Hub : Genes

DFNB31

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0390 0.0210 3.6e-02 0.002 0.002 0.000 0.001 0.001 1.9e-01 1.6e-01 3.0e-01 2.2e-01 2.1e-01
2 GTEx Adrenal Gland 0.3237 0.1126 4.4e-03 0.051 NA 0.071 NA 0.020 6.6e-03 NA 1.6e-03 NA 6.1e-02
3 GTEx Brain Cerebellar Hemisphere 0.3750 0.1000 1.3e-03 0.352 NA 0.325 NA 0.360 6.9e-10 NA 4.1e-09 NA 3.9e-10
4 GTEx Brain Cerebellum 0.3430 0.0990 1.2e-03 0.220 NA 0.232 NA 0.324 3.9e-07 NA 1.8e-07 NA 2.6e-10
5 GTEx Cells Transformed fibroblasts 0.4790 0.0550 0.0e+00 0.304 NA 0.446 NA 0.450 3.5e-23 NA 1.4e-36 NA 5.7e-37
6 GTEx Esophagus Mucosa 0.1830 0.0520 3.3e-04 0.087 NA 0.025 NA 0.051 1.9e-06 NA 8.5e-03 NA 2.5e-04
7 GTEx Heart Atrial Appendage 0.1630 0.0660 8.1e-03 0.130 NA 0.100 NA 0.141 2.0e-06 NA 3.1e-05 NA 7.1e-07
8 GTEx Nerve Tibial 0.1516 0.0590 9.6e-03 0.012 NA 0.005 NA 0.014 4.3e-02 NA 1.3e-01 NA 3.4e-02
9 GTEx Pancreas 0.2210 0.0760 2.9e-03 0.166 NA 0.092 NA 0.127 1.6e-07 NA 1.0e-04 NA 5.4e-06
10 GTEx Skin Not Sun Exposed Suprapubic 0.1860 0.0630 3.3e-03 0.035 NA 0.041 NA 0.033 4.9e-03 NA 2.7e-03 NA 6.6e-03
11 ROSMAP Brain Pre-frontal Cortex 0.1525 0.0312 4.7e-11 0.108 0.128 0.135 0.138 0.129 9.3e-14 3.7e-16 5.5e-17 2.7e-17 2.7e-16
12 YFS Blood 0.0426 0.0112 5.2e-07 0.021 0.023 0.022 0.024 0.024 1.7e-07 2.7e-08 7.1e-08 2.0e-08 1.5e-08
13 TCGA Breast Invasive Carcinoma 0.0310 0.0152 3.8e-03 -0.001 0.017 0.007 NA 0.005 5.3e-01 1.4e-04 1.0e-02 NA 2.2e-02
14 TCGA Brain Lower Grade Glioma 0.0672 0.0286 1.0e-06 0.009 0.062 0.053 NA 0.044 3.0e-02 1.4e-07 1.1e-06 NA 9.1e-06
15 TCGA Pheochromocytoma and Paraganglioma 0.1640 0.0780 8.4e-04 0.072 0.072 0.026 NA 0.037 8.5e-04 8.5e-04 3.1e-02 NA 1.4e-02
16 TCGA Prostate Adenocarcinoma 0.0945 0.0362 5.6e-05 0.011 0.042 0.033 NA 0.020 2.3e-02 3.0e-05 1.8e-04 NA 3.0e-03
17 TCGA Thyroid Carcinoma 0.0430 0.0230 5.8e-03 0.009 0.015 0.023 NA 0.015 4.2e-02 1.2e-02 2.5e-03 NA 1.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.6 1.0 4.1 0.6 -1.2 0.5 0.5 -0.0 -0.7 -0.5 1.0 -0.5 -0.7 1.1 -1.6 -0.6 1.0 0.6 -2.0 -1.6
Bipolar Disorder or Schizophrenia 0.6 1.6 6.4 1.5 -0.7 0.5 0.5 1.7 -0.2 1.2 0.9 -0.0 -0.1 1.8 -1.9 -0.0 1.3 1.2 -2.5 -1.4
Depressed Affect (Nagel 2018) 0.9 2.0 8.7 0.7 -2.1 0.9 0.7 0.1 -1.5 1.1 -1.4 -1.5 -1.7 -1.2 1.4 -3.0 -1.7 -0.9 -0.2 1.1
Depression (Nagel 2018) 0.3 0.5 1.4 0.9 -1.2 -0.6 -0.3 0.8 -0.7 1.2 -0.5 -0.6 -0.4 0.6 0.4 -0.9 -0.2 0.7 -0.6 0.8
Intelligence (Savage-Jansen 2018) 0.4 1.2 3.0 -1.5 -0.7 1.7 1.6 -0.2 -1.3 -0.4 0.9 -1.3 0.1 -1.5 0.4 -0.6 -1.0 -1.4 -1.0 0.0
Neuroticism (Nagel 2018) 1.0 2.3 9.5 1.2 -2.8 0.6 0.8 -0.3 -2.3 0.4 -0.9 -2.3 -1.7 -0.3 -0.2 -3.1 -1.2 -0.3 -1.8 0.2
Schizophrenia (2018) 0.6 1.2 5.0 1.4 0.1 0.3 0.2 2.2 0.3 1.9 0.4 0.4 0.5 1.4 -1.1 0.6 0.8 1.1 -1.7 -0.5
Schizophrenia vs Biploar Disorder 0.4 0.6 3.5 -0.6 -0.6 -0.0 0.2 -0.7 -0.7 -0.5 -1.9 -0.8 -0.4 -0.7 0.6 0.3 -1.2 -0.6 -0.4 0.5
Worry (Nagel 2018) 1.0 2.0 5.0 -0.4 -2.2 1.9 2.1 -1.1 -1.9 -0.6 -0.1 -1.9 -1.0 -0.8 0.2 -2.2 -1.5 -0.7 -1.6 0.7
Alzheimer’s Disease (in mother) 0.4 0.4 1.7 0.5 0.4 -0.5 -0.7 0.6 0.5 0.9 0.6 0.6 0.3 0.2 -0.6 -0.9 0.6 1.3 0.1 -0.8
Alzheimer’s Disease (in father) 0.4 0.4 2.7 1.6 -0.3 -0.8 -0.7 -0.5 -0.2 0.2 -0.4 -0.1 -0.6 -0.7 0.8 -0.5 -0.7 -0.1 0.9 0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 2.4 1.1 -0.9 -0.4 -0.5 0.3 -0.9 1.2 0.5 -0.7 -0.9 -1.3 0.7 -1.5 -1.1 0.4 0.4 -0.3
Crohns Disease (2017) 0.9 1.9 7.6 1.1 1.3 0.9 1.1 2.8 1.5 1.9 1.1 1.7 0.3 1.1 0.3 2.4 0.3 1.4 0.4 -0.0
Irritable Bowel Disease (IBD) 0.5 1.3 4.1 -0.4 1.1 1.4 2.0 1.8 -0.6 1.6 0.1 -0.1 -1.9 0.8 1.1 -0.1 -1.0 0.2 -0.6 0.7
Ulcerative Colitis (UC) 0.9 1.7 6.5 -1.3 0.4 1.3 1.9 0.2 -1.8 0.7 -0.4 -1.3 -2.5 0.3 1.3 -1.6 -1.5 -0.7 -1.2 1.0
Major Depression (MDD) 0.7 0.8 4.0 -1.6 -0.9 0.2 0.4 0.0 0.2 0.2 -0.3 0.3 -0.1 -1.6 2.0 -0.4 -0.8 -1.5 0.8 -0.2
Reaction Time 0.1 0.3 2.7 -0.0 1.6 0.2 0.3 0.1 0.6 0.2 -0.1 0.4 0.3 0.4 0.2 0.5 -0.2 0.6 -0.4 0.0
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.5 -0.7 -0.4 0.7 0.9 0.8 -1.1 1.2 -0.2 -1.1 -0.4 -1.2 0.4 -0.8 -1.1 -1.1 -0.2 0.1
Breast Cancer 0.7 1.8 4.3 1.1 2.0 -2.0 -2.0 -0.3 1.0 -0.8 -0.9 0.6 0.9 1.6 -1.0 2.1 1.3 1.1 -0.3 -1.7
Ovarian Cancer 0.5 0.7 3.8 -0.2 0.7 -0.5 -0.2 -0.5 0.7 -0.7 0.4 0.3 0.9 -0.6 1.2 0.2 0.2 -1.5 2.0 1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.2 1.2 0.2 -0.5 0.1 -0.1 -0.0 -0.2 0.1 -0.1 0.1 -0.7 -0.2 -0.7 -0.2 -0.3 0.4 -1.1 -1.0
Bipolar Disorder (2011) 1.4 1.4 4.5 0.9 0.7 0.6 -0.2 -1.1 0.1 -1.5 0.6 0.8 -0.2 1.5 -2.1 -1.1 1.6 1.3 -1.2 -1.8
Body Mass Index (BMI) (2010) 1.0 1.3 3.2 -1.4 -0.8 0.7 0.3 -0.8 -1.5 -0.2 -0.7 -1.5 -1.3 -1.7 0.8 -1.8 -1.0 -1.7 -0.4 1.1
Coronary Artery Disease (CAD) 1.1 1.3 11.5 -0.7 0.4 0.9 1.4 0.1 -0.2 0.3 1.0 -0.2 -0.3 -0.1 -0.9 -3.4 -0.3 -1.4 -0.7 -1.4
Crohns Disease (2012) 2.1 3.4 8.9 0.9 1.8 0.7 0.5 2.8 2.6 1.7 2.1 3.0 1.8 1.8 -0.4 2.6 1.9 1.5 1.1 -0.8
Mean Putamen Volume 1.7 1.9 8.3 1.9 2.9 -2.1 -2.2 0.1 1.2 0.3 0.7 1.6 0.5 0.1 0.2 0.2 1.5 0.5 1.8 0.8
Fasting Glucose 0.4 0.4 2.4 -0.0 1.5 -0.5 -0.4 -0.7 0.4 -0.6 -1.3 0.3 -0.3 0.9 -0.6 0.0 0.5 0.2 0.6 0.1
HbA1C 0.4 0.5 1.4 0.3 -0.2 -0.7 0.0 -0.9 -0.2 0.1 -1.0 0.0 -1.1 -0.8 0.7 -1.2 -0.3 -0.2 0.3 1.2
HDL Cholesterol 2.5 4.1 12.1 2.5 1.6 -2.4 -2.5 1.9 2.6 1.8 1.6 3.5 2.2 1.4 0.5 0.3 2.5 1.5 2.4 0.0
LDL Cholesterol 0.3 0.5 2.6 0.6 0.5 -0.4 -0.1 -1.1 0.6 -0.9 -0.7 0.8 -0.6 0.4 -0.7 -1.6 0.8 0.5 -0.5 -0.0
Lupus 0.1 0.2 0.8 -0.6 0.3 -0.5 0.1 0.0 -0.1 -0.1 0.4 0.1 0.9 -0.0 0.0 -0.5 -0.3 0.5 0.5 0.1
Neuroticism (2016) 0.3 0.4 1.6 0.3 -0.9 -0.8 -0.2 -1.3 -0.3 -1.0 -0.9 -0.3 -0.6 0.8 -0.1 -1.1 -0.0 -0.2 -0.3 -0.4
Primary Biliary Cirrhosis 0.3 0.5 2.6 0.1 0.3 -1.1 -0.9 -0.3 0.2 -0.7 1.6 0.4 0.5 1.0 -0.2 -0.2 0.7 0.5 -0.3 -0.5
Rheumatoid Arthritis 0.4 0.5 3.4 -1.9 0.2 0.2 0.4 -0.1 -0.3 -0.2 0.6 -0.2 1.1 -0.2 0.7 -0.9 0.2 -1.0 1.1 0.3
Schizophrenia (2014) 0.7 1.5 4.1 1.4 -0.6 0.6 0.7 1.4 0.6 0.8 0.9 0.5 0.7 2.0 -1.9 0.6 1.2 1.3 -2.0 -1.4
Triglycerides 1.5 2.5 5.8 -2.0 -1.4 2.1 2.3 -1.0 -1.9 -0.4 -0.7 -2.4 -2.0 -1.2 0.6 -1.4 -1.4 -1.8 -1.6 0.6
Type 2 Diabetes (T2D) (2012) 1.2 1.3 4.2 -2.0 -1.3 0.3 0.3 -1.0 -2.0 -1.0 -0.8 -1.3 -0.7 -0.5 -0.7 -2.0 -1.1 -0.6 -1.0 -0.8
Ulcerative Colitis 0.8 1.2 3.5 -1.5 1.3 1.7 1.9 -0.1 -0.9 0.3 1.2 -0.5 -1.2 0.1 0.7 -1.8 -0.6 -1.2 -0.3 0.3
Blood Eosinophil Count 0.5 4.2 10.8 2.5 1.0 0.9 1.4 1.7 -3.3 2.4 -2.2 -2.8 -3.2 -1.4 -1.4 -0.1 -2.3 0.1 -3.2 -0.2
Blood Platelet Count 0.6 6.4 27.8 -1.6 3.6 -0.2 0.4 -0.4 5.3 -0.7 2.9 5.1 2.9 1.0 0.2 -0.6 3.2 0.7 3.2 -0.1
Blood Red Count 0.7 6.4 14.7 -3.5 -3.1 3.0 2.3 0.9 -3.4 1.9 -2.0 -3.8 -3.1 -2.3 0.9 -1.6 -3.1 -1.6 -2.0 1.8
Blood White Count 0.6 4.8 18.8 -1.3 0.5 0.7 0.3 0.0 -3.3 1.7 -2.7 -3.2 -4.3 -1.8 1.5 -3.3 -3.0 -1.2 -0.8 0.9
Heel T-Score 0.4 3.0 7.8 -1.9 2.7 1.3 1.4 1.2 2.8 0.8 1.3 2.6 2.6 -0.0 0.9 1.3 1.4 -0.4 2.5 0.2
BMI 0.7 4.3 12.5 -0.7 -3.2 0.2 0.7 0.9 -3.1 2.0 -1.1 -3.5 -2.6 -2.7 1.4 -2.2 -2.8 -1.4 0.1 1.9
Height 0.3 5.6 16.6 -0.3 -2.2 0.9 0.7 -0.2 -4.0 0.6 -4.1 -3.8 -3.9 1.0 -1.2 -2.2 -2.2 -1.5 -3.3 -0.4
Waist Hip Ratio (WHR) 0.6 2.6 8.5 -1.4 -2.2 1.4 1.9 -0.5 -1.8 -0.1 -1.1 -2.0 -2.1 -1.4 0.5 -2.9 -2.2 -1.4 -0.6 1.0
Systolic Blood Pressure 0.6 2.9 22.8 0.2 4.8 -1.9 -1.3 0.0 2.5 0.2 0.5 2.4 0.3 1.2 0.0 -0.0 1.9 0.2 1.8 0.9
Smoking Status 1.2 2.8 7.9 -1.0 -0.2 -0.6 -0.3 -2.3 -2.7 -1.7 -2.0 -2.8 -2.8 -0.0 0.5 -2.2 -1.7 -1.0 -1.4 0.4
Allergy or Eczema 0.1 0.4 1.2 0.5 0.8 -0.3 0.3 0.1 0.7 -0.1 0.5 0.8 -0.1 0.7 -1.1 0.6 0.6 1.0 -0.8 -0.6
Cardiovascular Disease 0.2 0.7 4.1 0.2 0.9 -1.2 -0.7 1.0 0.3 1.8 -0.7 -0.0 -0.1 -0.1 0.3 -2.0 0.3 -0.4 0.2 -0.1
Hypothyroidism (self reported) 0.1 0.3 1.6 -0.1 0.7 1.0 1.2 -0.3 0.3 -0.3 -0.0 0.5 -0.5 -0.7 -0.1 -0.3 -0.5 0.1 0.4 -0.4
Respiratory disease 0.3 0.7 3.7 -0.0 -0.4 1.1 1.5 1.8 -0.1 1.9 0.3 0.2 -0.6 -0.4 0.0 0.4 -0.3 -0.4 -0.2 0.9
Type 2 Diabetes (T2D) (2018) 2.3 4.3 12.2 -1.2 1.2 2.1 2.3 0.4 -1.8 1.5 -2.3 -2.0 -2.5 -3.2 2.3 -2.3 -3.5 -1.8 -0.0 1.5
Lung FEV1/FVC ratio 0.6 2.8 9.9 -1.9 -1.2 0.8 1.0 -1.3 -2.6 -0.9 -0.3 -3.1 -1.3 -1.9 1.4 -1.0 -2.8 -1.4 -0.6 1.8
Lung FVC 0.4 2.2 7.7 -0.2 -2.8 0.2 0.0 -0.4 -2.1 0.4 -0.9 -2.1 -1.8 -1.7 2.2 0.1 -2.4 -1.2 0.1 1.0
Neuroticism 0.8 2.0 8.0 0.9 -2.8 1.0 0.9 0.1 -2.0 0.6 -0.2 -1.9 -1.2 -0.8 0.7 -2.8 -1.3 -1.0 -1.0 1.4
Chronotype (morning person) 0.7 1.7 4.7 -0.2 0.8 1.9 2.0 -2.2 -0.4 -2.0 -0.5 -0.3 -1.1 -0.9 1.2 -0.2 -1.4 -1.3 0.1 2.0
Hair Pigment 0.1 1.8 8.0 0.8 1.1 -2.8 -2.5 -0.4 1.4 -0.7 -0.1 1.6 0.8 1.3 -0.9 0.5 1.7 1.2 0.5 -0.7
Tanning 0.2 2.4 5.3 1.6 -0.7 -1.6 -1.9 -0.0 -0.4 -0.6 1.0 0.0 -0.8 2.3 -2.1 1.6 1.5 2.0 -2.3 -2.2
Hand grip strength (left) 0.2 0.6 3.8 0.3 -0.9 0.2 0.5 0.5 -0.9 0.4 -1.3 -0.8 -0.8 -0.1 -0.4 0.9 -0.6 0.1 -0.5 -1.9
Number of treatments/medications taken 0.8 1.5 6.0 -2.5 -0.5 0.4 1.1 0.1 -0.1 1.0 -0.2 -0.1 -1.7 -1.0 1.5 -1.6 -1.3 -1.4 1.0 1.7
Average weekly spirits intake 0.8 1.0 2.7 -0.6 -0.9 0.5 0.4 -0.2 -1.5 0.3 -1.3 -1.4 -1.6 -1.0 1.2 0.9 -1.6 -0.5 -0.4 1.1
Sensitivity / hurt feelings 1.3 2.2 7.7 0.7 -2.8 -0.4 -0.2 -1.6 -2.4 -1.1 -0.7 -2.1 -1.5 0.8 -0.9 -2.5 -0.6 0.4 -2.0 -0.1
Frequency of depressed mood in last 2 weeks 0.8 1.1 4.2 2.1 -1.3 -1.4 -1.5 0.3 -0.6 0.6 -0.8 -0.5 -0.4 1.0 -0.4 -0.7 0.3 1.5 -1.5 -0.3
Hearing difficulty/problems: Yes 0.9 1.3 6.7 -0.1 0.3 -0.9 -1.1 0.7 1.8 0.5 1.0 2.0 1.5 1.3 -0.6 -0.9 2.6 0.2 0.1 0.1
Relative age of first facial hair 0.3 0.5 2.7 -0.5 -0.7 -1.1 -0.9 -0.8 -0.7 -1.6 -1.0 -0.5 0.6 0.4 -0.3 -0.5 -0.0 -0.3 -0.4 0.2
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.9 0.2 1.4 -1.7 -1.3 0.6 1.1 0.4 0.5 0.8 1.0 1.3 -0.3 0.9 1.0 1.2 -0.4 -0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.6 -0.8 -0.3 1.2 1.1 -1.2 -0.2 -1.1 -0.4 -0.4 -0.9 -1.1 1.1 0.2 -0.8 -1.0 0.1 0.2
Ever had hysterectomy (womb removed) 1.0 1.1 5.7 -0.4 -0.1 1.3 1.1 -0.7 -1.1 -0.4 -0.2 -1.4 -1.0 -1.3 -1.0 -2.4 -1.3 -0.8 -0.7 -0.1
Systolic blood pressure, automated reading 0.2 0.7 5.6 -0.1 2.4 -0.8 -0.6 -0.1 1.1 0.0 -0.1 0.8 -0.3 -0.0 0.3 1.1 0.4 -0.1 1.1 0.7
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 6.7 -1.5 0.2 1.5 1.3 -1.8 -1.6 -1.3 -1.5 -1.5 -1.6 -1.9 2.1 -0.5 -2.4 -2.6 0.1 0.2
Angina 1.0 1.3 4.0 -1.0 0.9 0.7 0.8 -0.3 -0.6 0.8 -0.6 -0.4 -1.9 -1.5 1.9 -0.0 -2.0 -0.7 0.8 1.5
Medication for hormone replacement therapy 2.0 2.3 7.0 1.5 0.7 -2.3 -2.3 -0.8 1.3 -0.8 0.5 1.2 0.8 1.5 -2.6 0.7 1.9 2.4 -0.6 -0.9
Vitamin and mineral supplements 0.8 1.1 3.3 1.8 0.8 -1.1 -1.2 0.9 1.1 0.3 0.9 1.0 1.4 1.0 -0.5 1.4 0.7 0.9 0.7 -1.4
Supplements: Zinc 0.4 0.4 2.0 0.7 0.2 1.1 1.0 1.4 -0.1 1.1 -0.5 0.0 0.7 0.0 0.6 0.1 -0.3 0.1 -0.2 0.4
Medication: Co-codamol 0.6 0.7 4.2 -0.3 2.0 0.5 0.7 -0.4 -0.2 -0.1 0.2 -0.4 -0.7 -1.1 1.1 0.5 -1.2 -0.4 0.6 1.4
Medication: Metformin 3.3 4.6 11.7 -2.4 0.4 2.3 2.8 -1.2 -1.9 -0.7 -2.7 -1.9 -2.7 -3.0 1.8 -2.1 -3.4 -2.5 -0.4 0.6
Diabetes (father) 2.3 2.9 10.2 -0.3 0.3 1.0 1.3 0.2 -2.0 0.9 -2.1 -2.3 -1.8 -2.1 1.2 -3.2 -2.2 -2.0 -0.0 2.0
Diabetes (mother) 0.4 0.5 1.3 0.6 0.4 0.9 1.0 -0.9 -0.1 -0.4 0.7 -0.1 -1.1 -0.9 -0.7 -0.8 -0.5 0.5 -0.9 0.1
Severe depression (siblings) 1.3 1.4 4.9 -0.9 0.5 -0.0 0.1 1.5 2.2 1.8 1.1 2.0 1.8 0.5 -0.2 0.8 1.3 -0.0 1.0 -1.0
Pack years adult smoking proportion 0.4 0.6 1.7 0.5 1.0 -1.1 -0.5 0.0 -0.9 0.0 -1.3 -0.7 -0.7 -0.2 0.8 0.0 -0.8 1.1 -0.5 1.1
Impedance of leg (right) 1.4 7.0 16.8 2.1 2.4 -2.6 -2.9 -0.5 3.2 -1.3 0.6 3.4 2.8 3.9 -2.9 1.9 4.1 2.7 -0.3 -3.2
Leg fat-free mass (left) 1.0 5.2 17.5 -0.3 -2.5 1.0 1.3 0.2 -3.9 1.0 -2.1 -4.2 -3.0 -2.2 0.7 -2.7 -3.4 -2.0 -1.6 1.1
Trunk fat percentage 0.3 1.3 8.9 0.9 0.2 -2.1 -1.7 -0.3 -0.9 0.1 -1.0 -1.0 -0.9 -0.5 -0.4 -3.0 0.0 -0.4 0.3 0.3
Hand grip strength (right) 0.5 1.5 5.1 1.6 -1.2 -0.1 0.1 0.0 -1.9 0.1 -2.3 -1.7 -1.6 -0.7 -0.7 0.5 -1.3 0.2 -1.2 -1.4
Townsend deprivation index at recruitment 1.1 1.5 6.1 1.7 2.5 -0.7 -0.5 0.2 1.5 0.0 -0.1 1.3 0.4 1.4 -1.5 0.2 1.5 1.1 -0.5 -2.0
Current tobacco smoking 1.1 1.8 5.2 -0.8 -1.1 0.0 0.2 -1.1 -2.0 0.1 -0.7 -2.3 -2.2 -1.7 1.4 -1.5 -2.0 -0.7 -0.9 0.9
Average weekly fortified wine intake 0.8 0.9 3.3 1.1 0.9 -0.3 -0.6 0.3 0.3 -0.5 -0.4 0.3 0.7 1.7 -1.2 1.3 0.9 0.7 -0.8 -1.8
Maternal smoking around birth 0.6 0.9 2.9 0.8 0.7 -1.6 -1.7 -1.2 0.0 -0.8 -0.9 0.0 0.4 1.2 -0.6 1.0 0.9 0.6 -0.7 -0.8
Fed-up feelings 0.6 1.0 3.9 0.9 -2.0 -0.1 -0.1 -0.3 -1.0 0.3 -0.9 -0.9 -1.4 -1.0 1.5 -1.3 -1.1 -0.4 0.2 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 3.0 1.4 -0.9 -1.4 -1.2 0.1 0.2 0.0 0.5 0.3 0.4 1.1 -0.5 -0.2 0.9 1.7 -0.7 0.5
Relative age voice broke 0.5 0.7 2.4 -1.1 -1.1 0.3 0.3 -1.4 -0.7 -1.5 -1.4 -0.7 -0.1 -0.2 0.3 -0.8 -0.7 -1.0 -0.5 0.4
Taking other prescription medications 0.2 0.2 0.9 -0.5 0.7 -0.4 -0.4 -0.8 -0.3 -0.3 -0.1 -0.2 -0.9 0.4 0.4 -0.7 -0.6 -0.1 0.2 0.5
Age when periods started (menarche) 0.3 0.8 3.3 -1.0 0.8 0.7 1.1 0.5 1.8 0.5 -0.1 1.7 1.1 -0.0 0.6 1.1 0.4 -0.1 0.9 -0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.9 -1.4 0.1 0.3 0.2 -0.6 -0.4 -0.6 -0.8 -0.7 -0.7 0.3 -1.1 -1.0 -0.2 0.1 -0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.5 -1.6 1.5 0.6 0.8 0.3 1.7 0.2 0.6 1.4 1.3 0.4 0.3 1.9 0.9 -0.5 1.4 -0.7
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 3.1 -1.1 -0.6 0.7 0.8 0.7 0.8 0.5 0.1 0.8 0.8 0.1 0.6 1.8 0.0 0.4 0.6 -0.8
Qualifications: CSEs or equivalent 0.9 1.2 4.1 -0.2 -1.2 1.1 1.1 0.1 -0.6 0.3 -1.1 -0.9 -0.7 -1.7 1.6 -1.2 -1.1 -1.4 0.1 2.0
Serious illness, injury or assault to yourself 0.5 0.6 2.3 -0.4 -0.9 -0.2 -0.6 -0.6 -1.1 0.1 -0.2 -1.4 -1.0 0.1 0.1 -1.5 -0.4 -0.3 -1.2 0.3
High blood pressure 0.3 0.7 4.0 -0.5 -0.1 -1.3 -1.0 -0.0 -0.6 0.8 -0.6 -0.8 -1.2 -0.6 0.6 -2.0 -0.7 -1.0 0.2 0.2
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.8 0.7 1.9 0.1 0.7 0.3 0.9 0.2 0.4 1.0 0.1 0.6 -1.1 1.1 0.5 0.9 -0.9 -0.4
Multivitamins +/- minerals 0.1 0.1 0.8 -0.3 -0.4 0.1 0.5 0.2 0.2 0.3 -0.4 0.1 -0.6 0.2 -0.2 -0.9 0.5 0.1 -0.4 0.2
Stomach or abdominal pain in last month 1.0 1.2 3.5 -1.2 -0.5 0.7 0.7 -0.1 -1.2 0.4 -0.7 -1.4 -0.6 -1.9 0.9 -1.7 -1.7 -1.6 -0.0 1.0
Supplements: Glucosamine 1.8 2.3 12.6 -3.5 -0.9 2.0 2.3 0.0 -0.5 -0.0 -0.4 -0.7 -1.3 -1.6 1.8 -0.5 -1.3 -1.7 0.9 1.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 2.2 0.3 0.4 -0.5 -0.6 0.1 1.0 -0.3 -0.1 0.9 0.6 0.7 0.4 1.5 0.8 0.2 0.6 -0.1
Medication: Atenolol 0.5 0.6 2.1 0.6 0.6 -0.9 -1.0 -1.4 0.8 -1.4 -0.3 1.0 0.3 0.6 -0.3 -0.5 0.7 -0.3 0.6 0.3
Medication: Levothyroxine sodium 0.5 0.8 2.2 -1.5 0.7 0.8 1.4 -1.3 -0.9 -1.1 -0.4 -0.8 -1.2 -0.3 -0.1 -0.9 -1.0 -0.7 -1.0 0.2
Sitting height 0.0 0.3 1.1 0.9 -0.6 -0.8 -1.0 0.6 -0.4 0.4 -0.7 -0.3 0.4 0.2 -0.4 0.1 0.2 -0.2 0.2 -0.4
Chronic bronchitis/emphysema (father) 0.4 0.5 2.0 -1.0 0.0 1.3 1.4 -0.2 0.6 0.1 0.7 0.9 0.1 0.5 -0.4 -1.0 0.3 -0.2 -0.1 0.2
High blood pressure (mother) 0.6 0.9 4.6 -0.6 0.6 -0.2 -0.2 -1.4 0.9 -1.8 2.1 0.7 1.0 0.6 -0.2 0.0 1.0 -0.0 0.6 -0.4
Body mass index (BMI) 0.7 3.1 8.9 -0.5 -1.6 0.0 0.5 0.2 -2.6 1.1 -1.1 -3.0 -2.3 -2.7 1.2 -2.6 -2.6 -1.2 0.0 1.6
Impedance of leg (left) 1.7 8.3 21.2 2.5 2.5 -2.8 -3.1 -0.3 3.7 -1.2 0.9 4.0 3.3 4.1 -3.1 1.5 4.6 2.9 0.4 -3.0
Leg predicted mass (left) 0.9 5.0 17.0 -0.3 -2.5 1.0 1.2 0.1 -3.9 0.9 -2.0 -4.1 -2.9 -2.2 0.7 -2.6 -3.4 -2.0 -1.5 1.2
Trunk fat mass 0.5 2.0 10.6 0.5 -0.7 -1.5 -1.1 -0.2 -2.1 0.4 -1.6 -2.3 -1.6 -1.1 -0.0 -3.3 -1.1 -1.1 -0.1 0.7
Waist circumference 1.4 5.1 15.4 -1.1 -1.9 0.7 1.1 -0.5 -3.4 0.4 -1.7 -3.8 -3.1 -2.7 0.9 -3.9 -3.2 -2.0 -0.9 1.7
Number of incorrect matches in round 0.5 0.8 4.5 1.4 1.1 0.3 0.4 2.1 -0.0 2.1 0.4 -0.2 0.7 0.0 -0.4 0.1 -0.3 0.7 -0.2 0.2
Past tobacco smoking 1.0 1.9 4.2 1.8 -0.8 -0.6 -0.7 1.7 1.7 1.4 1.9 1.8 2.0 -0.1 -0.5 1.8 1.2 1.8 0.4 -0.1
Alcohol usually taken with meals 0.3 0.5 3.0 -0.6 -0.7 0.2 0.6 1.2 -0.1 1.1 -1.7 -0.1 -0.4 -0.1 -0.1 0.5 -0.4 -0.0 0.0 0.8
Nervous feelings 0.8 1.5 3.0 -1.1 -1.7 1.6 1.7 -1.2 -1.5 -1.0 0.6 -1.6 -0.7 -1.3 0.5 -0.9 -1.5 -0.5 -1.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 4.3 0.1 0.4 -0.9 -1.0 -1.1 -1.1 -0.8 -1.4 -1.2 -0.4 0.6 -0.1 -2.1 -0.1 0.7 -1.5 -0.0
Hearing difficulty/problems with background noise 0.6 1.0 3.5 0.2 0.3 -0.2 -0.4 1.0 1.7 1.2 0.6 1.7 1.0 0.8 -0.5 -1.3 1.9 0.6 0.5 0.2
Hair/balding pattern: Pattern 2 0.3 0.3 1.3 1.1 -0.3 0.4 0.3 0.6 0.2 0.8 -0.7 0.4 0.0 -0.9 -0.3 -0.1 -0.6 0.8 0.2 -0.7
Had menopause 0.3 0.4 1.4 -0.4 0.1 -0.2 0.2 -0.6 0.3 -1.1 -0.1 -0.0 -0.2 0.9 -0.8 1.2 0.4 0.3 -1.1 -0.7
Had other major operations 2.3 2.9 8.9 -2.6 -0.9 1.2 1.0 -1.9 -2.2 -1.4 -0.7 -2.2 -3.0 -1.0 -0.4 -1.3 -1.7 -0.8 -2.8 -0.3
Forced vital capacity (FVC) 0.3 1.1 7.2 -0.1 -2.7 -0.9 -0.9 -0.8 -1.5 -0.5 -1.3 -1.4 -0.4 0.6 -0.0 0.5 -0.7 -0.7 -1.1 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 3.7 -1.9 1.1 0.5 0.3 -0.6 0.5 -0.4 -0.1 0.2 0.4 0.7 -0.2 0.6 0.7 -0.5 0.1 -0.9
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 5.4 1.2 -1.4 -2.2 -2.1 0.0 0.8 -0.4 0.5 0.6 0.5 0.6 -0.8 0.7 1.0 2.1 0.4 -2.3
Qualifications: None of the above 0.3 0.6 4.8 0.6 0.6 0.6 0.5 -0.1 0.0 0.4 -2.2 0.0 -1.1 -0.4 0.3 -1.3 -0.7 0.3 0.0 0.1
Financial difficulties in last 2 years 2.1 2.9 7.9 0.1 -0.9 1.2 1.4 -0.7 -1.3 0.7 -2.8 -1.4 -1.6 -1.9 2.1 -2.2 -2.1 -2.4 0.3 2.5
Mouth/teeth dental problems 0.8 1.2 4.1 -0.1 0.3 -1.2 -1.4 1.1 1.5 0.5 0.6 1.7 2.0 0.5 0.8 1.5 1.0 0.2 1.4 0.6
Heart attack 0.5 0.6 2.0 -1.4 0.1 0.4 0.5 -1.4 0.2 -1.0 0.7 0.2 -0.2 -0.4 1.0 -1.2 -0.1 -1.1 0.6 0.8
Allergy 0.2 0.4 1.7 0.3 -0.6 -0.6 -1.0 -0.8 -0.4 -1.2 -0.1 -0.4 0.3 0.3 0.1 -1.3 0.4 -0.1 0.3 -1.1
Pain all over the body in last month 2.4 2.5 10.6 -0.7 -1.0 1.4 1.2 -1.3 -1.9 -0.2 -1.6 -1.9 -3.2 -1.0 0.6 -2.2 -2.2 -0.8 -1.1 1.7
Diabetes (self-reported) 1.8 2.7 6.6 -1.6 1.8 1.7 1.9 -0.8 -0.9 -0.4 -2.3 -1.0 -2.0 -2.3 1.6 -2.1 -2.6 -1.5 -0.1 1.0
Hayfever/allergic rhinitis (self-reported) 3.4 4.5 10.5 0.8 2.5 -1.8 -1.1 -0.5 3.0 -1.1 2.2 3.2 1.8 2.7 -2.1 2.5 3.2 2.3 0.2 -1.5
Medication: Ramipril 1.9 2.5 7.9 -1.0 -0.3 0.9 0.8 -0.2 -0.9 0.5 -0.3 -1.0 -1.5 -2.4 2.8 -2.2 -2.2 -2.3 1.7 1.9
Medication: Simvastatin 2.8 4.1 12.3 -3.4 -1.0 1.6 1.7 -1.7 -1.8 -0.9 -1.2 -1.7 -2.3 -2.2 1.7 -3.5 -2.2 -3.0 0.3 0.9
Fluid intelligence score 0.4 0.8 4.4 -0.7 0.5 1.2 1.1 0.4 -0.7 0.6 -0.3 -0.8 -1.0 -0.7 0.9 -1.1 -0.7 -2.1 0.2 0.3
Illnesses of siblings 0.7 1.0 3.6 1.1 -0.9 0.8 0.7 -1.2 -0.6 -0.9 -1.0 -0.7 -1.2 -0.1 -1.5 -1.0 -0.6 0.5 -1.9 -1.0
Neuroticism score 1.0 2.1 10.1 0.9 -2.7 0.9 1.0 -0.8 -1.9 -0.2 -0.8 -1.8 -1.4 -0.6 0.4 -3.2 -1.3 -0.3 -1.5 0.8
Weight 0.9 4.2 14.9 -0.1 -2.0 -0.2 0.2 0.1 -3.6 1.0 -2.2 -3.9 -2.8 -2.1 0.5 -2.9 -2.9 -1.6 -0.8 1.1
Impedance of arm (right) 1.6 7.4 19.9 1.4 3.5 -2.8 -2.9 -1.2 3.8 -2.4 0.1 4.1 2.3 3.7 -2.7 0.6 4.5 2.0 0.2 -2.6
Arm fat percentage (right) 0.3 1.3 8.6 0.1 -0.3 -1.4 -0.9 -0.7 -1.2 -0.0 -1.0 -1.5 -1.4 -1.3 0.1 -2.9 -0.7 -0.6 0.0 0.6
Trunk fat-free mass 1.1 6.6 24.6 -0.9 -3.2 1.6 1.6 -0.5 -4.7 0.5 -2.1 -5.0 -3.2 -1.9 0.7 -1.8 -4.0 -2.4 -1.9 0.9
Hip circumference 0.6 2.8 10.2 -0.3 -1.2 -0.6 -0.3 -0.4 -3.0 0.6 -1.5 -3.2 -2.5 -1.4 -0.0 -3.0 -1.8 -1.2 -1.1 0.8
Time employed in main current job 1.9 2.1 4.6 -1.7 -0.9 1.3 1.2 -0.8 -1.7 -0.5 -1.5 -1.7 -2.1 -2.1 1.4 -0.0 -2.0 -1.8 -0.0 1.6
Alcohol intake versus 10 years previously 0.3 0.5 1.6 0.8 0.2 0.9 0.8 0.9 -0.5 1.3 -0.7 -0.5 -1.2 -0.3 0.1 -0.7 -0.7 -0.2 -0.5 -0.0
Father’s age at death 0.2 0.3 1.2 -0.7 -0.3 -0.6 -0.0 1.1 -0.3 1.0 1.0 -0.1 -0.1 -0.4 0.4 -0.4 0.1 -0.6 0.6 0.3
Worrier / anxious feelings 0.6 1.1 5.5 1.0 -2.3 0.9 0.9 -0.5 -0.9 -0.7 -1.4 -0.8 -0.9 0.1 -0.2 -1.9 -0.4 0.1 -1.3 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 5.3 0.7 -1.1 0.2 0.3 -0.6 -0.5 -0.1 -0.9 -0.4 -1.2 0.2 -0.1 -2.3 -0.2 0.2 -1.3 0.4
Falls in the last year 0.8 1.0 3.3 -1.1 1.6 1.4 1.6 0.1 1.8 0.3 0.0 1.7 -0.0 -0.5 0.9 -0.9 0.3 -0.5 0.6 0.9
Hair/balding pattern: Pattern 3 0.3 0.5 3.5 -0.3 -0.4 0.1 0.2 -0.2 0.1 0.0 0.2 0.4 0.1 -0.7 0.4 -1.4 0.1 -0.6 1.2 1.9
Number of live births 1.4 1.9 7.2 -1.5 0.9 1.4 1.3 -1.5 -0.7 -1.1 -2.5 -0.7 -0.7 -1.4 1.4 -0.2 -1.5 -2.7 0.3 1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 5.2 -0.2 -2.3 -1.2 -1.1 -1.3 -1.3 -1.2 -0.8 -1.3 -0.3 0.5 -0.2 -0.1 -0.5 -0.5 -0.9 -0.9
Pulse rate 0.4 0.7 1.9 1.4 -1.1 -1.1 -1.3 -0.8 -1.1 -0.6 -0.1 -1.2 -0.5 0.1 -0.5 -0.0 0.0 0.6 -0.5 -0.6
Happiness 0.5 0.6 2.6 -0.8 -0.1 -0.6 -0.4 -1.3 0.0 -1.5 0.3 0.1 -0.2 1.1 -0.6 -0.5 0.6 0.1 -0.4 -1.6
Noisy workplace 0.8 1.0 3.4 0.8 -1.8 -0.3 -0.5 0.3 -1.4 1.2 -0.9 -1.5 -1.4 -0.5 -0.2 -1.4 -1.0 0.1 0.1 0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.5 -0.2 -1.1 0.1 0.1 0.1 0.9 0.0 1.2 1.0 0.4 0.6 -0.2 1.6 0.5 0.5 -0.1 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 5.9 -0.7 -0.1 0.4 0.6 -0.6 0.1 0.1 0.3 -0.2 -0.6 -1.7 2.0 -0.5 -1.2 -1.0 1.1 2.4
Mouth/teeth dental problems: Dentures 3.0 5.1 11.6 -2.1 -0.6 2.3 2.4 -2.1 -2.9 -0.9 -2.4 -3.1 -3.1 -2.2 1.6 -2.2 -3.4 -2.1 -1.1 1.5
Asthma 0.5 0.9 3.4 -0.3 0.0 0.8 1.1 1.7 0.9 1.6 1.8 1.0 0.6 0.1 0.1 1.3 0.4 -0.0 0.6 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.2 -0.6 0.1 1.5 1.4 0.1 0.2 0.7 -1.0 -0.0 -0.6 -0.5 0.1 0.1 -0.3 -0.8 -0.5 1.1
Medication: Cholesterol lowering 2.8 4.3 14.5 -2.2 0.5 1.4 1.6 -1.5 -0.9 -0.1 -0.8 -0.7 -1.8 -2.5 3.2 -3.7 -2.1 -3.8 1.9 2.1
Depression (self-reported) 0.2 0.3 1.0 -0.1 -0.2 -0.9 -1.0 -0.0 0.1 0.4 -0.7 0.0 -0.6 0.1 0.1 -0.3 -0.2 1.0 -0.6 -0.7
Medication: Lansoprazole 1.8 2.0 7.2 -2.7 1.0 2.5 2.0 -1.2 -0.5 -0.9 -0.8 -0.8 -0.8 -0.9 1.1 -1.6 -1.8 -1.8 0.5 0.4
Prospective memory result 1.0 1.2 4.0 0.9 1.1 -1.0 -1.0 0.7 2.0 0.4 0.6 2.0 1.3 0.0 -0.1 0.9 1.4 0.6 1.8 0.4
Lung cancer (father) 0.4 0.4 1.6 -0.3 -0.9 -0.6 -0.5 0.2 -0.3 0.7 -0.9 -0.3 0.1 -0.5 1.3 -0.6 -0.5 -0.7 0.8 0.8
Illnesses of mother 0.3 0.4 1.9 0.7 -0.5 0.2 -0.2 1.2 -0.3 0.9 -1.4 -0.4 -0.0 0.1 0.4 0.5 -0.4 -0.2 -0.0 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 2.4 -0.5 -1.6 -0.5 -0.3 -0.7 -0.9 -0.4 -1.1 -0.9 -0.5 -0.5 0.2 -0.6 -0.9 -0.6 -0.3 -0.2
Pulse wave Arterial Stiffness index 0.8 0.9 3.1 1.2 0.6 -1.8 -1.7 1.1 -0.5 1.1 -1.4 -0.6 0.5 0.3 0.5 0.4 -0.6 0.3 1.2 0.2
Impedance of arm (left) 1.1 5.2 14.6 1.2 3.3 -2.2 -2.3 -0.7 3.4 -1.7 0.3 3.7 2.2 3.0 -1.9 0.5 3.8 1.2 0.6 -1.8
Arm fat mass (right) 0.6 2.6 10.3 -0.1 -1.5 -0.7 -0.2 -0.3 -2.6 0.5 -1.4 -2.9 -2.1 -1.7 0.3 -3.2 -1.9 -1.1 -0.5 0.9
Trunk predicted mass 1.1 6.3 24.0 -0.9 -3.3 1.6 1.5 -0.4 -4.6 0.5 -2.1 -4.9 -3.1 -1.7 0.5 -1.8 -3.9 -2.3 -1.9 0.8
Standing height 0.2 1.8 6.1 0.7 -1.1 -0.5 -0.6 0.2 -2.3 0.3 -2.5 -2.2 -1.2 1.3 -1.4 -1.2 -0.8 -1.2 -1.8 -1.1
Length of working week for main job 0.9 1.0 4.1 0.5 -0.7 -0.4 -0.4 -1.5 -0.5 -0.8 -2.0 -0.5 -1.8 -0.9 0.3 -1.7 -0.9 0.2 -0.1 -0.3
Exposure to tobacco smoke at home 0.3 0.3 0.6 0.1 -0.0 0.3 0.2 -0.6 0.8 -0.7 -0.8 0.7 0.4 0.8 -0.5 -0.2 0.5 0.7 -0.6 -0.6
Breastfed as a baby 0.5 0.6 4.2 0.0 2.1 -0.8 -0.4 0.4 1.0 0.5 0.5 0.7 0.2 0.6 -0.4 0.1 0.7 -0.2 1.4 -0.8
Tense / ‘highly strung’ 0.6 1.0 3.5 0.2 -1.0 1.1 0.8 -1.5 -1.0 -0.9 -0.5 -1.0 -1.3 -0.7 0.0 -1.9 -1.0 -0.1 -1.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 6.2 -0.9 -1.3 0.4 0.6 -1.2 -1.8 -0.4 -1.9 -2.0 -2.0 -1.9 2.0 -2.2 -2.5 -1.7 0.0 2.4
Hair/balding pattern: Pattern 4 0.3 0.6 2.2 -0.6 -0.1 0.7 0.9 -0.2 1.1 -0.3 0.8 0.8 1.0 -0.1 -0.2 1.1 0.2 0.6 -1.2 -1.5
Birth weight of first child 0.5 0.9 3.4 0.1 -0.8 1.5 1.9 0.0 -0.9 0.1 0.6 -0.8 -0.3 -0.8 1.0 0.4 -1.4 -1.5 -0.0 0.8
Peak expiratory flow (PEF) 0.8 1.8 4.9 0.9 -0.8 -2.2 -1.9 -1.3 0.8 -1.8 0.5 0.9 0.6 1.8 -1.4 1.1 1.6 1.0 -0.2 -2.2
Pulse wave reflection index 0.8 1.0 5.5 0.5 0.3 -0.7 -0.3 2.3 0.1 2.3 -0.6 0.2 0.5 1.1 0.6 1.6 -0.2 0.4 0.5 -0.3
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.9 -0.1 0.0 0.0 -0.0 -0.5 0.3 0.1 -1.0 0.3 0.1 -0.3 0.0 0.1 -0.0 -0.1 -0.5 -0.4
Loud music exposure frequency 0.9 0.9 5.8 2.4 -0.9 -1.4 -1.3 0.8 -0.5 0.7 0.5 -0.6 0.8 0.5 -0.4 0.5 -0.2 0.9 -0.4 -1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 2.1 -1.4 -1.4 1.2 1.3 0.3 -0.4 0.3 0.6 -0.4 -0.0 -0.5 0.8 0.7 -0.7 -1.1 0.6 0.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.9 1.5 -0.3 -0.8 -0.8 -0.3 -0.0 -0.5 1.1 0.1 0.1 1.0 -1.4 0.3 0.8 0.9 -0.4 -1.7
Blood clot in the leg (DVT) 0.3 0.4 1.6 -0.8 -1.2 0.0 -0.2 -0.7 -0.6 -0.3 -0.3 -0.6 -0.7 -0.6 0.3 0.6 -0.6 -0.0 -0.6 1.3
Medication: Paracetamol 0.4 0.6 2.0 -1.1 0.6 1.4 1.2 -0.8 0.3 -1.1 0.5 0.2 -0.2 -0.7 0.4 -0.5 -0.2 -0.8 0.3 1.2
Headache pain in last month 0.4 0.6 3.7 1.1 0.4 0.2 -0.2 -0.6 -0.0 -1.0 -1.2 0.1 -0.3 0.6 -0.7 -1.9 0.7 -0.2 0.1 -0.8
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 13.8 0.8 -0.1 -0.3 -0.4 0.9 1.6 -0.8 1.9 1.4 2.6 2.0 -2.4 3.7 2.1 3.1 -0.8 -1.2
Glaucoma (self-reported) 0.5 0.6 5.9 -0.2 2.4 -0.3 -0.6 -0.7 0.4 -1.1 -0.2 0.3 0.6 0.4 0.3 0.4 0.2 -0.6 0.7 -0.1
Gout (self-reported) 0.4 0.6 3.8 0.7 -0.0 0.9 0.8 0.4 0.3 0.4 1.1 0.5 0.2 -0.4 0.9 1.9 -0.3 -0.4 0.9 -0.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 3.5 -1.2 0.3 1.6 1.9 -0.7 -0.5 -0.8 -0.6 -0.3 -0.8 -0.8 -0.1 -0.2 -1.0 -0.2 -0.5 0.3
Medication: Amlodipine 0.6 0.9 3.3 -1.8 -1.3 1.0 1.0 0.2 -0.4 0.5 0.1 -0.2 -0.4 -1.2 1.3 -0.9 -1.0 -1.2 0.5 0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 4.1 0.6 0.3 -0.4 -0.4 1.7 1.7 1.8 2.0 1.9 1.5 0.8 -0.4 -0.0 1.4 0.6 2.0 0.6
Birth weight 0.5 1.1 3.5 1.9 0.6 0.9 1.1 1.6 1.2 1.6 0.8 1.2 1.5 -0.1 -0.2 -0.8 0.5 -0.2 0.7 -0.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 5.2 0.9 -0.2 -1.8 -1.9 0.2 0.6 0.1 -0.3 0.6 1.0 1.0 -2.2 0.5 1.5 2.3 -1.7 -1.9
High blood pressure (siblings) 0.3 0.5 1.9 0.4 1.0 -1.4 -1.0 0.5 0.5 0.4 0.2 0.5 0.6 1.0 0.1 0.3 1.2 0.4 -0.0 0.5
Forced vital capacity (FVC), Best measure 0.2 0.7 3.0 -0.3 -1.6 -0.3 -0.3 -0.4 -1.2 -0.1 -1.7 -1.2 -0.9 -0.3 0.0 -0.2 -1.0 -0.7 -0.7 -0.2
Body fat percentage 0.3 1.2 8.2 0.8 -0.0 -1.8 -1.3 -0.3 -1.1 0.2 -1.0 -1.2 -1.0 -0.9 -0.2 -2.9 -0.4 -0.4 0.3 0.4
Leg fat percentage (right) 0.3 1.1 5.0 0.9 -0.8 -1.3 -0.8 0.1 -1.5 0.7 -0.8 -1.8 -1.1 -1.0 -0.2 -2.2 -1.0 0.1 -0.2 0.1
Arm fat-free mass (right) 1.1 5.7 22.3 -0.3 -3.4 1.4 1.5 0.3 -4.5 1.4 -1.4 -4.7 -2.6 -2.0 0.6 -1.9 -3.7 -2.0 -1.6 0.7
Exposure to tobacco smoke outside home 0.3 0.5 1.3 0.7 1.0 -0.8 -0.6 -0.4 0.7 -0.5 0.0 0.9 0.4 0.1 0.6 -0.0 0.6 0.8 0.8 1.1
Comparative body size at age 10 0.3 0.7 2.5 0.8 -1.0 -0.6 -0.1 -1.1 -0.2 -0.3 -0.2 -0.4 -1.6 -0.9 0.1 -1.5 -0.4 -0.8 -1.2 1.0
Number of full brothers 2.3 2.8 9.4 0.8 0.2 -3.1 -2.9 -2.3 0.2 -2.3 -0.5 0.1 0.5 1.4 -2.6 -0.0 1.6 2.0 -0.2 -2.0
Worry too long after embarrassment 0.5 0.9 5.1 2.3 0.4 -1.1 -1.2 0.2 -1.0 0.1 0.2 -0.8 -0.1 1.6 -1.1 -0.7 0.6 0.8 -0.2 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 5.2 -0.3 0.4 -1.3 -1.6 -1.0 0.2 -0.8 1.1 0.1 0.6 -1.5 2.3 -0.0 -0.6 -0.5 1.9 1.7
Wheeze or whistling in the chest in last year 0.2 0.3 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.9 -0.9 0.5 -0.8 -0.3 0.5 -0.7 -0.2 0.1 0.1 -0.1
Number of children fathered 0.7 0.8 2.5 -0.9 1.0 0.6 0.5 -0.8 0.0 -0.6 0.4 -0.0 -0.1 -1.0 1.4 -1.2 -0.7 -1.2 1.6 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 2.7 1.4 -0.9 0.7 0.5 -0.9 -1.4 -0.1 -1.1 -1.3 -1.6 -0.6 -0.3 -1.2 -1.0 -0.3 -1.2 0.7
Age at first live birth 0.1 0.2 1.0 -0.5 0.7 0.2 0.0 0.8 0.2 0.5 -0.1 0.4 0.0 0.4 0.2 1.0 0.4 -0.5 -0.4 -0.7
Pulse wave peak to peak time 0.7 0.9 3.1 -1.1 -0.6 1.8 1.7 -1.1 0.3 -1.1 1.0 0.4 -0.7 -0.2 -0.5 -0.5 0.4 -0.3 -1.4 -0.3
Health satisfaction 0.9 1.2 3.4 0.9 -0.9 -0.6 -0.4 -1.8 -1.0 -1.7 -0.1 -0.9 -1.2 -0.4 -1.3 -1.8 -0.4 0.8 -1.1 -0.9
Shortness of breath walking on level ground 0.2 0.2 0.6 0.4 0.1 -0.3 -0.1 0.2 0.4 -0.1 -0.0 0.6 0.5 0.7 -0.6 -0.5 0.8 0.6 -0.1 -0.2
Qualifications: College or University degree 0.3 0.8 4.0 0.4 -1.1 -0.2 0.1 0.1 -0.7 -0.3 0.5 -0.6 -0.1 0.0 -2.0 -0.4 0.2 0.6 -1.8 -1.8
Eye problems/disorders: None of the above 1.0 1.1 3.7 -0.1 1.9 0.4 0.6 1.4 1.4 0.7 1.4 1.2 1.2 0.5 0.4 1.8 0.9 0.2 1.1 -0.6
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.6 0.0 0.3 0.2 -0.4 -1.3 -0.9 -1.6 0.2 -1.2 -1.1 0.1 -0.1 0.9 -0.6 0.7 -1.0 -0.7
Emphysema/chronic bronchitis 1.4 1.6 7.5 -0.6 -0.6 0.8 0.6 -1.0 -1.1 -0.3 -2.7 -1.1 -2.1 -1.8 1.3 0.1 -1.8 -0.8 -0.3 0.8
Medication for pain relief, constipation, heartburn 1.0 1.8 6.3 1.8 -1.1 -2.5 -2.4 0.7 -0.3 0.1 -0.1 -0.1 0.9 1.6 -1.0 1.4 1.3 1.7 -0.5 -1.3
Neck or shoulder pain in last month 0.8 1.2 3.8 -0.6 0.1 2.0 1.9 1.5 1.2 1.5 0.3 1.1 -0.2 -0.8 1.6 0.4 -0.3 -0.1 0.7 0.8
Medication: Blood pressure 0.6 1.1 5.6 -0.0 -0.4 -0.6 -0.5 -0.2 -0.4 0.9 -0.8 -0.3 -1.1 -0.9 1.6 -2.4 -0.9 -1.8 0.9 0.8
Angina (self-reported) 1.4 1.9 6.1 -1.2 0.5 1.2 1.2 -0.2 -0.9 1.1 -0.9 -0.8 -2.2 -1.9 2.3 -0.4 -2.5 -1.0 0.6 1.6
Migraine (self-reported) 0.4 0.5 2.1 0.0 -1.1 -0.2 0.2 0.1 -0.3 0.4 0.0 -0.5 -0.7 0.9 -1.0 -0.8 0.1 0.0 -1.0 -1.4
Medication: Ibuprofen 1.0 1.2 4.0 -1.1 0.4 2.0 2.0 0.9 0.5 1.5 -1.2 0.3 -0.7 -0.9 0.9 0.7 -0.7 -1.0 -0.2 1.4
Medication: Allopurinol 0.2 0.3 1.7 0.8 0.0 -0.2 -0.1 0.3 0.1 0.7 0.5 0.4 0.2 -0.1 0.4 1.3 -0.3 0.1 0.9 -0.7
Medication: Omeprazole 2.5 2.9 9.2 0.1 -1.7 -0.2 -0.3 -1.4 -1.9 -0.1 -2.2 -1.9 -3.0 -2.2 1.6 -2.3 -2.5 -1.4 0.5 1.6
Medication: Seretide 50 evohaler 0.7 0.8 6.7 0.8 -0.3 0.4 0.2 1.7 -0.7 2.6 0.2 -0.4 -0.8 -0.3 0.3 -0.4 -0.6 0.3 -0.1 0.4
Mean time to correctly identify matches 0.1 0.3 1.5 -0.4 1.2 -0.4 -0.2 -0.0 0.3 -0.1 0.3 -0.1 -0.2 0.3 1.0 0.8 -0.6 0.1 0.3 0.7
Heart disease (mother) 2.1 2.6 6.8 -2.6 -0.4 2.3 2.2 -1.0 -1.9 -0.3 -1.1 -1.5 -1.5 -1.4 1.2 -2.0 -1.9 -2.1 -0.3 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.3 0.1 0.0 -0.8 -0.9 -0.8 0.1 -0.3 -1.0 0.2 -1.1 -0.7 0.8 -0.7 -0.4 -0.7 1.0 -0.3
Whole body fat mass 0.6 2.6 11.2 0.4 -1.1 -0.8 -0.4 -0.2 -2.6 0.6 -1.6 -2.9 -2.0 -1.6 0.2 -3.4 -1.8 -1.3 -0.4 0.9
Leg fat mass (right) 0.7 2.6 8.8 0.7 -1.5 -0.6 -0.1 0.4 -2.7 1.1 -1.5 -3.0 -2.0 -1.8 0.1 -2.8 -2.1 -0.8 -0.7 0.6
Arm predicted mass (right) 1.0 5.3 20.8 -0.5 -3.1 1.3 1.5 0.2 -4.3 1.1 -1.5 -4.6 -2.5 -1.9 0.6 -2.0 -3.5 -2.0 -1.6 0.8
Pulse rate, automated reading 0.1 0.3 1.4 1.0 -0.2 0.5 0.1 0.0 0.1 0.1 0.5 -0.0 -0.1 -0.2 -0.4 -1.0 0.4 0.6 -0.5 -1.2
Alcohol intake frequency. 0.8 1.8 4.8 1.8 -0.5 -1.9 -1.6 0.4 0.3 0.5 0.5 0.4 0.2 1.9 -2.1 -0.6 1.5 2.2 -1.0 -1.7
Comparative height size at age 10 0.3 1.8 5.4 0.4 -1.4 1.2 1.1 1.0 -1.9 1.6 -1.6 -2.1 -2.3 -0.5 0.2 -1.2 -1.7 -1.5 -0.5 0.0
Number of full sisters 0.8 1.0 3.7 0.1 0.5 -0.5 -0.7 -0.7 -1.6 0.1 -0.5 -1.9 -1.3 -0.5 1.5 -0.7 -1.5 -1.0 -0.5 0.3
Suffer from ‘nerves’ 0.3 0.5 2.1 0.4 -0.5 1.4 1.5 -0.9 -0.3 -0.7 0.5 -0.3 0.5 -0.2 -0.5 -0.2 -0.7 0.2 -0.9 -0.8
Overall health rating 0.5 1.0 9.6 -0.2 -0.3 0.3 0.7 -1.2 -0.7 -0.8 -0.8 -0.9 -0.7 -0.7 0.4 -3.1 -0.9 -0.5 -0.6 -0.0
Chest pain or discomfort 0.2 0.3 1.8 0.1 0.1 0.0 -0.0 -1.2 -0.1 -0.8 -0.0 -0.1 -0.5 0.8 0.2 -0.4 0.4 -0.0 -1.4 -0.4
Had major operations 0.4 0.5 2.2 -0.9 -0.8 -0.3 -0.2 -1.5 -0.5 -1.2 -0.0 -0.5 -0.6 -0.1 0.5 -1.0 -0.2 -0.8 0.2 0.8
Age at last live birth 0.2 0.4 1.3 -1.1 1.1 0.2 0.5 0.4 0.3 0.4 -0.2 0.6 0.0 0.0 0.6 1.0 0.2 -0.9 -0.4 -0.4
Family relationship satisfaction 0.2 0.3 0.7 -0.2 -0.3 -0.7 -0.2 -0.8 0.6 -0.8 0.6 0.8 0.1 -0.1 0.5 -0.3 0.4 -0.3 0.8 -0.4
Leg pain on walking 0.8 1.0 5.4 -1.4 -0.1 -0.9 -0.6 -0.6 0.1 -0.9 0.6 -0.1 -0.5 0.8 -1.2 0.8 0.6 1.2 -1.3 -2.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.4 0.3 0.7 -1.0 -1.2 -0.4 1.0 -0.3 0.3 1.0 0.5 0.1 1.0 1.8 0.3 0.9 1.0 0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 4.3 -2.1 -1.3 0.6 0.7 -0.9 -0.4 -0.5 -0.1 -0.4 -1.0 -0.4 1.0 -0.3 -0.5 -0.6 -0.0 0.8
Illness, injury, bereavement, stress in last 2 years 2.8 3.4 10.8 0.9 1.6 -0.2 -0.5 2.0 1.7 0.3 2.0 1.9 2.1 2.6 -2.1 3.3 2.3 2.1 -0.6 -1.9
Medication: Aspirin 1.0 1.3 3.6 -1.2 -0.0 1.4 1.7 -0.6 -0.3 0.4 0.1 -0.4 -1.3 -1.9 1.1 -1.8 -1.6 -1.0 0.3 0.9
Supplements: Vitamin C 0.7 0.8 2.3 -1.5 -1.3 1.5 1.4 -0.8 -0.6 -0.7 0.2 -0.8 -0.6 -0.5 0.7 -1.0 -0.7 -0.8 -0.4 0.2
Knee pain experienced in last month 0.4 0.5 3.4 -1.8 1.5 -0.2 -0.3 -0.7 0.3 -0.6 -0.6 0.2 -0.7 -0.0 0.3 -1.1 0.4 -0.1 0.3 -0.3
Hypertension (Self-reported) 0.2 0.6 2.9 -0.4 -0.4 -1.2 -0.8 0.2 -0.5 1.0 -0.2 -0.6 -1.0 -0.5 0.4 -1.7 -0.7 -0.7 0.2 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 3.1 -0.3 -0.3 -0.7 -1.1 -1.0 -0.6 -0.2 -1.8 -0.7 -1.5 -0.2 0.7 -1.2 -0.8 0.0 0.4 -0.3
Illnesses of father: Heart disease 0.7 1.0 3.7 -0.9 -1.0 -0.1 0.3 -1.6 -0.0 -1.8 0.1 0.0 -0.1 -0.7 1.3 0.6 -0.4 -1.4 1.9 0.4
Illnesses of siblings: Diabetes 1.4 1.8 8.3 -2.9 -0.5 -0.3 -0.4 -1.2 -1.2 -1.0 0.4 -1.3 -1.0 -1.8 1.8 -0.1 -1.4 -1.7 1.5 0.8
Smoking status: Previous 1.2 1.8 5.5 -2.3 1.1 1.2 1.3 -1.4 -1.2 -1.3 -1.3 -1.3 -1.5 -0.1 1.0 -1.6 -1.2 -2.2 0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.9 1.3 -1.6 -1.7 -1.7 0.4 -1.0 0.4 -1.3 -0.8 -0.4 0.5 -0.9 -0.6 -0.0 0.9 -0.4 -1.4
Whole body fat-free mass 1.1 6.0 22.1 -0.5 -3.1 1.3 1.4 -0.2 -4.5 0.8 -2.0 -4.7 -3.1 -2.0 0.6 -2.1 -3.8 -2.1 -1.9 0.8
Leg fat-free mass (right) 0.9 4.5 14.8 -0.3 -2.4 1.1 1.3 0.1 -3.7 0.9 -1.9 -3.8 -2.7 -2.1 0.6 -2.6 -3.2 -2.0 -1.3 1.2
Arm fat percentage (left) 0.4 1.5 9.5 -0.2 -0.5 -1.1 -0.5 -0.5 -1.5 0.1 -1.0 -1.7 -1.4 -1.7 0.5 -3.1 -1.1 -1.0 0.2 0.9
Average weekly red wine intake 0.5 0.7 2.8 -0.3 -0.2 0.9 0.6 -0.6 -1.0 -0.9 -1.3 -1.0 -0.4 -1.7 0.2 -0.4 -1.2 -0.8 0.2 0.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 0.7 0.7 0.0 0.1 0.1 0.0 -0.5 -0.1 0.0 -0.2 0.6 -0.6 -0.6 0.8 0.0 -0.7 -0.7
Mood swings 1.5 2.7 8.7 0.4 -1.2 1.5 1.5 0.7 -2.1 1.5 -2.1 -2.1 -2.1 -1.0 1.2 -3.0 -1.8 -1.0 -1.6 1.1
Loneliness, isolation 0.6 0.8 5.2 1.8 -0.3 -0.4 -0.5 -1.4 -0.6 -0.7 -0.7 -0.5 -0.4 0.0 -0.5 -2.3 -0.3 0.3 -0.9 -0.2
Long-standing illness, disability or infirmity 0.3 0.5 1.8 -0.6 0.9 -0.1 0.3 0.2 0.2 0.7 -0.4 0.1 -1.4 0.4 -0.7 -1.3 -0.2 0.8 -0.8 -1.0
Ever had bowel cancer screening 1.3 1.5 4.1 -1.5 -0.8 0.1 -0.0 -0.6 -1.8 -0.4 -1.1 -2.0 -1.2 -1.4 1.6 0.8 -1.8 -1.6 0.4 0.9
Diabetes diagnosed by doctor 3.5 5.8 14.7 -2.6 1.2 2.4 2.7 -1.1 -2.0 -0.2 -3.3 -2.1 -3.1 -3.2 2.4 -3.0 -3.8 -2.4 -0.3 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 3.1 -0.8 0.6 -0.6 -0.8 -1.8 -0.5 -1.2 -0.1 -0.6 -0.7 0.1 0.0 0.4 -0.1 -0.8 -0.2 -0.2
Friendships satisfaction 0.6 0.7 2.1 -1.1 -0.4 0.8 1.5 0.3 0.6 0.4 0.8 0.7 0.5 -1.2 1.0 -1.1 -0.5 -1.0 1.2 0.4
Qualifications: nursing, teaching 0.5 0.7 2.6 1.1 0.8 -0.3 -0.1 0.7 0.8 0.3 1.6 1.2 0.6 1.0 -0.9 0.8 0.9 1.2 0.3 -0.4
Commuting to job workplace: Walk 0.3 0.3 1.0 0.5 0.7 0.9 1.0 0.4 0.3 0.3 0.0 0.3 0.7 -0.5 -0.3 -0.7 -0.3 0.2 1.0 0.1
Eye problems/disorders: Cataract 1.7 2.0 6.9 -1.5 -2.6 -0.3 -0.5 -2.0 -1.3 -1.2 -0.7 -1.3 -2.1 -1.2 0.0 -2.2 -0.7 -0.2 -1.4 1.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.0 0.9 1.1 -0.5 -0.2 0.4 1.2 0.5 1.4 1.2 0.3 0.3 -1.0 0.3 1.4 0.9 -0.7 -1.1
Medication for cholesterol 0.4 0.6 2.7 1.2 0.2 0.6 0.1 1.2 0.0 0.9 -0.2 0.2 0.5 -0.1 1.4 1.6 0.0 -0.6 0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.5 0.4 0.1 0.9 1.2 0.2 -0.6 -0.1 0.0 -0.8 0.1 -1.1 -0.2 -1.0 -0.8 -0.1 -0.5 0.9
Back pain experienced in last month 0.2 0.3 1.5 0.6 -0.6 1.0 1.1 -0.6 -0.3 -0.5 0.1 -0.2 -0.7 0.2 -0.1 -0.5 -0.1 0.3 -1.2 0.1
Mineral and other dietary supplements 1.5 2.0 6.8 2.1 1.0 -1.7 -1.8 0.1 1.2 -0.1 -1.0 1.3 0.9 1.3 -1.7 0.7 1.0 2.1 -0.7 -2.6
Breast cancer (self-reported) 0.3 0.4 1.3 -0.2 -0.9 -0.3 -0.8 -0.2 -1.0 -0.3 0.0 -1.0 -0.5 0.3 0.4 0.7 -0.3 -0.1 -0.8 -1.1
Asthma (self-reported) 0.4 0.8 3.5 -0.1 -0.0 0.4 0.7 1.6 0.9 1.4 1.9 1.0 0.6 0.3 -0.2 1.2 0.6 0.2 0.2 0.7
Osteoporosis (self-reported) 0.7 0.9 3.8 -0.4 2.0 1.9 1.6 -0.4 0.0 -0.4 0.3 0.1 -0.1 -0.1 1.5 0.1 -0.4 -1.3 -0.5 0.6
Osteoarthritis (self-reported) 0.6 0.8 2.4 -0.5 1.4 0.1 0.2 -0.5 -0.9 -0.4 -1.5 -1.1 -1.2 0.7 -1.1 -1.3 -0.1 -0.6 -1.1 -0.9
Medication: Aspirin 0.6 0.8 2.3 -1.2 -0.2 1.1 1.5 -0.3 -0.1 0.5 0.1 -0.3 -1.2 -1.4 1.0 -1.0 -1.2 -0.6 -0.0 0.7
Medication: Gliclazide 1.5 1.7 9.2 -0.1 -0.1 0.5 0.9 -0.4 -1.4 0.1 -3.0 -1.5 -1.4 -0.9 -0.7 -2.5 -1.6 -0.7 -1.3 0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 2.0 -1.1 0.3 0.9 0.6 0.2 -0.1 -0.0 0.5 -0.3 0.6 0.6 -0.3 -0.2 0.1 -0.3 -1.4 -0.2
Smoking status: Current 1.1 1.7 5.4 -0.4 -1.0 -0.2 -0.0 -1.0 -2.0 0.1 -0.8 -2.3 -2.3 -1.2 1.2 -1.4 -1.9 -0.6 -1.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 5.3 -1.1 -1.6 -2.1 -2.3 -1.4 -0.4 -1.1 0.1 -0.5 0.0 -0.2 0.6 1.0 -0.0 -0.1 0.3 0.2
Whole body water mass 1.1 6.1 21.9 -0.7 -3.1 1.4 1.5 -0.3 -4.5 0.7 -2.1 -4.7 -3.1 -2.0 0.6 -2.2 -3.8 -2.2 -1.9 0.9
Leg predicted mass (right) 0.8 4.4 14.5 -0.3 -2.4 1.0 1.3 0.1 -3.6 0.9 -1.8 -3.8 -2.7 -2.1 0.5 -2.6 -3.1 -2.0 -1.3 1.1
Arm fat mass (left) 0.7 3.0 10.5 -0.3 -1.6 -0.5 0.0 -0.3 -2.8 0.6 -1.6 -3.1 -2.2 -2.0 0.4 -3.2 -2.2 -1.3 -0.6 1.1
Number of self-reported non-cancer illnesses 0.4 0.6 3.6 -1.1 -0.2 -0.9 -0.4 -0.3 -0.5 0.1 -0.8 -0.4 -1.6 0.3 -0.5 -1.9 -0.3 -0.0 -0.8 -0.4
Average weekly champagne plus white wine intake 0.4 0.5 2.0 -0.2 -0.3 -0.8 -0.7 -0.1 0.4 -0.0 0.0 0.6 0.6 1.4 -1.4 -0.9 1.1 0.5 -0.4 -0.4
Miserableness 0.2 0.4 2.8 1.7 -0.4 0.2 0.1 0.6 0.7 0.9 0.0 0.6 0.4 -0.5 0.2 -0.9 0.0 0.7 0.5 -0.2
Guilty feelings 1.6 2.4 8.8 1.8 -2.6 -0.7 -0.2 0.4 -2.1 0.6 -1.9 -2.0 -1.8 0.5 -1.5 -2.0 -0.2 0.5 -3.0 0.2
Wears glasses or contact lenses 0.5 0.6 2.1 -1.1 1.2 -0.6 -0.8 -0.9 -0.1 -0.7 0.4 0.1 -0.4 1.4 -0.2 -0.8 0.6 -0.5 0.4 1.3
Ever taken oral contraceptive pill 4.4 4.9 10.6 -1.9 -1.0 3.1 3.2 -1.6 -2.4 -0.2 -2.8 -2.5 -2.6 -1.9 1.2 -2.7 -3.0 -2.7 -0.8 0.4
Hearing aid user 0.6 0.7 2.8 0.7 0.3 -1.2 -1.5 -1.2 0.2 -1.1 0.5 0.4 -0.4 0.1 -0.8 -1.7 0.9 0.4 0.4 0.5
Mother’s age at death 0.3 0.4 1.5 -0.5 -0.4 -0.1 0.7 -1.0 -0.2 -1.1 -0.0 -0.3 -0.7 -0.6 -0.3 -1.2 -0.9 -0.4 -0.2 -0.2
Financial situation satisfaction 0.5 0.7 2.5 0.6 0.0 -1.0 -1.1 -1.6 0.8 -1.5 0.1 0.8 0.3 0.1 1.0 -0.2 0.2 -0.6 0.9 0.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.7 0.2 -1.2 0.1 0.2 0.8 0.2 0.3 -0.6 0.6 -0.2 0.6 -1.3 -0.4 0.5 0.8 -0.4 -0.7
Commuting to job workplace: Public transport 0.3 0.3 1.7 0.3 -0.3 0.2 0.2 1.1 0.2 1.3 -0.6 0.3 -0.0 0.2 0.2 -0.1 0.3 -0.3 0.4 1.1
Eye problems/disorders: Glaucoma 0.4 0.5 2.6 1.3 1.6 -1.1 -1.2 0.2 0.4 0.1 -0.3 0.3 0.7 0.2 -0.2 -0.0 0.3 0.2 0.6 0.7
Medication: Blood pressure 0.2 0.4 1.2 -0.9 -0.0 -0.2 0.3 0.0 -0.3 0.3 0.9 -0.4 -0.8 -1.1 0.1 -1.1 -0.8 -0.5 0.8 0.4
Pain type(s) experienced in last month: Hip pain 0.8 0.9 4.8 0.1 0.2 -0.8 -0.3 -0.4 -0.0 -0.6 -0.1 -0.2 0.5 1.5 -2.2 -1.3 1.2 1.2 -1.7 -0.4
Supplements: Fish oil (including cod liver oil) 1.5 2.0 8.0 -1.3 -1.1 1.7 1.6 0.3 -0.8 0.4 1.3 -1.0 -0.4 -1.9 1.9 -0.8 -1.2 -1.6 1.4 2.8
High cholesterol (Self-reported) 0.5 1.0 3.8 -1.8 -0.1 0.1 0.3 -0.0 0.2 1.0 0.0 0.1 -0.3 -0.9 1.4 -1.8 -0.4 -2.0 1.3 0.7
Medication: Bendroflumethiazide 0.2 0.3 1.7 -0.2 -0.0 0.2 0.3 0.4 -0.2 1.0 -0.5 -0.3 -1.3 -0.3 0.6 -0.0 -0.7 -0.3 0.3 0.1
Medication: Paracetamol 0.2 0.4 1.3 -1.2 0.5 0.9 0.8 0.6 0.9 -0.1 0.5 0.8 0.7 0.4 -0.1 0.4 0.5 -0.1 0.0 0.5
Medication: Lisinopril 0.1 0.2 0.7 -0.1 -0.3 0.2 0.5 -0.0 -0.4 0.2 -0.1 -0.3 -0.8 -0.6 -0.2 0.4 -0.6 -0.0 -0.3 -0.6
Medication: Atorvastatin 1.5 1.9 4.7 -0.8 1.4 1.7 1.7 0.3 -0.1 1.3 -0.9 -0.2 -1.2 -1.8 2.2 -1.0 -1.5 -1.9 1.1 1.8
Illnesses of father: High blood pressure 0.3 0.4 2.2 -0.1 0.6 -0.7 -0.6 -1.5 -0.1 -1.3 -0.1 -0.0 -0.4 -0.5 -0.4 -0.5 0.3 1.0 -0.1 -0.1
Alcohol drinker status: Never 1.0 1.2 3.3 1.2 1.5 -1.1 -1.3 0.2 1.2 -0.1 0.3 1.3 0.9 1.1 -1.8 -0.7 1.8 1.1 -0.3 -0.6
Ever smoked 0.7 1.3 3.9 -1.1 0.8 0.6 0.6 -1.4 -1.3 -1.0 -1.8 -1.3 -2.0 0.2 0.2 -1.8 -0.9 -1.0 -0.8 0.2
Basal metabolic rate 1.0 5.7 21.2 -0.4 -2.9 1.0 1.1 -0.2 -4.4 0.8 -2.1 -4.6 -3.1 -2.0 0.5 -2.5 -3.6 -2.0 -1.8 0.9
Leg fat percentage (left) 0.3 1.1 6.5 1.1 -0.7 -1.3 -0.8 0.2 -1.3 0.8 -0.8 -1.5 -0.9 -1.0 -0.4 -2.5 -0.8 0.1 0.2 0.2
Arm fat-free mass (left) 0.9 4.4 18.4 0.2 -2.9 1.0 1.0 0.3 -4.1 1.2 -1.7 -4.3 -2.4 -1.4 -0.0 -1.8 -3.1 -1.3 -1.9 0.4
Number of operations (self-reported) 0.9 1.3 4.8 -2.1 -0.6 0.7 0.6 -1.2 -1.7 -0.5 -0.5 -1.8 -2.2 -0.5 -0.3 -0.6 -1.2 -0.9 -1.1 -0.1
Average weekly beer plus cider intake 2.9 4.2 10.7 -1.2 -0.5 3.2 3.3 -0.9 -1.4 -0.9 0.1 -1.3 -1.6 -3.3 2.8 -2.2 -2.7 -2.9 0.5 1.3
Irritability 0.5 0.8 4.6 0.9 -1.7 0.5 0.7 -0.7 -0.3 -0.5 -0.8 -0.1 -0.6 -1.3 0.3 -2.1 -0.6 -0.7 -0.1 1.0
Risk taking 1.1 1.6 8.0 0.3 2.8 -1.2 -1.1 -1.7 1.1 -2.0 0.0 1.0 0.4 0.2 1.4 0.8 0.3 -0.8 2.1 0.3
Ever had prostate specific antigen (PSA) test 0.8 1.0 3.0 -1.1 0.2 0.9 1.3 -0.2 -0.7 -0.0 0.1 -0.6 0.1 -1.2 1.5 -0.6 -1.7 -1.5 1.3 1.0
Fractured/broken bones in last 5 years 0.5 0.7 6.5 -0.2 0.2 0.4 0.1 -0.7 -0.9 -0.6 -0.1 -0.8 -0.6 -0.0 -0.6 -0.6 -0.6 0.6 -2.6 -0.6
Age started oral contraceptive pill 0.7 0.9 3.3 0.4 -0.1 0.2 0.4 1.0 -0.7 1.3 -0.6 -0.8 -1.0 1.2 -1.2 0.5 -0.0 1.2 -1.4 -1.8
Diastolic blood pressure, automated reading 1.5 4.5 9.5 2.7 1.8 -3.1 -2.7 1.4 3.0 1.1 1.8 2.6 2.5 1.7 -0.9 1.7 3.0 1.6 1.8 -0.3
Ever depressed for a whole week 0.8 1.0 2.4 1.1 -1.6 -0.1 0.0 -1.4 -1.2 -1.5 -1.2 -1.2 -1.1 -0.9 0.1 -0.1 -1.0 0.3 -0.7 -0.7
Unable to work because of sickness or disability 1.0 1.3 6.0 0.3 1.5 -0.5 -0.4 0.3 2.5 0.7 1.1 2.2 1.5 0.4 0.3 -0.6 1.0 -0.1 1.8 0.3
Commuting to job workplace: Cycle 0.5 0.6 1.2 0.9 0.8 -0.8 -0.6 0.5 0.8 0.0 -0.2 0.9 0.3 0.9 -1.1 1.0 1.0 0.9 -0.1 -0.8
Myopia 1.3 1.9 8.5 0.5 1.1 -1.0 -1.0 -0.2 1.4 -1.2 0.8 1.0 1.0 2.3 -1.4 1.1 1.7 1.3 -1.4 -2.9
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.9 0.8 -0.3 1.5 1.2 0.3 0.8 -0.7 0.7 1.0 1.5 0.6 -0.7 2.0 0.9 0.9 -0.3 0.2
Cholesterol lowering medication 0.7 1.1 4.8 -2.2 0.5 1.0 1.3 -0.2 -0.8 0.4 -0.9 -1.0 -1.5 -0.7 0.5 -1.2 -1.1 -1.2 -0.0 0.7
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 6.6 0.1 -0.6 0.8 0.4 -1.2 -1.4 -0.1 -2.0 -1.6 -2.6 -2.0 1.3 -1.7 -2.3 -1.2 0.1 0.8
Pain experienced in last month 0.7 1.1 4.4 0.3 0.2 -0.9 -0.8 0.7 0.9 0.4 2.0 0.9 1.6 0.6 -0.7 2.1 0.9 1.1 0.3 -1.0
Supplements: Calcium 0.5 0.5 1.5 -0.0 0.3 1.0 1.1 -0.5 -1.0 -0.4 -0.5 -0.7 -0.0 -0.3 0.4 -1.0 -0.6 -1.2 -0.3 0.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.8 -0.0 -0.7 0.9 0.8 -0.5 -0.7 -0.2 0.3 -0.5 -0.7 0.0 0.5 -0.8 -0.4 -0.4 -0.3 0.0
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.2 -1.4 0.3 0.5 0.7 -1.5 0.1 -1.0 0.5 0.1 -0.5 -0.4 1.1 -1.1 -0.2 -1.2 0.5 1.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.8 -0.8 -1.3 -0.1 -0.3 -1.1 -0.3 -0.9 0.2 -0.4 -0.3 -0.4 0.2 0.6 -0.3 -0.0 -0.5 1.0
Heart disease (siblings) 1.5 1.8 5.2 -1.5 -0.8 0.9 0.6 -0.3 -2.0 0.4 -1.7 -1.9 -1.0 -1.3 1.4 -0.5 -2.3 -1.4 0.3 1.9
Alcohol drinker status: Previous 0.7 0.8 4.7 2.2 0.2 -1.3 -0.8 0.5 0.4 0.8 0.5 0.4 -0.4 0.9 -1.1 -0.1 0.6 1.4 -1.0 -0.4
Pack years of smoking 0.4 0.7 1.9 0.8 1.1 -1.3 -0.7 -0.0 -0.8 -0.2 -1.4 -0.7 -0.6 0.3 0.6 0.3 -0.6 1.2 -0.6 0.9
Impedance of whole body 1.5 7.6 21.5 2.0 3.4 -2.7 -2.8 -0.3 4.0 -1.3 0.8 4.3 3.2 3.6 -2.5 0.9 4.6 2.1 0.8 -2.3
Leg fat mass (left) 0.6 2.5 8.2 0.9 -1.5 -0.9 -0.4 0.5 -2.6 1.2 -1.5 -2.8 -1.9 -1.6 -0.1 -2.9 -1.9 -0.6 -0.5 0.6
Arm predicted mass (left) 1.0 5.1 19.4 -0.4 -3.0 1.4 1.4 0.2 -4.2 1.1 -1.5 -4.4 -2.6 -1.7 0.4 -2.1 -3.4 -1.7 -1.8 0.9