TWAS hub - KLF9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.2470	0.0890	0.00240	0.024	NA	0.086	NA	0.061	0.0320	NA	0.00017	NA	0.0015
2	METSIM	Adipose	0.0469	0.0204	0.00300	0.003	0.016	0.009	0.017	0.004	0.1100	0.0018	0.01600	0.00098	0.0640
3	TCGA	Breast Invasive Carcinoma	0.0112	0.0069	0.00380	0.009	0.006	0.002	NA	0.003	0.0055	0.0180	0.12000	NA	0.0590
4	TCGA	Thyroid Carcinoma	0.0430	0.0220	0.00039	0.005	0.016	-0.001	NA	0.001	0.0910	0.0099	0.38000	NA	0.2300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Blood Platelet Count	6.1	70.4	121.0	3.1	5.7	11.0	10.9
Qualifications: None of the above	5.8	12.4	23.7	-3.6	-1.1	-4.9	-3.4
Qualifications: O levels/GCSEs or equivalent	4.6	7.3	11.5	2.1	2.3	3.4	2.8
Migraine (self-reported)	4.0	5.0	8.2	2.2	2.9	2.1	1.6
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.3	13.1	1.0	2.6	3.5	3.6
Medication: Bendroflumethiazide	3.7	5.6	11.5	-1.0	-2.1	-3.4	-2.3
Maternal smoking around birth	3.6	5.2	7.1	-1.9	-2.1	-2.7	-2.3
Alcohol drinker status: Never	3.4	4.1	8.4	2.0	2.9	1.6	1.2
Depression (self-reported)	3.3	3.9	6.2	1.0	2.3	-1.8	-2.5
Headache pain in last month	3.3	5.7	9.4	2.0	2.3	3.1	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.8	0.7	3.0	3.1	2.6
Hearing difficulty/problems with background noise	3.0	4.8	8.4	0.3	-2.9	-1.6	-2.9
Exposure to tobacco smoke at home	3.0	3.4	4.9	-1.9	0.9	-2.2	-2.1
Peak expiratory flow (PEF)	3.0	7.1	10.4	2.1	2.4	3.2	2.8
Ever taken oral contraceptive pill	3.0	3.4	5.7	2.1	2.4	1.3	1.3
Qualifications: A levels/AS levels or equivalent	2.8	6.2	13.8	1.8	0.2	3.7	2.8
Heel T-Score	2.7	21.7	29.4	2.8	4.8	5.2	5.4
Pain all over the body in last month	2.5	2.7	4.6	-0.6	-1.1	-2.1	-2.1
Hair/balding pattern: Pattern 4	2.5	6.1	9.2	-1.9	-1.8	-3.0	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	5.6	0.8	-1.6	-1.4	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	7.5	0.6	2.7	2.7	2.7
Exposure to tobacco smoke outside home	2.4	3.2	6.4	-0.1	-0.7	-2.5	-2.4
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	7.0	0.2	1.4	2.6	1.6
HDL Cholesterol	2.3	3.9	7.9	0.4	1.1	2.5	2.8
Neuroticism (2016)	2.3	3.4	6.7	2.6	1.3	2.0	1.1
Blood White Count	2.2	16.2	20.2	2.6	4.3	4.4	4.5
Hand grip strength (left)	2.2	5.7	12.7	-1.6	-2.2	-3.6	-1.6
Ever had hysterectomy (womb removed)	2.2	2.4	4.6	-0.0	2.2	1.7	1.6
High blood pressure (siblings)	2.1	3.0	6.7	-0.8	-0.5	-2.6	-2.1
Qualifications: College or University degree	2.1	6.7	13.7	2.6	1.0	3.7	2.3
Hand grip strength (right)	2.0	5.4	10.0	-1.9	-2.4	-3.2	-1.3
Medication: Simvastatin	2.0	2.9	6.1	0.2	-1.3	-2.5	-2.0
Birth weight	2.0	4.4	9.1	-0.5	-0.3	-3.0	-2.8
Wheeze or whistling in the chest in last year	2.0	3.6	5.4	-2.3	-0.8	-2.3	-1.8
Osteoarthritis (self-reported)	2.0	2.6	4.6	-0.8	-0.8	-2.1	-2.1
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.8	-1.2	-1.1	-2.2	-1.6
Verbal and Numeric Reasoning (VNR)	1.9	4.4	12.0	0.1	0.4	3.5	2.4
Townsend deprivation index at recruitment	1.9	2.7	5.1	-0.8	-2.3	-1.2	-1.9
Number of full brothers	1.9	2.4	4.5	-0.2	-0.8	-2.1	-2.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.0	1.1	1.7	1.6	1.6
Ulcerative Colitis (UC)	1.8	3.4	7.5	-0.8	0.4	-2.7	-2.3
Happiness	1.8	2.1	6.5	-0.3	-0.2	-1.4	-2.5
Birth weight of first child	1.8	3.3	7.9	-0.7	0.0	-2.2	-2.8
Illnesses of father: Heart disease	1.8	2.5	6.7	0.8	2.6	1.4	0.9
Ulcerative Colitis	1.7	2.5	3.9	1.6	-0.3	-2.0	-1.8
Number of children fathered	1.7	1.9	3.5	-1.9	-1.0	-1.4	-1.0
Miserableness	1.7	2.9	6.2	2.5	-0.7	-0.6	-2.1
Bipolar Disorder (2011)	1.6	1.6	3.3	0.4	1.5	1.8	0.7
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.9	1.4	1.6	-0.5	-2.0
Hearing difficulty/problems: Yes	1.6	2.4	5.6	-0.7	-1.8	-0.6	-2.4
Financial difficulties in last 2 years	1.6	2.1	4.0	-0.6	-1.0	-2.0	-1.8
Fluid intelligence score	1.6	3.4	10.6	0.0	0.5	3.2	1.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.8	0.9	1.4	1.7	1.4
Supplements: Glucosamine	1.5	1.9	3.4	1.8	1.2	1.0	1.4
Alcohol intake versus 10 years previously	1.5	2.2	3.3	-1.6	-1.8	-1.4	-1.1
Number of live births	1.5	2.1	4.8	-1.4	-0.1	-2.2	-1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.7	3.2	-0.8	-0.6	-1.8	-1.6
Emphysema/chronic bronchitis	1.5	1.7	3.4	-1.8	-1.3	-1.1	-0.5
Qualifications: nursing, teaching	1.5	2.3	4.5	1.6	-0.9	2.1	1.0
Coronary Artery Disease (CAD)	1.4	1.6	3.5	0.4	-0.4	1.6	1.9
Impedance of arm (right)	1.4	6.5	17.1	-0.0	-0.0	4.1	3.0
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.7	0.6	1.3	-1.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.8	0.5	-0.4	-1.2	-2.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.4	0.2	-1.2	-1.5	-1.5
Mouth/teeth dental problems: Dentures	1.3	2.2	6.5	-2.6	0.9	0.8	1.0
Loud music exposure frequency	1.3	1.4	3.3	0.8	-1.8	-0.8	-1.1
Commuting to job workplace: Walk	1.3	1.4	2.5	1.0	-1.6	1.1	0.9
Irritability	1.3	2.2	4.4	2.1	1.6	1.4	0.5
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.3	0.2	0.5	-1.3	-1.8
Age when periods started (menarche)	1.2	3.0	7.5	0.7	1.6	2.7	1.2
Number of incorrect matches in round	1.2	1.9	6.5	0.7	2.6	0.3	0.7
Pulse wave peak to peak time	1.2	1.4	2.8	0.3	0.6	1.5	1.7
Had major operations	1.2	1.4	2.3	-1.5	-1.3	-0.3	-1.2
Hearing aid user	1.2	1.3	2.8	-0.7	-1.7	1.4	0.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.9	0.4	0.5	1.7	1.6
Lung FEV1/FVC ratio	1.1	5.7	8.8	2.2	2.2	3.0	2.0
Average weekly spirits intake	1.1	1.4	2.2	-0.5	-1.4	-1.5	-1.0
Medication for hormone replacement therapy	1.1	1.2	2.9	-0.5	-1.1	-0.7	-1.7
Medication: Co-codamol	1.1	1.3	2.7	0.6	1.6	1.0	1.0
Past tobacco smoking	1.1	2.0	3.3	0.7	1.8	1.4	1.4
Medication: Cholesterol lowering	1.1	1.8	2.9	0.2	-1.2	-1.7	-1.6
Pulse wave Arterial Stiffness index	1.1	1.3	2.6	-0.4	-0.7	-1.4	-1.6
Eye problems/disorders: None of the above	1.1	1.3	4.2	0.6	0.6	0.5	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-0.9	-0.5	-0.9	-1.8
Medication: Gliclazide	1.1	1.2	2.4	1.5	0.6	0.8	1.2
Number of self-reported non-cancer illnesses	1.1	1.8	2.8	-0.2	-1.3	-1.7	-1.7
Guilty feelings	1.1	1.7	2.6	1.1	0.5	1.6	1.6
Mother’s age at death	1.1	1.4	2.0	0.9	1.0	1.4	1.3
Ever depressed for a whole week	1.1	1.4	4.2	-0.4	2.1	-0.4	-1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.2	0.5	2.0	0.3	0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.5	0.2	2.1	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.6	0.5	2.4	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	7.2	0.9	1.0	2.7	2.1
Impedance of arm (left)	1.0	4.7	12.1	0.1	0.6	3.5	2.5
Illnesses of father: None of the above (group 1)	1.0	1.3	1.9	-0.8	-1.1	-1.4	-1.1
Bipolar Disorder (2018)	0.9	1.5	2.4	0.9	1.5	1.6	0.7
Intelligence (Savage-Jansen 2018)	0.9	2.9	6.4	-0.7	1.6	2.5	1.4
Breast Cancer	0.9	2.2	6.4	2.5	-0.1	-1.4	-0.6
Neuroticism	0.9	2.1	3.2	1.7	1.3	1.8	0.8
High blood pressure	0.9	2.6	6.5	0.6	0.2	-2.5	-1.9
High blood pressure (mother)	0.9	1.3	1.9	-1.3	0.0	-1.4	-1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.8	-0.4	-1.9	0.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.6	-1.3	-0.9	-1.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.5	1.6	1.1	-0.0	-1.0
Hypertension (Self-reported)	0.9	2.5	5.4	1.1	0.3	-2.3	-1.8
Average weekly champagne plus white wine intake	0.9	1.2	2.1	1.5	1.3	0.8	0.6
Commuting to job workplace: Public transport	0.9	1.0	1.6	1.1	0.4	1.3	1.0
Medication: Lisinopril	0.9	1.1	2.6	-1.6	-1.3	-0.2	0.4
Medication: Atorvastatin	0.9	1.1	2.0	-0.7	1.3	0.5	1.4
Illnesses of father: High blood pressure	0.9	1.1	3.2	-0.2	-1.8	-0.7	-0.8
Fractured/broken bones in last 5 years	0.9	1.2	1.9	-0.0	-1.1	-1.4	-1.3
Age started oral contraceptive pill	0.9	1.1	2.1	-0.5	-0.1	1.4	1.4
Diastolic blood pressure, automated reading	0.9	2.7	4.7	-0.6	-2.2	-2.0	-1.3
Alcohol drinker status: Previous	0.9	1.1	2.4	-0.8	0.3	-1.6	-1.1
Depression (Nagel 2018)	0.8	1.2	3.2	0.8	-0.8	-0.5	-1.8
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.1	0.4	-0.9	-1.2
Crohns Disease (2012)	0.8	1.3	2.4	1.6	-0.5	-0.8	-1.3
Alcohol usually taken with meals	0.8	1.3	2.2	1.5	-1.5	0.8	-0.0
Had menopause	0.8	1.0	2.6	-0.6	1.6	0.9	0.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.6	0.0	1.1	-1.0	-1.3
Mouth/teeth dental problems	0.8	1.2	4.3	2.1	0.5	-0.1	-0.1
Heart attack	0.8	1.0	1.8	-0.3	1.3	1.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.9	-0.0	-1.7	-0.4	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.0	1.7	1.0	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.1	0.8	1.2	2.5	1.4
Tense / ‘highly strung’	0.8	1.4	3.3	-0.8	1.8	1.0	0.8
Medication: Amlodipine	0.8	1.1	1.8	-0.7	0.8	-1.3	-1.3
Number of full sisters	0.8	1.0	3.2	-1.8	-0.5	-0.7	-0.4
Family relationship satisfaction	0.8	1.0	3.6	0.4	-0.5	-0.1	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.9	-0.2	-0.7	-1.4	-1.2
Average weekly red wine intake	0.8	1.2	2.5	0.7	-1.6	1.1	0.7
Ever had bowel cancer screening	0.8	0.9	1.8	1.0	-0.2	-0.9	-1.3
Osteoporosis (self-reported)	0.8	1.0	1.9	0.7	-0.7	-1.1	-1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.1	-0.2	1.2	1.5	0.7
Irritable Bowel Disease (IBD)	0.7	1.7	3.5	0.3	-0.2	-1.9	-1.8
Lupus	0.7	1.1	1.8	0.9	1.1	-1.4	-0.7
Primary Biliary Cirrhosis	0.7	1.0	1.6	0.9	1.2	-0.6	-1.3
Hypothyroidism (self reported)	0.7	1.5	2.8	-0.7	-1.2	1.2	1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.7	0.2	1.3	-0.7	-1.1
Vitamin and mineral supplements	0.7	0.9	2.6	-0.5	-1.6	0.5	0.7
Diabetes (mother)	0.7	0.9	2.4	0.5	-1.6	-0.4	-0.9
Relative age voice broke	0.7	1.1	2.6	0.6	0.4	1.6	1.1
Stomach or abdominal pain in last month	0.7	0.9	2.1	-0.5	-1.4	0.4	-1.1
Waist circumference	0.7	2.5	5.6	-0.5	0.5	-2.4	-2.0
Worry too long after embarrassment	0.7	1.2	4.3	2.1	-0.2	0.5	-0.4
Medication: Blood pressure	0.7	1.3	2.1	1.2	0.2	-1.3	-1.4
Medication: Omeprazole	0.7	0.8	1.3	-0.1	1.0	-0.9	-1.1
Heart disease (mother)	0.7	0.9	2.3	1.5	0.5	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.2	-0.6	0.4	-1.5	-0.8
Loneliness, isolation	0.7	1.0	2.4	0.3	1.2	-0.3	-1.6
Back pain experienced in last month	0.7	1.0	3.6	-0.2	1.9	0.0	0.4
Mineral and other dietary supplements	0.7	1.0	2.3	-0.7	-1.5	-0.7	-0.8
Breast cancer (self-reported)	0.7	0.8	1.6	1.3	-0.6	0.9	0.8
Ever smoked	0.7	1.3	2.3	-0.7	-0.8	-1.5	-1.3
Number of operations (self-reported)	0.7	1.0	3.0	0.4	-0.9	1.7	0.4
Cholesterol lowering medication	0.7	1.0	1.8	-0.9	1.2	-1.3	0.0
Supplements: Calcium	0.7	0.8	1.1	-0.6	1.1	-0.9	-1.0
Alzheimer’s Disease (in father)	0.6	0.7	2.1	0.7	0.2	1.4	0.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	1.1	1.2	-0.4	-0.6
Schizophrenia (2014)	0.6	1.2	3.0	0.9	-0.8	0.7	-1.7
Triglycerides	0.6	1.0	2.3	0.4	0.5	-1.1	-1.5
Cardiovascular Disease	0.6	1.8	3.3	1.3	1.2	-1.8	-0.9
Chronotype (morning person)	0.6	1.4	2.2	-1.4	1.5	0.3	1.3
Relative age of first facial hair	0.6	1.3	1.8	-0.9	-1.0	1.3	1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	1.2	0.4	0.2	-1.2
Severe depression (siblings)	0.6	0.7	2.6	0.4	1.6	-0.3	0.2
Fed-up feelings	0.6	1.0	3.2	0.7	-0.1	-0.6	-1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	1.3	-0.8	0.3	-0.6
Body mass index (BMI)	0.6	2.4	5.0	-0.2	1.1	-2.2	-1.8
Lung cancer (father)	0.6	0.7	2.0	0.6	1.4	0.3	0.7
Gout (self-reported)	0.6	0.8	1.6	-0.2	-1.1	-1.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	1.8	-0.5	-1.3	1.1	1.3
Pulse rate, automated reading	0.6	1.9	3.5	-1.2	-1.9	-1.4	-0.7
Illnesses of siblings: Diabetes	0.6	0.8	1.5	0.7	-0.2	1.2	1.0
Eye problems/disorders: Cataract	0.6	0.7	2.1	-0.7	-0.5	0.1	-1.4
Wears glasses or contact lenses	0.6	0.7	1.6	1.2	-1.0	0.5	0.3
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.9	0.7	-0.4	-0.2	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.6	-1.1	-0.5	1.9	1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	-1.2	-0.8	0.0	-0.9
Prostate Cancer	0.5	0.7	1.5	-1.2	-0.1	-0.1	-1.2
Age at First Birth	0.5	0.8	1.6	-0.9	0.2	1.3	0.8
Systolic blood pressure, automated reading	0.5	1.5	3.1	-1.0	-0.9	1.1	1.7
Current tobacco smoking	0.5	0.8	2.3	-0.3	1.5	0.3	0.9
Average weekly fortified wine intake	0.5	0.6	1.2	-0.3	0.9	1.1	0.6
Qualifications: CSEs or equivalent	0.5	0.6	1.4	0.3	0.6	-1.2	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.7	-0.3	-1.9	0.4	0.1
Medication: Atenolol	0.5	0.6	1.2	1.1	0.0	-1.1	-0.4
Diabetes (self-reported)	0.5	0.7	2.2	1.5	-0.4	0.5	0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.8	-1.7	-0.4	0.3	0.1
Arm fat-free mass (right)	0.5	2.6	5.8	-0.3	0.8	-2.4	-2.0
Shortness of breath walking on level ground	0.5	0.6	1.3	-1.2	-0.8	-0.0	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	-1.3	-1.0	0.9	-0.0
Neck or shoulder pain in last month	0.5	0.7	1.5	-1.2	-0.8	-0.6	-0.5
Leg fat mass (right)	0.5	2.1	4.3	-0.4	1.0	-2.1	-1.7
Arm predicted mass (right)	0.5	2.4	5.5	-0.4	0.4	-2.3	-2.0
Chest pain or discomfort	0.5	0.7	2.2	-0.8	-1.5	0.2	0.1
Financial situation satisfaction	0.5	0.6	1.1	-0.4	-0.3	-1.0	-1.0
Medication: Blood pressure	0.5	1.0	3.4	-0.3	-0.2	-1.8	-0.8
High cholesterol (Self-reported)	0.5	1.0	3.1	-0.1	-0.4	-1.8	-0.7
Leg fat percentage (left)	0.5	1.7	3.8	-0.7	0.7	-1.9	-1.5
Pain experienced in last month	0.5	0.8	2.6	-0.1	-1.6	-0.7	-0.3
Pack years of smoking	0.5	0.7	1.8	-0.6	-0.5	-1.3	-0.6
Impedance of whole body	0.5	2.4	6.5	-0.2	-0.2	2.5	1.7
Leg fat mass (left)	0.5	2.1	4.2	-0.5	1.0	-2.1	-1.7
Bipolar Disorder or Schizophrenia	0.4	0.9	1.9	1.1	0.1	1.4	-0.5
Schizophrenia (2018)	0.4	0.9	1.5	0.7	-1.1	0.5	-1.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	-0.9	-0.2	-0.4	-1.0
Fasting Glucose	0.4	0.4	0.8	0.9	-0.4	0.9	0.2
Number of treatments/medications taken	0.4	0.6	1.0	0.9	0.7	-1.0	-0.4
Supplements: Zinc	0.4	0.5	0.8	-0.9	-0.7	0.8	0.3
Pack years adult smoking proportion	0.4	0.5	1.4	-0.6	-0.3	-1.2	-0.5
Serious illness, injury or assault to yourself	0.4	0.4	0.7	0.8	-0.8	0.3	-0.5
Medication: Levothyroxine sodium	0.4	0.7	1.1	0.8	0.3	1.0	0.9
Forced vital capacity (FVC)	0.4	1.6	3.3	-0.0	0.9	1.8	1.5
Neuroticism score	0.4	0.8	1.6	1.3	1.1	0.4	-0.6
Hip circumference	0.4	1.6	3.7	-0.7	0.4	-1.4	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.7	0.6	-0.7	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.4	1.2	-0.2	0.5
Leg fat percentage (right)	0.4	1.4	2.9	-0.4	0.8	-1.7	-1.4
Age at first live birth	0.4	0.7	1.3	0.8	-0.2	1.2	0.9
Medication: Seretide 50 evohaler	0.4	0.4	1.1	-1.1	0.1	0.3	0.7
Supplements: Vitamin C	0.4	0.5	1.3	1.1	0.6	-0.2	-0.5
Smoking status: Previous	0.4	0.6	1.7	-0.2	-1.3	-0.5	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.9	-0.1	-1.4	-0.2	-0.6
Medication for cholesterol	0.4	0.7	1.7	0.4	-0.2	1.3	0.8
Medication: Aspirin	0.4	0.5	1.0	1.0	0.5	0.1	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.0	0.3	1.4	0.4	0.1
Arm fat-free mass (left)	0.4	2.2	4.8	-0.3	0.2	-2.2	-1.9
Commuting to job workplace: Cycle	0.4	0.5	1.0	-1.0	-0.7	0.1	0.5
Arm predicted mass (left)	0.4	2.0	4.4	-0.2	0.0	-2.1	-1.9
Worry (Nagel 2018)	0.3	0.7	1.5	-0.7	0.3	1.2	0.9
HbA1C	0.3	0.3	1.0	0.5	-0.1	0.0	-1.0
Rheumatoid Arthritis	0.3	0.4	0.9	0.9	0.1	0.7	0.5
BMI	0.3	2.0	5.5	1.1	2.3	-1.0	-0.6
Allergy or Eczema	0.3	0.8	2.6	0.5	-1.6	0.3	0.3
Lung FVC	0.3	1.4	2.4	-0.6	1.1	1.6	1.2
Taking other prescription medications	0.3	0.5	1.2	0.3	0.2	-1.1	-0.8
Allergy	0.3	0.7	1.9	0.6	1.4	0.3	-0.7
Weight	0.3	1.4	2.2	-0.3	1.1	-1.5	-1.4
Medication: Lansoprazole	0.3	0.3	0.6	-0.7	0.7	-0.4	0.2
Length of working week for main job	0.3	0.3	0.9	-1.0	0.2	0.2	-0.3
Breastfed as a baby	0.3	0.4	1.2	-0.6	-1.1	0.1	-0.3
Pulse wave reflection index	0.3	0.4	1.1	1.1	0.1	0.1	-0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	-0.2	-1.2	0.4	0.1
Body fat percentage	0.3	1.1	1.6	-0.4	1.2	-1.2	-1.1
Health satisfaction	0.3	0.3	0.8	0.4	0.5	0.9	-0.4
Whole body fat mass	0.3	1.4	2.3	-0.5	1.0	-1.5	-1.4
Suffer from ‘nerves’	0.3	0.4	1.1	0.4	1.1	0.2	-0.6
Medication: Aspirin	0.3	0.4	1.1	1.1	0.6	-0.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	1.0	-1.0	-0.3	-0.4
Arm fat percentage (left)	0.3	1.2	2.6	-0.2	1.6	-1.1	-1.0
Mood swings	0.3	0.6	0.9	0.5	0.7	-0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.6	-0.4	0.3	1.0
Smoking status: Current	0.3	0.4	1.2	-0.5	1.1	-0.0	0.4
Arm fat mass (left)	0.3	1.3	2.2	-0.4	1.1	-1.5	-1.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	-0.2	0.2	-0.6	-0.9
Myopia	0.3	0.4	1.2	-0.3	-1.1	-0.1	-0.4
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.8	0.7	-0.4	0.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.5	-0.4	-0.3	-1.2
Major Depression (MDD)	0.2	0.2	0.6	0.5	0.2	0.8	0.2
Mean Putamen Volume	0.2	0.3	0.5	0.7	0.7	-0.0	0.4
Blood Eosinophil Count	0.2	1.6	3.3	0.3	1.8	1.4	1.0
Blood Red Count	0.2	1.8	3.0	1.7	1.3	0.9	1.3
Waist Hip Ratio (WHR)	0.2	0.7	1.4	1.2	-0.5	-0.3	1.0
Systolic Blood Pressure	0.2	0.9	2.2	-0.9	-0.7	0.4	1.5
Sensitivity / hurt feelings	0.2	0.3	0.7	0.6	0.3	0.0	-0.8
Angina	0.2	0.3	0.9	1.0	-0.1	-0.0	0.5
Medication: Metformin	0.2	0.3	0.6	0.8	-0.5	0.4	0.4
Diabetes (father)	0.2	0.2	0.5	-0.6	-0.0	0.7	0.4
Trunk fat percentage	0.2	0.8	1.7	-0.4	1.3	-0.7	-1.1
Multivitamins +/- minerals	0.2	0.3	0.7	-0.1	0.9	-0.3	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.4	0.1	0.4	0.7
Impedance of leg (left)	0.2	0.8	1.2	-1.1	-1.1	0.9	0.4
Trunk fat mass	0.2	0.9	1.4	-0.3	1.1	-1.0	-1.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	-0.3	-0.8	-0.1	0.3
Had other major operations	0.2	0.3	0.5	0.6	0.0	0.4	0.7
Arm fat percentage (right)	0.2	0.6	1.4	-0.1	1.2	-0.7	-0.7
Trunk fat-free mass	0.2	1.1	2.5	-0.1	0.1	-1.6	-1.4
Father’s age at death	0.2	0.3	0.8	0.0	-0.7	0.9	-0.1
Falls in the last year	0.2	0.2	0.5	-0.3	-0.7	0.4	-0.2
Noisy workplace	0.2	0.3	0.7	0.4	-0.4	-0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.3	0.6	0.5	0.6	0.4
Prospective memory result	0.2	0.2	0.8	-0.0	-0.9	-0.3	-0.1
Illnesses of mother	0.2	0.3	0.8	0.0	-0.2	0.9	0.5
Arm fat mass (right)	0.2	1.0	1.6	-0.4	0.9	-1.3	-1.2
Trunk predicted mass	0.2	1.0	2.2	-0.0	0.2	-1.5	-1.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	0.2	0.8	0.1	0.3
Medication: Paracetamol	0.2	0.4	1.0	0.4	1.0	0.1	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	-0.4	0.5	1.3	0.5
Comparative body size at age 10	0.2	0.5	1.0	0.7	0.6	1.0	0.3
Angina (self-reported)	0.2	0.3	0.8	0.9	-0.1	-0.0	0.5
Medication: Allopurinol	0.2	0.2	0.4	0.7	-0.3	-0.6	-0.3
Alcohol intake frequency.	0.2	0.4	0.5	-0.5	0.5	0.7	0.7
Leg pain on walking	0.2	0.3	0.6	0.3	0.8	0.5	0.2
Knee pain experienced in last month	0.2	0.2	0.6	0.3	0.5	0.8	-0.1
Whole body fat-free mass	0.2	1.1	2.2	0.0	0.4	-1.5	-1.4
Diabetes diagnosed by doctor	0.2	0.4	0.6	0.7	-0.7	-0.7	0.1
Friendships satisfaction	0.2	0.3	0.7	-0.4	-0.8	0.5	-0.2
Whole body water mass	0.2	1.0	2.2	0.0	0.3	-1.5	-1.4
Basal metabolic rate	0.2	1.3	2.6	-0.1	0.5	-1.6	-1.5
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.0	0.7	-0.8	0.1
Risk taking	0.2	0.3	0.7	0.1	0.4	-0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.2	0.7	0.5	0.6
Heart disease (siblings)	0.2	0.3	0.7	-0.8	0.6	0.1	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.6	0.1	-0.4	0.8	-0.3
Crohns Disease (2017)	0.1	0.2	0.9	0.9	-0.1	-0.1	-0.2
Reaction Time	0.1	0.2	0.6	-0.3	-0.3	0.5	0.8
Ovarian Cancer	0.1	0.1	0.2	0.3	-0.1	-0.5	0.1
Height	0.1	1.0	1.8	-0.1	-1.2	1.3	0.9
Smoking Status	0.1	0.3	0.8	-0.9	-0.0	-0.5	0.1
Respiratory disease	0.1	0.2	0.5	-0.7	-0.3	-0.2	0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.3	-0.6	0.3	0.3
Impedance of leg (right)	0.1	0.6	1.3	-0.5	-0.8	1.1	0.6
Leg fat-free mass (left)	0.1	0.6	1.0	0.3	0.8	-1.0	-0.8
Leg predicted mass (left)	0.1	0.6	0.9	0.2	0.8	-1.0	-0.8
Nervous feelings	0.1	0.2	0.5	-0.7	0.1	0.7	-0.0
Illnesses of siblings	0.1	0.2	0.6	0.2	-0.1	0.8	0.1
Time employed in main current job	0.1	0.1	0.2	-0.4	0.0	-0.2	-0.4
Worrier / anxious feelings	0.1	0.2	0.5	0.2	0.5	0.2	-0.7
Pulse rate	0.1	0.2	0.6	0.2	0.8	-0.4	0.4
Asthma	0.1	0.2	0.6	-0.8	-0.0	-0.1	0.4
Standing height	0.1	0.6	1.5	-0.3	-0.4	1.2	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	0.4	-0.0	0.3
Glaucoma (self-reported)	0.1	0.2	0.4	-0.2	0.1	-0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	-0.1	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.0	0.6	0.2	-0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.5	-0.1	0.2	0.2
Comparative height size at age 10	0.1	0.5	1.0	-1.0	0.6	0.6	0.5
Overall health rating	0.1	0.3	1.1	-1.0	0.3	-0.2	0.3
Age at last live birth	0.1	0.2	0.7	0.8	-0.2	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.1	-0.0	0.7	-0.3
Leg fat-free mass (right)	0.1	0.6	1.0	0.2	0.7	-1.0	-0.8
Asthma (self-reported)	0.1	0.3	0.8	-0.9	0.0	-0.1	0.5
Leg predicted mass (right)	0.1	0.6	1.1	0.1	0.6	-1.1	-0.9
Medication: Paracetamol	0.1	0.1	0.4	0.2	0.2	-0.1	0.6
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.2	0.5	-0.1	-0.2
LDL Cholesterol	0.0	0.1	0.1	-0.1	-0.3	0.1	-0.4
Hair Pigment	0.0	0.9	1.9	0.9	1.4	0.1	0.9
Tanning	0.0	0.6	1.8	0.1	0.4	1.4	0.6
Sitting height	0.0	0.1	0.2	-0.4	0.1	0.2	-0.1
Medication: Ramipril	0.0	0.1	0.1	0.2	-0.1	-0.1	-0.4
Mean time to correctly identify matches	0.0	0.1	0.2	0.0	-0.4	0.4	-0.2

Hub : Genes

KLF9

Models

Trait associations