Hub : Genes

DFNB31

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0390	0.0210	3.6e-02	0.002	0.002	0.000	0.001	0.001	1.9e-01	1.6e-01	3.0e-01	2.2e-01	2.1e-01
2	GTEx	Adrenal Gland	0.3237	0.1126	4.4e-03	0.051	NA	0.071	NA	0.020	6.6e-03	NA	1.6e-03	NA	6.1e-02
3	GTEx	Brain Cerebellar Hemisphere	0.3750	0.1000	1.3e-03	0.352	NA	0.325	NA	0.360	6.9e-10	NA	4.1e-09	NA	3.9e-10
4	GTEx	Brain Cerebellum	0.3430	0.0990	1.2e-03	0.220	NA	0.232	NA	0.324	3.9e-07	NA	1.8e-07	NA	2.6e-10
5	GTEx	Cells Transformed fibroblasts	0.4790	0.0550	0.0e+00	0.304	NA	0.446	NA	0.450	3.5e-23	NA	1.4e-36	NA	5.7e-37
6	GTEx	Esophagus Mucosa	0.1830	0.0520	3.3e-04	0.087	NA	0.025	NA	0.051	1.9e-06	NA	8.5e-03	NA	2.5e-04
7	GTEx	Heart Atrial Appendage	0.1630	0.0660	8.1e-03	0.130	NA	0.100	NA	0.141	2.0e-06	NA	3.1e-05	NA	7.1e-07
8	GTEx	Nerve Tibial	0.1516	0.0590	9.6e-03	0.012	NA	0.005	NA	0.014	4.3e-02	NA	1.3e-01	NA	3.4e-02
9	GTEx	Pancreas	0.2210	0.0760	2.9e-03	0.166	NA	0.092	NA	0.127	1.6e-07	NA	1.0e-04	NA	5.4e-06
10	GTEx	Skin Not Sun Exposed Suprapubic	0.1860	0.0630	3.3e-03	0.035	NA	0.041	NA	0.033	4.9e-03	NA	2.7e-03	NA	6.6e-03
11	ROSMAP	Brain Pre-frontal Cortex	0.1525	0.0312	4.7e-11	0.108	0.128	0.135	0.138	0.129	9.3e-14	3.7e-16	5.5e-17	2.7e-17	2.7e-16
12	YFS	Blood	0.0426	0.0112	5.2e-07	0.021	0.023	0.022	0.024	0.024	1.7e-07	2.7e-08	7.1e-08	2.0e-08	1.5e-08
13	TCGA	Breast Invasive Carcinoma	0.0310	0.0152	3.8e-03	-0.001	0.017	0.007	NA	0.005	5.3e-01	1.4e-04	1.0e-02	NA	2.2e-02
14	TCGA	Brain Lower Grade Glioma	0.0672	0.0286	1.0e-06	0.009	0.062	0.053	NA	0.044	3.0e-02	1.4e-07	1.1e-06	NA	9.1e-06
15	TCGA	Pheochromocytoma and Paraganglioma	0.1640	0.0780	8.4e-04	0.072	0.072	0.026	NA	0.037	8.5e-04	8.5e-04	3.1e-02	NA	1.4e-02
16	TCGA	Prostate Adenocarcinoma	0.0945	0.0362	5.6e-05	0.011	0.042	0.033	NA	0.020	2.3e-02	3.0e-05	1.8e-04	NA	3.0e-03
17	TCGA	Thyroid Carcinoma	0.0430	0.0230	5.8e-03	0.009	0.015	0.023	NA	0.015	4.2e-02	1.2e-02	2.5e-03	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Bipolar Disorder (2018)	0.6	1.0	4.1	0.6	-1.2	0.5	0.5	-0.0	-0.7	-0.5	1.0	-0.5	-0.7	1.1	-1.6	-0.6	1.0	0.6	-2.0	-1.6
Bipolar Disorder or Schizophrenia	0.6	1.6	6.4	1.5	-0.7	0.5	0.5	1.7	-0.2	1.2	0.9	-0.0	-0.1	1.8	-1.9	-0.0	1.3	1.2	-2.5	-1.4
Depressed Affect (Nagel 2018)	0.9	2.0	8.7	0.7	-2.1	0.9	0.7	0.1	-1.5	1.1	-1.4	-1.5	-1.7	-1.2	1.4	-3.0	-1.7	-0.9	-0.2	1.1
Depression (Nagel 2018)	0.3	0.5	1.4	0.9	-1.2	-0.6	-0.3	0.8	-0.7	1.2	-0.5	-0.6	-0.4	0.6	0.4	-0.9	-0.2	0.7	-0.6	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.0	-1.5	-0.7	1.7	1.6	-0.2	-1.3	-0.4	0.9	-1.3	0.1	-1.5	0.4	-0.6	-1.0	-1.4	-1.0	0.0
Neuroticism (Nagel 2018)	1.0	2.3	9.5	1.2	-2.8	0.6	0.8	-0.3	-2.3	0.4	-0.9	-2.3	-1.7	-0.3	-0.2	-3.1	-1.2	-0.3	-1.8	0.2
Schizophrenia (2018)	0.6	1.2	5.0	1.4	0.1	0.3	0.2	2.2	0.3	1.9	0.4	0.4	0.5	1.4	-1.1	0.6	0.8	1.1	-1.7	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	3.5	-0.6	-0.6	-0.0	0.2	-0.7	-0.7	-0.5	-1.9	-0.8	-0.4	-0.7	0.6	0.3	-1.2	-0.6	-0.4	0.5
Worry (Nagel 2018)	1.0	2.0	5.0	-0.4	-2.2	1.9	2.1	-1.1	-1.9	-0.6	-0.1	-1.9	-1.0	-0.8	0.2	-2.2	-1.5	-0.7	-1.6	0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.7	0.5	0.4	-0.5	-0.7	0.6	0.5	0.9	0.6	0.6	0.3	0.2	-0.6	-0.9	0.6	1.3	0.1	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	2.7	1.6	-0.3	-0.8	-0.7	-0.5	-0.2	0.2	-0.4	-0.1	-0.6	-0.7	0.8	-0.5	-0.7	-0.1	0.9	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	1.1	-0.9	-0.4	-0.5	0.3	-0.9	1.2	0.5	-0.7	-0.9	-1.3	0.7	-1.5	-1.1	0.4	0.4	-0.3
Crohns Disease (2017)	0.9	1.9	7.6	1.1	1.3	0.9	1.1	2.8	1.5	1.9	1.1	1.7	0.3	1.1	0.3	2.4	0.3	1.4	0.4	-0.0
Irritable Bowel Disease (IBD)	0.5	1.3	4.1	-0.4	1.1	1.4	2.0	1.8	-0.6	1.6	0.1	-0.1	-1.9	0.8	1.1	-0.1	-1.0	0.2	-0.6	0.7
Ulcerative Colitis (UC)	0.9	1.7	6.5	-1.3	0.4	1.3	1.9	0.2	-1.8	0.7	-0.4	-1.3	-2.5	0.3	1.3	-1.6	-1.5	-0.7	-1.2	1.0
Major Depression (MDD)	0.7	0.8	4.0	-1.6	-0.9	0.2	0.4	0.0	0.2	0.2	-0.3	0.3	-0.1	-1.6	2.0	-0.4	-0.8	-1.5	0.8	-0.2
Reaction Time	0.1	0.3	2.7	-0.0	1.6	0.2	0.3	0.1	0.6	0.2	-0.1	0.4	0.3	0.4	0.2	0.5	-0.2	0.6	-0.4	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	-0.7	-0.4	0.7	0.9	0.8	-1.1	1.2	-0.2	-1.1	-0.4	-1.2	0.4	-0.8	-1.1	-1.1	-0.2	0.1
Breast Cancer	0.7	1.8	4.3	1.1	2.0	-2.0	-2.0	-0.3	1.0	-0.8	-0.9	0.6	0.9	1.6	-1.0	2.1	1.3	1.1	-0.3	-1.7
Ovarian Cancer	0.5	0.7	3.8	-0.2	0.7	-0.5	-0.2	-0.5	0.7	-0.7	0.4	0.3	0.9	-0.6	1.2	0.2	0.2	-1.5	2.0	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.2	1.2	0.2	-0.5	0.1	-0.1	-0.0	-0.2	0.1	-0.1	0.1	-0.7	-0.2	-0.7	-0.2	-0.3	0.4	-1.1	-1.0
Bipolar Disorder (2011)	1.4	1.4	4.5	0.9	0.7	0.6	-0.2	-1.1	0.1	-1.5	0.6	0.8	-0.2	1.5	-2.1	-1.1	1.6	1.3	-1.2	-1.8
Body Mass Index (BMI) (2010)	1.0	1.3	3.2	-1.4	-0.8	0.7	0.3	-0.8	-1.5	-0.2	-0.7	-1.5	-1.3	-1.7	0.8	-1.8	-1.0	-1.7	-0.4	1.1
Coronary Artery Disease (CAD)	1.1	1.3	11.5	-0.7	0.4	0.9	1.4	0.1	-0.2	0.3	1.0	-0.2	-0.3	-0.1	-0.9	-3.4	-0.3	-1.4	-0.7	-1.4
Crohns Disease (2012)	2.1	3.4	8.9	0.9	1.8	0.7	0.5	2.8	2.6	1.7	2.1	3.0	1.8	1.8	-0.4	2.6	1.9	1.5	1.1	-0.8
Mean Putamen Volume	1.7	1.9	8.3	1.9	2.9	-2.1	-2.2	0.1	1.2	0.3	0.7	1.6	0.5	0.1	0.2	0.2	1.5	0.5	1.8	0.8
Fasting Glucose	0.4	0.4	2.4	-0.0	1.5	-0.5	-0.4	-0.7	0.4	-0.6	-1.3	0.3	-0.3	0.9	-0.6	0.0	0.5	0.2	0.6	0.1
HbA1C	0.4	0.5	1.4	0.3	-0.2	-0.7	0.0	-0.9	-0.2	0.1	-1.0	0.0	-1.1	-0.8	0.7	-1.2	-0.3	-0.2	0.3	1.2
HDL Cholesterol	2.5	4.1	12.1	2.5	1.6	-2.4	-2.5	1.9	2.6	1.8	1.6	3.5	2.2	1.4	0.5	0.3	2.5	1.5	2.4	0.0
LDL Cholesterol	0.3	0.5	2.6	0.6	0.5	-0.4	-0.1	-1.1	0.6	-0.9	-0.7	0.8	-0.6	0.4	-0.7	-1.6	0.8	0.5	-0.5	-0.0
Lupus	0.1	0.2	0.8	-0.6	0.3	-0.5	0.1	0.0	-0.1	-0.1	0.4	0.1	0.9	-0.0	0.0	-0.5	-0.3	0.5	0.5	0.1
Neuroticism (2016)	0.3	0.4	1.6	0.3	-0.9	-0.8	-0.2	-1.3	-0.3	-1.0	-0.9	-0.3	-0.6	0.8	-0.1	-1.1	-0.0	-0.2	-0.3	-0.4
Primary Biliary Cirrhosis	0.3	0.5	2.6	0.1	0.3	-1.1	-0.9	-0.3	0.2	-0.7	1.6	0.4	0.5	1.0	-0.2	-0.2	0.7	0.5	-0.3	-0.5
Rheumatoid Arthritis	0.4	0.5	3.4	-1.9	0.2	0.2	0.4	-0.1	-0.3	-0.2	0.6	-0.2	1.1	-0.2	0.7	-0.9	0.2	-1.0	1.1	0.3
Schizophrenia (2014)	0.7	1.5	4.1	1.4	-0.6	0.6	0.7	1.4	0.6	0.8	0.9	0.5	0.7	2.0	-1.9	0.6	1.2	1.3	-2.0	-1.4
Triglycerides	1.5	2.5	5.8	-2.0	-1.4	2.1	2.3	-1.0	-1.9	-0.4	-0.7	-2.4	-2.0	-1.2	0.6	-1.4	-1.4	-1.8	-1.6	0.6
Type 2 Diabetes (T2D) (2012)	1.2	1.3	4.2	-2.0	-1.3	0.3	0.3	-1.0	-2.0	-1.0	-0.8	-1.3	-0.7	-0.5	-0.7	-2.0	-1.1	-0.6	-1.0	-0.8
Ulcerative Colitis	0.8	1.2	3.5	-1.5	1.3	1.7	1.9	-0.1	-0.9	0.3	1.2	-0.5	-1.2	0.1	0.7	-1.8	-0.6	-1.2	-0.3	0.3
Blood Eosinophil Count	0.5	4.2	10.8	2.5	1.0	0.9	1.4	1.7	-3.3	2.4	-2.2	-2.8	-3.2	-1.4	-1.4	-0.1	-2.3	0.1	-3.2	-0.2
Blood Platelet Count	0.6	6.4	27.8	-1.6	3.6	-0.2	0.4	-0.4	5.3	-0.7	2.9	5.1	2.9	1.0	0.2	-0.6	3.2	0.7	3.2	-0.1
Blood Red Count	0.7	6.4	14.7	-3.5	-3.1	3.0	2.3	0.9	-3.4	1.9	-2.0	-3.8	-3.1	-2.3	0.9	-1.6	-3.1	-1.6	-2.0	1.8
Blood White Count	0.6	4.8	18.8	-1.3	0.5	0.7	0.3	0.0	-3.3	1.7	-2.7	-3.2	-4.3	-1.8	1.5	-3.3	-3.0	-1.2	-0.8	0.9
Heel T-Score	0.4	3.0	7.8	-1.9	2.7	1.3	1.4	1.2	2.8	0.8	1.3	2.6	2.6	-0.0	0.9	1.3	1.4	-0.4	2.5	0.2
BMI	0.7	4.3	12.5	-0.7	-3.2	0.2	0.7	0.9	-3.1	2.0	-1.1	-3.5	-2.6	-2.7	1.4	-2.2	-2.8	-1.4	0.1	1.9
Height	0.3	5.6	16.6	-0.3	-2.2	0.9	0.7	-0.2	-4.0	0.6	-4.1	-3.8	-3.9	1.0	-1.2	-2.2	-2.2	-1.5	-3.3	-0.4
Waist Hip Ratio (WHR)	0.6	2.6	8.5	-1.4	-2.2	1.4	1.9	-0.5	-1.8	-0.1	-1.1	-2.0	-2.1	-1.4	0.5	-2.9	-2.2	-1.4	-0.6	1.0
Systolic Blood Pressure	0.6	2.9	22.8	0.2	4.8	-1.9	-1.3	0.0	2.5	0.2	0.5	2.4	0.3	1.2	0.0	-0.0	1.9	0.2	1.8	0.9
Smoking Status	1.2	2.8	7.9	-1.0	-0.2	-0.6	-0.3	-2.3	-2.7	-1.7	-2.0	-2.8	-2.8	-0.0	0.5	-2.2	-1.7	-1.0	-1.4	0.4
Allergy or Eczema	0.1	0.4	1.2	0.5	0.8	-0.3	0.3	0.1	0.7	-0.1	0.5	0.8	-0.1	0.7	-1.1	0.6	0.6	1.0	-0.8	-0.6
Cardiovascular Disease	0.2	0.7	4.1	0.2	0.9	-1.2	-0.7	1.0	0.3	1.8	-0.7	-0.0	-0.1	-0.1	0.3	-2.0	0.3	-0.4	0.2	-0.1
Hypothyroidism (self reported)	0.1	0.3	1.6	-0.1	0.7	1.0	1.2	-0.3	0.3	-0.3	-0.0	0.5	-0.5	-0.7	-0.1	-0.3	-0.5	0.1	0.4	-0.4
Respiratory disease	0.3	0.7	3.7	-0.0	-0.4	1.1	1.5	1.8	-0.1	1.9	0.3	0.2	-0.6	-0.4	0.0	0.4	-0.3	-0.4	-0.2	0.9
Type 2 Diabetes (T2D) (2018)	2.3	4.3	12.2	-1.2	1.2	2.1	2.3	0.4	-1.8	1.5	-2.3	-2.0	-2.5	-3.2	2.3	-2.3	-3.5	-1.8	-0.0	1.5
Lung FEV1/FVC ratio	0.6	2.8	9.9	-1.9	-1.2	0.8	1.0	-1.3	-2.6	-0.9	-0.3	-3.1	-1.3	-1.9	1.4	-1.0	-2.8	-1.4	-0.6	1.8
Lung FVC	0.4	2.2	7.7	-0.2	-2.8	0.2	0.0	-0.4	-2.1	0.4	-0.9	-2.1	-1.8	-1.7	2.2	0.1	-2.4	-1.2	0.1	1.0
Neuroticism	0.8	2.0	8.0	0.9	-2.8	1.0	0.9	0.1	-2.0	0.6	-0.2	-1.9	-1.2	-0.8	0.7	-2.8	-1.3	-1.0	-1.0	1.4
Chronotype (morning person)	0.7	1.7	4.7	-0.2	0.8	1.9	2.0	-2.2	-0.4	-2.0	-0.5	-0.3	-1.1	-0.9	1.2	-0.2	-1.4	-1.3	0.1	2.0
Hair Pigment	0.1	1.8	8.0	0.8	1.1	-2.8	-2.5	-0.4	1.4	-0.7	-0.1	1.6	0.8	1.3	-0.9	0.5	1.7	1.2	0.5	-0.7
Tanning	0.2	2.4	5.3	1.6	-0.7	-1.6	-1.9	-0.0	-0.4	-0.6	1.0	0.0	-0.8	2.3	-2.1	1.6	1.5	2.0	-2.3	-2.2
Hand grip strength (left)	0.2	0.6	3.8	0.3	-0.9	0.2	0.5	0.5	-0.9	0.4	-1.3	-0.8	-0.8	-0.1	-0.4	0.9	-0.6	0.1	-0.5	-1.9
Number of treatments/medications taken	0.8	1.5	6.0	-2.5	-0.5	0.4	1.1	0.1	-0.1	1.0	-0.2	-0.1	-1.7	-1.0	1.5	-1.6	-1.3	-1.4	1.0	1.7
Average weekly spirits intake	0.8	1.0	2.7	-0.6	-0.9	0.5	0.4	-0.2	-1.5	0.3	-1.3	-1.4	-1.6	-1.0	1.2	0.9	-1.6	-0.5	-0.4	1.1
Sensitivity / hurt feelings	1.3	2.2	7.7	0.7	-2.8	-0.4	-0.2	-1.6	-2.4	-1.1	-0.7	-2.1	-1.5	0.8	-0.9	-2.5	-0.6	0.4	-2.0	-0.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.2	2.1	-1.3	-1.4	-1.5	0.3	-0.6	0.6	-0.8	-0.5	-0.4	1.0	-0.4	-0.7	0.3	1.5	-1.5	-0.3
Hearing difficulty/problems: Yes	0.9	1.3	6.7	-0.1	0.3	-0.9	-1.1	0.7	1.8	0.5	1.0	2.0	1.5	1.3	-0.6	-0.9	2.6	0.2	0.1	0.1
Relative age of first facial hair	0.3	0.5	2.7	-0.5	-0.7	-1.1	-0.9	-0.8	-0.7	-1.6	-1.0	-0.5	0.6	0.4	-0.3	-0.5	-0.0	-0.3	-0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	0.2	1.4	-1.7	-1.3	0.6	1.1	0.4	0.5	0.8	1.0	1.3	-0.3	0.9	1.0	1.2	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	-0.8	-0.3	1.2	1.1	-1.2	-0.2	-1.1	-0.4	-0.4	-0.9	-1.1	1.1	0.2	-0.8	-1.0	0.1	0.2
Ever had hysterectomy (womb removed)	1.0	1.1	5.7	-0.4	-0.1	1.3	1.1	-0.7	-1.1	-0.4	-0.2	-1.4	-1.0	-1.3	-1.0	-2.4	-1.3	-0.8	-0.7	-0.1
Systolic blood pressure, automated reading	0.2	0.7	5.6	-0.1	2.4	-0.8	-0.6	-0.1	1.1	0.0	-0.1	0.8	-0.3	-0.0	0.3	1.1	0.4	-0.1	1.1	0.7
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	6.7	-1.5	0.2	1.5	1.3	-1.8	-1.6	-1.3	-1.5	-1.5	-1.6	-1.9	2.1	-0.5	-2.4	-2.6	0.1	0.2
Angina	1.0	1.3	4.0	-1.0	0.9	0.7	0.8	-0.3	-0.6	0.8	-0.6	-0.4	-1.9	-1.5	1.9	-0.0	-2.0	-0.7	0.8	1.5
Medication for hormone replacement therapy	2.0	2.3	7.0	1.5	0.7	-2.3	-2.3	-0.8	1.3	-0.8	0.5	1.2	0.8	1.5	-2.6	0.7	1.9	2.4	-0.6	-0.9
Vitamin and mineral supplements	0.8	1.1	3.3	1.8	0.8	-1.1	-1.2	0.9	1.1	0.3	0.9	1.0	1.4	1.0	-0.5	1.4	0.7	0.9	0.7	-1.4
Supplements: Zinc	0.4	0.4	2.0	0.7	0.2	1.1	1.0	1.4	-0.1	1.1	-0.5	0.0	0.7	0.0	0.6	0.1	-0.3	0.1	-0.2	0.4
Medication: Co-codamol	0.6	0.7	4.2	-0.3	2.0	0.5	0.7	-0.4	-0.2	-0.1	0.2	-0.4	-0.7	-1.1	1.1	0.5	-1.2	-0.4	0.6	1.4
Medication: Metformin	3.3	4.6	11.7	-2.4	0.4	2.3	2.8	-1.2	-1.9	-0.7	-2.7	-1.9	-2.7	-3.0	1.8	-2.1	-3.4	-2.5	-0.4	0.6
Diabetes (father)	2.3	2.9	10.2	-0.3	0.3	1.0	1.3	0.2	-2.0	0.9	-2.1	-2.3	-1.8	-2.1	1.2	-3.2	-2.2	-2.0	-0.0	2.0
Diabetes (mother)	0.4	0.5	1.3	0.6	0.4	0.9	1.0	-0.9	-0.1	-0.4	0.7	-0.1	-1.1	-0.9	-0.7	-0.8	-0.5	0.5	-0.9	0.1
Severe depression (siblings)	1.3	1.4	4.9	-0.9	0.5	-0.0	0.1	1.5	2.2	1.8	1.1	2.0	1.8	0.5	-0.2	0.8	1.3	-0.0	1.0	-1.0
Pack years adult smoking proportion	0.4	0.6	1.7	0.5	1.0	-1.1	-0.5	0.0	-0.9	0.0	-1.3	-0.7	-0.7	-0.2	0.8	0.0	-0.8	1.1	-0.5	1.1
Impedance of leg (right)	1.4	7.0	16.8	2.1	2.4	-2.6	-2.9	-0.5	3.2	-1.3	0.6	3.4	2.8	3.9	-2.9	1.9	4.1	2.7	-0.3	-3.2
Leg fat-free mass (left)	1.0	5.2	17.5	-0.3	-2.5	1.0	1.3	0.2	-3.9	1.0	-2.1	-4.2	-3.0	-2.2	0.7	-2.7	-3.4	-2.0	-1.6	1.1
Trunk fat percentage	0.3	1.3	8.9	0.9	0.2	-2.1	-1.7	-0.3	-0.9	0.1	-1.0	-1.0	-0.9	-0.5	-0.4	-3.0	0.0	-0.4	0.3	0.3
Hand grip strength (right)	0.5	1.5	5.1	1.6	-1.2	-0.1	0.1	0.0	-1.9	0.1	-2.3	-1.7	-1.6	-0.7	-0.7	0.5	-1.3	0.2	-1.2	-1.4
Townsend deprivation index at recruitment	1.1	1.5	6.1	1.7	2.5	-0.7	-0.5	0.2	1.5	0.0	-0.1	1.3	0.4	1.4	-1.5	0.2	1.5	1.1	-0.5	-2.0
Current tobacco smoking	1.1	1.8	5.2	-0.8	-1.1	0.0	0.2	-1.1	-2.0	0.1	-0.7	-2.3	-2.2	-1.7	1.4	-1.5	-2.0	-0.7	-0.9	0.9
Average weekly fortified wine intake	0.8	0.9	3.3	1.1	0.9	-0.3	-0.6	0.3	0.3	-0.5	-0.4	0.3	0.7	1.7	-1.2	1.3	0.9	0.7	-0.8	-1.8
Maternal smoking around birth	0.6	0.9	2.9	0.8	0.7	-1.6	-1.7	-1.2	0.0	-0.8	-0.9	0.0	0.4	1.2	-0.6	1.0	0.9	0.6	-0.7	-0.8
Fed-up feelings	0.6	1.0	3.9	0.9	-2.0	-0.1	-0.1	-0.3	-1.0	0.3	-0.9	-0.9	-1.4	-1.0	1.5	-1.3	-1.1	-0.4	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.0	1.4	-0.9	-1.4	-1.2	0.1	0.2	0.0	0.5	0.3	0.4	1.1	-0.5	-0.2	0.9	1.7	-0.7	0.5
Relative age voice broke	0.5	0.7	2.4	-1.1	-1.1	0.3	0.3	-1.4	-0.7	-1.5	-1.4	-0.7	-0.1	-0.2	0.3	-0.8	-0.7	-1.0	-0.5	0.4
Taking other prescription medications	0.2	0.2	0.9	-0.5	0.7	-0.4	-0.4	-0.8	-0.3	-0.3	-0.1	-0.2	-0.9	0.4	0.4	-0.7	-0.6	-0.1	0.2	0.5
Age when periods started (menarche)	0.3	0.8	3.3	-1.0	0.8	0.7	1.1	0.5	1.8	0.5	-0.1	1.7	1.1	-0.0	0.6	1.1	0.4	-0.1	0.9	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.9	-1.4	0.1	0.3	0.2	-0.6	-0.4	-0.6	-0.8	-0.7	-0.7	0.3	-1.1	-1.0	-0.2	0.1	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.5	-1.6	1.5	0.6	0.8	0.3	1.7	0.2	0.6	1.4	1.3	0.4	0.3	1.9	0.9	-0.5	1.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	3.1	-1.1	-0.6	0.7	0.8	0.7	0.8	0.5	0.1	0.8	0.8	0.1	0.6	1.8	0.0	0.4	0.6	-0.8
Qualifications: CSEs or equivalent	0.9	1.2	4.1	-0.2	-1.2	1.1	1.1	0.1	-0.6	0.3	-1.1	-0.9	-0.7	-1.7	1.6	-1.2	-1.1	-1.4	0.1	2.0
Serious illness, injury or assault to yourself	0.5	0.6	2.3	-0.4	-0.9	-0.2	-0.6	-0.6	-1.1	0.1	-0.2	-1.4	-1.0	0.1	0.1	-1.5	-0.4	-0.3	-1.2	0.3
High blood pressure	0.3	0.7	4.0	-0.5	-0.1	-1.3	-1.0	-0.0	-0.6	0.8	-0.6	-0.8	-1.2	-0.6	0.6	-2.0	-0.7	-1.0	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.8	0.7	1.9	0.1	0.7	0.3	0.9	0.2	0.4	1.0	0.1	0.6	-1.1	1.1	0.5	0.9	-0.9	-0.4
Multivitamins +/- minerals	0.1	0.1	0.8	-0.3	-0.4	0.1	0.5	0.2	0.2	0.3	-0.4	0.1	-0.6	0.2	-0.2	-0.9	0.5	0.1	-0.4	0.2
Stomach or abdominal pain in last month	1.0	1.2	3.5	-1.2	-0.5	0.7	0.7	-0.1	-1.2	0.4	-0.7	-1.4	-0.6	-1.9	0.9	-1.7	-1.7	-1.6	-0.0	1.0
Supplements: Glucosamine	1.8	2.3	12.6	-3.5	-0.9	2.0	2.3	0.0	-0.5	-0.0	-0.4	-0.7	-1.3	-1.6	1.8	-0.5	-1.3	-1.7	0.9	1.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	2.2	0.3	0.4	-0.5	-0.6	0.1	1.0	-0.3	-0.1	0.9	0.6	0.7	0.4	1.5	0.8	0.2	0.6	-0.1
Medication: Atenolol	0.5	0.6	2.1	0.6	0.6	-0.9	-1.0	-1.4	0.8	-1.4	-0.3	1.0	0.3	0.6	-0.3	-0.5	0.7	-0.3	0.6	0.3
Medication: Levothyroxine sodium	0.5	0.8	2.2	-1.5	0.7	0.8	1.4	-1.3	-0.9	-1.1	-0.4	-0.8	-1.2	-0.3	-0.1	-0.9	-1.0	-0.7	-1.0	0.2
Sitting height	0.0	0.3	1.1	0.9	-0.6	-0.8	-1.0	0.6	-0.4	0.4	-0.7	-0.3	0.4	0.2	-0.4	0.1	0.2	-0.2	0.2	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	2.0	-1.0	0.0	1.3	1.4	-0.2	0.6	0.1	0.7	0.9	0.1	0.5	-0.4	-1.0	0.3	-0.2	-0.1	0.2
High blood pressure (mother)	0.6	0.9	4.6	-0.6	0.6	-0.2	-0.2	-1.4	0.9	-1.8	2.1	0.7	1.0	0.6	-0.2	0.0	1.0	-0.0	0.6	-0.4
Body mass index (BMI)	0.7	3.1	8.9	-0.5	-1.6	0.0	0.5	0.2	-2.6	1.1	-1.1	-3.0	-2.3	-2.7	1.2	-2.6	-2.6	-1.2	0.0	1.6
Impedance of leg (left)	1.7	8.3	21.2	2.5	2.5	-2.8	-3.1	-0.3	3.7	-1.2	0.9	4.0	3.3	4.1	-3.1	1.5	4.6	2.9	0.4	-3.0
Leg predicted mass (left)	0.9	5.0	17.0	-0.3	-2.5	1.0	1.2	0.1	-3.9	0.9	-2.0	-4.1	-2.9	-2.2	0.7	-2.6	-3.4	-2.0	-1.5	1.2
Trunk fat mass	0.5	2.0	10.6	0.5	-0.7	-1.5	-1.1	-0.2	-2.1	0.4	-1.6	-2.3	-1.6	-1.1	-0.0	-3.3	-1.1	-1.1	-0.1	0.7
Waist circumference	1.4	5.1	15.4	-1.1	-1.9	0.7	1.1	-0.5	-3.4	0.4	-1.7	-3.8	-3.1	-2.7	0.9	-3.9	-3.2	-2.0	-0.9	1.7
Number of incorrect matches in round	0.5	0.8	4.5	1.4	1.1	0.3	0.4	2.1	-0.0	2.1	0.4	-0.2	0.7	0.0	-0.4	0.1	-0.3	0.7	-0.2	0.2
Past tobacco smoking	1.0	1.9	4.2	1.8	-0.8	-0.6	-0.7	1.7	1.7	1.4	1.9	1.8	2.0	-0.1	-0.5	1.8	1.2	1.8	0.4	-0.1
Alcohol usually taken with meals	0.3	0.5	3.0	-0.6	-0.7	0.2	0.6	1.2	-0.1	1.1	-1.7	-0.1	-0.4	-0.1	-0.1	0.5	-0.4	-0.0	0.0	0.8
Nervous feelings	0.8	1.5	3.0	-1.1	-1.7	1.6	1.7	-1.2	-1.5	-1.0	0.6	-1.6	-0.7	-1.3	0.5	-0.9	-1.5	-0.5	-1.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.3	0.1	0.4	-0.9	-1.0	-1.1	-1.1	-0.8	-1.4	-1.2	-0.4	0.6	-0.1	-2.1	-0.1	0.7	-1.5	-0.0
Hearing difficulty/problems with background noise	0.6	1.0	3.5	0.2	0.3	-0.2	-0.4	1.0	1.7	1.2	0.6	1.7	1.0	0.8	-0.5	-1.3	1.9	0.6	0.5	0.2
Hair/balding pattern: Pattern 2	0.3	0.3	1.3	1.1	-0.3	0.4	0.3	0.6	0.2	0.8	-0.7	0.4	0.0	-0.9	-0.3	-0.1	-0.6	0.8	0.2	-0.7
Had menopause	0.3	0.4	1.4	-0.4	0.1	-0.2	0.2	-0.6	0.3	-1.1	-0.1	-0.0	-0.2	0.9	-0.8	1.2	0.4	0.3	-1.1	-0.7
Had other major operations	2.3	2.9	8.9	-2.6	-0.9	1.2	1.0	-1.9	-2.2	-1.4	-0.7	-2.2	-3.0	-1.0	-0.4	-1.3	-1.7	-0.8	-2.8	-0.3
Forced vital capacity (FVC)	0.3	1.1	7.2	-0.1	-2.7	-0.9	-0.9	-0.8	-1.5	-0.5	-1.3	-1.4	-0.4	0.6	-0.0	0.5	-0.7	-0.7	-1.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	3.7	-1.9	1.1	0.5	0.3	-0.6	0.5	-0.4	-0.1	0.2	0.4	0.7	-0.2	0.6	0.7	-0.5	0.1	-0.9
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	5.4	1.2	-1.4	-2.2	-2.1	0.0	0.8	-0.4	0.5	0.6	0.5	0.6	-0.8	0.7	1.0	2.1	0.4	-2.3
Qualifications: None of the above	0.3	0.6	4.8	0.6	0.6	0.6	0.5	-0.1	0.0	0.4	-2.2	0.0	-1.1	-0.4	0.3	-1.3	-0.7	0.3	0.0	0.1
Financial difficulties in last 2 years	2.1	2.9	7.9	0.1	-0.9	1.2	1.4	-0.7	-1.3	0.7	-2.8	-1.4	-1.6	-1.9	2.1	-2.2	-2.1	-2.4	0.3	2.5
Mouth/teeth dental problems	0.8	1.2	4.1	-0.1	0.3	-1.2	-1.4	1.1	1.5	0.5	0.6	1.7	2.0	0.5	0.8	1.5	1.0	0.2	1.4	0.6
Heart attack	0.5	0.6	2.0	-1.4	0.1	0.4	0.5	-1.4	0.2	-1.0	0.7	0.2	-0.2	-0.4	1.0	-1.2	-0.1	-1.1	0.6	0.8
Allergy	0.2	0.4	1.7	0.3	-0.6	-0.6	-1.0	-0.8	-0.4	-1.2	-0.1	-0.4	0.3	0.3	0.1	-1.3	0.4	-0.1	0.3	-1.1
Pain all over the body in last month	2.4	2.5	10.6	-0.7	-1.0	1.4	1.2	-1.3	-1.9	-0.2	-1.6	-1.9	-3.2	-1.0	0.6	-2.2	-2.2	-0.8	-1.1	1.7
Diabetes (self-reported)	1.8	2.7	6.6	-1.6	1.8	1.7	1.9	-0.8	-0.9	-0.4	-2.3	-1.0	-2.0	-2.3	1.6	-2.1	-2.6	-1.5	-0.1	1.0
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	10.5	0.8	2.5	-1.8	-1.1	-0.5	3.0	-1.1	2.2	3.2	1.8	2.7	-2.1	2.5	3.2	2.3	0.2	-1.5
Medication: Ramipril	1.9	2.5	7.9	-1.0	-0.3	0.9	0.8	-0.2	-0.9	0.5	-0.3	-1.0	-1.5	-2.4	2.8	-2.2	-2.2	-2.3	1.7	1.9
Medication: Simvastatin	2.8	4.1	12.3	-3.4	-1.0	1.6	1.7	-1.7	-1.8	-0.9	-1.2	-1.7	-2.3	-2.2	1.7	-3.5	-2.2	-3.0	0.3	0.9
Fluid intelligence score	0.4	0.8	4.4	-0.7	0.5	1.2	1.1	0.4	-0.7	0.6	-0.3	-0.8	-1.0	-0.7	0.9	-1.1	-0.7	-2.1	0.2	0.3
Illnesses of siblings	0.7	1.0	3.6	1.1	-0.9	0.8	0.7	-1.2	-0.6	-0.9	-1.0	-0.7	-1.2	-0.1	-1.5	-1.0	-0.6	0.5	-1.9	-1.0
Neuroticism score	1.0	2.1	10.1	0.9	-2.7	0.9	1.0	-0.8	-1.9	-0.2	-0.8	-1.8	-1.4	-0.6	0.4	-3.2	-1.3	-0.3	-1.5	0.8
Weight	0.9	4.2	14.9	-0.1	-2.0	-0.2	0.2	0.1	-3.6	1.0	-2.2	-3.9	-2.8	-2.1	0.5	-2.9	-2.9	-1.6	-0.8	1.1
Impedance of arm (right)	1.6	7.4	19.9	1.4	3.5	-2.8	-2.9	-1.2	3.8	-2.4	0.1	4.1	2.3	3.7	-2.7	0.6	4.5	2.0	0.2	-2.6
Arm fat percentage (right)	0.3	1.3	8.6	0.1	-0.3	-1.4	-0.9	-0.7	-1.2	-0.0	-1.0	-1.5	-1.4	-1.3	0.1	-2.9	-0.7	-0.6	0.0	0.6
Trunk fat-free mass	1.1	6.6	24.6	-0.9	-3.2	1.6	1.6	-0.5	-4.7	0.5	-2.1	-5.0	-3.2	-1.9	0.7	-1.8	-4.0	-2.4	-1.9	0.9
Hip circumference	0.6	2.8	10.2	-0.3	-1.2	-0.6	-0.3	-0.4	-3.0	0.6	-1.5	-3.2	-2.5	-1.4	-0.0	-3.0	-1.8	-1.2	-1.1	0.8
Time employed in main current job	1.9	2.1	4.6	-1.7	-0.9	1.3	1.2	-0.8	-1.7	-0.5	-1.5	-1.7	-2.1	-2.1	1.4	-0.0	-2.0	-1.8	-0.0	1.6
Alcohol intake versus 10 years previously	0.3	0.5	1.6	0.8	0.2	0.9	0.8	0.9	-0.5	1.3	-0.7	-0.5	-1.2	-0.3	0.1	-0.7	-0.7	-0.2	-0.5	-0.0
Father’s age at death	0.2	0.3	1.2	-0.7	-0.3	-0.6	-0.0	1.1	-0.3	1.0	1.0	-0.1	-0.1	-0.4	0.4	-0.4	0.1	-0.6	0.6	0.3
Worrier / anxious feelings	0.6	1.1	5.5	1.0	-2.3	0.9	0.9	-0.5	-0.9	-0.7	-1.4	-0.8	-0.9	0.1	-0.2	-1.9	-0.4	0.1	-1.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	5.3	0.7	-1.1	0.2	0.3	-0.6	-0.5	-0.1	-0.9	-0.4	-1.2	0.2	-0.1	-2.3	-0.2	0.2	-1.3	0.4
Falls in the last year	0.8	1.0	3.3	-1.1	1.6	1.4	1.6	0.1	1.8	0.3	0.0	1.7	-0.0	-0.5	0.9	-0.9	0.3	-0.5	0.6	0.9
Hair/balding pattern: Pattern 3	0.3	0.5	3.5	-0.3	-0.4	0.1	0.2	-0.2	0.1	0.0	0.2	0.4	0.1	-0.7	0.4	-1.4	0.1	-0.6	1.2	1.9
Number of live births	1.4	1.9	7.2	-1.5	0.9	1.4	1.3	-1.5	-0.7	-1.1	-2.5	-0.7	-0.7	-1.4	1.4	-0.2	-1.5	-2.7	0.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	5.2	-0.2	-2.3	-1.2	-1.1	-1.3	-1.3	-1.2	-0.8	-1.3	-0.3	0.5	-0.2	-0.1	-0.5	-0.5	-0.9	-0.9
Pulse rate	0.4	0.7	1.9	1.4	-1.1	-1.1	-1.3	-0.8	-1.1	-0.6	-0.1	-1.2	-0.5	0.1	-0.5	-0.0	0.0	0.6	-0.5	-0.6
Happiness	0.5	0.6	2.6	-0.8	-0.1	-0.6	-0.4	-1.3	0.0	-1.5	0.3	0.1	-0.2	1.1	-0.6	-0.5	0.6	0.1	-0.4	-1.6
Noisy workplace	0.8	1.0	3.4	0.8	-1.8	-0.3	-0.5	0.3	-1.4	1.2	-0.9	-1.5	-1.4	-0.5	-0.2	-1.4	-1.0	0.1	0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.5	-0.2	-1.1	0.1	0.1	0.1	0.9	0.0	1.2	1.0	0.4	0.6	-0.2	1.6	0.5	0.5	-0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	5.9	-0.7	-0.1	0.4	0.6	-0.6	0.1	0.1	0.3	-0.2	-0.6	-1.7	2.0	-0.5	-1.2	-1.0	1.1	2.4
Mouth/teeth dental problems: Dentures	3.0	5.1	11.6	-2.1	-0.6	2.3	2.4	-2.1	-2.9	-0.9	-2.4	-3.1	-3.1	-2.2	1.6	-2.2	-3.4	-2.1	-1.1	1.5
Asthma	0.5	0.9	3.4	-0.3	0.0	0.8	1.1	1.7	0.9	1.6	1.8	1.0	0.6	0.1	0.1	1.3	0.4	-0.0	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.2	-0.6	0.1	1.5	1.4	0.1	0.2	0.7	-1.0	-0.0	-0.6	-0.5	0.1	0.1	-0.3	-0.8	-0.5	1.1
Medication: Cholesterol lowering	2.8	4.3	14.5	-2.2	0.5	1.4	1.6	-1.5	-0.9	-0.1	-0.8	-0.7	-1.8	-2.5	3.2	-3.7	-2.1	-3.8	1.9	2.1
Depression (self-reported)	0.2	0.3	1.0	-0.1	-0.2	-0.9	-1.0	-0.0	0.1	0.4	-0.7	0.0	-0.6	0.1	0.1	-0.3	-0.2	1.0	-0.6	-0.7
Medication: Lansoprazole	1.8	2.0	7.2	-2.7	1.0	2.5	2.0	-1.2	-0.5	-0.9	-0.8	-0.8	-0.8	-0.9	1.1	-1.6	-1.8	-1.8	0.5	0.4
Prospective memory result	1.0	1.2	4.0	0.9	1.1	-1.0	-1.0	0.7	2.0	0.4	0.6	2.0	1.3	0.0	-0.1	0.9	1.4	0.6	1.8	0.4
Lung cancer (father)	0.4	0.4	1.6	-0.3	-0.9	-0.6	-0.5	0.2	-0.3	0.7	-0.9	-0.3	0.1	-0.5	1.3	-0.6	-0.5	-0.7	0.8	0.8
Illnesses of mother	0.3	0.4	1.9	0.7	-0.5	0.2	-0.2	1.2	-0.3	0.9	-1.4	-0.4	-0.0	0.1	0.4	0.5	-0.4	-0.2	-0.0	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.4	-0.5	-1.6	-0.5	-0.3	-0.7	-0.9	-0.4	-1.1	-0.9	-0.5	-0.5	0.2	-0.6	-0.9	-0.6	-0.3	-0.2
Pulse wave Arterial Stiffness index	0.8	0.9	3.1	1.2	0.6	-1.8	-1.7	1.1	-0.5	1.1	-1.4	-0.6	0.5	0.3	0.5	0.4	-0.6	0.3	1.2	0.2
Impedance of arm (left)	1.1	5.2	14.6	1.2	3.3	-2.2	-2.3	-0.7	3.4	-1.7	0.3	3.7	2.2	3.0	-1.9	0.5	3.8	1.2	0.6	-1.8
Arm fat mass (right)	0.6	2.6	10.3	-0.1	-1.5	-0.7	-0.2	-0.3	-2.6	0.5	-1.4	-2.9	-2.1	-1.7	0.3	-3.2	-1.9	-1.1	-0.5	0.9
Trunk predicted mass	1.1	6.3	24.0	-0.9	-3.3	1.6	1.5	-0.4	-4.6	0.5	-2.1	-4.9	-3.1	-1.7	0.5	-1.8	-3.9	-2.3	-1.9	0.8
Standing height	0.2	1.8	6.1	0.7	-1.1	-0.5	-0.6	0.2	-2.3	0.3	-2.5	-2.2	-1.2	1.3	-1.4	-1.2	-0.8	-1.2	-1.8	-1.1
Length of working week for main job	0.9	1.0	4.1	0.5	-0.7	-0.4	-0.4	-1.5	-0.5	-0.8	-2.0	-0.5	-1.8	-0.9	0.3	-1.7	-0.9	0.2	-0.1	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.1	-0.0	0.3	0.2	-0.6	0.8	-0.7	-0.8	0.7	0.4	0.8	-0.5	-0.2	0.5	0.7	-0.6	-0.6
Breastfed as a baby	0.5	0.6	4.2	0.0	2.1	-0.8	-0.4	0.4	1.0	0.5	0.5	0.7	0.2	0.6	-0.4	0.1	0.7	-0.2	1.4	-0.8
Tense / ‘highly strung’	0.6	1.0	3.5	0.2	-1.0	1.1	0.8	-1.5	-1.0	-0.9	-0.5	-1.0	-1.3	-0.7	0.0	-1.9	-1.0	-0.1	-1.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	6.2	-0.9	-1.3	0.4	0.6	-1.2	-1.8	-0.4	-1.9	-2.0	-2.0	-1.9	2.0	-2.2	-2.5	-1.7	0.0	2.4
Hair/balding pattern: Pattern 4	0.3	0.6	2.2	-0.6	-0.1	0.7	0.9	-0.2	1.1	-0.3	0.8	0.8	1.0	-0.1	-0.2	1.1	0.2	0.6	-1.2	-1.5
Birth weight of first child	0.5	0.9	3.4	0.1	-0.8	1.5	1.9	0.0	-0.9	0.1	0.6	-0.8	-0.3	-0.8	1.0	0.4	-1.4	-1.5	-0.0	0.8
Peak expiratory flow (PEF)	0.8	1.8	4.9	0.9	-0.8	-2.2	-1.9	-1.3	0.8	-1.8	0.5	0.9	0.6	1.8	-1.4	1.1	1.6	1.0	-0.2	-2.2
Pulse wave reflection index	0.8	1.0	5.5	0.5	0.3	-0.7	-0.3	2.3	0.1	2.3	-0.6	0.2	0.5	1.1	0.6	1.6	-0.2	0.4	0.5	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.9	-0.1	0.0	0.0	-0.0	-0.5	0.3	0.1	-1.0	0.3	0.1	-0.3	0.0	0.1	-0.0	-0.1	-0.5	-0.4
Loud music exposure frequency	0.9	0.9	5.8	2.4	-0.9	-1.4	-1.3	0.8	-0.5	0.7	0.5	-0.6	0.8	0.5	-0.4	0.5	-0.2	0.9	-0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.1	-1.4	-1.4	1.2	1.3	0.3	-0.4	0.3	0.6	-0.4	-0.0	-0.5	0.8	0.7	-0.7	-1.1	0.6	0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.9	1.5	-0.3	-0.8	-0.8	-0.3	-0.0	-0.5	1.1	0.1	0.1	1.0	-1.4	0.3	0.8	0.9	-0.4	-1.7
Blood clot in the leg (DVT)	0.3	0.4	1.6	-0.8	-1.2	0.0	-0.2	-0.7	-0.6	-0.3	-0.3	-0.6	-0.7	-0.6	0.3	0.6	-0.6	-0.0	-0.6	1.3
Medication: Paracetamol	0.4	0.6	2.0	-1.1	0.6	1.4	1.2	-0.8	0.3	-1.1	0.5	0.2	-0.2	-0.7	0.4	-0.5	-0.2	-0.8	0.3	1.2
Headache pain in last month	0.4	0.6	3.7	1.1	0.4	0.2	-0.2	-0.6	-0.0	-1.0	-1.2	0.1	-0.3	0.6	-0.7	-1.9	0.7	-0.2	0.1	-0.8
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	13.8	0.8	-0.1	-0.3	-0.4	0.9	1.6	-0.8	1.9	1.4	2.6	2.0	-2.4	3.7	2.1	3.1	-0.8	-1.2
Glaucoma (self-reported)	0.5	0.6	5.9	-0.2	2.4	-0.3	-0.6	-0.7	0.4	-1.1	-0.2	0.3	0.6	0.4	0.3	0.4	0.2	-0.6	0.7	-0.1
Gout (self-reported)	0.4	0.6	3.8	0.7	-0.0	0.9	0.8	0.4	0.3	0.4	1.1	0.5	0.2	-0.4	0.9	1.9	-0.3	-0.4	0.9	-0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.5	-1.2	0.3	1.6	1.9	-0.7	-0.5	-0.8	-0.6	-0.3	-0.8	-0.8	-0.1	-0.2	-1.0	-0.2	-0.5	0.3
Medication: Amlodipine	0.6	0.9	3.3	-1.8	-1.3	1.0	1.0	0.2	-0.4	0.5	0.1	-0.2	-0.4	-1.2	1.3	-0.9	-1.0	-1.2	0.5	0.5
Medication: Ventolin 100micrograms inhaler	1.3	1.6	4.1	0.6	0.3	-0.4	-0.4	1.7	1.7	1.8	2.0	1.9	1.5	0.8	-0.4	-0.0	1.4	0.6	2.0	0.6
Birth weight	0.5	1.1	3.5	1.9	0.6	0.9	1.1	1.6	1.2	1.6	0.8	1.2	1.5	-0.1	-0.2	-0.8	0.5	-0.2	0.7	-0.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	5.2	0.9	-0.2	-1.8	-1.9	0.2	0.6	0.1	-0.3	0.6	1.0	1.0	-2.2	0.5	1.5	2.3	-1.7	-1.9
High blood pressure (siblings)	0.3	0.5	1.9	0.4	1.0	-1.4	-1.0	0.5	0.5	0.4	0.2	0.5	0.6	1.0	0.1	0.3	1.2	0.4	-0.0	0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	3.0	-0.3	-1.6	-0.3	-0.3	-0.4	-1.2	-0.1	-1.7	-1.2	-0.9	-0.3	0.0	-0.2	-1.0	-0.7	-0.7	-0.2
Body fat percentage	0.3	1.2	8.2	0.8	-0.0	-1.8	-1.3	-0.3	-1.1	0.2	-1.0	-1.2	-1.0	-0.9	-0.2	-2.9	-0.4	-0.4	0.3	0.4
Leg fat percentage (right)	0.3	1.1	5.0	0.9	-0.8	-1.3	-0.8	0.1	-1.5	0.7	-0.8	-1.8	-1.1	-1.0	-0.2	-2.2	-1.0	0.1	-0.2	0.1
Arm fat-free mass (right)	1.1	5.7	22.3	-0.3	-3.4	1.4	1.5	0.3	-4.5	1.4	-1.4	-4.7	-2.6	-2.0	0.6	-1.9	-3.7	-2.0	-1.6	0.7
Exposure to tobacco smoke outside home	0.3	0.5	1.3	0.7	1.0	-0.8	-0.6	-0.4	0.7	-0.5	0.0	0.9	0.4	0.1	0.6	-0.0	0.6	0.8	0.8	1.1
Comparative body size at age 10	0.3	0.7	2.5	0.8	-1.0	-0.6	-0.1	-1.1	-0.2	-0.3	-0.2	-0.4	-1.6	-0.9	0.1	-1.5	-0.4	-0.8	-1.2	1.0
Number of full brothers	2.3	2.8	9.4	0.8	0.2	-3.1	-2.9	-2.3	0.2	-2.3	-0.5	0.1	0.5	1.4	-2.6	-0.0	1.6	2.0	-0.2	-2.0
Worry too long after embarrassment	0.5	0.9	5.1	2.3	0.4	-1.1	-1.2	0.2	-1.0	0.1	0.2	-0.8	-0.1	1.6	-1.1	-0.7	0.6	0.8	-0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.2	-0.3	0.4	-1.3	-1.6	-1.0	0.2	-0.8	1.1	0.1	0.6	-1.5	2.3	-0.0	-0.6	-0.5	1.9	1.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	0.8	0.7	0.6	0.5	0.4	0.3	0.9	-0.9	0.5	-0.8	-0.3	0.5	-0.7	-0.2	0.1	0.1	-0.1
Number of children fathered	0.7	0.8	2.5	-0.9	1.0	0.6	0.5	-0.8	0.0	-0.6	0.4	-0.0	-0.1	-1.0	1.4	-1.2	-0.7	-1.2	1.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.7	1.4	-0.9	0.7	0.5	-0.9	-1.4	-0.1	-1.1	-1.3	-1.6	-0.6	-0.3	-1.2	-1.0	-0.3	-1.2	0.7
Age at first live birth	0.1	0.2	1.0	-0.5	0.7	0.2	0.0	0.8	0.2	0.5	-0.1	0.4	0.0	0.4	0.2	1.0	0.4	-0.5	-0.4	-0.7
Pulse wave peak to peak time	0.7	0.9	3.1	-1.1	-0.6	1.8	1.7	-1.1	0.3	-1.1	1.0	0.4	-0.7	-0.2	-0.5	-0.5	0.4	-0.3	-1.4	-0.3
Health satisfaction	0.9	1.2	3.4	0.9	-0.9	-0.6	-0.4	-1.8	-1.0	-1.7	-0.1	-0.9	-1.2	-0.4	-1.3	-1.8	-0.4	0.8	-1.1	-0.9
Shortness of breath walking on level ground	0.2	0.2	0.6	0.4	0.1	-0.3	-0.1	0.2	0.4	-0.1	-0.0	0.6	0.5	0.7	-0.6	-0.5	0.8	0.6	-0.1	-0.2
Qualifications: College or University degree	0.3	0.8	4.0	0.4	-1.1	-0.2	0.1	0.1	-0.7	-0.3	0.5	-0.6	-0.1	0.0	-2.0	-0.4	0.2	0.6	-1.8	-1.8
Eye problems/disorders: None of the above	1.0	1.1	3.7	-0.1	1.9	0.4	0.6	1.4	1.4	0.7	1.4	1.2	1.2	0.5	0.4	1.8	0.9	0.2	1.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.6	0.0	0.3	0.2	-0.4	-1.3	-0.9	-1.6	0.2	-1.2	-1.1	0.1	-0.1	0.9	-0.6	0.7	-1.0	-0.7
Emphysema/chronic bronchitis	1.4	1.6	7.5	-0.6	-0.6	0.8	0.6	-1.0	-1.1	-0.3	-2.7	-1.1	-2.1	-1.8	1.3	0.1	-1.8	-0.8	-0.3	0.8
Medication for pain relief, constipation, heartburn	1.0	1.8	6.3	1.8	-1.1	-2.5	-2.4	0.7	-0.3	0.1	-0.1	-0.1	0.9	1.6	-1.0	1.4	1.3	1.7	-0.5	-1.3
Neck or shoulder pain in last month	0.8	1.2	3.8	-0.6	0.1	2.0	1.9	1.5	1.2	1.5	0.3	1.1	-0.2	-0.8	1.6	0.4	-0.3	-0.1	0.7	0.8
Medication: Blood pressure	0.6	1.1	5.6	-0.0	-0.4	-0.6	-0.5	-0.2	-0.4	0.9	-0.8	-0.3	-1.1	-0.9	1.6	-2.4	-0.9	-1.8	0.9	0.8
Angina (self-reported)	1.4	1.9	6.1	-1.2	0.5	1.2	1.2	-0.2	-0.9	1.1	-0.9	-0.8	-2.2	-1.9	2.3	-0.4	-2.5	-1.0	0.6	1.6
Migraine (self-reported)	0.4	0.5	2.1	0.0	-1.1	-0.2	0.2	0.1	-0.3	0.4	0.0	-0.5	-0.7	0.9	-1.0	-0.8	0.1	0.0	-1.0	-1.4
Medication: Ibuprofen	1.0	1.2	4.0	-1.1	0.4	2.0	2.0	0.9	0.5	1.5	-1.2	0.3	-0.7	-0.9	0.9	0.7	-0.7	-1.0	-0.2	1.4
Medication: Allopurinol	0.2	0.3	1.7	0.8	0.0	-0.2	-0.1	0.3	0.1	0.7	0.5	0.4	0.2	-0.1	0.4	1.3	-0.3	0.1	0.9	-0.7
Medication: Omeprazole	2.5	2.9	9.2	0.1	-1.7	-0.2	-0.3	-1.4	-1.9	-0.1	-2.2	-1.9	-3.0	-2.2	1.6	-2.3	-2.5	-1.4	0.5	1.6
Medication: Seretide 50 evohaler	0.7	0.8	6.7	0.8	-0.3	0.4	0.2	1.7	-0.7	2.6	0.2	-0.4	-0.8	-0.3	0.3	-0.4	-0.6	0.3	-0.1	0.4
Mean time to correctly identify matches	0.1	0.3	1.5	-0.4	1.2	-0.4	-0.2	-0.0	0.3	-0.1	0.3	-0.1	-0.2	0.3	1.0	0.8	-0.6	0.1	0.3	0.7
Heart disease (mother)	2.1	2.6	6.8	-2.6	-0.4	2.3	2.2	-1.0	-1.9	-0.3	-1.1	-1.5	-1.5	-1.4	1.2	-2.0	-1.9	-2.1	-0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.1	0.0	-0.8	-0.9	-0.8	0.1	-0.3	-1.0	0.2	-1.1	-0.7	0.8	-0.7	-0.4	-0.7	1.0	-0.3
Whole body fat mass	0.6	2.6	11.2	0.4	-1.1	-0.8	-0.4	-0.2	-2.6	0.6	-1.6	-2.9	-2.0	-1.6	0.2	-3.4	-1.8	-1.3	-0.4	0.9
Leg fat mass (right)	0.7	2.6	8.8	0.7	-1.5	-0.6	-0.1	0.4	-2.7	1.1	-1.5	-3.0	-2.0	-1.8	0.1	-2.8	-2.1	-0.8	-0.7	0.6
Arm predicted mass (right)	1.0	5.3	20.8	-0.5	-3.1	1.3	1.5	0.2	-4.3	1.1	-1.5	-4.6	-2.5	-1.9	0.6	-2.0	-3.5	-2.0	-1.6	0.8
Pulse rate, automated reading	0.1	0.3	1.4	1.0	-0.2	0.5	0.1	0.0	0.1	0.1	0.5	-0.0	-0.1	-0.2	-0.4	-1.0	0.4	0.6	-0.5	-1.2
Alcohol intake frequency.	0.8	1.8	4.8	1.8	-0.5	-1.9	-1.6	0.4	0.3	0.5	0.5	0.4	0.2	1.9	-2.1	-0.6	1.5	2.2	-1.0	-1.7
Comparative height size at age 10	0.3	1.8	5.4	0.4	-1.4	1.2	1.1	1.0	-1.9	1.6	-1.6	-2.1	-2.3	-0.5	0.2	-1.2	-1.7	-1.5	-0.5	0.0
Number of full sisters	0.8	1.0	3.7	0.1	0.5	-0.5	-0.7	-0.7	-1.6	0.1	-0.5	-1.9	-1.3	-0.5	1.5	-0.7	-1.5	-1.0	-0.5	0.3
Suffer from ‘nerves’	0.3	0.5	2.1	0.4	-0.5	1.4	1.5	-0.9	-0.3	-0.7	0.5	-0.3	0.5	-0.2	-0.5	-0.2	-0.7	0.2	-0.9	-0.8
Overall health rating	0.5	1.0	9.6	-0.2	-0.3	0.3	0.7	-1.2	-0.7	-0.8	-0.8	-0.9	-0.7	-0.7	0.4	-3.1	-0.9	-0.5	-0.6	-0.0
Chest pain or discomfort	0.2	0.3	1.8	0.1	0.1	0.0	-0.0	-1.2	-0.1	-0.8	-0.0	-0.1	-0.5	0.8	0.2	-0.4	0.4	-0.0	-1.4	-0.4
Had major operations	0.4	0.5	2.2	-0.9	-0.8	-0.3	-0.2	-1.5	-0.5	-1.2	-0.0	-0.5	-0.6	-0.1	0.5	-1.0	-0.2	-0.8	0.2	0.8
Age at last live birth	0.2	0.4	1.3	-1.1	1.1	0.2	0.5	0.4	0.3	0.4	-0.2	0.6	0.0	0.0	0.6	1.0	0.2	-0.9	-0.4	-0.4
Family relationship satisfaction	0.2	0.3	0.7	-0.2	-0.3	-0.7	-0.2	-0.8	0.6	-0.8	0.6	0.8	0.1	-0.1	0.5	-0.3	0.4	-0.3	0.8	-0.4
Leg pain on walking	0.8	1.0	5.4	-1.4	-0.1	-0.9	-0.6	-0.6	0.1	-0.9	0.6	-0.1	-0.5	0.8	-1.2	0.8	0.6	1.2	-1.3	-2.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.4	0.3	0.7	-1.0	-1.2	-0.4	1.0	-0.3	0.3	1.0	0.5	0.1	1.0	1.8	0.3	0.9	1.0	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	4.3	-2.1	-1.3	0.6	0.7	-0.9	-0.4	-0.5	-0.1	-0.4	-1.0	-0.4	1.0	-0.3	-0.5	-0.6	-0.0	0.8
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	10.8	0.9	1.6	-0.2	-0.5	2.0	1.7	0.3	2.0	1.9	2.1	2.6	-2.1	3.3	2.3	2.1	-0.6	-1.9
Medication: Aspirin	1.0	1.3	3.6	-1.2	-0.0	1.4	1.7	-0.6	-0.3	0.4	0.1	-0.4	-1.3	-1.9	1.1	-1.8	-1.6	-1.0	0.3	0.9
Supplements: Vitamin C	0.7	0.8	2.3	-1.5	-1.3	1.5	1.4	-0.8	-0.6	-0.7	0.2	-0.8	-0.6	-0.5	0.7	-1.0	-0.7	-0.8	-0.4	0.2
Knee pain experienced in last month	0.4	0.5	3.4	-1.8	1.5	-0.2	-0.3	-0.7	0.3	-0.6	-0.6	0.2	-0.7	-0.0	0.3	-1.1	0.4	-0.1	0.3	-0.3
Hypertension (Self-reported)	0.2	0.6	2.9	-0.4	-0.4	-1.2	-0.8	0.2	-0.5	1.0	-0.2	-0.6	-1.0	-0.5	0.4	-1.7	-0.7	-0.7	0.2	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.1	-0.3	-0.3	-0.7	-1.1	-1.0	-0.6	-0.2	-1.8	-0.7	-1.5	-0.2	0.7	-1.2	-0.8	0.0	0.4	-0.3
Illnesses of father: Heart disease	0.7	1.0	3.7	-0.9	-1.0	-0.1	0.3	-1.6	-0.0	-1.8	0.1	0.0	-0.1	-0.7	1.3	0.6	-0.4	-1.4	1.9	0.4
Illnesses of siblings: Diabetes	1.4	1.8	8.3	-2.9	-0.5	-0.3	-0.4	-1.2	-1.2	-1.0	0.4	-1.3	-1.0	-1.8	1.8	-0.1	-1.4	-1.7	1.5	0.8
Smoking status: Previous	1.2	1.8	5.5	-2.3	1.1	1.2	1.3	-1.4	-1.2	-1.3	-1.3	-1.3	-1.5	-0.1	1.0	-1.6	-1.2	-2.2	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.9	1.3	-1.6	-1.7	-1.7	0.4	-1.0	0.4	-1.3	-0.8	-0.4	0.5	-0.9	-0.6	-0.0	0.9	-0.4	-1.4
Whole body fat-free mass	1.1	6.0	22.1	-0.5	-3.1	1.3	1.4	-0.2	-4.5	0.8	-2.0	-4.7	-3.1	-2.0	0.6	-2.1	-3.8	-2.1	-1.9	0.8
Leg fat-free mass (right)	0.9	4.5	14.8	-0.3	-2.4	1.1	1.3	0.1	-3.7	0.9	-1.9	-3.8	-2.7	-2.1	0.6	-2.6	-3.2	-2.0	-1.3	1.2
Arm fat percentage (left)	0.4	1.5	9.5	-0.2	-0.5	-1.1	-0.5	-0.5	-1.5	0.1	-1.0	-1.7	-1.4	-1.7	0.5	-3.1	-1.1	-1.0	0.2	0.9
Average weekly red wine intake	0.5	0.7	2.8	-0.3	-0.2	0.9	0.6	-0.6	-1.0	-0.9	-1.3	-1.0	-0.4	-1.7	0.2	-0.4	-1.2	-0.8	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.7	0.7	0.0	0.1	0.1	0.0	-0.5	-0.1	0.0	-0.2	0.6	-0.6	-0.6	0.8	0.0	-0.7	-0.7
Mood swings	1.5	2.7	8.7	0.4	-1.2	1.5	1.5	0.7	-2.1	1.5	-2.1	-2.1	-2.1	-1.0	1.2	-3.0	-1.8	-1.0	-1.6	1.1
Loneliness, isolation	0.6	0.8	5.2	1.8	-0.3	-0.4	-0.5	-1.4	-0.6	-0.7	-0.7	-0.5	-0.4	0.0	-0.5	-2.3	-0.3	0.3	-0.9	-0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.8	-0.6	0.9	-0.1	0.3	0.2	0.2	0.7	-0.4	0.1	-1.4	0.4	-0.7	-1.3	-0.2	0.8	-0.8	-1.0
Ever had bowel cancer screening	1.3	1.5	4.1	-1.5	-0.8	0.1	-0.0	-0.6	-1.8	-0.4	-1.1	-2.0	-1.2	-1.4	1.6	0.8	-1.8	-1.6	0.4	0.9
Diabetes diagnosed by doctor	3.5	5.8	14.7	-2.6	1.2	2.4	2.7	-1.1	-2.0	-0.2	-3.3	-2.1	-3.1	-3.2	2.4	-3.0	-3.8	-2.4	-0.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	3.1	-0.8	0.6	-0.6	-0.8	-1.8	-0.5	-1.2	-0.1	-0.6	-0.7	0.1	0.0	0.4	-0.1	-0.8	-0.2	-0.2
Friendships satisfaction	0.6	0.7	2.1	-1.1	-0.4	0.8	1.5	0.3	0.6	0.4	0.8	0.7	0.5	-1.2	1.0	-1.1	-0.5	-1.0	1.2	0.4
Qualifications: nursing, teaching	0.5	0.7	2.6	1.1	0.8	-0.3	-0.1	0.7	0.8	0.3	1.6	1.2	0.6	1.0	-0.9	0.8	0.9	1.2	0.3	-0.4
Commuting to job workplace: Walk	0.3	0.3	1.0	0.5	0.7	0.9	1.0	0.4	0.3	0.3	0.0	0.3	0.7	-0.5	-0.3	-0.7	-0.3	0.2	1.0	0.1
Eye problems/disorders: Cataract	1.7	2.0	6.9	-1.5	-2.6	-0.3	-0.5	-2.0	-1.3	-1.2	-0.7	-1.3	-2.1	-1.2	0.0	-2.2	-0.7	-0.2	-1.4	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	0.9	1.1	-0.5	-0.2	0.4	1.2	0.5	1.4	1.2	0.3	0.3	-1.0	0.3	1.4	0.9	-0.7	-1.1
Medication for cholesterol	0.4	0.6	2.7	1.2	0.2	0.6	0.1	1.2	0.0	0.9	-0.2	0.2	0.5	-0.1	1.4	1.6	0.0	-0.6	0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.5	0.4	0.1	0.9	1.2	0.2	-0.6	-0.1	0.0	-0.8	0.1	-1.1	-0.2	-1.0	-0.8	-0.1	-0.5	0.9
Back pain experienced in last month	0.2	0.3	1.5	0.6	-0.6	1.0	1.1	-0.6	-0.3	-0.5	0.1	-0.2	-0.7	0.2	-0.1	-0.5	-0.1	0.3	-1.2	0.1
Mineral and other dietary supplements	1.5	2.0	6.8	2.1	1.0	-1.7	-1.8	0.1	1.2	-0.1	-1.0	1.3	0.9	1.3	-1.7	0.7	1.0	2.1	-0.7	-2.6
Breast cancer (self-reported)	0.3	0.4	1.3	-0.2	-0.9	-0.3	-0.8	-0.2	-1.0	-0.3	0.0	-1.0	-0.5	0.3	0.4	0.7	-0.3	-0.1	-0.8	-1.1
Asthma (self-reported)	0.4	0.8	3.5	-0.1	-0.0	0.4	0.7	1.6	0.9	1.4	1.9	1.0	0.6	0.3	-0.2	1.2	0.6	0.2	0.2	0.7
Osteoporosis (self-reported)	0.7	0.9	3.8	-0.4	2.0	1.9	1.6	-0.4	0.0	-0.4	0.3	0.1	-0.1	-0.1	1.5	0.1	-0.4	-1.3	-0.5	0.6
Osteoarthritis (self-reported)	0.6	0.8	2.4	-0.5	1.4	0.1	0.2	-0.5	-0.9	-0.4	-1.5	-1.1	-1.2	0.7	-1.1	-1.3	-0.1	-0.6	-1.1	-0.9
Medication: Aspirin	0.6	0.8	2.3	-1.2	-0.2	1.1	1.5	-0.3	-0.1	0.5	0.1	-0.3	-1.2	-1.4	1.0	-1.0	-1.2	-0.6	-0.0	0.7
Medication: Gliclazide	1.5	1.7	9.2	-0.1	-0.1	0.5	0.9	-0.4	-1.4	0.1	-3.0	-1.5	-1.4	-0.9	-0.7	-2.5	-1.6	-0.7	-1.3	0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	2.0	-1.1	0.3	0.9	0.6	0.2	-0.1	-0.0	0.5	-0.3	0.6	0.6	-0.3	-0.2	0.1	-0.3	-1.4	-0.2
Smoking status: Current	1.1	1.7	5.4	-0.4	-1.0	-0.2	-0.0	-1.0	-2.0	0.1	-0.8	-2.3	-2.3	-1.2	1.2	-1.4	-1.9	-0.6	-1.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.3	-1.1	-1.6	-2.1	-2.3	-1.4	-0.4	-1.1	0.1	-0.5	0.0	-0.2	0.6	1.0	-0.0	-0.1	0.3	0.2
Whole body water mass	1.1	6.1	21.9	-0.7	-3.1	1.4	1.5	-0.3	-4.5	0.7	-2.1	-4.7	-3.1	-2.0	0.6	-2.2	-3.8	-2.2	-1.9	0.9
Leg predicted mass (right)	0.8	4.4	14.5	-0.3	-2.4	1.0	1.3	0.1	-3.6	0.9	-1.8	-3.8	-2.7	-2.1	0.5	-2.6	-3.1	-2.0	-1.3	1.1
Arm fat mass (left)	0.7	3.0	10.5	-0.3	-1.6	-0.5	0.0	-0.3	-2.8	0.6	-1.6	-3.1	-2.2	-2.0	0.4	-3.2	-2.2	-1.3	-0.6	1.1
Number of self-reported non-cancer illnesses	0.4	0.6	3.6	-1.1	-0.2	-0.9	-0.4	-0.3	-0.5	0.1	-0.8	-0.4	-1.6	0.3	-0.5	-1.9	-0.3	-0.0	-0.8	-0.4
Average weekly champagne plus white wine intake	0.4	0.5	2.0	-0.2	-0.3	-0.8	-0.7	-0.1	0.4	-0.0	0.0	0.6	0.6	1.4	-1.4	-0.9	1.1	0.5	-0.4	-0.4
Miserableness	0.2	0.4	2.8	1.7	-0.4	0.2	0.1	0.6	0.7	0.9	0.0	0.6	0.4	-0.5	0.2	-0.9	0.0	0.7	0.5	-0.2
Guilty feelings	1.6	2.4	8.8	1.8	-2.6	-0.7	-0.2	0.4	-2.1	0.6	-1.9	-2.0	-1.8	0.5	-1.5	-2.0	-0.2	0.5	-3.0	0.2
Wears glasses or contact lenses	0.5	0.6	2.1	-1.1	1.2	-0.6	-0.8	-0.9	-0.1	-0.7	0.4	0.1	-0.4	1.4	-0.2	-0.8	0.6	-0.5	0.4	1.3
Ever taken oral contraceptive pill	4.4	4.9	10.6	-1.9	-1.0	3.1	3.2	-1.6	-2.4	-0.2	-2.8	-2.5	-2.6	-1.9	1.2	-2.7	-3.0	-2.7	-0.8	0.4
Hearing aid user	0.6	0.7	2.8	0.7	0.3	-1.2	-1.5	-1.2	0.2	-1.1	0.5	0.4	-0.4	0.1	-0.8	-1.7	0.9	0.4	0.4	0.5
Mother’s age at death	0.3	0.4	1.5	-0.5	-0.4	-0.1	0.7	-1.0	-0.2	-1.1	-0.0	-0.3	-0.7	-0.6	-0.3	-1.2	-0.9	-0.4	-0.2	-0.2
Financial situation satisfaction	0.5	0.7	2.5	0.6	0.0	-1.0	-1.1	-1.6	0.8	-1.5	0.1	0.8	0.3	0.1	1.0	-0.2	0.2	-0.6	0.9	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.7	0.2	-1.2	0.1	0.2	0.8	0.2	0.3	-0.6	0.6	-0.2	0.6	-1.3	-0.4	0.5	0.8	-0.4	-0.7
Commuting to job workplace: Public transport	0.3	0.3	1.7	0.3	-0.3	0.2	0.2	1.1	0.2	1.3	-0.6	0.3	-0.0	0.2	0.2	-0.1	0.3	-0.3	0.4	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.6	1.3	1.6	-1.1	-1.2	0.2	0.4	0.1	-0.3	0.3	0.7	0.2	-0.2	-0.0	0.3	0.2	0.6	0.7
Medication: Blood pressure	0.2	0.4	1.2	-0.9	-0.0	-0.2	0.3	0.0	-0.3	0.3	0.9	-0.4	-0.8	-1.1	0.1	-1.1	-0.8	-0.5	0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.8	0.9	4.8	0.1	0.2	-0.8	-0.3	-0.4	-0.0	-0.6	-0.1	-0.2	0.5	1.5	-2.2	-1.3	1.2	1.2	-1.7	-0.4
Supplements: Fish oil (including cod liver oil)	1.5	2.0	8.0	-1.3	-1.1	1.7	1.6	0.3	-0.8	0.4	1.3	-1.0	-0.4	-1.9	1.9	-0.8	-1.2	-1.6	1.4	2.8
High cholesterol (Self-reported)	0.5	1.0	3.8	-1.8	-0.1	0.1	0.3	-0.0	0.2	1.0	0.0	0.1	-0.3	-0.9	1.4	-1.8	-0.4	-2.0	1.3	0.7
Medication: Bendroflumethiazide	0.2	0.3	1.7	-0.2	-0.0	0.2	0.3	0.4	-0.2	1.0	-0.5	-0.3	-1.3	-0.3	0.6	-0.0	-0.7	-0.3	0.3	0.1
Medication: Paracetamol	0.2	0.4	1.3	-1.2	0.5	0.9	0.8	0.6	0.9	-0.1	0.5	0.8	0.7	0.4	-0.1	0.4	0.5	-0.1	0.0	0.5
Medication: Lisinopril	0.1	0.2	0.7	-0.1	-0.3	0.2	0.5	-0.0	-0.4	0.2	-0.1	-0.3	-0.8	-0.6	-0.2	0.4	-0.6	-0.0	-0.3	-0.6
Medication: Atorvastatin	1.5	1.9	4.7	-0.8	1.4	1.7	1.7	0.3	-0.1	1.3	-0.9	-0.2	-1.2	-1.8	2.2	-1.0	-1.5	-1.9	1.1	1.8
Illnesses of father: High blood pressure	0.3	0.4	2.2	-0.1	0.6	-0.7	-0.6	-1.5	-0.1	-1.3	-0.1	-0.0	-0.4	-0.5	-0.4	-0.5	0.3	1.0	-0.1	-0.1
Alcohol drinker status: Never	1.0	1.2	3.3	1.2	1.5	-1.1	-1.3	0.2	1.2	-0.1	0.3	1.3	0.9	1.1	-1.8	-0.7	1.8	1.1	-0.3	-0.6
Ever smoked	0.7	1.3	3.9	-1.1	0.8	0.6	0.6	-1.4	-1.3	-1.0	-1.8	-1.3	-2.0	0.2	0.2	-1.8	-0.9	-1.0	-0.8	0.2
Basal metabolic rate	1.0	5.7	21.2	-0.4	-2.9	1.0	1.1	-0.2	-4.4	0.8	-2.1	-4.6	-3.1	-2.0	0.5	-2.5	-3.6	-2.0	-1.8	0.9
Leg fat percentage (left)	0.3	1.1	6.5	1.1	-0.7	-1.3	-0.8	0.2	-1.3	0.8	-0.8	-1.5	-0.9	-1.0	-0.4	-2.5	-0.8	0.1	0.2	0.2
Arm fat-free mass (left)	0.9	4.4	18.4	0.2	-2.9	1.0	1.0	0.3	-4.1	1.2	-1.7	-4.3	-2.4	-1.4	-0.0	-1.8	-3.1	-1.3	-1.9	0.4
Number of operations (self-reported)	0.9	1.3	4.8	-2.1	-0.6	0.7	0.6	-1.2	-1.7	-0.5	-0.5	-1.8	-2.2	-0.5	-0.3	-0.6	-1.2	-0.9	-1.1	-0.1
Average weekly beer plus cider intake	2.9	4.2	10.7	-1.2	-0.5	3.2	3.3	-0.9	-1.4	-0.9	0.1	-1.3	-1.6	-3.3	2.8	-2.2	-2.7	-2.9	0.5	1.3
Irritability	0.5	0.8	4.6	0.9	-1.7	0.5	0.7	-0.7	-0.3	-0.5	-0.8	-0.1	-0.6	-1.3	0.3	-2.1	-0.6	-0.7	-0.1	1.0
Risk taking	1.1	1.6	8.0	0.3	2.8	-1.2	-1.1	-1.7	1.1	-2.0	0.0	1.0	0.4	0.2	1.4	0.8	0.3	-0.8	2.1	0.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.0	-1.1	0.2	0.9	1.3	-0.2	-0.7	-0.0	0.1	-0.6	0.1	-1.2	1.5	-0.6	-1.7	-1.5	1.3	1.0
Fractured/broken bones in last 5 years	0.5	0.7	6.5	-0.2	0.2	0.4	0.1	-0.7	-0.9	-0.6	-0.1	-0.8	-0.6	-0.0	-0.6	-0.6	-0.6	0.6	-2.6	-0.6
Age started oral contraceptive pill	0.7	0.9	3.3	0.4	-0.1	0.2	0.4	1.0	-0.7	1.3	-0.6	-0.8	-1.0	1.2	-1.2	0.5	-0.0	1.2	-1.4	-1.8
Diastolic blood pressure, automated reading	1.5	4.5	9.5	2.7	1.8	-3.1	-2.7	1.4	3.0	1.1	1.8	2.6	2.5	1.7	-0.9	1.7	3.0	1.6	1.8	-0.3
Ever depressed for a whole week	0.8	1.0	2.4	1.1	-1.6	-0.1	0.0	-1.4	-1.2	-1.5	-1.2	-1.2	-1.1	-0.9	0.1	-0.1	-1.0	0.3	-0.7	-0.7
Unable to work because of sickness or disability	1.0	1.3	6.0	0.3	1.5	-0.5	-0.4	0.3	2.5	0.7	1.1	2.2	1.5	0.4	0.3	-0.6	1.0	-0.1	1.8	0.3
Commuting to job workplace: Cycle	0.5	0.6	1.2	0.9	0.8	-0.8	-0.6	0.5	0.8	0.0	-0.2	0.9	0.3	0.9	-1.1	1.0	1.0	0.9	-0.1	-0.8
Myopia	1.3	1.9	8.5	0.5	1.1	-1.0	-1.0	-0.2	1.4	-1.2	0.8	1.0	1.0	2.3	-1.4	1.1	1.7	1.3	-1.4	-2.9
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.9	0.8	-0.3	1.5	1.2	0.3	0.8	-0.7	0.7	1.0	1.5	0.6	-0.7	2.0	0.9	0.9	-0.3	0.2
Cholesterol lowering medication	0.7	1.1	4.8	-2.2	0.5	1.0	1.3	-0.2	-0.8	0.4	-0.9	-1.0	-1.5	-0.7	0.5	-1.2	-1.1	-1.2	-0.0	0.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	6.6	0.1	-0.6	0.8	0.4	-1.2	-1.4	-0.1	-2.0	-1.6	-2.6	-2.0	1.3	-1.7	-2.3	-1.2	0.1	0.8
Pain experienced in last month	0.7	1.1	4.4	0.3	0.2	-0.9	-0.8	0.7	0.9	0.4	2.0	0.9	1.6	0.6	-0.7	2.1	0.9	1.1	0.3	-1.0
Supplements: Calcium	0.5	0.5	1.5	-0.0	0.3	1.0	1.1	-0.5	-1.0	-0.4	-0.5	-0.7	-0.0	-0.3	0.4	-1.0	-0.6	-1.2	-0.3	0.9
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	-0.0	-0.7	0.9	0.8	-0.5	-0.7	-0.2	0.3	-0.5	-0.7	0.0	0.5	-0.8	-0.4	-0.4	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.2	-1.4	0.3	0.5	0.7	-1.5	0.1	-1.0	0.5	0.1	-0.5	-0.4	1.1	-1.1	-0.2	-1.2	0.5	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.8	-0.8	-1.3	-0.1	-0.3	-1.1	-0.3	-0.9	0.2	-0.4	-0.3	-0.4	0.2	0.6	-0.3	-0.0	-0.5	1.0
Heart disease (siblings)	1.5	1.8	5.2	-1.5	-0.8	0.9	0.6	-0.3	-2.0	0.4	-1.7	-1.9	-1.0	-1.3	1.4	-0.5	-2.3	-1.4	0.3	1.9
Alcohol drinker status: Previous	0.7	0.8	4.7	2.2	0.2	-1.3	-0.8	0.5	0.4	0.8	0.5	0.4	-0.4	0.9	-1.1	-0.1	0.6	1.4	-1.0	-0.4
Pack years of smoking	0.4	0.7	1.9	0.8	1.1	-1.3	-0.7	-0.0	-0.8	-0.2	-1.4	-0.7	-0.6	0.3	0.6	0.3	-0.6	1.2	-0.6	0.9
Impedance of whole body	1.5	7.6	21.5	2.0	3.4	-2.7	-2.8	-0.3	4.0	-1.3	0.8	4.3	3.2	3.6	-2.5	0.9	4.6	2.1	0.8	-2.3
Leg fat mass (left)	0.6	2.5	8.2	0.9	-1.5	-0.9	-0.4	0.5	-2.6	1.2	-1.5	-2.8	-1.9	-1.6	-0.1	-2.9	-1.9	-0.6	-0.5	0.6
Arm predicted mass (left)	1.0	5.1	19.4	-0.4	-3.0	1.4	1.4	0.2	-4.2	1.1	-1.5	-4.4	-2.6	-1.7	0.4	-2.1	-3.4	-1.7	-1.8	0.9