Best TWAS P=8.21e-27 · Best GWAS P=1.21e-79 conditioned to 1.39e-20
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GDAP2 | 0.06 | 0.01 | blup | 407 | 0.04 | 2.5e-05 | -4.8 | 6.0 | 2.1e-09 | 0.29 | 0.54 | 0.06 | FALSE |
| 2 | GTEx | Colon Transverse | GDAP2 | 0.19 | -0.01 | enet | 40 | 0.00 | 3.4e-01 | 8.8 | 7.7 | 1.4e-14 | 0.42 | 0.04 | 0.40 | TRUE |
| 3 | GTEx | Heart Left Ventricle | FAM46C | 0.25 | 0.14 | lasso | 4 | 0.17 | 1.9e-09 | -6.4 | 7.1 | 1.3e-12 | 0.18 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Thyroid | GDAP2 | 0.09 | 0.04 | lasso | 6 | 0.02 | 2.0e-02 | -4.8 | -6.8 | 7.5e-12 | -0.26 | 0.33 | 0.03 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | FAM46C | 0.04 | 0.00 | bslmm | 409 | 0.01 | 4.1e-02 | -11.6 | -9.5 | 2.5e-21 | -0.39 | 0.04 | 0.38 | TRUE |
| 6 | YFS | Blood | FAM46C | 0.04 | 0.01 | bslmm | 394 | 0.01 | 6.8e-04 | 11.0 | -8.5 | 1.6e-17 | -0.50 | 0.13 | 0.45 | TRUE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FAM46C | 0.12 | 0.00 | blup | 77 | 0.05 | 1.6e-03 | 10.3 | -10.7 | 8.2e-27 | -0.55 | 0.02 | 0.23 | TRUE |