TWAS hub - RGS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1060	0.0310	1.3e-05	0.010	0.051	0.007	0.049	0.010	2.0e-02	7.2e-07	4.1e-02	1.3e-06	2.1e-02
2	GTEx	Esophagus Mucosa	0.1750	0.0550	2.1e-03	0.011	NA	0.023	NA	0.018	6.0e-02	NA	1.0e-02	NA	2.1e-02
3	GTEx	Thyroid	0.2990	0.0650	6.6e-05	0.111	NA	0.119	NA	0.118	8.1e-09	NA	2.3e-09	NA	2.5e-09
4	GTEx	Whole Blood	0.2560	0.0600	1.6e-04	0.139	NA	0.078	NA	0.124	9.5e-13	NA	1.0e-07	NA	1.6e-11
5	TCGA	Prostate Adenocarcinoma	0.0401	0.0239	1.3e-03	0.041	0.029	0.018	NA	0.032	3.8e-05	5.0e-04	5.2e-03	NA	2.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Deep venous thrombosis (DVT) (self-reported)	5.0	6.4	13.1	1.2	2.7	3.1	-3.6	0.7
Blood clot in the leg (DVT)	4.6	5.9	12.1	1.1	2.6	3.0	-3.5	0.7
Alcohol drinker status: Never	4.2	5.0	13.0	0.9	-1.9	-2.7	3.6	0.4
Pulse rate	3.7	6.2	12.6	3.4	1.1	1.9	-1.5	3.5
Systolic blood pressure, automated reading	3.3	9.6	17.1	-1.6	-3.9	-3.7	4.1	-0.4
Schizophrenia vs Biploar Disorder	3.1	4.1	5.2	1.7	2.1	2.3	-1.8	2.2
Systolic Blood Pressure	3.1	15.5	29.7	-2.3	-4.2	-4.9	5.5	-0.6
Number of children fathered	3.1	3.5	8.9	-3.0	-1.9	-0.5	0.5	-2.1
Supplements: Vitamin C	3.1	3.7	6.6	1.7	0.5	2.5	-1.6	2.6
Crohns Disease (2012)	2.8	4.5	7.1	-0.6	2.7	2.4	-2.3	-2.0
Had major operations	2.8	3.3	5.8	-2.4	-2.2	-0.6	0.6	-2.3
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.6	-2.4	-1.5	2.0	-1.1	-1.3
Fluid intelligence score	2.5	5.2	6.8	2.6	2.6	2.0	-2.2	2.0
Commuting to job workplace: Walk	2.5	2.7	6.2	2.3	0.9	0.9	-0.7	2.5
Medication: Paracetamol	2.3	3.8	7.6	1.1	-1.6	-2.6	2.8	0.6
Medication: Paracetamol	2.3	3.5	7.0	0.6	-2.1	-2.2	2.6	0.8
Ever had hysterectomy (womb removed)	2.2	2.5	4.6	0.1	1.9	2.1	-2.1	0.2
Breast cancer (self-reported)	2.2	2.6	8.0	1.7	0.1	-1.0	1.1	2.8
Medication: Gliclazide	2.2	2.4	3.8	1.4	1.9	0.7	-1.5	2.0
Alzheimer’s Disease (including proxy)	2.1	3.0	7.4	-1.8	1.8	0.8	-0.7	-2.7
Fasting Glucose	2.0	2.4	3.9	0.8	-1.8	-1.7	1.1	2.0
Blood Red Count	2.0	18.9	43.7	6.0	-1.7	-2.4	2.5	6.6
Had menopause	2.0	2.5	4.4	-0.8	-2.1	-1.2	2.0	1.4
Prospective memory result	2.0	2.5	4.4	-1.8	-1.2	-1.5	2.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	5.5	2.0	0.7	-1.1	0.8	2.4
Ever had bowel cancer screening	2.0	2.3	4.1	0.6	-2.0	-1.9	1.8	0.6
Crohns Disease (2017)	1.9	4.1	8.7	0.2	3.0	1.8	-2.7	-1.1
Medication: Lansoprazole	1.8	2.0	4.3	1.0	-1.3	-2.1	1.7	0.7
Hair/balding pattern: Pattern 4	1.8	4.4	16.2	4.0	0.5	-1.8	-0.1	1.6
Mouth/teeth dental problems: Loose teeth	1.8	2.2	7.3	-2.7	-1.5	-0.6	0.6	-0.8
Illnesses of siblings: Diabetes	1.8	2.2	5.7	0.6	-1.2	-2.4	2.0	0.1
Medication: Aspirin	1.8	2.3	8.1	2.8	-0.1	-0.4	-0.6	1.7
Alzheimer’s Disease (in father)	1.7	1.9	4.8	-2.2	1.6	0.7	-0.2	-1.1
Medication: Atenolol	1.7	2.1	5.1	0.5	-1.4	-1.8	2.3	0.1
Financial difficulties in last 2 years	1.7	2.3	4.8	-1.2	2.2	0.7	-0.5	-2.1
Time employed in main current job	1.7	1.9	5.1	-0.9	-0.9	-1.7	2.3	-0.2
Health satisfaction	1.7	2.3	5.0	1.3	-0.8	-1.9	2.2	-0.7
Ever taken oral contraceptive pill	1.7	1.9	4.1	1.3	2.0	1.4	-0.6	1.2
Irritable Bowel Disease (IBD)	1.6	3.9	7.6	0.1	2.8	2.0	-2.7	-0.4
Migraine (self-reported)	1.6	1.9	2.7	1.6	1.2	1.6	-0.9	1.6
Pulse rate, automated reading	1.6	5.2	13.0	3.5	1.0	0.1	0.0	3.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.9	-0.8	-2.4	-1.0	0.8	1.2
Back pain experienced in last month	1.6	2.4	6.5	-2.1	-0.9	-0.2	0.4	-2.6
Average weekly champagne plus white wine intake	1.6	2.2	5.1	-2.0	-0.0	-0.6	1.2	-2.3
Alzheimer’s Disease (in mother)	1.5	1.7	5.3	-0.9	1.2	0.7	-0.8	-2.3
Trunk fat-free mass	1.5	8.6	28.6	5.3	2.1	-0.6	-0.1	3.0
Trunk predicted mass	1.5	8.5	28.4	5.3	2.1	-0.6	-0.2	3.0
Length of working week for main job	1.5	1.6	4.2	-1.4	0.9	1.0	-2.1	-0.6
High blood pressure (siblings)	1.5	2.1	3.6	-1.5	-1.2	-1.9	1.8	-0.2
Forced vital capacity (FVC), Best measure	1.5	5.6	10.6	3.3	2.4	0.5	-1.8	2.9
Arm fat-free mass (right)	1.5	7.7	25.5	5.1	1.9	0.3	-0.8	2.9
Comparative body size at age 10	1.5	4.0	7.7	-0.0	2.4	1.5	-2.1	-2.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.2	0.4	-0.8	-2.1	2.0	-0.1
Eye problems/disorders: Glaucoma	1.5	1.7	2.7	1.4	-1.2	-1.5	0.5	1.6
Arm fat-free mass (left)	1.5	7.6	22.5	4.7	2.4	0.2	-0.9	3.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	5.3	0.8	0.3	-1.0	1.5	2.3
Hand grip strength (right)	1.4	3.9	7.3	0.9	2.5	2.0	-2.7	1.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.0	-0.1	1.1	1.4	-1.7	1.4
Multivitamins +/- minerals	1.4	1.8	8.7	-2.9	0.1	0.5	0.1	0.0
Illnesses of siblings	1.4	1.9	3.5	-0.0	1.8	1.9	-1.6	-0.6
Lung cancer (father)	1.4	1.7	3.1	1.3	0.2	-1.8	1.6	1.1
Medication: Aspirin	1.4	1.9	6.7	2.6	-0.7	-0.4	-0.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.3	2.3	2.5	0.7	-0.9	1.2
Qualifications: nursing, teaching	1.4	2.2	4.0	0.3	2.0	1.9	-1.7	-0.6
Alcohol drinker status: Previous	1.4	1.6	2.9	-0.6	1.5	1.7	-1.6	-0.4
Arm predicted mass (left)	1.4	7.3	22.8	4.8	2.3	0.4	-1.0	2.8
Blood Platelet Count	1.3	14.9	42.1	-3.9	-1.8	-2.8	2.5	-6.5
Vitamin and mineral supplements	1.3	1.8	2.9	1.7	-0.4	-1.7	1.1	-1.3
High blood pressure (mother)	1.3	1.8	4.1	0.6	0.3	1.7	-1.1	2.0
Nervous feelings	1.3	2.5	6.1	-0.1	-0.8	-2.5	2.4	0.0
Diabetes (self-reported)	1.3	2.0	5.9	0.2	1.6	1.1	-2.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	9.4	3.1	1.7	-0.2	-1.1	2.7
Arm predicted mass (right)	1.3	6.8	23.4	4.8	1.7	0.2	-0.6	2.7
Myopia	1.3	1.9	3.7	0.8	1.9	1.0	-1.4	1.5
Breast Cancer	1.2	2.8	8.1	-1.7	0.5	1.2	-1.2	-2.8
Primary Biliary Cirrhosis	1.2	1.8	4.0	1.5	-1.3	0.9	-0.2	2.0
Ulcerative Colitis	1.2	1.8	3.6	0.2	1.9	1.8	-1.5	0.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.0	0.5	2.2	0.9	-1.2	0.9
Medication: Co-codamol	1.2	1.4	3.6	0.9	0.6	1.3	-1.9	0.6
Forced vital capacity (FVC)	1.2	4.5	8.5	2.9	2.1	0.6	-1.7	2.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.0	2.2	1.0	0.3	-1.2	1.4
Tense / ‘highly strung’	1.2	2.0	4.5	0.2	-0.7	-1.7	2.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.4	0.5	-2.1	-0.0	1.0	1.2
Neck or shoulder pain in last month	1.2	1.6	2.8	-1.6	-1.7	-1.1	1.0	-0.8
Heart disease (mother)	1.2	1.5	2.8	1.2	-0.4	-1.7	0.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.4	6.5	2.6	0.5	0.8	-2.0	0.9
Financial situation satisfaction	1.2	1.5	2.5	-1.0	0.3	-1.4	1.6	-1.4
Hearing difficulty/problems: Yes	1.1	1.6	3.3	1.2	1.3	1.0	-0.9	1.8
Medication for hormone replacement therapy	1.1	1.2	4.1	-2.0	-0.9	0.4	0.0	-1.0
Chronic bronchitis/emphysema (father)	1.1	1.3	4.6	-2.1	-0.5	-0.1	0.9	-0.8
Medication: Simvastatin	1.1	1.6	3.3	1.8	-1.0	-0.6	1.0	1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	6.8	2.6	0.7	0.8	-0.0	2.1
Standing height	1.1	10.6	25.4	4.8	1.9	-0.3	0.4	5.0
Birth weight of first child	1.1	2.0	3.3	1.8	-1.2	-0.9	1.2	1.7
Peak expiratory flow (PEF)	1.1	2.6	5.3	2.3	1.6	0.5	-1.0	1.9
Pulse wave reflection index	1.1	1.4	3.8	-1.5	0.9	-0.3	-0.2	-1.9
Medication for pain relief, constipation, heartburn	1.1	2.0	4.0	-0.8	1.3	2.0	-1.7	-0.9
Medication: Omeprazole	1.1	1.3	3.2	1.2	0.3	-0.8	1.2	1.8
Whole body fat-free mass	1.1	6.4	20.9	4.6	2.4	-0.0	-0.7	2.2
Mineral and other dietary supplements	1.1	1.5	4.7	2.2	-0.6	-1.0	0.1	1.2
Whole body water mass	1.1	6.2	19.9	4.5	2.4	-0.1	-0.6	2.2
Pain experienced in last month	1.1	1.8	4.6	2.1	-0.1	-0.9	1.1	1.5
Basal cell carcinoma (self-reported)	1.1	1.3	2.5	-0.8	1.6	-0.6	1.3	-1.3
Heart disease (siblings)	1.1	1.4	3.3	1.8	-0.4	-0.2	-0.9	1.6
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.9	0.8	1.6	2.4	-2.0	1.3
Worry (Nagel 2018)	1.0	2.2	5.8	-1.4	-0.5	-1.7	2.4	-0.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	0.8	0.8	1.4	-0.7	1.6
Diabetes (father)	1.0	1.2	4.3	-0.6	1.1	-0.1	-0.2	-2.1
Supplements: Glucosamine	1.0	1.4	2.9	-1.5	1.7	1.0	-0.6	-0.5
Sitting height	1.0	7.0	15.8	4.0	1.3	-1.4	0.8	3.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	6.8	2.6	1.6	-0.1	-1.0	2.4
Loud music exposure frequency	1.0	1.1	1.7	1.1	0.8	-1.1	0.9	1.3
Mean time to correctly identify matches	1.0	1.9	4.9	-2.2	-1.5	-0.6	0.5	-1.2
Friendships satisfaction	1.0	1.2	3.1	-0.4	1.3	-1.8	0.6	-0.9
Medication for cholesterol	1.0	1.5	4.3	0.1	2.1	1.1	-1.4	-0.3
Medication: Atorvastatin	1.0	1.2	2.3	1.5	1.0	0.5	-1.4	0.6
Basal metabolic rate	1.0	5.6	17.2	4.2	2.6	0.1	-0.9	1.8
Diastolic blood pressure, automated reading	1.0	3.1	6.2	-2.5	-1.8	-1.3	1.7	-1.2
Ulcerative Colitis (UC)	0.9	1.8	3.8	0.1	1.5	1.7	-1.9	0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.4	0.6	2.1	1.7	-1.6	1.0
Lupus	0.9	1.4	4.4	-2.1	-1.3	-0.2	0.7	-0.6
Hypothyroidism (self reported)	0.9	2.0	5.2	1.5	-0.8	-0.7	1.1	2.3
Taking other prescription medications	0.9	1.4	2.0	1.4	-1.1	-1.0	1.2	1.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	-1.6	-0.7	-0.1	0.6	-1.5
Comparative height size at age 10	0.9	5.0	15.5	3.9	0.3	0.0	-0.2	3.1
Average weekly red wine intake	0.9	1.3	4.6	0.5	-2.1	-0.0	1.2	0.7
Commuting to job workplace: Public transport	0.9	1.1	2.3	1.3	0.0	-1.5	0.5	1.1
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.3	-2.1	-0.2	0.0	0.5	-1.1
Fractured/broken bones in last 5 years	0.9	1.1	2.6	0.1	-1.6	-0.6	1.6	-0.2
Ever depressed for a whole week	0.9	1.1	3.0	0.9	0.8	-1.7	1.0	0.0
Pack years of smoking	0.9	1.3	5.1	-2.3	0.2	0.3	0.3	-1.0
Height	0.8	16.3	45.3	5.3	2.8	0.1	-0.3	6.7
Chronotype (morning person)	0.8	1.9	4.6	0.3	2.1	0.5	-1.4	1.7
Average weekly spirits intake	0.8	1.0	3.0	-0.2	-0.9	-1.7	1.0	0.0
Pack years adult smoking proportion	0.8	1.3	5.0	-2.2	0.6	0.7	0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	2.7	-1.5	-0.7	-1.2	1.7	-1.5
Medication: Levothyroxine sodium	0.8	1.4	3.2	0.1	0.0	-1.1	1.5	1.8
Worrier / anxious feelings	0.8	1.5	2.9	-1.0	-1.1	-1.6	1.7	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	-1.6	-0.8	-0.2	-0.3	-1.0
Depression (self-reported)	0.8	1.0	2.7	-1.6	0.4	-0.5	0.1	-1.3
Illnesses of mother	0.8	1.0	2.9	-1.1	-0.6	0.2	0.5	-1.7
Medication: Seretide 50 evohaler	0.8	1.0	3.8	-1.9	-0.4	0.8	0.0	-0.4
Overall health rating	0.8	1.7	2.8	-0.7	-1.5	-0.9	1.5	-1.7
Smoking status: Previous	0.8	1.2	3.5	-1.9	-0.9	-0.6	1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.4	-0.0	-1.4	-0.3	0.3	-1.5
Commuting to job workplace: Cycle	0.8	1.0	3.1	0.1	0.3	-1.8	1.1	-0.8
Neuroticism (Nagel 2018)	0.7	1.6	3.5	-1.3	0.1	-1.7	1.9	0.1
Reaction Time	0.7	1.3	4.0	-2.0	-0.7	0.2	-0.3	-1.4
Rheumatoid Arthritis	0.7	1.0	3.8	-0.4	-1.9	0.2	0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.9	2.0	-1.4	0.8	0.1	0.2	-1.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.2	0.9	1.0	0.7	-1.8	0.9
Townsend deprivation index at recruitment	0.7	1.0	2.4	-0.7	1.2	0.8	-1.6	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	3.3	0.1	1.8	0.7	-0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	-0.3	1.5	-0.9	0.3	-1.0
Allergy	0.7	1.5	4.2	1.7	-0.6	-0.2	0.0	2.1
Weight	0.7	3.2	7.7	2.8	2.5	0.4	-1.3	0.4
Arm fat percentage (right)	0.7	2.8	7.2	-0.3	1.9	0.7	-1.6	-2.7
Mouth/teeth dental problems: Dentures	0.7	1.1	3.7	-1.9	-0.2	-0.5	0.7	-1.1
Asthma	0.7	1.4	3.3	-1.8	0.4	0.9	-0.6	-1.4
Medication: Amlodipine	0.7	1.0	2.7	0.1	0.7	1.2	-1.7	-0.3
Eye problems/disorders: None of the above	0.7	0.8	1.9	-0.2	0.9	1.4	-1.1	0.3
Angina (self-reported)	0.7	0.9	3.0	-0.1	-1.7	-0.5	0.9	-0.7
Family relationship satisfaction	0.7	0.9	2.9	0.3	0.2	-1.7	1.1	-0.5
Leg fat-free mass (right)	0.7	3.9	8.6	2.9	2.9	0.7	-1.3	0.6
Arm fat percentage (left)	0.7	2.8	8.0	-0.4	1.6	0.8	-1.5	-2.8
Leg predicted mass (right)	0.7	3.7	8.5	2.8	2.9	0.6	-1.2	0.5
Medication: Blood pressure	0.7	1.3	3.2	-0.1	-1.2	-1.3	1.8	0.4
Supplements: Calcium	0.7	0.7	2.1	-0.2	1.2	0.1	-0.1	1.5
Depression (Nagel 2018)	0.6	0.8	2.1	0.7	1.5	0.0	-0.0	1.3
Blood White Count	0.6	4.1	13.8	3.7	1.2	-1.2	0.1	1.9
Sensitivity / hurt feelings	0.6	1.1	2.9	-0.6	-1.3	-0.7	1.7	0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.4	1.5	0.1	-0.6	-0.6	0.5
Angina	0.6	0.8	2.8	0.2	-1.7	-0.4	0.6	-0.6
Medication: Metformin	0.6	0.8	1.9	0.9	0.9	0.0	-0.8	1.4
Leg fat-free mass (left)	0.6	3.4	7.8	2.8	2.7	0.5	-1.1	0.5
Average weekly fortified wine intake	0.6	0.6	1.5	-0.6	-0.7	-1.2	0.6	-0.8
Stomach or abdominal pain in last month	0.6	0.8	1.9	-0.6	-0.2	1.4	-1.1	-0.6
Leg predicted mass (left)	0.6	3.3	7.8	2.8	2.7	0.5	-1.0	0.5
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	0.5	1.4	-0.6	-0.2	-0.9
Impedance of arm (right)	0.6	2.6	10.7	-3.3	-0.3	0.0	0.6	-1.3
Hip circumference	0.6	2.5	3.7	1.9	1.9	1.3	-1.9	-0.3
Father’s age at death	0.6	0.8	2.4	-0.3	-1.5	0.1	0.3	-1.1
Happiness	0.6	0.7	1.6	-0.1	0.0	-1.1	0.9	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-1.5	0.4	-0.4	0.3	-1.2
Impedance of arm (left)	0.6	2.8	11.3	-3.4	-0.5	0.4	0.4	-1.5
Breastfed as a baby	0.6	0.7	2.2	1.1	-1.5	-0.3	0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.4	0.3	0.4	-1.6	1.3	-0.5
Worry too long after embarrassment	0.6	1.0	1.7	-0.9	-1.3	-0.9	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.7	0.3	-0.1	-1.1	1.3	0.8
Medication: Bendroflumethiazide	0.6	0.9	2.4	-0.5	-0.5	-1.2	1.5	-0.2
Cholesterol lowering medication	0.6	0.9	2.3	1.5	-0.5	-0.8	0.6	1.1
Leg fat mass (left)	0.6	2.4	4.3	1.1	2.1	1.2	-2.0	-0.9
Age at First Birth	0.5	0.8	1.5	0.7	-1.2	-0.6	1.2	0.2
Blood Eosinophil Count	0.5	3.7	8.1	-1.8	-2.8	-1.5	2.3	-0.1
Smoking Status	0.5	1.3	5.3	-2.3	-0.7	0.5	0.5	-0.2
Allergy or Eczema	0.5	1.3	3.6	-0.7	-0.6	-0.7	1.2	-1.9
Number of treatments/medications taken	0.5	0.9	1.7	1.1	-0.9	-0.5	0.7	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.6	0.2	1.6	-0.2	-0.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.8	0.6	0.3	-0.3	0.1	-1.4
Body mass index (BMI)	0.5	2.1	4.0	0.8	1.7	0.6	-1.6	-2.0
Number of incorrect matches in round	0.5	0.8	1.7	-1.1	-0.4	-0.5	0.8	-1.3
Alcohol usually taken with meals	0.5	0.8	1.8	-0.7	0.7	-0.9	0.5	-1.3
Pain all over the body in last month	0.5	0.6	1.2	-0.7	-1.0	0.2	0.3	-1.1
Medication: Cholesterol lowering	0.5	0.7	1.6	1.2	-0.6	-0.0	0.3	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	1.2	-0.8	-0.6	0.8	0.1
Arm fat mass (right)	0.5	2.2	5.0	1.3	2.2	0.8	-1.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.0	-0.9	1.0	0.9	-0.8	-0.9
Glaucoma (self-reported)	0.5	0.6	1.3	1.1	-0.6	-1.0	-0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.3	0.8	-0.4	-0.4	1.0	1.8
Body fat percentage	0.5	1.8	3.5	-0.3	1.3	0.9	-1.7	-1.9
Wheeze or whistling in the chest in last year	0.5	0.8	3.1	-1.8	0.1	0.3	0.2	-1.0
Pulse wave peak to peak time	0.5	0.6	1.0	-0.9	1.0	0.6	-0.8	0.1
Medication: Ibuprofen	0.5	0.6	1.9	-1.4	0.7	0.2	-0.4	-0.8
Leg fat mass (right)	0.5	1.9	3.2	1.3	1.8	1.0	-1.8	-0.6
Number of full sisters	0.5	0.7	2.0	-0.1	-1.0	1.4	-0.4	0.3
Leg pain on walking	0.5	0.6	1.3	0.3	1.1	0.8	-0.9	0.2
Asthma (self-reported)	0.5	1.0	2.4	-1.6	0.3	0.5	-0.4	-1.4
Arm fat mass (left)	0.5	2.2	4.4	1.4	2.1	0.9	-1.7	-1.1
Mother’s age at death	0.5	0.6	2.1	0.1	0.9	0.4	0.1	1.4
Leg fat percentage (left)	0.5	2.0	5.0	0.6	1.4	1.1	-2.2	-1.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.7	-0.2	1.9	1.1	-1.2	-0.3
Bipolar Disorder (2011)	0.4	0.4	0.8	0.8	-0.5	-0.4	-0.1	0.9
Triglycerides	0.4	0.6	1.8	-1.0	-0.4	-0.0	0.2	-1.3
BMI	0.4	2.2	3.3	1.3	1.4	1.2	-1.7	-1.8
Lung FEV1/FVC ratio	0.4	1.9	4.0	0.8	-1.4	-2.0	1.6	0.5
Relative age of first facial hair	0.4	0.8	1.8	-0.3	1.1	-1.4	0.4	-0.8
Supplements: Zinc	0.4	0.5	1.7	-0.3	0.1	-0.7	1.3	-0.0
Diabetes (mother)	0.4	0.5	1.2	1.1	-0.0	-1.1	0.4	0.1
Impedance of leg (right)	0.4	1.9	4.4	-1.1	-2.1	-0.2	0.9	1.8
Trunk fat percentage	0.4	1.8	3.4	-0.3	1.2	1.1	-1.6	-1.8
Relative age voice broke	0.4	0.7	1.6	0.5	-0.7	-1.3	0.8	0.5
Serious illness, injury or assault to yourself	0.4	0.5	2.4	-0.2	-0.2	0.1	-0.1	1.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.5	1.2	-0.4	-0.3	-0.0	0.9
Trunk fat mass	0.4	1.7	3.1	1.0	1.8	1.0	-1.6	-0.9
Waist circumference	0.4	1.3	2.5	1.6	1.6	0.2	-0.8	-1.0
Past tobacco smoking	0.4	0.7	2.1	1.5	0.5	0.4	-1.0	0.4
Had other major operations	0.4	0.5	0.8	0.4	-0.7	0.9	-0.5	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	-0.3	0.7	-0.9	0.0	-1.7
Medication: Ramipril	0.4	0.5	0.9	0.9	-0.3	-0.6	0.4	0.9
Hair/balding pattern: Pattern 3	0.4	0.5	2.1	-0.1	-0.0	-0.2	0.7	-1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	1.2	-0.8	-0.4	0.3	0.3
Medication: Allopurinol	0.4	0.5	1.3	-0.8	-0.6	-0.2	0.5	-1.1
Whole body fat mass	0.4	1.8	3.9	1.0	2.0	0.9	-1.6	-0.9
Chest pain or discomfort	0.4	0.5	1.0	-1.0	-0.5	-0.3	0.5	-1.0
Illnesses of father: Heart disease	0.4	0.5	1.8	-0.1	-0.8	0.1	0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	-0.7	0.3	0.7	-0.5	-1.0
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	1.1	-1.2	-0.5	0.4	0.9
Guilty feelings	0.4	0.6	1.4	-1.2	-0.3	-0.5	0.8	-0.6
Wears glasses or contact lenses	0.4	0.5	1.1	-1.0	-0.7	-0.1	-0.0	-0.9
Hearing aid user	0.4	0.4	1.4	0.7	-0.2	0.2	-0.3	1.2
Illnesses of father: High blood pressure	0.4	0.4	0.9	-0.3	0.2	1.0	-0.9	-0.5
Ever smoked	0.4	0.7	1.4	-1.2	-0.5	-0.5	1.2	-0.4
Number of operations (self-reported)	0.4	0.5	1.3	-0.1	0.1	1.0	-1.2	-0.6
Average weekly beer plus cider intake	0.4	0.6	2.5	-1.6	-0.4	0.0	0.4	-0.4
Risk taking	0.4	0.6	1.3	-1.1	0.2	0.9	-0.8	-0.6
Schizophrenia (2018)	0.3	0.5	1.4	0.9	-0.6	1.2	-0.2	-0.1
Major Depression (MDD)	0.3	0.3	1.1	-0.3	-0.5	0.1	0.2	1.1
Ovarian Cancer	0.3	0.4	0.7	0.8	0.0	0.4	0.5	0.9
LDL Cholesterol	0.3	0.4	1.2	0.6	0.3	-0.7	-0.0	1.1
Lung FVC	0.3	1.3	2.3	1.3	1.0	0.1	-1.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.5	0.1	-1.2	0.0	-0.1	0.8
Severe depression (siblings)	0.3	0.3	0.7	-0.3	-0.4	0.9	-0.1	-0.7
Age when periods started (menarche)	0.3	0.7	2.2	0.2	0.1	-1.5	1.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	0.0	1.4	-0.5	-0.5	-1.1
High blood pressure	0.3	0.8	2.1	-0.5	-1.4	-0.6	1.1	0.2
Impedance of leg (left)	0.3	1.5	3.2	-1.1	-1.6	0.4	0.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.2	-0.2	-0.5	-0.1	1.4
Hearing difficulty/problems with background noise	0.3	0.5	0.9	0.5	0.5	0.7	-0.9	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.3	-0.8	-0.3	-1.2	0.5	0.0
Falls in the last year	0.3	0.4	1.0	1.0	-0.4	0.6	-0.0	0.6
Noisy workplace	0.3	0.4	0.6	0.6	-0.8	-0.8	0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.9	-0.8	-0.3	-0.0	-0.8
Gout (self-reported)	0.3	0.4	1.2	-1.1	-0.1	0.2	-0.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.0	-0.8	0.2	1.1	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	-0.3	-0.2	-0.1	-0.1	-1.3
Leg fat percentage (right)	0.3	1.1	2.9	0.6	0.8	0.7	-1.7	-1.1
Emphysema/chronic bronchitis	0.3	0.3	1.3	0.2	1.1	-0.3	-0.4	0.4
Medication: Blood pressure	0.3	0.5	1.1	0.6	0.1	-1.1	0.5	1.0
Knee pain experienced in last month	0.3	0.5	1.3	-0.8	-1.2	0.4	-0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	1.3	0.9	0.4	-0.6	0.3	1.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	0.6	-0.0	0.1	-0.6	1.0
High cholesterol (Self-reported)	0.3	0.5	1.7	1.3	-0.3	0.3	-0.5	0.7
Medication: Lisinopril	0.3	0.4	1.0	-0.3	1.0	-0.5	-0.4	0.5
Impedance of whole body	0.3	1.5	6.2	-2.5	-1.0	0.6	0.4	-0.1
Bipolar Disorder (2018)	0.2	0.4	0.6	-0.6	-0.7	-0.5	-0.4	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.2	0.9	-0.7	0.5	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.1	-0.9	-0.0	0.8	-0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.9	0.4	0.0	-0.2	-0.3
Mean Putamen Volume	0.2	0.2	0.6	0.3	-0.4	0.1	-0.4	0.8
HbA1C	0.2	0.2	0.4	0.4	-0.2	-0.1	0.5	0.7
Neuroticism (2016)	0.2	0.4	0.8	-0.1	0.2	-0.8	0.9	0.6
Schizophrenia (2014)	0.2	0.5	1.4	0.3	0.2	1.0	-0.5	-1.2
Waist Hip Ratio (WHR)	0.2	0.7	1.5	0.7	1.2	-0.6	0.4	-1.1
Respiratory disease	0.2	0.5	0.9	-0.4	1.0	0.2	-0.8	-0.8
Neuroticism	0.2	0.4	0.7	-0.8	0.7	0.7	0.1	0.5
Hand grip strength (left)	0.2	0.6	1.3	0.3	0.8	-0.1	-1.1	1.1
Maternal smoking around birth	0.2	0.3	0.7	0.8	-0.1	0.6	0.0	0.7
Neuroticism score	0.2	0.4	0.9	-0.7	-0.1	-0.7	0.9	0.5
Number of live births	0.2	0.3	0.5	-0.7	-0.7	-0.1	0.7	-0.4
Exposure to tobacco smoke at home	0.2	0.3	0.9	-0.5	0.3	-0.2	-0.3	-0.9
Birth weight	0.2	0.4	1.2	-0.5	1.1	0.6	-0.4	-0.0
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.7	0.2	-0.7	-0.3	0.6
Number of full brothers	0.2	0.3	0.8	-0.0	-0.2	-0.9	0.7	-0.0
Age at first live birth	0.2	0.3	0.8	0.6	-0.4	-0.3	0.3	0.9
Shortness of breath walking on level ground	0.2	0.2	0.6	-0.5	0.8	0.2	0.1	-0.0
Qualifications: College or University degree	0.2	0.5	0.9	0.9	0.8	1.0	-0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.1	0.8	0.2	-0.1	-0.6
Suffer from ‘nerves’	0.2	0.3	0.8	-0.5	-0.4	-0.4	0.9	0.6
Age at last live birth	0.2	0.3	0.6	-0.4	-0.4	-0.8	0.6	-0.5
Hypertension (Self-reported)	0.2	0.6	1.8	-0.2	-1.4	-0.6	0.8	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.8	-0.2	0.3	-0.6	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.1	0.6	0.4	-0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.8	-0.9	0.2	-0.1	0.1
Smoking status: Current	0.2	0.3	0.4	-0.6	-0.6	-0.3	0.5	-0.6
Miserableness	0.2	0.4	1.6	-0.6	1.3	-0.1	-0.0	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	0.0	-0.8	-0.5	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.1	0.2	0.7	-0.4	0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	0.4	-0.8	0.6	-0.4	-0.6
Heel T-Score	0.1	0.9	1.6	-0.7	1.1	0.9	-0.8	-1.2
Tanning	0.1	1.4	2.6	-1.5	-0.3	0.9	-1.1	-1.6
Fed-up feelings	0.1	0.2	0.4	-0.6	0.5	-0.5	-0.2	-0.4
Qualifications: None of the above	0.1	0.2	0.7	-0.8	-0.0	-0.4	0.2	0.3
Mouth/teeth dental problems	0.1	0.2	0.5	0.7	0.4	0.5	0.1	0.5
Heart attack	0.1	0.2	0.5	0.2	0.2	0.7	-0.3	0.5
Headache pain in last month	0.1	0.2	1.0	0.2	1.0	-0.2	0.0	-0.4
Mood swings	0.1	0.2	0.6	-0.4	0.5	0.2	-0.8	0.1
Loneliness, isolation	0.1	0.1	0.5	0.4	0.7	-0.1	0.2	-0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.7	-0.0	0.2	0.0	0.7
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.4	0.4	-0.3	-0.8	0.3
Osteoporosis (self-reported)	0.1	0.2	0.4	0.4	0.5	0.2	-0.2	0.6
Osteoarthritis (self-reported)	0.1	0.1	0.5	-0.7	-0.3	0.1	-0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.6	-0.7	-0.1	-0.1	0.0
Irritability	0.1	0.2	0.5	-0.7	0.6	-0.1	-0.4	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.3	-0.5	0.3	-0.0	-0.5
Age started oral contraceptive pill	0.1	0.2	0.5	0.3	0.7	0.1	0.4	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.2	-0.1	0.4	0.1	0.0	0.2
Cardiovascular Disease	0.0	0.2	0.3	-0.4	-0.3	-0.5	0.5	0.3
Hair Pigment	0.0	1.1	3.3	-0.3	0.5	-1.2	0.7	-1.8
Current tobacco smoking	0.0	0.1	0.2	-0.5	-0.1	0.2	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.0	-0.1	0.4	-0.1	0.1
Alcohol intake frequency.	0.0	0.1	0.3	-0.2	0.3	0.5	-0.4	0.1

Hub : Genes

RGS3

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Trait associations