	-1.5	-0.5	-0.9	0.8
Impedance of arm (left)	0.5	2.4	7.0	2.0	1.6	2.6	1.4	1.3	0.7	1.6	1.2	1.0	0.8	-1.9
Arm fat mass (right)	1.0	4.2	8.8	-2.2	-2.2	-0.7	-1.5	-2.8	-1.6	-3.0	-2.0	-1.0	-1.8	2.6
Trunk predicted mass	1.0	5.9	9.9	-1.5	-3.1	-1.8	-3.0	-2.5	-1.7	-3.1	-2.6	-1.6	-2.5	2.3
Standing height	0.3	3.0	6.7	-0.1	-2.6	-0.5	-2.5	-1.9	-1.2	-2.2	-1.9	-1.0	-2.0	0.9
Length of working week for main job	0.7	0.7	2.3	0.7	1.1	0.9	0.3	1.2	0.2	1.5	0.3	-0.4	-0.2	-1.1
Exposure to tobacco smoke at home	0.7	0.8	2.2	0.3	-0.8	0.3	1.5	-0.1	0.7	-0.1	0.4	1.3	1.4	-1.3
Breastfed as a baby	0.8	1.0	1.8	0.9	1.2	0.8	1.3	0.8	1.3	1.2	1.0	0.8	0.8	-0.7
Tense / ‘highly strung’	0.2	0.3	1.0	-0.2	-1.0	-0.8	-0.1	-0.4	-0.1	-1.0	0.0	0.1	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.9	-0.6	-1.1	-0.8	0.6	-0.8	1.3	-0.8	1.0	1.7	0.5	1.2
Hair/balding pattern: Pattern 4	0.8	1.9	6.7	-0.6	-1.1	0.2	-1.2	0.9	-2.6	1.0	-1.6	-2.2	-0.4	-1.5
Birth weight of first child	0.6	1.2	3.9	0.6	1.3	0.5	-0.8	1.5	0.2	1.6	0.2	-0.2	-1.1	-2.0
Peak expiratory flow (PEF)	0.2	0.4	1.7	-0.6	0.7	-1.3	-0.2	0.2	0.6	-0.2	-0.1	0.1	-0.5	1.0
Pulse wave reflection index	1.1	1.4	3.4	-1.5	0.1	-1.2	-0.1	-1.9	1.4	-1.2	0.6	1.5	0.5	1.6
Ever highly irritable/argumentative for 2 days	1.6	1.9	5.5	-1.9	-0.8	-1.4	-0.3	-1.7	1.3	-1.7	0.0	1.3	-0.6	2.4
Loud music exposure frequency	0.2	0.2	1.2	0.3	0.2	-0.4	-0.4	0.1	-0.2	0.2	0.3	0.1	-1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.8	-1.4	-2.2	-0.3	-1.1	-0.4	-1.6	-0.9	-1.6	-2.0	-0.5	0.9
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.4	0.0	-1.6	-0.7	-1.8	-1.0	-1.0	-1.7	-1.7	-1.1	-2.3	1.0
Blood clot in the leg (DVT)	2.6	3.4	7.1	1.6	2.1	1.9	1.9	1.8	0.9	2.7	2.6	1.4	1.5	-1.1
Medication: Paracetamol	0.3	0.5	2.1	-0.6	-0.5	-0.3	-0.1	-1.0	0.2	-1.4	-0.4	0.3	0.1	1.2
Headache pain in last month	0.8	1.4	6.2	-0.4	0.0	-0.3	0.8	-1.3	2.5	-0.8	0.8	1.6	1.1	1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.6	2.0	1.9	-0.0	0.7	2.6	0.5	1.7	0.6	-0.0	0.9	-0.8
Glaucoma (self-reported)	0.6	0.8	3.4	-0.2	-1.9	-1.2	-0.0	0.3	-0.8	0.5	-0.1	-0.7	0.4	-1.4
Gout (self-reported)	0.2	0.2	0.8	0.3	0.5	-0.3	-0.2	0.6	-0.4	0.5	-0.3	-0.9	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	12.0	-3.3	-1.3	-3.5	0.3	-2.7	0.9	-2.6	-0.5	0.7	0.6	2.2
Medication: Amlodipine	0.8	1.1	5.2	-0.8	-1.7	-0.6	-0.4	-2.3	0.2	-1.5	-0.4	0.6	-0.4	0.3
Medication: Ventolin 100micrograms inhaler	0.7	1.0	2.0	0.5	1.4	1.2	0.6	1.3	0.7	1.4	1.1	0.3	0.7	-0.7
Birth weight	0.9	1.9	5.6	2.1	1.8	-0.1	-0.1	2.2	-0.9	1.3	0.5	-0.4	-0.6	-2.4
Chronic bronchitis/emphysema (mother)	2.2	2.5	6.9	-0.7	-1.5	-0.9	-2.6	-1.3	-1.4	-1.4	-1.9	-1.1	-2.6	0.4
High blood pressure (siblings)	0.4	0.5	1.6	-0.4	-0.2	0.5	-0.3	-0.0	-0.7	1.0	-0.7	-0.9	-0.9	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.9	2.8	-0.5	-1.2	-1.0	-0.4	-0.7	1.4	-0.9	0.1	0.8	-0.2	1.7
Body fat percentage	0.4	1.6	4.3	-1.4	-1.1	0.1	-0.6	-2.1	-1.2	-1.8	-1.2	-0.6	-1.1	1.4
Leg fat percentage (right)	0.3	1.1	3.0	-1.5	-0.6	-0.4	-0.4	-1.7	-0.9	-1.7	-1.1	-0.6	-0.8	0.9
Arm fat-free mass (right)	0.8	4.3	6.6	-1.7	-2.1	-1.8	-2.4	-1.9	-1.8	-2.6	-2.1	-1.5	-1.9	2.5
Exposure to tobacco smoke outside home	0.1	0.2	0.8	-0.5	0.2	0.3	0.6	0.2	-0.2	-0.0	0.0	-0.3	0.9	0.4
Comparative body size at age 10	0.2	0.5	2.5	-0.6	-0.5	-1.6	-0.5	-0.8	-0.3	-0.5	-0.8	-0.4	-0.5	0.7
Number of full brothers	1.3	1.6	5.0	-1.5	-1.2	-1.7	0.0	-2.2	0.5	-2.2	-0.8	0.7	-0.0	0.6
Worry too long after embarrassment	0.3	0.4	2.5	-0.3	-0.6	-1.6	-0.1	-0.7	0.0	-0.9	-0.4	0.3	-0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	5.5	-1.3	-1.5	-1.3	-1.4	-1.7	-0.3	-2.3	-0.7	0.2	-1.3	1.8
Wheeze or whistling in the chest in last year	0.9	1.6	5.3	-0.4	-1.3	0.3	-1.4	-1.0	-1.4	-0.9	-1.6	-1.1	-2.3	0.6
Number of children fathered	2.3	2.6	6.2	1.4	1.9	1.9	0.8	2.3	0.6	2.5	1.0	-0.2	1.2	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.2	0.3	-0.6	0.2	0.3	0.8	0.2	0.1	-0.4	0.9	-0.8
Age at first live birth	0.9	1.7	6.8	2.6	0.8	1.5	-0.2	2.2	-0.7	1.4	0.2	-0.4	0.1	-1.0
Pulse wave peak to peak time	1.6	1.9	4.8	2.2	0.0	2.2	1.3	1.8	-0.1	1.5	1.4	0.5	0.9	-0.8
Health satisfaction	0.2	0.3	1.5	-0.1	-0.4	-1.2	-0.3	-0.1	-0.4	0.1	-0.5	0.1	-0.8	0.7
Shortness of breath walking on level ground	0.5	0.6	2.9	-0.4	-0.4	-1.7	-0.2	-0.4	0.7	-0.6	-0.2	0.8	-0.9	1.0
Qualifications: College or University degree	0.5	1.7	4.1	1.7	1.0	0.3	-0.9	2.0	-0.8	1.4	-0.2	-1.6	-1.8	-1.3
Eye problems/disorders: None of the above	0.6	0.7	3.4	-0.7	-0.7	0.9	0.1	-0.8	0.9	-0.9	-0.2	0.4	-0.0	1.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.9	-1.6	-1.2	-1.7	-0.6	-1.1	0.0	-1.3	-0.5	-0.1	0.1	0.2
Emphysema/chronic bronchitis	1.1	1.3	3.4	-1.4	-0.6	-1.2	-1.3	-1.4	-0.6	-1.9	-0.8	-0.1	-1.3	0.7
Medication for pain relief, constipation, heartburn	0.7	1.3	3.7	1.9	1.6	0.9	0.9	1.4	1.2	1.0	0.7	0.6	0.5	-0.9
Neck or shoulder pain in last month	1.3	1.9	4.7	-2.2	-0.9	-2.0	0.2	-1.6	0.9	-1.7	-0.8	0.2	0.6	2.0
Medication: Blood pressure	3.6	6.4	20.0	-3.2	-3.3	-1.3	-1.8	-4.5	-1.1	-3.2	-1.9	-0.3	-1.9	2.3
Angina (self-reported)	1.8	2.4	5.6	-1.2	1.3	-1.0	1.6	1.7	-0.3	2.4	2.2	1.0	1.8	-1.5
Migraine (self-reported)	1.2	1.5	3.7	0.8	1.6	0.5	1.4	0.9	0.6	1.2	1.6	1.2	1.9	-0.6
Medication: Ibuprofen	1.5	1.8	3.0	-1.0	-1.4	-0.7	-1.7	-1.6	-1.1	-0.9	-1.7	-1.2	-1.7	0.9
Medication: Allopurinol	0.7	1.0	2.6	-0.6	-0.3	-1.0	-1.1	-0.2	-1.2	-0.9	-1.1	-1.2	-1.6	0.6
Medication: Omeprazole	0.5	0.6	2.0	-0.2	1.2	-0.2	0.3	0.7	-0.5	1.3	-0.6	-0.6	-0.1	-1.4
Medication: Seretide 50 evohaler	1.6	1.8	5.5	-0.3	-0.7	0.5	-2.0	-0.5	-2.2	-0.3	-1.4	-1.3	-2.4	0.6
Mean time to correctly identify matches	0.8	1.4	4.3	-1.1	-1.7	-0.7	0.7	-1.7	1.1	-1.3	0.1	0.7	0.4	2.1
Heart disease (mother)	1.0	1.2	3.7	-1.6	-1.6	-1.9	-1.3	-0.2	-1.5	-0.1	-0.1	-0.4	-0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	4.7	-1.2	-0.9	-0.8	-0.6	-1.5	0.7	-2.0	-0.8	0.6	-1.5	2.2
Whole body fat mass	0.9	3.7	7.1	-1.8	-2.0	-0.5	-1.5	-2.7	-1.7	-2.6	-2.0	-1.1	-1.9	2.2
Leg fat mass (right)	0.7	2.5	4.8	-1.6	-1.4	-0.6	-1.3	-2.1	-1.6	-2.2	-1.8	-1.3	-1.6	1.5
Arm predicted mass (right)	1.1	5.5	8.3	-1.9	-2.6	-2.0	-2.9	-2.2	-2.1	-2.7	-2.4	-1.8	-2.3	2.6
Pulse rate, automated reading	0.1	0.4	1.5	-0.2	0.6	-0.3	-0.8	0.6	-0.4	0.2	-0.8	-0.5	-1.2	-0.5
Alcohol intake frequency.	0.3	0.7	2.7	-1.6	0.2	0.5	0.7	-1.4	0.2	-0.1	0.2	0.7	1.0	0.7
Comparative height size at age 10	0.4	2.0	7.1	0.7	-1.2	1.7	-2.2	-1.1	-1.4	-1.0	-0.9	-0.9	-2.7	0.3
Number of full sisters	2.8	3.4	5.6	-2.1	-2.0	-1.1	-1.8	-2.1	-1.8	-2.0	-2.4	-1.7	-1.7	0.8
Suffer from ‘nerves’	0.2	0.4	1.5	0.0	-1.2	-0.6	-0.7	-0.5	0.3	-0.6	-0.8	-0.5	-0.4	-0.1
Overall health rating	0.3	0.7	1.5	-1.1	-0.2	-0.8	1.2	-1.0	0.8	-0.3	0.2	0.9	0.4	1.2
Chest pain or discomfort	0.3	0.4	2.5	-0.8	-0.6	-1.6	0.2	-0.4	0.1	-0.6	-0.4	0.0	-0.2	0.3
Had major operations	0.3	0.3	1.4	0.1	-0.9	0.4	-0.1	-0.9	-0.1	-1.2	0.3	0.5	0.1	0.3
Age at last live birth	0.4	0.6	2.9	1.7	0.6	0.2	0.5	1.0	-0.7	0.7	0.4	0.2	0.6	-0.3
Family relationship satisfaction	0.8	1.0	3.4	-0.8	-1.1	-0.5	0.0	-1.8	0.8	-1.3	-0.0	1.2	-0.7	0.9
Leg pain on walking	1.5	1.9	4.3	-1.8	-0.9	-0.8	-1.7	-1.0	-1.3	-0.1	-1.4	-1.0	-2.1	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.8	-0.8	-1.1	-0.7	-1.1	-0.7	-1.0	-0.8	-1.3	-0.8	-1.9	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.6	-1.0	0.0	-0.7	-0.4	0.4	-0.5	-0.4	-0.6	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	5.0	2.2	2.1	1.4	1.0	1.9	-0.4	2.0	1.4	0.4	0.9	-1.8
Medication: Aspirin	1.1	1.5	5.2	-2.3	-2.2	-1.4	-1.2	-0.3	-1.5	0.1	0.1	-0.8	-0.1	-0.1
Supplements: Vitamin C	1.3	1.5	3.5	-0.3	-1.9	0.8	-1.9	-0.5	-0.5	-1.2	-1.6	-1.2	-1.7	-0.4
Knee pain experienced in last month	0.5	0.8	2.2	-0.4	-1.2	-0.3	-1.2	-1.5	-0.6	-0.8	-0.4	-0.1	-1.3	1.1
Hypertension (Self-reported)	1.2	3.4	12.2	-2.5	-2.4	-1.4	-0.7	-3.5	-0.2	-2.4	-1.1	-0.1	-1.2	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.3	1.4	0.3	-0.0	-0.5	0.6	-0.4	0.2	-0.1	-0.2	-1.8	-0.0
Illnesses of father: Heart disease	2.9	4.0	16.5	-0.7	2.4	0.6	0.2	3.2	-1.1	4.1	0.8	-1.3	0.2	-2.5
Illnesses of siblings: Diabetes	0.5	0.6	3.2	-0.1	-0.1	-0.8	-0.7	-0.5	-0.0	-0.3	-0.3	0.6	-1.2	-1.8
Smoking status: Previous	1.1	1.7	6.5	2.5	0.5	1.7	-0.6	0.7	-0.3	0.3	-0.6	-0.9	-2.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-0.5	-1.1	-0.2	-0.8	-1.0	-0.5	-1.1	-1.1	-0.5	-0.4	0.7
Whole body fat-free mass	0.8	4.7	7.5	-1.4	-2.7	-1.5	-2.6	-2.2	-1.6	-2.7	-2.4	-1.4	-2.4	2.3
Leg fat-free mass (right)	0.5	2.6	4.4	-0.9	-2.0	-0.8	-1.8	-1.7	-1.1	-2.0	-1.7	-0.8	-1.9	2.1
Arm fat percentage (left)	0.7	2.7	5.9	-1.8	-1.6	0.0	-1.0	-2.3	-1.4	-2.4	-1.7	-0.8	-1.6	2.0
Average weekly red wine intake	0.3	0.5	1.6	0.9	1.3	0.1	0.4	1.3	0.4	0.6	0.6	0.4	-0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	-0.8	0.2	-0.2	0.4	-0.8	0.0	-0.9	-0.2	0.5	1.1	0.3
Mood swings	1.2	2.2	5.0	-2.2	-0.9	-2.2	-0.6	-2.2	0.5	-1.7	-0.5	0.6	-0.2	2.2
Loneliness, isolation	0.9	1.2	2.4	-0.3	-0.4	-1.5	1.1	-1.4	1.1	-1.4	0.5	1.6	0.9	1.1
Long-standing illness, disability or infirmity	1.6	2.4	9.9	-1.4	-1.9	-3.2	-0.9	-2.0	-0.9	-1.4	-1.1	-0.4	-1.4	0.6
Ever had bowel cancer screening	0.1	0.2	0.4	0.6	0.0	0.1	0.5	-0.4	0.5	-0.5	0.6	0.3	0.2	-0.1
Diabetes diagnosed by doctor	0.5	0.9	4.3	0.0	0.6	-1.2	-0.6	0.8	0.4	1.1	0.3	-0.0	-0.8	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	3.4	1.2	1.2	0.3	1.5	0.9	1.1	1.5	1.8	1.8	1.5	-1.4
Friendships satisfaction	2.7	3.3	5.5	-1.8	-2.3	-2.2	-2.2	-2.1	-0.9	-2.2	-1.6	-0.4	-2.2	0.6
Qualifications: nursing, teaching	0.3	0.5	1.8	0.6	1.0	-0.2	-0.1	1.3	-0.1	1.0	-0.6	-0.9	-0.4	-0.7
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.6	-0.4	-0.8	0.5	-0.8	-0.4	-1.1	-1.2	-0.4	0.8	0.0
Eye problems/disorders: Cataract	0.8	0.9	3.2	0.8	1.0	-0.0	-0.8	0.7	-1.8	1.0	-0.5	-0.8	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	8.3	2.9	2.5	1.1	0.9	1.8	0.6	2.2	1.9	0.9	0.2	-2.4
Medication for cholesterol	0.9	1.3	4.5	1.4	1.5	2.1	0.9	1.5	0.3	0.8	0.8	0.1	1.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	5.9	-0.9	-1.0	-0.7	-0.3	-0.9	-1.3	-1.1	0.0	0.6	-0.6	2.4
Back pain experienced in last month	2.8	4.0	9.7	-2.3	-1.3	-2.2	-1.5	-3.1	0.5	-2.7	-2.0	0.1	-1.7	2.4
Mineral and other dietary supplements	3.6	4.8	8.0	2.3	2.4	1.0	2.0	2.4	2.3	2.8	2.7	1.6	1.6	-2.3
Breast cancer (self-reported)	0.4	0.5	1.8	-0.3	0.1	0.1	-1.3	-0.5	0.3	-0.8	-1.3	-0.7	-0.8	0.0
Asthma (self-reported)	0.1	0.1	0.8	0.1	0.1	0.3	-0.2	-0.5	-0.1	-0.2	0.1	-0.3	-0.9	0.2
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.4	-1.2	-1.2	-1.2	0.6	-0.2	-0.2	-0.4	-0.5	-0.5	0.2
Osteoarthritis (self-reported)	2.0	2.6	5.4	2.1	2.1	1.3	2.0	0.9	1.6	1.4	1.8	2.3	0.4	0.1
Medication: Aspirin	0.7	1.0	4.5	-2.1	-1.7	-1.1	-0.7	-0.2	-1.0	0.3	0.6	-0.3	0.3	-0.2
Medication: Gliclazide	0.4	0.4	2.0	-1.2	-0.5	-1.4	0.1	-0.0	0.5	0.5	0.2	0.2	-0.3	-0.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.3	1.5	-1.5	1.3	-0.6	0.2	-1.1	-0.5	-0.5	-0.9	0.3	-1.2
Smoking status: Current	0.2	0.3	1.9	-1.4	0.2	-0.5	0.3	-0.4	0.1	0.0	0.3	0.5	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	-0.5	0.5	-0.4	1.1	0.3	1.3	-0.1	0.5	0.7	1.0	1.1
Whole body water mass	0.9	4.9	7.9	-1.4	-2.7	-1.4	-2.7	-2.3	-1.7	-2.8	-2.5	-1.5	-2.4	2.4
Leg predicted mass (right)	0.5	2.6	4.5	-0.9	-2.1	-0.7	-1.8	-1.8	-1.1	-2.1	-1.7	-0.8	-1.8	2.1
Arm fat mass (left)	1.1	4.7	9.3	-2.3	-2.2	-0.7	-1.7	-2.9	-1.8	-3.1	-2.2	-1.3	-1.9	2.7
Number of self-reported non-cancer illnesses	0.6	1.0	2.8	-0.8	-0.2	-0.4	0.6	-1.4	1.2	-0.5	1.3	1.7	-0.6	1.3
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.5	-0.4	-0.3	-0.6	0.5	-0.0	0.1	0.2	-0.6	-0.7	-0.3
Miserableness	0.8	1.3	3.0	-0.8	-1.0	-1.7	-1.6	-0.6	-0.8	-0.9	-1.2	-1.2	-1.4	-0.5
Guilty feelings	0.8	1.2	3.7	-0.9	-1.3	-0.0	-0.4	-1.9	-0.0	-1.8	-0.8	0.1	-1.0	1.2
Wears glasses or contact lenses	1.4	1.6	4.7	-0.1	-0.2	0.5	1.3	-0.6	1.7	0.0	1.9	1.9	1.1	2.2
Ever taken oral contraceptive pill	0.6	0.7	2.5	-1.2	-0.3	-1.6	-0.3	-0.6	-0.3	-0.5	-0.7	-0.4	0.2	1.3
Hearing aid user	1.1	1.2	3.2	1.8	0.8	1.7	1.2	0.1	1.1	1.2	0.5	0.4	0.7	-1.2
Mother’s age at death	0.5	0.6	1.7	1.3	1.0	1.0	0.2	1.1	-0.1	0.7	0.4	-0.1	-0.9	-0.1
Financial situation satisfaction	1.5	1.9	4.5	-1.7	-2.1	-0.8	-1.0	-1.0	-0.9	-1.8	-1.7	-0.9	-0.6	1.6
Tinnitus: Yes, now most or all of the time	2.4	2.9	7.9	-2.1	-1.6	-1.1	-0.8	-2.8	-1.0	-2.7	-1.7	-0.5	-1.0	1.6
Commuting to job workplace: Public transport	0.7	0.9	4.0	0.6	0.7	1.1	0.6	0.9	-0.6	0.7	-0.1	-0.8	1.1	-2.0
Eye problems/disorders: Glaucoma	0.6	0.7	3.5	-0.8	-1.3	-1.9	0.1	-0.0	-0.3	0.4	0.1	-0.6	0.5	-1.0
Medication: Blood pressure	1.0	2.0	9.8	-1.3	-1.6	-3.1	-0.7	-2.0	-0.2	-1.3	-0.8	-0.1	-0.9	0.6
Pain type(s) experienced in last month: Hip pain	4.1	5.2	13.0	-3.6	-2.6	-3.0	-1.1	-3.2	-0.4	-2.8	-2.0	-0.6	0.4	2.3
Supplements: Fish oil (including cod liver oil)	2.9	3.8	5.9	-2.4	-2.4	-0.9	-2.0	-2.0	-2.0	-2.3	-2.3	-1.2	-1.3	1.9
High cholesterol (Self-reported)	0.3	0.6	2.7	-1.6	-1.1	-0.5	0.1	-1.2	-0.1	-0.8	0.1	0.3	0.4	0.2
Medication: Bendroflumethiazide	2.5	3.8	11.5	-3.4	-2.1	-2.1	-1.0	-2.9	-0.2	-2.4	-1.9	-1.1	-0.2	0.9
Medication: Paracetamol	0.7	1.1	2.8	-1.5	-1.2	-1.3	-0.5	-1.0	-0.0	-1.5	-0.8	-0.1	0.4	1.7
Medication: Lisinopril	1.8	2.3	4.2	-2.0	-1.5	-1.6	-1.5	-2.0	-1.3	-1.8	-1.3	-0.8	-1.7	0.3
Medication: Atorvastatin	0.4	0.5	2.6	-0.5	-0.1	0.3	0.1	1.0	-0.4	1.6	1.0	0.4	-0.1	0.2
Illnesses of father: High blood pressure	0.9	1.2	3.0	-1.5	0.3	-0.3	0.7	-1.2	1.3	-0.9	0.4	1.4	0.8	1.7
Alcohol drinker status: Never	0.4	0.4	1.1	-1.1	0.4	-0.7	-0.6	-0.5	-0.8	0.1	-1.0	-0.8	-0.0	0.1
Ever smoked	0.2	0.4	1.6	1.3	0.4	0.0	-0.2	-0.1	0.1	-0.4	-0.6	-0.3	-1.3	-0.1
Basal metabolic rate	0.9	4.9	8.1	-1.6	-2.7	-1.3	-2.6	-2.3	-1.6	-2.9	-2.4	-1.4	-2.4	2.4
Leg fat percentage (left)	0.3	1.1	3.5	-1.7	-0.9	-0.6	-0.0	-1.9	-0.6	-1.6	-0.6	0.0	-0.3	1.2
Arm fat-free mass (left)	1.2	6.0	10.8	-2.2	-2.7	-2.4	-2.7	-2.6	-1.7	-3.3	-2.5	-1.5	-2.0	2.7
Number of operations (self-reported)	1.0	1.5	3.2	-0.1	-1.8	-0.7	-1.5	-0.9	-1.3	-1.7	-1.0	-1.3	-1.6	0.0
Average weekly beer plus cider intake	1.2	1.8	3.6	-0.8	-1.6	-1.2	-1.5	-1.1	-1.0	-1.0	-1.9	-0.9	-1.8	1.4
Irritability	3.0	5.1	9.3	-1.7	-3.1	-2.1	-2.7	-2.3	-2.3	-2.9	-1.8	-1.1	-2.4	1.7
Risk taking	0.5	0.7	3.2	1.8	0.5	0.3	-0.2	1.4	-0.2	0.3	0.6	-0.0	-1.3	0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	-0.1	0.4	-0.5	0.5	0.1	1.0	-0.8	0.2	0.4	0.7	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.1	0.1	-0.6	0.4	-0.8	-0.2	-0.8	-0.1	0.3	-0.2	0.5
Age started oral contraceptive pill	1.9	2.4	4.9	1.9	1.2	1.4	-0.5	2.2	-1.9	1.7	-0.3	-2.1	-0.8	-1.4
Diastolic blood pressure, automated reading	1.4	4.3	10.4	-1.2	-2.1	-0.8	-1.6	-3.2	-0.8	-2.7	-2.6	-1.1	-2.7	2.1
Ever depressed for a whole week	2.6	3.2	9.1	1.0	1.4	-0.9	2.1	0.8	3.0	1.3	2.5	2.4	1.5	0.9
Unable to work because of sickness or disability	0.8	1.0	1.9	-1.1	-1.3	-1.3	-0.6	-0.6	-1.2	-1.4	-1.1	-0.7	-0.3	0.8
Commuting to job workplace: Cycle	1.4	1.7	5.4	1.8	0.8	0.2	1.4	0.3	2.2	0.8	1.3	2.3	-0.2	-0.1
Myopia	0.3	0.5	1.6	0.9	-1.3	-0.3	0.6	-0.4	1.0	-0.4	0.7	0.7	0.3	0.4
Vascular/heart problems diagnosed by doctor	1.1	3.0	9.7	2.8	2.5	1.9	0.5	3.1	0.3	1.7	0.7	-0.1	0.8	-1.0
Cholesterol lowering medication	0.4	0.6	3.6	-1.9	-0.8	-1.6	-0.4	-0.3	-0.3	0.4	-0.2	-0.0	0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-0.6	0.8	-0.2	-0.2	0.1	-1.0	0.5	-1.1	-0.8	-0.8	-1.1
Pain experienced in last month	3.1	5.2	14.9	2.6	2.5	2.6	1.0	3.9	-0.2	3.3	1.6	-0.4	0.9	-2.8
Supplements: Calcium	0.7	0.7	3.4	-0.2	-0.2	0.6	1.0	0.9	0.9	0.3	0.9	0.7	1.8	-0.5
Basal cell carcinoma (self-reported)	0.9	1.1	7.0	1.7	1.2	0.3	-0.1	0.1	0.2	0.0	-0.4	-0.8	0.3	-2.6
Heart attack/myocardial infarction (self-reported)	1.5	2.0	5.6	-0.0	0.8	-1.2	1.4	1.6	-0.3	2.4	1.9	0.9	1.2	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.3	3.0	7.0	1.5	1.9	1.5	1.9	1.5	1.1	2.3	2.6	1.6	1.6	-0.9
Heart disease (siblings)	2.4	3.0	6.3	1.9	1.2	-0.4	1.8	0.7	1.6	1.6	2.4	2.5	1.1	-2.4
Alcohol drinker status: Previous	0.2	0.2	0.9	-0.5	0.7	-0.4	0.7	0.2	0.3	0.4	-0.0	0.1	0.2	-0.9
Pack years of smoking	0.4	0.6	2.4	-0.4	0.5	1.4	0.4	-0.0	1.5	0.1	0.4	0.6	0.5	0.7
Impedance of whole body	0.5	2.4	3.6	1.5	1.8	1.6	1.7	1.2	1.1	1.7	1.6	1.3	1.6	-1.9
Leg fat mass (left)	0.6	2.2	4.6	-1.6	-1.5	-0.6	-1.0	-2.1	-1.4	-2.1	-1.4	-0.8	-1.3	1.7
Arm predicted mass (left)	1.1	5.6	9.9	-2.1	-2.7	-2.3	-2.6	-2.7	-1.6	-3.1	-2.4	-1.4	-1.9	2.7