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chr9:32,999,087-36,556,091

Best TWAS P=3.56e-23 · Best GWAS P=2.79e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	VCP	0.13	0.01	lasso	6	0.03	2.2e-03	-8.38	8.2	2.1e-16	0.06	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	VCP	0.13	0.02	enet	25	0.04	2.7e-03	-7.82	6.7	2.9e-11	0.15	0.02	0.94	FALSE
3	GTEx	Adipose Visceral Omentum	PIGO	0.10	0.07	enet	4	0.04	3.6e-03	6.59	6.4	1.9e-10	0.04	0.34	0.09	TRUE
4	GTEx	Adrenal Gland	NPR2	0.23	0.06	lasso	12	0.08	9.4e-04	-3.06	6.5	8.3e-11	-0.70	0.02	0.93	FALSE
5	GTEx	Adrenal Gland	TPM2	0.29	0.22	lasso	5	0.25	1.8e-09	7.62	-5.3	1.2e-07	0.05	0.98	0.00	FALSE
6	GTEx	Artery Aorta	GBA2	0.15	0.10	lasso	6	0.07	9.8e-05	-7.75	7.6	2.1e-14	-0.64	0.18	0.74	FALSE
7	GTEx	Artery Aorta	SPAG8	0.11	0.10	lasso	7	0.06	2.0e-04	5.22	-5.7	1.2e-08	0.23	0.73	0.04	FALSE
8	GTEx	Artery Aorta	VCP	0.16	0.12	enet	9	0.13	2.0e-07	-8.26	7.6	2.2e-14	0.05	0.00	1.00	FALSE
9	GTEx	Artery Aorta	PIGO	0.14	0.11	lasso	3	0.10	4.1e-06	-7.82	8.0	1.9e-15	0.03	0.23	0.76	FALSE
10	GTEx	Artery Tibial	NPR2	0.15	0.03	enet	17	0.13	3.6e-10	0.55	6.3	3.3e-10	-0.32	0.04	0.95	FALSE
11	GTEx	Artery Tibial	VCP	0.08	0.05	lasso	5	0.05	4.5e-05	-8.38	8.3	8.4e-17	0.06	0.01	0.99	FALSE
12	GTEx	Artery Tibial	PIGO	0.05	0.00	lasso	6	0.00	8.6e-01	6.59	5.5	3.6e-08	0.11	0.09	0.19	FALSE
13	GTEx	Brain Cerebellar Hemisphere	CD72	0.48	0.37	enet	10	0.36	5.0e-10	-5.45	-5.7	1.3e-08	0.16	0.88	0.01	FALSE
14	GTEx	Brain Cerebellar Hemisphere	TPM2	0.56	0.55	lasso	3	0.56	2.7e-17	7.62	-7.8	6.3e-15	0.30	1.00	0.00	FALSE
15	GTEx	Brain Cerebellum	TPM2	0.63	0.43	lasso	4	0.53	4.0e-18	7.62	-8.1	6.6e-16	0.31	1.00	0.00	FALSE
16	GTEx	Brain Cerebellum	RMRP	0.27	0.00	enet	15	0.02	7.9e-02	1.90	5.5	4.4e-08	-0.20	0.04	0.33	FALSE
17	GTEx	Brain Hippocampus	TMEM8B	0.27	0.14	enet	15	0.14	4.4e-04	7.62	-5.8	7.9e-09	0.11	0.12	0.09	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	TPM2	0.29	0.30	lasso	8	0.29	2.0e-08	7.62	-6.1	1.1e-09	0.15	0.87	0.01	FALSE
19	GTEx	Breast Mammary Tissue (Female)	OR13E1P	0.06	0.05	lasso	2	0.01	1.4e-01	5.56	-5.6	2.7e-08	0.21	0.06	0.05	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	ARHGEF39	0.28	0.00	enet	10	0.01	1.0e-01	5.03	-6.1	1.1e-09	0.47	0.02	0.70	TRUE
21	GTEx	Cells EBV-transformed lymphocytes	FANCG	0.15	0.01	lasso	9	0.00	2.6e-01	-5.70	5.6	1.9e-08	0.04	0.08	0.11	FALSE
22	GTEx	Cells Transformed fibroblasts	VCP	0.22	0.16	lasso	4	0.15	1.4e-11	-8.26	8.4	4.0e-17	0.06	0.00	1.00	TRUE
23	GTEx	Cells Transformed fibroblasts	PIGO	0.04	0.04	enet	12	0.03	1.5e-03	6.60	7.8	5.4e-15	0.08	0.03	0.88	FALSE
24	GTEx	Colon Transverse	GBA2	0.11	0.15	lasso	2	0.15	1.2e-07	-7.73	-7.4	1.9e-13	0.66	0.82	0.07	FALSE
25	GTEx	Colon Transverse	VCP	0.12	0.05	lasso	5	0.07	4.8e-04	-7.41	8.1	8.3e-16	0.04	0.02	0.93	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	VCP	0.13	0.05	enet	19	0.09	3.2e-04	-7.41	6.4	1.2e-10	0.02	0.05	0.81	FALSE
27	GTEx	Esophagus Mucosa	GBA2	0.10	0.11	lasso	2	0.13	4.5e-09	-7.73	-6.5	7.6e-11	0.74	0.61	0.38	TRUE
28	GTEx	Esophagus Mucosa	FANCG	0.11	0.00	lasso	7	0.01	5.7e-02	-4.90	-5.7	1.3e-08	0.03	0.03	0.54	FALSE
29	GTEx	Esophagus Muscularis	VCP	0.12	0.10	enet	6	0.12	9.3e-08	-7.81	7.8	7.0e-15	0.06	0.26	0.74	FALSE
30	GTEx	Heart Atrial Appendage	GBA2	0.12	0.13	enet	8	0.14	1.2e-06	-7.73	-7.5	8.6e-14	0.65	0.74	0.17	FALSE
31	GTEx	Heart Left Ventricle	GBA2	0.29	0.22	lasso	5	0.18	5.2e-10	-7.63	-7.7	1.0e-14	0.72	0.27	0.73	FALSE
32	GTEx	Heart Left Ventricle	NPR2	0.13	0.00	lasso	5	0.00	3.1e-01	2.10	-5.4	6.8e-08	0.71	0.02	0.74	FALSE
33	GTEx	Liver	NPR2	0.18	0.04	lasso	3	0.02	1.1e-01	5.51	-5.7	1.0e-08	0.24	0.16	0.05	FALSE
34	GTEx	Lung	VCP	0.16	0.07	enet	19	0.07	4.9e-06	-8.32	6.4	1.2e-10	0.01	0.00	0.99	TRUE
35	GTEx	Lung	PIGO	0.06	0.00	lasso	5	0.00	5.4e-01	-7.80	8.4	6.2e-17	0.05	0.02	0.88	FALSE
36	GTEx	Muscle Skeletal	GBA2	0.15	0.11	lasso	5	0.08	1.4e-08	-7.63	-7.5	4.9e-14	0.66	0.65	0.35	TRUE
37	GTEx	Muscle Skeletal	TPM2	0.06	0.02	lasso	5	0.02	6.2e-03	8.45	9.9	3.6e-23	-0.60	0.02	0.95	TRUE
38	GTEx	Nerve Tibial	GBA2	0.11	0.11	lasso	1	0.09	3.4e-07	-7.74	7.7	9.8e-15	-0.66	0.94	0.04	FALSE
39	GTEx	Nerve Tibial	NPR2	0.13	0.03	lasso	4	0.08	3.1e-06	-7.69	6.9	6.9e-12	-0.65	0.02	0.97	FALSE
40	GTEx	Nerve Tibial	VCP	0.21	0.08	lasso	7	0.10	2.7e-07	-8.32	8.1	6.8e-16	0.06	0.00	1.00	FALSE
41	GTEx	Nerve Tibial	PIGO	0.09	0.01	lasso	7	0.00	2.1e-01	-5.70	6.4	1.8e-10	0.01	0.17	0.20	FALSE
42	GTEx	Pancreas	TPM2	0.11	0.15	lasso	2	0.14	1.8e-06	7.62	-7.6	2.5e-14	0.29	0.44	0.15	FALSE
43	GTEx	Pancreas	FANCG	0.39	0.37	lasso	3	0.36	3.1e-16	-7.80	7.8	6.6e-15	0.05	0.26	0.74	FALSE
44	GTEx	Skin Sun Exposed Lower leg	FANCG	0.07	0.07	lasso	3	0.07	4.2e-06	-6.50	-6.8	7.5e-12	-0.05	0.88	0.11	FALSE
45	GTEx	Testis	PIGO	0.26	0.30	enet	11	0.26	6.0e-12	-5.90	5.7	1.4e-08	0.05	1.00	0.00	TRUE
46	GTEx	Testis	FANCG	0.23	0.12	enet	23	0.13	2.4e-06	-5.70	-5.7	9.5e-09	-0.07	0.99	0.00	FALSE
47	GTEx	Thyroid	NPR2	0.09	0.07	enet	32	0.05	6.9e-05	-7.69	6.8	7.2e-12	-0.62	0.03	0.93	FALSE
48	GTEx	Whole Blood	GBA2	0.10	0.07	lasso	4	0.04	5.4e-05	-7.63	-8.4	6.3e-17	0.74	0.14	0.86	FALSE
49	GTEx	Whole Blood	VCP	0.11	0.11	lasso	3	0.09	5.9e-09	-7.82	8.0	1.1e-15	0.05	0.12	0.88	FALSE
50	METSIM	Adipose	TPM2	0.12	0.13	lasso	5	0.14	1.1e-19	7.62	-6.2	4.6e-10	0.14	1.00	0.00	FALSE
51	NTR	Blood	DNAJB5	0.02	0.01	bslmm	338	0.01	2.3e-04	-6.45	-6.8	1.3e-11	-0.03	0.20	0.74	FALSE
52	NTR	Blood	RGP1	0.03	0.03	lasso	1	0.02	2.1e-08	-7.75	7.8	9.0e-15	-0.66	0.99	0.01	FALSE
53	NTR	Blood	TPM2	0.04	0.04	lasso	4	0.04	2.3e-13	7.54	-7.2	4.4e-13	0.29	1.00	0.00	FALSE
54	NTR	Blood	VCP	0.02	0.01	bslmm	337	0.01	4.8e-05	-7.51	7.2	4.6e-13	0.01	0.12	0.86	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	UBE2R2	0.22	0.20	bslmm	338	0.21	1.9e-26	-5.04	5.2	2.0e-07	0.08	0.05	0.95	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	TPM2	0.55	0.60	enet	21	0.61	1.1e-100	7.47	-6.7	2.1e-11	0.21	1.00	0.00	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	RP11-112J3.16	0.11	0.12	bslmm	410	0.11	1.5e-13	6.28	-5.4	5.7e-08	0.18	1.00	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	RP11-384P7.7	0.44	0.36	lasso	6	0.40	1.7e-55	-4.75	-5.4	5.6e-08	-0.07	0.18	0.81	TRUE
59	YFS	Blood	TPM2	0.46	0.50	enet	22	0.50	1.1e-194	7.62	-6.9	6.7e-12	0.26	1.00	0.00	FALSE
60	YFS	Blood	VCP	0.05	0.06	lasso	5	0.05	3.5e-17	-8.32	8.3	1.1e-16	0.07	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PIGO	0.05	0.03	lasso	2	0.03	6.1e-04	6.60	6.7	2.0e-11	0.04	0.04	0.24	FALSE
62	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SPAG8	0.04	0.01	blup	47	0.01	5.3e-02	-5.47	-5.6	1.9e-08	0.50	0.03	0.57	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf128	0.14	0.15	blup	50	0.16	1.4e-32	5.59	-5.9	3.1e-09	0.20	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	PIGO	0.02	0.00	blup	43	0.01	1.0e-02	5.05	8.0	8.8e-16	0.04	0.01	0.66	FALSE
65	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GBA2	0.07	0.03	blup	44	0.03	1.1e-02	-5.47	-8.5	1.3e-17	0.54	0.03	0.13	FALSE
66	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PIGO	0.12	0.02	blup	42	0.05	1.2e-03	-5.70	5.6	1.8e-08	-0.02	0.02	0.18	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	GBA2	0.10	0.04	enet	15	0.07	1.0e-04	-7.75	-6.1	1.1e-09	0.63	0.05	0.58	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	PIGO	0.09	0.03	blup	42	0.05	6.5e-04	6.60	7.4	1.6e-13	0.02	0.01	0.85	FALSE
69	The Cancer Genome Atlas	Esophageal Carcinoma	GBA2	0.11	0.10	lasso	1	0.08	1.8e-03	-7.63	-7.6	2.3e-14	0.65	0.04	0.33	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GBA2	0.05	0.05	blup	44	0.05	3.7e-06	-9.79	-9.4	8.2e-21	0.84	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIGO	0.02	0.00	blup	42	0.02	5.5e-03	-7.41	7.8	5.7e-15	0.04	0.01	0.91	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VCP	0.03	0.01	blup	40	0.02	2.5e-03	-7.41	7.9	2.3e-15	0.04	0.01	0.95	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GBA2	0.07	0.08	lasso	4	0.07	6.4e-05	-7.75	-7.8	9.0e-15	0.66	0.19	0.31	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TPM2	0.11	0.08	enet	6	0.11	1.0e-06	7.05	-6.2	7.6e-10	0.26	0.65	0.02	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	TPM2	0.11	0.16	lasso	5	0.17	3.5e-19	7.54	-5.7	1.6e-08	0.07	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	C9orf128	0.07	0.07	lasso	2	0.07	1.6e-08	5.59	-5.7	1.5e-08	0.26	0.99	0.01	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf128	0.02	0.01	blup	50	0.01	2.3e-02	5.59	-6.1	1.1e-09	0.27	0.14	0.15	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf128	0.11	0.18	lasso	2	0.16	3.7e-16	5.59	-5.6	2.2e-08	0.21	0.99	0.01	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1045	0.02	0.02	blup	39	0.02	5.6e-03	-5.11	6.9	4.1e-12	0.07	0.05	0.37	TRUE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIGO	0.06	0.04	enet	4	0.05	1.5e-05	-5.06	5.5	3.0e-08	-0.01	0.85	0.04	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM8B	0.04	0.02	blup	58	0.05	1.5e-05	6.28	6.5	6.1e-11	-0.39	0.01	0.98	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	GBA2	0.04	0.03	blup	44	0.02	1.0e-02	-7.74	-8.9	4.5e-19	0.62	0.06	0.16	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf100	0.08	0.00	blup	58	0.04	3.8e-05	3.92	6.3	2.2e-10	-0.67	0.02	0.81	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf128	0.12	0.19	lasso	1	0.20	8.5e-19	5.59	-5.6	2.2e-08	0.21	1.00	0.00	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	VCP	0.02	0.02	enet	5	0.02	1.2e-02	-7.80	8.4	5.0e-17	0.04	0.01	0.87	FALSE
86	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CCDC107	0.25	0.03	lasso	5	0.04	3.5e-02	-3.79	-5.7	1.4e-08	0.33	0.01	0.06	FALSE
87	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SPAG8	0.18	0.07	blup	47	0.09	1.7e-03	5.69	-6.4	1.9e-10	0.35	0.02	0.28	FALSE