TWAS hub - GDAP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.021	0.00019	0.013	0.037	0.034	NA	0.027	0.00990	2.5e-05	4.2e-05	NA	0.00025
2	GTEx	Colon Transverse	0.186	0.065	0.00130	-0.006	NA	0.000	NA	-0.004	0.83000	NA	3.4e-01	NA	0.53000
3	GTEx	Thyroid	0.092	0.042	0.00360	0.037	NA	0.002	NA	0.016	0.00077	NA	2.3e-01	NA	0.02000
4	TCGA	Thyroid Carcinoma	0.030	0.021	0.00290	0.013	0.023	0.012	NA	0.013	0.01800	2.5e-03	2.2e-02	NA	0.01800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Hair/balding pattern: Pattern 4	10.9	26.4	35.3	-5.9	-4.0	5.2	5.2
Breast Cancer	6.1	14.7	34.2	-4.2	-5.8	2.6	0.1
Bipolar Disorder (2011)	5.0	4.9	9.2	-1.9	-0.5	3.0	2.5
Depression (self-reported)	4.8	5.8	10.0	-2.2	-1.0	3.2	2.7
Supplements: Vitamin C	4.3	5.1	10.3	3.2	1.9	-1.8	-1.8
Medication: Co-codamol	4.0	4.7	9.6	1.5	1.2	-3.1	-2.3
Coronary Artery Disease (CAD)	3.5	4.2	6.6	-2.6	-0.4	2.4	2.1
Medication: Atenolol	3.5	4.4	6.3	-2.5	-0.9	2.2	2.3
Blood Platelet Count	3.4	39.7	59.1	6.0	7.7	-6.8	-4.1
Mouth/teeth dental problems	3.3	5.0	9.5	-1.9	-1.2	3.1	2.4
Wears glasses or contact lenses	3.0	3.5	5.1	2.3	-0.1	-2.0	-2.2
Diabetes (mother)	2.9	3.8	5.4	-2.3	-2.0	2.0	1.2
Pain all over the body in last month	2.9	3.1	5.4	1.0	-1.1	-2.3	-2.1
Mouth/teeth dental problems: Mouth ulcers	2.8	4.4	7.2	1.3	1.6	-2.7	-2.4
Financial difficulties in last 2 years	2.7	3.7	6.4	-2.5	-0.9	2.1	1.7
Worrier / anxious feelings	2.7	5.0	6.8	-2.4	-2.0	2.6	1.8
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	4.6	1.7	-1.5	-2.0	-2.1
Had major operations	2.6	3.1	6.7	-1.3	-0.6	2.6	1.9
Medication: Paracetamol	2.6	4.0	6.3	2.2	0.2	-2.5	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.3	4.8	-1.8	-0.5	2.1	2.2
Hair/balding pattern: Pattern 2	2.3	2.9	3.9	1.3	2.0	-1.6	-1.8
Medication: Aspirin	2.2	2.9	4.5	-2.1	0.6	1.7	2.0
Heart disease (siblings)	2.2	2.7	5.9	-2.4	0.1	1.5	1.6
Severe depression (siblings)	2.1	2.4	3.7	-1.7	0.5	1.9	1.6
Medication: Ibuprofen	2.1	2.5	3.3	1.3	-1.8	-1.5	-1.7
Ever depressed for a whole week	2.1	2.6	2.9	-1.7	-1.5	1.7	1.5
HbA1C	2.0	2.2	3.6	-1.6	-0.1	1.9	1.6
High blood pressure (siblings)	2.0	2.8	5.0	2.2	1.9	-1.5	-0.7
Medication: Atorvastatin	2.0	2.5	5.1	-1.6	-0.2	2.2	1.6
Triglycerides	1.9	3.1	6.0	-2.4	-2.4	1.0	-0.2
Diabetes (father)	1.9	2.3	6.0	-2.4	-0.7	1.1	1.2
Medication: Paracetamol	1.9	3.2	5.2	1.7	0.6	-2.3	-2.1
Chronic bronchitis/emphysema (mother)	1.9	2.2	6.1	-2.5	0.2	1.0	1.2
Leg pain on walking	1.9	2.3	6.4	-1.4	-2.5	0.9	0.3
Medication: Aspirin	1.9	2.5	4.8	-2.2	0.7	1.3	1.7
Qualifications: nursing, teaching	1.9	2.9	4.8	-2.2	-0.6	1.9	1.8
Heart attack	1.8	2.4	3.7	-1.9	-1.7	1.4	0.9
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.4	-1.1	-1.2	1.8	1.5
Knee pain experienced in last month	1.8	2.8	6.4	-2.5	-1.7	1.3	0.2
Worry (Nagel 2018)	1.7	3.5	10.0	-1.4	-3.2	1.3	0.6
Vitamin and mineral supplements	1.7	2.4	7.1	-2.7	-0.1	0.7	1.4
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.1	-1.8	-1.5	1.4	0.8
Commuting to job workplace: Public transport	1.7	2.1	4.9	1.5	2.2	-1.0	-0.5
Depression (Nagel 2018)	1.6	2.4	3.7	-1.5	-0.9	1.9	1.7
Lung FVC	1.6	8.1	18.1	1.8	-2.2	-2.5	-4.3
Serious illness, injury or assault to yourself	1.6	1.9	3.5	1.9	0.2	-1.5	-1.3
Wheeze or whistling in the chest in last year	1.6	2.9	8.4	-0.6	0.8	1.5	2.9
Suffer from ‘nerves’	1.6	2.6	6.7	-1.7	-2.6	0.8	0.4
Angina	1.5	2.0	3.8	-1.3	-1.9	1.3	0.9
Breastfed as a baby	1.5	1.9	4.1	2.0	0.4	-0.7	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.5	-1.2	0.7	1.5	1.9
Angina (self-reported)	1.5	2.0	5.2	-1.2	-2.3	1.0	0.6
Commuting to job workplace: Walk	1.5	1.6	3.9	0.9	2.0	0.5	1.2
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.2	-1.8	-1.5	1.3	0.9
Multivitamins +/- minerals	1.4	1.8	4.2	2.0	-1.2	-0.3	-1.1
Falls in the last year	1.4	1.9	4.2	-1.1	-0.1	1.5	2.0
Number of children fathered	1.4	1.6	4.1	2.0	0.5	-1.2	-0.7
Smoking status: Previous	1.4	2.2	5.5	1.6	2.4	-0.4	0.7
Medication: Bendroflumethiazide	1.4	2.2	3.2	1.8	1.7	-1.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.4	-2.1	-0.5	1.4	1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	3.6	-1.9	-1.9	1.8	0.4
High cholesterol (Self-reported)	1.3	2.3	4.5	0.8	-2.1	-1.3	-1.6
Bipolar Disorder (2018)	1.2	1.9	3.1	-1.7	0.5	1.8	1.2
Past tobacco smoking	1.2	2.3	7.4	-1.1	-2.7	-0.1	-0.8
Medication: Simvastatin	1.2	1.8	3.5	-0.3	-1.9	-1.3	-1.4
Commuting to job workplace: Cycle	1.2	1.4	2.4	1.4	1.6	-0.8	-0.7
Neuroticism (Nagel 2018)	1.1	2.5	4.3	-1.5	-1.6	2.1	0.9
LDL Cholesterol	1.1	1.7	5.1	-1.0	-2.2	0.8	-0.5
Neuroticism (2016)	1.1	1.6	2.6	-1.0	0.3	1.6	1.6
Pack years adult smoking proportion	1.1	1.7	3.3	-1.8	-1.8	0.6	0.1
Father’s age at death	1.1	1.4	3.6	1.9	0.8	-0.8	-0.9
Birth weight	1.1	2.4	4.3	-1.7	-0.8	2.1	1.4
Exposure to tobacco smoke outside home	1.1	1.5	3.3	0.2	-0.6	-1.5	-1.8
Comparative body size at age 10	1.1	2.9	5.8	1.6	-1.1	-1.5	-2.4
Supplements: Calcium	1.1	1.2	2.8	-0.8	0.6	1.7	1.0
Alcohol drinker status: Previous	1.1	1.2	3.6	-1.0	1.9	-0.3	0.3
Pack years of smoking	1.1	1.6	3.2	-1.8	-1.8	0.5	0.1
Respiratory disease	1.0	2.2	4.1	-0.0	2.0	1.0	1.9
Medication for hormone replacement therapy	1.0	1.1	3.5	-0.4	-1.9	0.9	-0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.5	-0.5	-1.9	0.6	0.3
Medication: Levothyroxine sodium	1.0	1.6	4.2	-1.2	-2.0	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	8.5	0.2	-2.9	-0.5	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	9.9	-0.3	-3.1	-0.2	-1.7
Exposure to tobacco smoke at home	1.0	1.1	3.0	-0.5	-1.7	-0.7	-0.9
Birth weight of first child	1.0	1.9	3.1	-0.7	-1.8	1.5	1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	1.1	0.6	-1.4	-1.3
Migraine (self-reported)	1.0	1.3	2.3	-1.5	0.9	0.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.0	1.2	0.3	-1.6	-2.0
Number of operations (self-reported)	1.0	1.5	2.5	-1.2	0.5	1.6	1.3
Major Depression (MDD)	0.9	1.0	1.8	-0.8	1.2	0.6	1.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.2	-1.8	0.2	0.7	0.6
Hypothyroidism (self reported)	0.9	2.1	4.3	-1.5	-2.1	1.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.8	-1.3	-0.3	1.2	1.1
Trunk fat percentage	0.9	3.5	8.5	-2.9	-0.4	0.9	2.1
Townsend deprivation index at recruitment	0.9	1.2	3.0	-0.7	1.7	-1.0	-0.7
Qualifications: CSEs or equivalent	0.9	1.1	3.5	-0.4	-1.9	0.9	-0.4
Hearing difficulty/problems with background noise	0.9	1.4	2.4	-0.8	-0.7	1.4	1.6
Had other major operations	0.9	1.1	2.2	-1.5	-0.3	1.1	1.0
Neck or shoulder pain in last month	0.9	1.3	3.2	0.5	-0.1	-1.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-1.5	1.0	0.5	1.0
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-1.5	-0.1	1.0	1.0
Loneliness, isolation	0.9	1.2	2.8	-1.7	-1.2	0.8	0.2
Alcohol drinker status: Never	0.9	1.0	3.0	0.7	-0.4	-1.7	-0.6
Ever smoked	0.9	1.6	5.3	0.2	2.3	0.7	0.8
Pain experienced in last month	0.9	1.6	3.2	0.4	1.8	1.3	1.1
Number of incorrect matches in round	0.8	1.3	3.3	0.2	-0.6	-1.2	-1.8
Number of live births	0.8	1.1	1.8	-1.1	-1.0	1.3	0.8
Medication: Lansoprazole	0.8	0.9	3.0	-0.1	-1.7	-0.5	-0.7
Medication: Allopurinol	0.8	1.0	2.1	1.4	0.0	-1.1	-0.9
Age at last live birth	0.8	1.2	2.0	-1.3	-0.7	1.4	0.8
Average weekly red wine intake	0.8	1.2	2.1	1.0	1.4	0.2	1.2
Long-standing illness, disability or infirmity	0.8	1.2	3.4	-1.8	-1.1	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.2	-0.5	-0.9	1.5	0.6
Unable to work because of sickness or disability	0.8	1.0	2.3	-0.7	-0.2	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.7	-1.3	-1.1	1.6	0.4
Hearing difficulty/problems: Yes	0.7	1.0	2.0	-0.7	-0.3	1.3	1.4
Relative age of first facial hair	0.7	1.3	3.5	-0.7	-0.4	-1.9	-1.1
Chronic bronchitis/emphysema (father)	0.7	0.9	1.4	-0.2	1.2	0.8	1.1
Trunk fat mass	0.7	2.9	6.5	-2.5	-0.7	1.1	1.8
Forced vital capacity (FVC)	0.7	2.7	5.3	1.2	-2.3	-0.5	-2.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.5	-0.8	1.0	0.7	1.2
Asthma	0.7	1.4	3.2	1.3	1.8	-0.2	0.7
Impedance of arm (left)	0.7	3.1	6.3	-2.5	0.2	1.2	2.1
Forced vital capacity (FVC), Best measure	0.7	2.5	7.1	0.2	-2.7	0.1	-1.7
Body fat percentage	0.7	2.8	7.9	-2.8	-0.5	0.6	1.6
Asthma (self-reported)	0.7	1.4	3.4	1.1	1.8	0.2	0.9
Medication: Lisinopril	0.7	0.9	2.0	-0.6	1.4	0.2	1.1
Impedance of whole body	0.7	3.4	7.2	-2.7	0.4	1.4	2.0
Ulcerative Colitis (UC)	0.6	1.1	1.6	1.2	1.2	-1.3	-0.4
Ovarian Cancer	0.6	0.8	1.2	-1.1	-0.9	-0.6	-0.9
HDL Cholesterol	0.6	1.1	2.6	1.6	0.4	-0.7	-1.0
Systolic Blood Pressure	0.6	3.1	5.5	2.3	-0.6	-1.9	-1.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.3	-1.2	-0.7	0.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.9	-1.4	0.5	0.6	0.3
Maternal smoking around birth	0.6	0.9	2.2	-1.5	-0.8	0.6	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.4	-0.9	-0.8	-1.1
Stomach or abdominal pain in last month	0.6	0.7	2.1	-0.8	-1.4	-0.3	-0.2
High blood pressure (mother)	0.6	0.8	1.3	1.1	0.4	-1.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	-1.4	-0.7	1.0	0.6
Impedance of arm (right)	0.6	2.9	5.0	-2.2	0.1	1.3	2.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-0.7	-0.6	1.4	0.9
Happiness	0.6	0.8	1.6	-0.8	-0.3	1.3	0.8
Prospective memory result	0.6	0.7	1.4	0.3	1.2	-0.6	-1.0
Number of full brothers	0.6	0.7	1.7	-0.9	-1.3	0.2	-0.6
Qualifications: College or University degree	0.6	2.0	2.9	-1.5	-0.7	1.7	1.6
Medication: Blood pressure	0.6	1.1	1.6	-0.5	1.1	1.2	1.3
Leg fat mass (right)	0.6	2.5	6.4	-2.5	-1.2	0.8	1.2
Chest pain or discomfort	0.6	0.9	1.8	-1.3	-1.1	0.6	0.3
Breast cancer (self-reported)	0.6	0.7	1.6	0.4	1.3	-1.0	-0.2
Mother’s age at death	0.6	0.7	1.2	0.9	-0.3	-1.1	-0.9
Average weekly beer plus cider intake	0.6	0.9	2.1	0.7	-0.3	-0.9	-1.4
Cholesterol lowering medication	0.6	0.9	2.5	-1.6	-1.0	-0.3	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.2	-0.9	-1.1	0.4	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	-0.3	-1.5	0.0	-0.6
Blood Red Count	0.5	5.3	8.8	-1.8	3.0	2.1	2.1
Height	0.5	9.7	19.8	-1.7	-0.2	4.5	4.0
Impedance of leg (right)	0.5	2.2	6.2	-2.5	0.1	1.0	1.3
Supplements: Glucosamine	0.5	0.6	1.6	1.3	0.3	-0.4	-0.8
Allergy	0.5	1.2	4.2	0.1	-2.1	-0.1	-0.8
Diabetes (self-reported)	0.5	0.8	1.1	-0.9	-1.0	-0.8	-0.8
Neuroticism score	0.5	0.9	1.7	-0.8	-1.3	1.1	0.4
Noisy workplace	0.5	0.6	1.3	-0.4	0.6	0.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-1.0	-0.6	0.7	0.6
Length of working week for main job	0.5	0.6	1.8	-0.0	-1.3	0.5	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.7	-1.2	0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.0	-1.4	-0.6	0.6	-0.4
Leg fat percentage (right)	0.5	1.7	5.9	-2.4	-0.5	-0.1	0.9
Worry too long after embarrassment	0.5	0.9	1.6	-0.2	0.8	1.3	1.1
Age at first live birth	0.5	0.9	1.8	-0.6	0.5	1.3	1.2
Comparative height size at age 10	0.5	2.5	4.2	-1.2	-0.7	2.0	2.1
Overall health rating	0.5	1.0	1.3	-1.0	-1.1	-1.1	-0.5
Diabetes diagnosed by doctor	0.5	0.9	1.6	-1.3	-1.1	-0.7	-0.5
Osteoarthritis (self-reported)	0.5	0.7	1.3	-1.2	-1.1	0.0	0.4
Miserableness	0.5	0.9	2.7	-0.6	0.2	1.6	0.8
Guilty feelings	0.5	0.7	1.1	-0.7	0.7	1.0	1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.0	1.1	-0.1	0.2
Medication: Blood pressure	0.5	1.0	2.5	-0.8	1.6	-0.8	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	1.1	-0.4	-0.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	0.4	-0.4	-1.0	-1.1
Leg fat mass (left)	0.5	2.1	5.8	-2.4	-1.0	0.7	1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.8	-0.3	1.2	0.6	1.4
Schizophrenia (2018)	0.4	0.9	1.5	1.0	1.2	-0.6	0.8
Lupus	0.4	0.6	0.9	0.4	0.8	-0.9	-0.9
Primary Biliary Cirrhosis	0.4	0.6	2.4	0.1	1.6	0.1	0.1
Blood Eosinophil Count	0.4	3.4	12.0	0.2	3.5	-0.6	1.1
Waist Hip Ratio (WHR)	0.4	1.6	3.1	-1.8	1.2	0.6	1.2
Neuroticism	0.4	1.0	2.0	-0.7	-1.4	1.2	0.3
Sensitivity / hurt feelings	0.4	0.7	1.2	-0.8	-1.0	1.1	-0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.5	-0.4	-1.0	-0.8
Supplements: Zinc	0.4	0.4	0.7	0.8	0.7	-0.5	-0.4
Medication: Metformin	0.4	0.6	1.0	-0.9	0.1	0.6	1.0
Fed-up feelings	0.4	0.8	1.8	-0.9	-1.3	0.7	-0.0
High blood pressure	0.4	1.1	2.7	0.2	1.6	-0.2	1.2
Sitting height	0.4	2.6	4.5	-1.6	-2.1	1.8	0.6
Impedance of leg (left)	0.4	1.8	5.1	-2.3	0.5	0.8	1.2
Had menopause	0.4	0.5	0.7	0.8	0.3	-0.8	-0.6
Qualifications: None of the above	0.4	0.9	1.5	-0.0	0.8	-1.2	-1.2
Medication: Ramipril	0.4	0.5	0.9	-0.9	-0.4	0.6	0.8
Illnesses of siblings	0.4	0.6	1.8	-0.3	-1.4	0.5	-0.5
Arm fat percentage (right)	0.4	1.5	4.0	-2.0	-0.5	0.1	1.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.5	0.5	-1.4	-0.7
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-0.7	-0.2	0.5	1.0
Standing height	0.4	4.2	9.0	-1.3	-0.8	3.0	2.3
Peak expiratory flow (PEF)	0.4	0.8	2.9	-0.2	-1.7	0.4	-0.5
Loud music exposure frequency	0.4	0.4	1.0	0.5	1.0	0.0	0.5
Health satisfaction	0.4	0.5	1.4	0.3	-1.2	-0.7	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.1	-1.1	0.5	-0.4	0.5
Whole body fat mass	0.4	1.8	4.6	-2.2	-0.7	0.7	1.3
Alcohol intake frequency.	0.4	1.0	3.2	-1.8	-0.7	-0.6	-0.2
Number of full sisters	0.4	0.5	1.3	-0.2	0.7	0.5	1.1
Arm fat percentage (left)	0.4	1.6	4.9	-2.2	-0.6	0.0	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.0	0.4	0.4	0.7
Medication for cholesterol	0.4	0.6	1.3	1.1	-0.1	-0.4	-0.9
Back pain experienced in last month	0.4	0.6	1.7	-0.3	1.3	0.2	0.8
Mineral and other dietary supplements	0.4	0.5	1.0	-1.0	0.3	0.1	1.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-1.2	0.8	0.5	0.7
Leg fat percentage (left)	0.4	1.4	4.9	-2.2	-0.2	-0.2	0.8
Irritability	0.4	0.6	1.6	0.4	-1.2	0.9	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	0.0	-1.3	0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	0.6	-0.9	-0.5	-1.5
Crohns Disease (2017)	0.3	0.6	1.6	-1.3	-0.5	-0.1	0.7
Prostate Cancer	0.3	0.4	1.2	-0.7	-0.1	-0.1	-1.1
Fasting Glucose	0.3	0.4	0.9	-0.2	-0.9	0.7	0.1
Ulcerative Colitis	0.3	0.4	0.7	0.5	0.8	-0.2	0.8
Heel T-Score	0.3	2.4	3.3	-1.6	-1.0	1.8	1.6
Allergy or Eczema	0.3	0.7	1.2	-0.8	1.1	0.3	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-1.2	-0.9	-0.2	-0.3
Hand grip strength (left)	0.3	0.8	1.4	1.1	-1.2	0.6	-0.3
Average weekly spirits intake	0.3	0.4	1.0	-1.0	-0.5	-0.3	-0.2
Leg fat-free mass (left)	0.3	1.4	2.3	-0.8	-1.1	1.5	1.3
Average weekly fortified wine intake	0.3	0.3	0.7	0.2	-0.2	0.9	0.8
Relative age voice broke	0.3	0.5	1.4	-0.4	1.2	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	-0.8	1.0	0.6	0.9
Leg predicted mass (left)	0.3	1.4	2.4	-0.7	-1.1	1.5	1.2
Waist circumference	0.3	1.1	3.9	-2.0	-0.2	-0.3	0.4
Nervous feelings	0.3	0.5	0.7	-0.8	0.2	0.8	0.8
Weight	0.3	1.2	2.0	-1.4	-0.9	0.9	1.2
Alcohol intake versus 10 years previously	0.3	0.5	0.8	-0.8	0.1	-0.7	-0.9
Medication: Cholesterol lowering	0.3	0.5	0.9	1.0	-0.7	-0.1	-0.7
Arm fat mass (right)	0.3	1.0	2.4	-1.6	-0.4	0.4	1.1
Pulse wave reflection index	0.3	0.3	0.7	-0.1	-0.8	-0.6	-0.5
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.3	-0.3	-0.9	-0.6
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.3	0.3	0.5	0.9
Hypertension (Self-reported)	0.3	0.9	2.0	-0.4	1.2	0.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	-0.8	-0.6	1.1	0.5
Eye problems/disorders: Cataract	0.3	0.3	0.5	0.7	0.3	-0.6	-0.5
Osteoporosis (self-reported)	0.3	0.4	1.2	1.1	0.4	-0.4	-0.1
Arm fat mass (left)	0.3	1.2	3.2	-1.8	-0.5	0.4	1.1
Hearing aid user	0.3	0.3	1.2	1.1	-0.1	-0.3	0.0
Risk taking	0.3	0.4	1.1	1.0	0.3	0.0	0.6
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.5	-0.8	0.7	0.4
Diastolic blood pressure, automated reading	0.3	0.9	2.2	1.5	0.8	-0.6	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.7	-0.4	-0.4	0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.4	-0.8	0.1	-0.4
Reaction Time	0.2	0.4	0.7	-0.2	-0.8	0.8	0.4
Age at First Birth	0.2	0.2	0.5	-0.7	0.2	-0.6	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.2	-0.0	-0.7	-0.7
Mean Putamen Volume	0.2	0.2	0.5	-0.7	-0.1	-0.1	-0.4
Rheumatoid Arthritis	0.2	0.2	0.6	-0.2	0.4	-0.8	-0.3
Schizophrenia (2014)	0.2	0.5	1.2	0.4	0.8	-0.1	1.1
Smoking Status	0.2	0.6	1.2	-0.3	0.7	1.1	0.7
Cardiovascular Disease	0.2	0.5	1.1	0.5	0.6	-1.1	-0.6
Lung FEV1/FVC ratio	0.2	1.1	1.7	-0.7	-1.3	-0.9	-1.2
Number of treatments/medications taken	0.2	0.4	1.3	-0.3	1.1	-0.3	0.2
Systolic blood pressure, automated reading	0.2	0.6	1.9	1.4	-0.3	-0.6	-0.4
Current tobacco smoking	0.2	0.3	0.8	-0.5	0.1	0.9	0.2
Taking other prescription medications	0.2	0.3	0.9	0.2	0.1	-0.7	-0.9
Fluid intelligence score	0.2	0.4	0.6	-0.7	0.2	0.8	0.7
Hip circumference	0.2	0.9	1.6	-1.3	-0.9	-0.9	-0.7
Headache pain in last month	0.2	0.4	1.1	-1.1	-0.6	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.8	-0.5	-0.5	-0.2
Glaucoma (self-reported)	0.2	0.2	0.6	-0.3	-0.1	0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.5	-0.1	0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.5	-0.2	-0.6	-0.4
Mean time to correctly identify matches	0.2	0.4	0.7	0.4	0.5	0.6	0.8
Pulse rate, automated reading	0.2	0.7	2.0	0.6	-0.1	-1.4	-0.8
Family relationship satisfaction	0.2	0.2	0.4	0.6	-0.4	0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.1	0.2	0.8	0.7
Illnesses of father: Heart disease	0.2	0.2	0.6	-0.3	-0.2	-0.5	-0.8
Leg fat-free mass (right)	0.2	1.0	1.9	-0.4	-0.9	1.4	1.1
Mood swings	0.2	0.4	1.1	-0.5	-0.3	1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.2	0.4	0.3
Medication: Gliclazide	0.2	0.2	0.5	0.4	0.7	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.6	-0.8	0.1	-0.1
Leg predicted mass (right)	0.2	1.0	1.8	-0.3	-0.9	1.4	1.1
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.7	0.6	-0.3	0.2
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.3	-0.6	0.6	0.3
Financial situation satisfaction	0.2	0.3	0.6	-0.0	-0.8	-0.0	-0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.5	0.6	0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.8	-0.4	0.1	-0.1
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	0.5	-0.4	-0.5
Age started oral contraceptive pill	0.2	0.3	1.0	-0.2	1.0	0.2	0.4
Myopia	0.2	0.3	0.9	-0.5	1.0	-0.0	0.2
Basal cell carcinoma (self-reported)	0.2	0.3	1.0	0.3	1.0	-0.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.3	0.5	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.2	0.1	0.5	0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.2	0.8	-0.9	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.2	0.5	0.5
Blood White Count	0.1	0.6	1.3	0.1	-0.4	-0.9	-1.1
BMI	0.1	0.6	1.1	-0.4	-0.9	-1.0	-0.5
Chronotype (morning person)	0.1	0.3	0.9	0.5	-0.2	-0.3	-1.0
Hair Pigment	0.1	1.8	3.8	0.5	0.2	-2.0	-1.8
Tanning	0.1	1.4	3.6	1.9	1.3	-0.4	0.4
Hand grip strength (right)	0.1	0.3	1.0	1.0	-0.0	0.5	0.2
Age when periods started (menarche)	0.1	0.3	1.1	0.3	-0.2	1.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.3	-0.5	-0.0	0.7
Body mass index (BMI)	0.1	0.3	0.6	-0.8	-0.5	-0.5	0.1
Alcohol usually taken with meals	0.1	0.1	0.3	-0.1	0.5	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.3	-0.6	-0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.6	-0.4	-0.2	0.2
Trunk fat-free mass	0.1	0.3	0.8	0.5	-0.5	0.9	0.0
Time employed in main current job	0.1	0.1	0.2	0.5	-0.1	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.5	-0.7	0.2	-0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.4	-0.0	0.7	-0.5
Lung cancer (father)	0.1	0.1	0.2	-0.4	-0.4	0.3	0.1
Illnesses of mother	0.1	0.1	0.3	-0.2	0.1	-0.4	-0.5
Trunk predicted mass	0.1	0.3	0.7	0.6	-0.5	0.8	0.0
Tense / ‘highly strung’	0.1	0.1	0.5	0.1	-0.3	-0.0	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.0	0.4	0.2	-0.7
Gout (self-reported)	0.1	0.1	0.4	0.4	0.1	-0.6	-0.1
Medication: Amlodipine	0.1	0.1	0.3	-0.4	0.2	0.1	0.5
Arm fat-free mass (right)	0.1	0.4	0.9	-0.1	-0.9	0.9	0.0
Pulse wave peak to peak time	0.1	0.1	0.4	0.4	0.1	-0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.5	-0.5	0.1	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.1	0.7	0.5	0.2
Medication: Omeprazole	0.1	0.1	0.2	-0.0	0.3	-0.5	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.1	-0.1	0.6	0.4
Heart disease (mother)	0.1	0.2	0.4	0.2	-0.7	0.3	0.0
Arm predicted mass (right)	0.1	0.4	1.0	-0.0	-0.5	1.0	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.1	0.1	0.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.2	-0.1	0.5	0.6
Whole body fat-free mass	0.1	0.7	1.7	-0.1	-0.9	1.3	0.6
Ever had bowel cancer screening	0.1	0.1	0.3	0.4	0.5	-0.1	-0.2
Friendships satisfaction	0.1	0.2	0.5	0.2	-0.2	0.7	0.2
Smoking status: Current	0.1	0.2	0.5	-0.3	0.2	0.7	-0.1
Whole body water mass	0.1	0.6	1.4	-0.0	-0.7	1.2	0.6
Basal metabolic rate	0.1	0.8	1.6	-0.5	-0.8	1.2	0.9
Arm fat-free mass (left)	0.1	0.3	0.7	0.2	-0.3	0.9	0.5
Crohns Disease (2012)	0.0	0.1	0.2	-0.5	0.2	-0.1	0.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Pulse rate	0.0	0.0	0.1	0.1	0.0	-0.2	-0.3
Arm predicted mass (left)	0.0	0.2	0.6	0.0	-0.3	0.8	0.5

Hub : Genes

GDAP2

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Trait associations