Hub : Genes

GDAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.021	0.00019	0.013	0.037	0.034	NA	0.027	0.00990	2.5e-05	4.2e-05	NA	0.00025
2	GTEx	Colon Transverse	0.186	0.065	0.00130	-0.006	NA	0.000	NA	-0.004	0.83000	NA	3.4e-01	NA	0.53000
3	GTEx	Thyroid	0.092	0.042	0.00360	0.037	NA	0.002	NA	0.016	0.00077	NA	2.3e-01	NA	0.02000
4	TCGA	Thyroid Carcinoma	0.030	0.021	0.00290	0.013	0.023	0.012	NA	0.013	0.01800	2.5e-03	2.2e-02	NA	0.01800

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.9	3.1	-1.7	0.5	1.8	1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	1.8	-0.3	1.2	0.6	1.4
Depressed Affect (Nagel 2018)	0.7	1.5	2.7	-1.3	-1.1	1.6	0.4
Depression (Nagel 2018)	1.6	2.4	3.7	-1.5	-0.9	1.9	1.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.2	0.1	0.5	0.6
Neuroticism (Nagel 2018)	1.1	2.5	4.3	-1.5	-1.6	2.1	0.9
Schizophrenia (2018)	0.4	0.9	1.5	1.0	1.2	-0.6	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.7	-0.4	-0.4	0.1
Worry (Nagel 2018)	1.7	3.5	10.0	-1.4	-3.2	1.3	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.4	-0.8	0.1	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.2	-0.9	-1.1	0.4	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	-0.3	-1.5	0.0	-0.6
Crohns Disease (2017)	0.3	0.6	1.6	-1.3	-0.5	-0.1	0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.2	0.8	-0.9	0.1
Ulcerative Colitis (UC)	0.6	1.1	1.6	1.2	1.2	-1.3	-0.4
Major Depression (MDD)	0.9	1.0	1.8	-0.8	1.2	0.6	1.3
Reaction Time	0.2	0.4	0.7	-0.2	-0.8	0.8	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.2	0.5	0.5
Breast Cancer	6.1	14.7	34.2	-4.2	-5.8	2.6	0.1
Ovarian Cancer	0.6	0.8	1.2	-1.1	-0.9	-0.6	-0.9
Prostate Cancer	0.3	0.4	1.2	-0.7	-0.1	-0.1	-1.1
Age at First Birth	0.2	0.2	0.5	-0.7	0.2	-0.6	-0.1
Bipolar Disorder (2011)	5.0	4.9	9.2	-1.9	-0.5	3.0	2.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.2	-0.0	-0.7	-0.7
Coronary Artery Disease (CAD)	3.5	4.2	6.6	-2.6	-0.4	2.4	2.1
Crohns Disease (2012)	0.0	0.1	0.2	-0.5	0.2	-0.1	0.1
Mean Putamen Volume	0.2	0.2	0.5	-0.7	-0.1	-0.1	-0.4
Fasting Glucose	0.3	0.4	0.9	-0.2	-0.9	0.7	0.1
HbA1C	2.0	2.2	3.6	-1.6	-0.1	1.9	1.6
HDL Cholesterol	0.6	1.1	2.6	1.6	0.4	-0.7	-1.0
LDL Cholesterol	1.1	1.7	5.1	-1.0	-2.2	0.8	-0.5
Lupus	0.4	0.6	0.9	0.4	0.8	-0.9	-0.9
Neuroticism (2016)	1.1	1.6	2.6	-1.0	0.3	1.6	1.6
Primary Biliary Cirrhosis	0.4	0.6	2.4	0.1	1.6	0.1	0.1
Rheumatoid Arthritis	0.2	0.2	0.6	-0.2	0.4	-0.8	-0.3
Schizophrenia (2014)	0.2	0.5	1.2	0.4	0.8	-0.1	1.1
Triglycerides	1.9	3.1	6.0	-2.4	-2.4	1.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.2	-1.8	0.2	0.7	0.6
Ulcerative Colitis	0.3	0.4	0.7	0.5	0.8	-0.2	0.8
Blood Eosinophil Count	0.4	3.4	12.0	0.2	3.5	-0.6	1.1
Blood Platelet Count	3.4	39.7	59.1	6.0	7.7	-6.8	-4.1
Blood Red Count	0.5	5.3	8.8	-1.8	3.0	2.1	2.1
Blood White Count	0.1	0.6	1.3	0.1	-0.4	-0.9	-1.1
Heel T-Score	0.3	2.4	3.3	-1.6	-1.0	1.8	1.6
BMI	0.1	0.6	1.1	-0.4	-0.9	-1.0	-0.5
Height	0.5	9.7	19.8	-1.7	-0.2	4.5	4.0
Waist Hip Ratio (WHR)	0.4	1.6	3.1	-1.8	1.2	0.6	1.2
Systolic Blood Pressure	0.6	3.1	5.5	2.3	-0.6	-1.9	-1.8
Smoking Status	0.2	0.6	1.2	-0.3	0.7	1.1	0.7
Allergy or Eczema	0.3	0.7	1.2	-0.8	1.1	0.3	0.9
Cardiovascular Disease	0.2	0.5	1.1	0.5	0.6	-1.1	-0.6
Hypothyroidism (self reported)	0.9	2.1	4.3	-1.5	-2.1	1.4	0.1
Respiratory disease	1.0	2.2	4.1	-0.0	2.0	1.0	1.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-1.2	-0.9	-0.2	-0.3
Lung FEV1/FVC ratio	0.2	1.1	1.7	-0.7	-1.3	-0.9	-1.2
Lung FVC	1.6	8.1	18.1	1.8	-2.2	-2.5	-4.3
Neuroticism	0.4	1.0	2.0	-0.7	-1.4	1.2	0.3
Chronotype (morning person)	0.1	0.3	0.9	0.5	-0.2	-0.3	-1.0
Hair Pigment	0.1	1.8	3.8	0.5	0.2	-2.0	-1.8
Tanning	0.1	1.4	3.6	1.9	1.3	-0.4	0.4
Hand grip strength (left)	0.3	0.8	1.4	1.1	-1.2	0.6	-0.3
Number of treatments/medications taken	0.2	0.4	1.3	-0.3	1.1	-0.3	0.2
Average weekly spirits intake	0.3	0.4	1.0	-1.0	-0.5	-0.3	-0.2
Sensitivity / hurt feelings	0.4	0.7	1.2	-0.8	-1.0	1.1	-0.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.3	-1.2	-0.7	0.9	0.9
Hearing difficulty/problems: Yes	0.7	1.0	2.0	-0.7	-0.3	1.3	1.4
Relative age of first facial hair	0.7	1.3	3.5	-0.7	-0.4	-1.9	-1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.8	-1.3	-0.3	1.2	1.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.5	-0.4	-1.0	-0.8
Systolic blood pressure, automated reading	0.2	0.6	1.9	1.4	-0.3	-0.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.9	-1.4	0.5	0.6	0.3
Angina	1.5	2.0	3.8	-1.3	-1.9	1.3	0.9
Medication for hormone replacement therapy	1.0	1.1	3.5	-0.4	-1.9	0.9	-0.2
Vitamin and mineral supplements	1.7	2.4	7.1	-2.7	-0.1	0.7	1.4
Supplements: Zinc	0.4	0.4	0.7	0.8	0.7	-0.5	-0.4
Medication: Co-codamol	4.0	4.7	9.6	1.5	1.2	-3.1	-2.3
Medication: Metformin	0.4	0.6	1.0	-0.9	0.1	0.6	1.0
Diabetes (father)	1.9	2.3	6.0	-2.4	-0.7	1.1	1.2
Diabetes (mother)	2.9	3.8	5.4	-2.3	-2.0	2.0	1.2
Severe depression (siblings)	2.1	2.4	3.7	-1.7	0.5	1.9	1.6
Pack years adult smoking proportion	1.1	1.7	3.3	-1.8	-1.8	0.6	0.1
Impedance of leg (right)	0.5	2.2	6.2	-2.5	0.1	1.0	1.3
Leg fat-free mass (left)	0.3	1.4	2.3	-0.8	-1.1	1.5	1.3
Trunk fat percentage	0.9	3.5	8.5	-2.9	-0.4	0.9	2.1
Hand grip strength (right)	0.1	0.3	1.0	1.0	-0.0	0.5	0.2
Townsend deprivation index at recruitment	0.9	1.2	3.0	-0.7	1.7	-1.0	-0.7
Current tobacco smoking	0.2	0.3	0.8	-0.5	0.1	0.9	0.2
Average weekly fortified wine intake	0.3	0.3	0.7	0.2	-0.2	0.9	0.8
Maternal smoking around birth	0.6	0.9	2.2	-1.5	-0.8	0.6	0.5
Fed-up feelings	0.4	0.8	1.8	-0.9	-1.3	0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.3	4.8	-1.8	-0.5	2.1	2.2
Relative age voice broke	0.3	0.5	1.4	-0.4	1.2	0.1	0.6
Taking other prescription medications	0.2	0.3	0.9	0.2	0.1	-0.7	-0.9
Age when periods started (menarche)	0.1	0.3	1.1	0.3	-0.2	1.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.4	-0.9	-0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.3	-0.5	-0.0	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.5	-0.5	-1.9	0.6	0.3
Qualifications: CSEs or equivalent	0.9	1.1	3.5	-0.4	-1.9	0.9	-0.4
Serious illness, injury or assault to yourself	1.6	1.9	3.5	1.9	0.2	-1.5	-1.3
High blood pressure	0.4	1.1	2.7	0.2	1.6	-0.2	1.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	-0.8	1.0	0.6	0.9
Multivitamins +/- minerals	1.4	1.8	4.2	2.0	-1.2	-0.3	-1.1
Stomach or abdominal pain in last month	0.6	0.7	2.1	-0.8	-1.4	-0.3	-0.2
Supplements: Glucosamine	0.5	0.6	1.6	1.3	0.3	-0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.1	-1.8	-1.5	1.4	0.8
Medication: Atenolol	3.5	4.4	6.3	-2.5	-0.9	2.2	2.3
Medication: Levothyroxine sodium	1.0	1.6	4.2	-1.2	-2.0	0.7	-0.6
Sitting height	0.4	2.6	4.5	-1.6	-2.1	1.8	0.6
Chronic bronchitis/emphysema (father)	0.7	0.9	1.4	-0.2	1.2	0.8	1.1
High blood pressure (mother)	0.6	0.8	1.3	1.1	0.4	-1.1	-0.8
Body mass index (BMI)	0.1	0.3	0.6	-0.8	-0.5	-0.5	0.1
Impedance of leg (left)	0.4	1.8	5.1	-2.3	0.5	0.8	1.2
Leg predicted mass (left)	0.3	1.4	2.4	-0.7	-1.1	1.5	1.2
Trunk fat mass	0.7	2.9	6.5	-2.5	-0.7	1.1	1.8
Waist circumference	0.3	1.1	3.9	-2.0	-0.2	-0.3	0.4
Number of incorrect matches in round	0.8	1.3	3.3	0.2	-0.6	-1.2	-1.8
Past tobacco smoking	1.2	2.3	7.4	-1.1	-2.7	-0.1	-0.8
Alcohol usually taken with meals	0.1	0.1	0.3	-0.1	0.5	0.1	0.5
Nervous feelings	0.3	0.5	0.7	-0.8	0.2	0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	-1.4	-0.7	1.0	0.6
Hearing difficulty/problems with background noise	0.9	1.4	2.4	-0.8	-0.7	1.4	1.6
Hair/balding pattern: Pattern 2	2.3	2.9	3.9	1.3	2.0	-1.6	-1.8
Had menopause	0.4	0.5	0.7	0.8	0.3	-0.8	-0.6
Had other major operations	0.9	1.1	2.2	-1.5	-0.3	1.1	1.0
Forced vital capacity (FVC)	0.7	2.7	5.3	1.2	-2.3	-0.5	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.3	-0.6	-0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.6	-0.4	-0.2	0.2
Qualifications: None of the above	0.4	0.9	1.5	-0.0	0.8	-1.2	-1.2
Financial difficulties in last 2 years	2.7	3.7	6.4	-2.5	-0.9	2.1	1.7
Mouth/teeth dental problems	3.3	5.0	9.5	-1.9	-1.2	3.1	2.4
Heart attack	1.8	2.4	3.7	-1.9	-1.7	1.4	0.9
Allergy	0.5	1.2	4.2	0.1	-2.1	-0.1	-0.8
Pain all over the body in last month	2.9	3.1	5.4	1.0	-1.1	-2.3	-2.1
Diabetes (self-reported)	0.5	0.8	1.1	-0.9	-1.0	-0.8	-0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.5	-0.8	1.0	0.7	1.2
Medication: Ramipril	0.4	0.5	0.9	-0.9	-0.4	0.6	0.8
Medication: Simvastatin	1.2	1.8	3.5	-0.3	-1.9	-1.3	-1.4
Fluid intelligence score	0.2	0.4	0.6	-0.7	0.2	0.8	0.7
Illnesses of siblings	0.4	0.6	1.8	-0.3	-1.4	0.5	-0.5
Neuroticism score	0.5	0.9	1.7	-0.8	-1.3	1.1	0.4
Weight	0.3	1.2	2.0	-1.4	-0.9	0.9	1.2
Impedance of arm (right)	0.6	2.9	5.0	-2.2	0.1	1.3	2.2
Arm fat percentage (right)	0.4	1.5	4.0	-2.0	-0.5	0.1	1.3
Trunk fat-free mass	0.1	0.3	0.8	0.5	-0.5	0.9	0.0
Hip circumference	0.2	0.9	1.6	-1.3	-0.9	-0.9	-0.7
Time employed in main current job	0.1	0.1	0.2	0.5	-0.1	0.1	0.3
Alcohol intake versus 10 years previously	0.3	0.5	0.8	-0.8	0.1	-0.7	-0.9
Father’s age at death	1.1	1.4	3.6	1.9	0.8	-0.8	-0.9
Worrier / anxious feelings	2.7	5.0	6.8	-2.4	-2.0	2.6	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.5	-0.7	0.2	-0.1	0.2
Falls in the last year	1.4	1.9	4.2	-1.1	-0.1	1.5	2.0
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-0.7	-0.6	1.4	0.9
Number of live births	0.8	1.1	1.8	-1.1	-1.0	1.3	0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	8.5	0.2	-2.9	-0.5	-2.1
Pulse rate	0.0	0.0	0.1	0.1	0.0	-0.2	-0.3
Happiness	0.6	0.8	1.6	-0.8	-0.3	1.3	0.8
Noisy workplace	0.5	0.6	1.3	-0.4	0.6	0.7	1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.4	-0.0	0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-1.0	-0.6	0.7	0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.5	0.5	-1.4	-0.7
Asthma	0.7	1.4	3.2	1.3	1.8	-0.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	4.6	1.7	-1.5	-2.0	-2.1
Medication: Cholesterol lowering	0.3	0.5	0.9	1.0	-0.7	-0.1	-0.7
Depression (self-reported)	4.8	5.8	10.0	-2.2	-1.0	3.2	2.7
Medication: Lansoprazole	0.8	0.9	3.0	-0.1	-1.7	-0.5	-0.7
Prospective memory result	0.6	0.7	1.4	0.3	1.2	-0.6	-1.0
Lung cancer (father)	0.1	0.1	0.2	-0.4	-0.4	0.3	0.1
Illnesses of mother	0.1	0.1	0.3	-0.2	0.1	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	9.9	-0.3	-3.1	-0.2	-1.7
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-0.7	-0.2	0.5	1.0
Impedance of arm (left)	0.7	3.1	6.3	-2.5	0.2	1.2	2.1
Arm fat mass (right)	0.3	1.0	2.4	-1.6	-0.4	0.4	1.1
Trunk predicted mass	0.1	0.3	0.7	0.6	-0.5	0.8	0.0
Standing height	0.4	4.2	9.0	-1.3	-0.8	3.0	2.3
Length of working week for main job	0.5	0.6	1.8	-0.0	-1.3	0.5	-0.6
Exposure to tobacco smoke at home	1.0	1.1	3.0	-0.5	-1.7	-0.7	-0.9
Breastfed as a baby	1.5	1.9	4.1	2.0	0.4	-0.7	-1.6
Tense / ‘highly strung’	0.1	0.1	0.5	0.1	-0.3	-0.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.4	-2.1	-0.5	1.4	1.3
Hair/balding pattern: Pattern 4	10.9	26.4	35.3	-5.9	-4.0	5.2	5.2
Birth weight of first child	1.0	1.9	3.1	-0.7	-1.8	1.5	1.3
Peak expiratory flow (PEF)	0.4	0.8	2.9	-0.2	-1.7	0.4	-0.5
Pulse wave reflection index	0.3	0.3	0.7	-0.1	-0.8	-0.6	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.7	-1.2	0.6	-0.2
Loud music exposure frequency	0.4	0.4	1.0	0.5	1.0	0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.0	-1.4	-0.6	0.6	-0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	1.1	0.6	-1.4	-1.3
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.0	0.4	0.2	-0.7
Medication: Paracetamol	1.9	3.2	5.2	1.7	0.6	-2.3	-2.1
Headache pain in last month	0.2	0.4	1.1	-1.1	-0.6	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.8	-0.5	-0.5	-0.2
Glaucoma (self-reported)	0.2	0.2	0.6	-0.3	-0.1	0.8	-0.4
Gout (self-reported)	0.1	0.1	0.4	0.4	0.1	-0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	3.6	-1.9	-1.9	1.8	0.4
Medication: Amlodipine	0.1	0.1	0.3	-0.4	0.2	0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.5	-0.1	0.3	0.7
Birth weight	1.1	2.4	4.3	-1.7	-0.8	2.1	1.4
Chronic bronchitis/emphysema (mother)	1.9	2.2	6.1	-2.5	0.2	1.0	1.2
High blood pressure (siblings)	2.0	2.8	5.0	2.2	1.9	-1.5	-0.7
Forced vital capacity (FVC), Best measure	0.7	2.5	7.1	0.2	-2.7	0.1	-1.7
Body fat percentage	0.7	2.8	7.9	-2.8	-0.5	0.6	1.6
Leg fat percentage (right)	0.5	1.7	5.9	-2.4	-0.5	-0.1	0.9
Arm fat-free mass (right)	0.1	0.4	0.9	-0.1	-0.9	0.9	0.0
Exposure to tobacco smoke outside home	1.1	1.5	3.3	0.2	-0.6	-1.5	-1.8
Comparative body size at age 10	1.1	2.9	5.8	1.6	-1.1	-1.5	-2.4
Number of full brothers	0.6	0.7	1.7	-0.9	-1.3	0.2	-0.6
Worry too long after embarrassment	0.5	0.9	1.6	-0.2	0.8	1.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.5	-1.2	0.7	1.5	1.9
Wheeze or whistling in the chest in last year	1.6	2.9	8.4	-0.6	0.8	1.5	2.9
Number of children fathered	1.4	1.6	4.1	2.0	0.5	-1.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.5	-0.2	-0.6	-0.4
Age at first live birth	0.5	0.9	1.8	-0.6	0.5	1.3	1.2
Pulse wave peak to peak time	0.1	0.1	0.4	0.4	0.1	-0.1	-0.6
Health satisfaction	0.4	0.5	1.4	0.3	-1.2	-0.7	-0.1
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.3	-0.3	-0.9	-0.6
Qualifications: College or University degree	0.6	2.0	2.9	-1.5	-0.7	1.7	1.6
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.3	0.3	0.5	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.5	-0.5	0.1	-0.4
Emphysema/chronic bronchitis	0.4	0.4	1.1	-1.1	0.5	-0.4	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.1	0.7	0.5	0.2
Neck or shoulder pain in last month	0.9	1.3	3.2	0.5	-0.1	-1.8	-1.3
Medication: Blood pressure	0.6	1.1	1.6	-0.5	1.1	1.2	1.3
Angina (self-reported)	1.5	2.0	5.2	-1.2	-2.3	1.0	0.6
Migraine (self-reported)	1.0	1.3	2.3	-1.5	0.9	0.9	1.1
Medication: Ibuprofen	2.1	2.5	3.3	1.3	-1.8	-1.5	-1.7
Medication: Allopurinol	0.8	1.0	2.1	1.4	0.0	-1.1	-0.9
Medication: Omeprazole	0.1	0.1	0.2	-0.0	0.3	-0.5	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.1	-0.1	0.6	0.4
Mean time to correctly identify matches	0.2	0.4	0.7	0.4	0.5	0.6	0.8
Heart disease (mother)	0.1	0.2	0.4	0.2	-0.7	0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-1.5	1.0	0.5	1.0
Whole body fat mass	0.4	1.8	4.6	-2.2	-0.7	0.7	1.3
Leg fat mass (right)	0.6	2.5	6.4	-2.5	-1.2	0.8	1.2
Arm predicted mass (right)	0.1	0.4	1.0	-0.0	-0.5	1.0	0.3
Pulse rate, automated reading	0.2	0.7	2.0	0.6	-0.1	-1.4	-0.8
Alcohol intake frequency.	0.4	1.0	3.2	-1.8	-0.7	-0.6	-0.2
Comparative height size at age 10	0.5	2.5	4.2	-1.2	-0.7	2.0	2.1
Number of full sisters	0.4	0.5	1.3	-0.2	0.7	0.5	1.1
Suffer from ‘nerves’	1.6	2.6	6.7	-1.7	-2.6	0.8	0.4
Overall health rating	0.5	1.0	1.3	-1.0	-1.1	-1.1	-0.5
Chest pain or discomfort	0.6	0.9	1.8	-1.3	-1.1	0.6	0.3
Had major operations	2.6	3.1	6.7	-1.3	-0.6	2.6	1.9
Age at last live birth	0.8	1.2	2.0	-1.3	-0.7	1.4	0.8
Family relationship satisfaction	0.2	0.2	0.4	0.6	-0.4	0.6	-0.1
Leg pain on walking	1.9	2.3	6.4	-1.4	-2.5	0.9	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.1	0.2	0.8	0.7
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.4	-1.1	-1.2	1.8	1.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.1	0.1	0.6	0.2
Medication: Aspirin	1.9	2.5	4.8	-2.2	0.7	1.3	1.7
Supplements: Vitamin C	4.3	5.1	10.3	3.2	1.9	-1.8	-1.8
Knee pain experienced in last month	1.8	2.8	6.4	-2.5	-1.7	1.3	0.2
Hypertension (Self-reported)	0.3	0.9	2.0	-0.4	1.2	0.3	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.2	-0.1	0.5	0.6
Illnesses of father: Heart disease	0.2	0.2	0.6	-0.3	-0.2	-0.5	-0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-1.5	-0.1	1.0	1.0
Smoking status: Previous	1.4	2.2	5.5	1.6	2.4	-0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	-0.8	-0.6	1.1	0.5
Whole body fat-free mass	0.1	0.7	1.7	-0.1	-0.9	1.3	0.6
Leg fat-free mass (right)	0.2	1.0	1.9	-0.4	-0.9	1.4	1.1
Arm fat percentage (left)	0.4	1.6	4.9	-2.2	-0.6	0.0	1.0
Average weekly red wine intake	0.8	1.2	2.1	1.0	1.4	0.2	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.0	0.4	0.4	0.7
Mood swings	0.2	0.4	1.1	-0.5	-0.3	1.1	-0.0
Loneliness, isolation	0.9	1.2	2.8	-1.7	-1.2	0.8	0.2
Long-standing illness, disability or infirmity	0.8	1.2	3.4	-1.8	-1.1	0.3	0.2
Ever had bowel cancer screening	0.1	0.1	0.3	0.4	0.5	-0.1	-0.2
Diabetes diagnosed by doctor	0.5	0.9	1.6	-1.3	-1.1	-0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.2	0.4	0.3
Friendships satisfaction	0.1	0.2	0.5	0.2	-0.2	0.7	0.2
Qualifications: nursing, teaching	1.9	2.9	4.8	-2.2	-0.6	1.9	1.8
Commuting to job workplace: Walk	1.5	1.6	3.9	0.9	2.0	0.5	1.2
Eye problems/disorders: Cataract	0.3	0.3	0.5	0.7	0.3	-0.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.8	4.4	7.2	1.3	1.6	-2.7	-2.4
Medication for cholesterol	0.4	0.6	1.3	1.1	-0.1	-0.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.2	-0.5	-0.9	1.5	0.6
Back pain experienced in last month	0.4	0.6	1.7	-0.3	1.3	0.2	0.8
Mineral and other dietary supplements	0.4	0.5	1.0	-1.0	0.3	0.1	1.0
Breast cancer (self-reported)	0.6	0.7	1.6	0.4	1.3	-1.0	-0.2
Asthma (self-reported)	0.7	1.4	3.4	1.1	1.8	0.2	0.9
Osteoporosis (self-reported)	0.3	0.4	1.2	1.1	0.4	-0.4	-0.1
Osteoarthritis (self-reported)	0.5	0.7	1.3	-1.2	-1.1	0.0	0.4
Medication: Aspirin	2.2	2.9	4.5	-2.1	0.6	1.7	2.0
Medication: Gliclazide	0.2	0.2	0.5	0.4	0.7	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.6	-0.8	0.1	-0.1
Smoking status: Current	0.1	0.2	0.5	-0.3	0.2	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.0	1.2	0.3	-1.6	-2.0
Whole body water mass	0.1	0.6	1.4	-0.0	-0.7	1.2	0.6
Leg predicted mass (right)	0.2	1.0	1.8	-0.3	-0.9	1.4	1.1
Arm fat mass (left)	0.3	1.2	3.2	-1.8	-0.5	0.4	1.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-1.2	0.8	0.5	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.7	0.6	-0.3	0.2
Miserableness	0.5	0.9	2.7	-0.6	0.2	1.6	0.8
Guilty feelings	0.5	0.7	1.1	-0.7	0.7	1.0	1.0
Wears glasses or contact lenses	3.0	3.5	5.1	2.3	-0.1	-2.0	-2.2
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.3	-0.6	0.6	0.3
Hearing aid user	0.3	0.3	1.2	1.1	-0.1	-0.3	0.0
Mother’s age at death	0.6	0.7	1.2	0.9	-0.3	-1.1	-0.9
Financial situation satisfaction	0.2	0.3	0.6	-0.0	-0.8	-0.0	-0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.0	1.1	-0.1	0.2
Commuting to job workplace: Public transport	1.7	2.1	4.9	1.5	2.2	-1.0	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.5	0.6	0.1	-0.4
Medication: Blood pressure	0.5	1.0	2.5	-0.8	1.6	-0.8	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.8	-0.4	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	1.1	-0.4	-0.2	-1.0
High cholesterol (Self-reported)	1.3	2.3	4.5	0.8	-2.1	-1.3	-1.6
Medication: Bendroflumethiazide	1.4	2.2	3.2	1.8	1.7	-1.6	-0.4
Medication: Paracetamol	2.6	4.0	6.3	2.2	0.2	-2.5	-2.2
Medication: Lisinopril	0.7	0.9	2.0	-0.6	1.4	0.2	1.1
Medication: Atorvastatin	2.0	2.5	5.1	-1.6	-0.2	2.2	1.6
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	0.5	-0.4	-0.5
Alcohol drinker status: Never	0.9	1.0	3.0	0.7	-0.4	-1.7	-0.6
Ever smoked	0.9	1.6	5.3	0.2	2.3	0.7	0.8
Basal metabolic rate	0.1	0.8	1.6	-0.5	-0.8	1.2	0.9
Leg fat percentage (left)	0.4	1.4	4.9	-2.2	-0.2	-0.2	0.8
Arm fat-free mass (left)	0.1	0.3	0.7	0.2	-0.3	0.9	0.5
Number of operations (self-reported)	1.0	1.5	2.5	-1.2	0.5	1.6	1.3
Average weekly beer plus cider intake	0.6	0.9	2.1	0.7	-0.3	-0.9	-1.4
Irritability	0.4	0.6	1.6	0.4	-1.2	0.9	0.1
Risk taking	0.3	0.4	1.1	1.0	0.3	0.0	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	0.0	-1.3	0.4	-0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.5	-0.8	0.7	0.4
Age started oral contraceptive pill	0.2	0.3	1.0	-0.2	1.0	0.2	0.4
Diastolic blood pressure, automated reading	0.3	0.9	2.2	1.5	0.8	-0.6	0.8
Ever depressed for a whole week	2.1	2.6	2.9	-1.7	-1.5	1.7	1.5
Unable to work because of sickness or disability	0.8	1.0	2.3	-0.7	-0.2	-1.0	-1.5
Commuting to job workplace: Cycle	1.2	1.4	2.4	1.4	1.6	-0.8	-0.7
Myopia	0.2	0.3	0.9	-0.5	1.0	-0.0	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	0.6	-0.9	-0.5	-1.5
Cholesterol lowering medication	0.6	0.9	2.5	-1.6	-1.0	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	0.4	-0.4	-1.0	-1.1
Pain experienced in last month	0.9	1.6	3.2	0.4	1.8	1.3	1.1
Supplements: Calcium	1.1	1.2	2.8	-0.8	0.6	1.7	1.0
Basal cell carcinoma (self-reported)	0.2	0.3	1.0	0.3	1.0	-0.1	-0.0
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.2	-1.8	-1.5	1.3	0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.3	0.5	-0.1	-0.8
Heart disease (siblings)	2.2	2.7	5.9	-2.4	0.1	1.5	1.6
Alcohol drinker status: Previous	1.1	1.2	3.6	-1.0	1.9	-0.3	0.3
Pack years of smoking	1.1	1.6	3.2	-1.8	-1.8	0.5	0.1
Impedance of whole body	0.7	3.4	7.2	-2.7	0.4	1.4	2.0
Leg fat mass (left)	0.5	2.1	5.8	-2.4	-1.0	0.7	1.1
Arm predicted mass (left)	0.0	0.2	0.6	0.0	-0.3	0.8	0.5