Hub : Genes

FAM46C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.2517 0.0613 2.1e-05 0.138 NA 0.166 NA 0.172 8.9e-08 NA 3.5e-09 NA 1.9e-09
2 ROSMAP Brain Pre-frontal Cortex 0.0357 0.0188 2.8e-02 0.001 0.006 -0.002 0.007 0.000 2.2e-01 4.9e-02 9.9e-01 0.04000 2.9e-01
3 YFS Blood 0.0363 0.0135 1.1e-03 0.007 0.005 0.005 0.008 0.006 2.3e-03 7.3e-03 8.2e-03 0.00068 3.0e-03
4 TCGA Cervical Squamous Cell Carcinoma 0.1180 0.0580 4.4e-03 0.003 0.051 0.037 NA 0.022 2.1e-01 1.6e-03 6.2e-03 NA 2.9e-02
5 TCGA Brain Lower Grade Glioma 0.1246 0.0427 7.3e-09 0.080 0.085 0.094 NA 0.090 2.4e-09 7.6e-10 8.4e-11 NA 2.3e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 1.0 -1.0 -1.0 -0.9 1.0 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.4 0.9 0.4 -0.2 -0.3 -0.9 0.9
Depressed Affect (Nagel 2018) 0.7 1.4 2.7 -1.4 -0.9 -0.5 1.6 -1.0
Depression (Nagel 2018) 1.3 2.0 3.0 -1.7 -1.7 -1.4 1.4 0.4
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.8 -1.4 2.2 2.0 0.9 0.5
Neuroticism (Nagel 2018) 0.5 1.3 2.3 -1.3 -1.1 -1.0 1.5 -0.4
Schizophrenia (2018) 0.7 1.5 3.0 1.2 0.6 0.4 -1.7 1.6
Schizophrenia vs Biploar Disorder 1.3 1.7 4.1 0.4 2.0 1.6 -0.6 1.2
Worry (Nagel 2018) 0.3 0.5 1.3 -0.2 -0.9 -0.6 1.2 -0.4
Alzheimer’s Disease (in mother) 0.3 0.4 1.1 -1.1 0.2 0.3 0.6 0.4
Alzheimer’s Disease (in father) 0.5 0.5 1.8 -0.6 -0.5 -0.6 -1.3 0.1
Alzheimer’s Disease (including proxy) 0.2 0.3 1.4 -1.2 0.1 -0.3 -0.0 0.3
Crohns Disease (2017) 0.3 0.7 2.1 0.2 -0.3 0.9 -0.8 1.4
Irritable Bowel Disease (IBD) 0.5 1.1 3.6 -0.1 -0.4 0.3 -1.2 1.9
Ulcerative Colitis (UC) 0.7 1.3 3.0 0.4 -1.1 -0.6 -1.7 1.3
Major Depression (MDD) 0.5 0.7 1.5 -0.8 -0.9 0.5 -0.4 1.2
Reaction Time 0.3 0.5 1.0 -0.9 1.0 -0.1 0.8 0.3
Verbal and Numeric Reasoning (VNR) 1.3 3.1 6.9 -1.8 2.6 1.9 -0.4 1.3
Breast Cancer 3.8 9.1 14.4 -2.6 3.2 0.7 3.8 -3.7
Ovarian Cancer 0.2 0.2 0.6 -0.1 0.5 -0.8 0.4 0.1
Prostate Cancer 0.2 0.3 0.6 -0.5 -0.8 -0.1 0.7 -0.5
Age at First Birth 1.4 2.0 4.8 -0.7 2.2 1.1 -0.2 1.8
Bipolar Disorder (2011) 2.1 2.1 3.3 0.0 -1.6 1.1 1.8 -1.8
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 0.4 -0.9 1.0 -0.0 -0.8
Coronary Artery Disease (CAD) 1.3 1.5 6.2 -1.0 -0.5 2.5 -0.0 -0.0
Crohns Disease (2012) 0.2 0.4 0.8 -0.0 -0.4 0.6 -0.7 0.9
Mean Putamen Volume 0.2 0.2 0.3 -0.5 0.5 0.3 -0.6 0.1
Fasting Glucose 1.2 1.4 3.0 1.3 -1.6 -0.0 0.0 -1.7
HbA1C 0.9 1.1 2.9 0.2 -1.1 1.7 0.6 -0.9
HDL Cholesterol 0.3 0.6 1.2 -0.4 1.1 -0.2 0.9 -0.8
LDL Cholesterol 1.3 2.0 5.0 -0.6 0.8 1.2 1.6 -2.2
Lupus 0.3 0.4 1.0 0.6 -1.0 0.6 -0.1 -0.5
Neuroticism (2016) 2.5 3.6 10.6 1.9 -3.2 0.7 -1.6 -0.7
Primary Biliary Cirrhosis 2.3 3.3 8.8 2.4 -3.0 -0.5 0.3 -1.4
Rheumatoid Arthritis 1.3 1.8 5.1 -1.3 1.4 0.7 0.1 2.3
Schizophrenia (2014) 0.4 1.0 2.4 0.9 0.2 0.6 -1.1 1.6
Triglycerides 0.7 1.1 2.6 -0.7 0.4 1.6 0.9 -1.3
Type 2 Diabetes (T2D) (2012) 1.3 1.4 3.5 -1.3 0.6 1.3 1.9 0.4
Ulcerative Colitis 0.5 0.8 2.0 0.4 -0.4 -0.2 -1.4 1.2
Blood Eosinophil Count 0.7 5.1 8.1 2.3 -2.8 -0.9 -2.8 1.9
Blood Platelet Count 6.0 69.2 114.5 7.1 -9.5 -8.5 -10.7 4.3
Blood Red Count 2.1 20.3 60.4 0.4 -5.6 -7.8 -3.2 0.1
Blood White Count 1.3 9.7 18.3 4.1 -4.3 -0.9 -1.0 -3.4
Heel T-Score 0.4 3.2 7.8 2.3 -1.1 0.8 -1.1 -2.8
BMI 1.3 7.5 21.4 3.0 -4.6 -0.4 -1.9 -1.8
Height 0.7 14.1 31.0 -5.6 3.9 2.6 2.9 3.0
Waist Hip Ratio (WHR) 0.4 1.7 7.6 -0.5 0.5 0.2 -0.2 2.8
Systolic Blood Pressure 0.4 2.0 3.2 -1.5 -1.4 -1.8 -0.6 1.5
Smoking Status 0.7 1.6 6.5 0.2 -2.6 -0.9 0.5 -0.4
Allergy or Eczema 0.5 1.3 4.2 -0.7 1.4 0.1 -0.1 2.0
Cardiovascular Disease 0.3 1.0 4.2 -0.3 -2.1 -0.6 -0.6 -0.2
Hypothyroidism (self reported) 1.8 4.0 6.9 -1.9 2.6 1.1 2.6 -1.3
Respiratory disease 1.1 2.4 7.3 -1.4 -1.0 -1.3 -0.1 2.7
Type 2 Diabetes (T2D) (2018) 1.0 1.9 5.4 0.3 0.5 2.3 0.9 -1.8
Lung FEV1/FVC ratio 0.1 0.3 0.8 -0.5 0.5 -0.3 -0.0 -0.9
Lung FVC 0.7 3.7 14.6 -1.2 3.8 0.3 1.0 -1.2
Neuroticism 0.6 1.5 5.2 -0.1 -2.3 -1.3 0.8 -0.3
Chronotype (morning person) 0.4 0.8 1.6 0.2 0.9 1.3 0.4 -1.3
Hair Pigment 0.1 2.0 4.8 1.6 -2.2 -0.8 -0.5 -1.4
Tanning 0.2 1.8 6.1 -0.1 2.5 0.4 -0.3 1.7
Hand grip strength (left) 0.5 1.3 3.7 -0.5 1.9 0.5 0.5 -1.5
Number of treatments/medications taken 0.5 1.0 4.3 -0.4 -2.1 0.0 0.4 0.6
Average weekly spirits intake 0.4 0.5 0.8 0.6 0.8 0.6 -0.9 -0.4
Sensitivity / hurt feelings 0.5 0.9 2.7 0.3 -1.1 0.1 0.6 -1.6
Frequency of depressed mood in last 2 weeks 1.0 1.5 4.0 -0.5 -2.0 -1.5 0.6 0.6
Hearing difficulty/problems: Yes 0.5 0.8 1.3 -0.2 -1.1 -1.1 -1.0 0.7
Relative age of first facial hair 0.5 0.9 3.8 -0.2 0.1 -0.1 -0.9 2.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.0 -1.0 -0.7 0.4 1.0 -0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 1.4 0.6 0.5 -0.1 -0.8
Ever had hysterectomy (womb removed) 0.9 1.0 2.0 -1.3 1.4 0.3 0.7 0.9
Systolic blood pressure, automated reading 0.5 1.4 4.4 -2.1 -0.7 -0.7 0.3 1.3
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 3.2 0.4 -1.0 1.0 1.8 -1.7
Angina 0.5 0.6 1.4 -0.3 -0.7 0.5 -1.0 -1.2
Medication for hormone replacement therapy 1.5 1.7 7.8 0.5 0.5 0.2 -0.5 -2.8
Vitamin and mineral supplements 1.9 2.6 3.3 -1.8 1.7 1.8 0.5 1.8
Supplements: Zinc 0.5 0.6 0.8 0.8 0.9 -0.7 -0.2 -0.9
Medication: Co-codamol 3.4 3.9 9.3 1.4 -1.5 -1.2 -3.0 2.1
Medication: Metformin 0.4 0.5 1.0 -1.0 0.0 1.0 0.7 0.5
Diabetes (father) 0.6 0.8 3.3 -0.6 -0.1 0.3 1.8 -0.3
Diabetes (mother) 1.9 2.5 5.7 0.4 -2.4 -0.2 1.1 -2.3
Severe depression (siblings) 0.7 0.8 1.6 -0.8 -1.2 -0.1 1.3 -0.1
Pack years adult smoking proportion 1.0 1.5 3.7 -1.9 1.5 -0.0 1.3 0.1
Impedance of leg (right) 0.5 2.6 7.1 -1.8 2.7 0.3 1.1 1.1
Leg fat-free mass (left) 0.2 1.0 3.4 -0.3 -1.9 1.2 0.0 -0.4
Trunk fat percentage 0.4 1.5 7.1 -0.2 -2.7 0.0 0.0 0.6
Hand grip strength (right) 0.2 0.5 1.2 0.7 0.8 0.3 0.2 -1.1
Townsend deprivation index at recruitment 1.2 1.7 5.6 0.9 -2.4 -1.4 0.2 -0.1
Current tobacco smoking 0.7 1.1 2.0 -0.0 -1.2 -0.9 1.4 -1.2
Average weekly fortified wine intake 0.6 0.7 2.9 -0.7 0.2 0.2 1.7 0.1
Maternal smoking around birth 1.0 1.4 3.2 -1.8 0.9 1.1 -1.0 0.9
Fed-up feelings 0.6 1.1 2.7 -0.0 -1.6 -0.6 0.1 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 5.7 -1.1 -2.4 -1.2 0.6 -0.4
Relative age voice broke 0.9 1.4 3.7 -1.2 1.2 0.4 0.5 1.9
Taking other prescription medications 0.5 0.8 1.4 -1.1 -0.8 -0.8 1.2 -0.5
Age when periods started (menarche) 1.0 2.4 4.1 -1.4 1.7 1.0 2.0 -1.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 0.1 0.5 0.9 0.0 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 4.3 2.0 0.1 1.1 -2.1 -0.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.7 0.5 -0.8 -0.1 -0.3
Qualifications: CSEs or equivalent 0.7 1.0 2.1 -1.0 0.2 1.5 0.2 -1.3
Serious illness, injury or assault to yourself 0.7 0.9 3.1 -0.1 -0.1 -1.8 -0.7 0.9
High blood pressure 0.5 1.4 2.7 -1.3 -1.5 -0.4 0.1 1.6
Hayfever, allergic rhinitis or eczema 1.1 2.3 4.0 -1.6 2.0 1.0 0.6 1.9
Multivitamins +/- minerals 2.0 2.6 3.5 1.6 -1.5 -1.8 -1.2 -1.9
Stomach or abdominal pain in last month 0.7 0.9 2.0 -0.5 -1.4 -1.1 1.0 -0.4
Supplements: Glucosamine 1.7 2.2 4.7 2.2 -0.5 -1.5 -1.7 -1.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.4 -0.3 -0.6 1.2 0.8 -0.4
Medication: Atenolol 0.3 0.4 1.3 -0.0 -0.7 1.1 -0.1 -0.4
Medication: Levothyroxine sodium 2.4 4.1 8.1 -1.8 2.6 0.8 2.8 -1.4
Sitting height 0.4 3.1 6.2 -2.5 1.7 1.1 2.3 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 2.0 -1.4 -0.8 -0.5 0.8 1.3
High blood pressure (mother) 2.0 2.7 5.2 -0.4 -2.0 -2.3 -1.2 1.8
Body mass index (BMI) 1.0 4.5 17.1 1.7 -4.1 -0.7 -1.2 -0.7
Impedance of leg (left) 0.4 1.7 5.0 -1.4 2.2 -0.0 1.0 0.7
Leg predicted mass (left) 0.2 1.0 3.6 -0.3 -1.9 1.1 -0.0 -0.4
Trunk fat mass 0.4 1.6 7.8 -0.0 -2.8 0.1 -0.1 0.2
Waist circumference 0.5 2.0 7.1 1.0 -2.7 -0.5 -0.7 0.9
Number of incorrect matches in round 0.4 0.6 2.7 0.6 0.2 1.6 0.3 0.2
Past tobacco smoking 1.6 2.9 7.2 -1.4 2.7 1.1 1.8 -0.9
Alcohol usually taken with meals 1.6 2.5 6.0 -0.2 2.5 1.9 1.6 0.6
Nervous feelings 0.5 1.0 4.4 0.3 -2.1 -0.2 -0.1 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 6.1 0.2 -2.5 -1.1 0.0 -0.1
Hearing difficulty/problems with background noise 0.5 0.8 2.2 -0.7 -1.5 -0.9 -0.8 0.1
Hair/balding pattern: Pattern 2 1.3 1.6 4.1 -1.3 1.4 -2.0 0.4 0.5
Had menopause 1.2 1.5 4.3 -0.8 1.5 -0.2 -0.7 2.1
Had other major operations 0.8 1.0 3.3 0.2 -1.8 0.4 0.3 -1.2
Forced vital capacity (FVC) 0.6 2.2 7.0 -1.2 2.6 0.3 1.4 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.0 1.2 0.7 1.1 -1.7 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.9 -0.5 -0.1 -0.8 0.4 1.0
Qualifications: None of the above 1.3 2.7 5.7 2.0 -2.4 -0.6 -1.9 0.1
Financial difficulties in last 2 years 0.5 0.7 1.4 -0.9 -0.4 0.7 0.9 -1.2
Mouth/teeth dental problems 3.0 4.7 9.6 -1.7 3.1 2.6 1.5 -1.4
Heart attack 1.5 2.0 4.7 -1.7 1.2 2.2 0.8 0.2
Allergy 0.6 1.4 4.6 1.1 -1.0 -0.3 0.3 -2.1
Pain all over the body in last month 1.5 1.6 4.0 0.4 0.8 -0.7 -2.0 1.6
Diabetes (self-reported) 1.0 1.6 3.9 -0.4 0.8 2.0 0.8 -1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.2 -0.7 0.7 1.1 0.2 1.8
Medication: Ramipril 0.2 0.2 0.8 -0.9 -0.5 0.0 -0.3 -0.3
Medication: Simvastatin 0.6 0.9 1.7 1.0 -0.8 0.1 -1.1 -1.3
Fluid intelligence score 0.8 1.6 2.5 -1.4 1.6 1.4 0.3 1.2
Illnesses of siblings 1.6 2.3 6.8 0.5 1.9 0.7 0.4 -2.6
Neuroticism score 0.5 1.1 2.8 0.2 -1.7 -1.0 0.8 -0.9
Weight 0.4 1.8 8.6 0.3 -2.9 0.2 -0.3 -0.1
Impedance of arm (right) 1.5 7.2 15.5 -3.4 3.9 0.3 1.0 2.8
Arm fat percentage (right) 0.6 2.4 9.4 0.4 -3.1 -1.1 -1.0 0.7
Trunk fat-free mass 0.1 0.6 2.0 0.3 -1.4 0.7 0.1 -0.7
Hip circumference 0.6 2.7 8.9 1.4 -3.0 -1.2 -0.3 -1.0
Time employed in main current job 1.4 1.6 3.8 1.3 -1.4 -1.9 -1.0 0.0
Alcohol intake versus 10 years previously 0.7 1.0 2.0 1.1 -1.4 0.2 -1.4 0.1
Father’s age at death 0.5 0.7 1.7 1.3 0.1 0.7 -0.8 -0.7
Worrier / anxious feelings 0.8 1.5 5.0 -0.4 -1.3 0.5 2.2 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 5.8 -1.8 -2.4 -2.0 0.3 2.0
Falls in the last year 1.3 1.8 4.6 -1.5 -1.0 0.8 0.5 2.1
Hair/balding pattern: Pattern 3 0.5 0.7 1.8 -1.3 1.0 0.2 0.5 -0.6
Number of live births 0.9 1.3 5.6 -0.5 -2.4 -0.1 -0.7 0.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 5.6 -1.1 2.4 0.4 1.2 -1.4
Pulse rate 0.3 0.5 0.9 -0.9 0.5 -0.9 0.6 -0.0
Happiness 0.9 1.1 3.1 -1.8 -0.9 -0.8 1.1 -0.0
Noisy workplace 0.7 0.8 2.9 0.3 -1.7 0.4 0.6 -0.8
Qualifications: A levels/AS levels or equivalent 0.9 2.1 8.2 0.3 0.9 0.7 2.9 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 2.3 0.1 -1.5 -0.2 0.4 -0.2
Mouth/teeth dental problems: Dentures 0.9 1.5 4.6 -0.8 -0.2 -0.2 -1.4 2.2
Asthma 1.0 1.9 6.3 -0.9 -0.6 -1.0 -1.1 2.5
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 7.2 1.4 -2.7 -2.0 -0.2 -0.4
Medication: Cholesterol lowering 0.5 0.7 2.5 -0.5 0.1 0.9 -0.3 -1.6
Depression (self-reported) 0.5 0.6 1.0 -0.6 -1.0 0.1 1.0 -0.9
Medication: Lansoprazole 0.3 0.3 0.7 -0.6 -0.7 0.1 0.8 -0.4
Prospective memory result 1.5 1.8 3.9 1.5 -2.0 -0.6 0.4 -1.6
Lung cancer (father) 0.5 0.6 1.2 -1.1 0.5 -0.8 0.0 1.0
Illnesses of mother 1.6 2.0 5.4 0.6 2.3 1.6 -0.1 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 5.4 -0.8 2.3 1.2 1.1 -2.0
Pulse wave Arterial Stiffness index 0.8 1.0 4.7 -0.1 -2.2 -0.0 -0.4 0.1
Impedance of arm (left) 1.3 6.0 12.6 -2.9 3.5 1.2 0.7 2.5
Arm fat mass (right) 0.5 2.1 9.3 0.5 -3.1 -0.6 -0.9 0.3
Trunk predicted mass 0.1 0.6 1.8 0.3 -1.3 0.7 0.1 -0.6
Standing height 0.5 4.8 9.2 -3.0 2.4 2.1 1.7 1.4
Length of working week for main job 0.7 0.8 1.7 -0.1 0.9 -0.8 0.8 -1.3
Exposure to tobacco smoke at home 1.6 1.8 5.6 -0.0 -1.3 -2.4 -1.2 -0.5
Breastfed as a baby 0.6 0.7 1.9 0.8 0.7 -1.4 -0.3 -0.7
Tense / ‘highly strung’ 1.2 2.0 5.5 0.7 -1.4 -2.3 -0.8 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 4.7 -2.2 -0.1 0.4 0.0 1.3
Hair/balding pattern: Pattern 4 2.0 4.8 16.6 -2.0 -0.5 4.1 1.8 -0.3
Birth weight of first child 1.3 2.3 6.2 0.5 -0.8 1.5 2.5 -1.5
Peak expiratory flow (PEF) 0.2 0.4 1.2 -0.6 0.2 0.5 0.2 -1.1
Pulse wave reflection index 0.5 0.6 2.2 0.5 -1.5 0.1 -0.6 0.1
Ever highly irritable/argumentative for 2 days 1.5 1.8 3.9 0.8 -2.0 1.2 0.8 -1.5
Loud music exposure frequency 0.7 0.7 1.0 -1.0 1.0 0.9 -0.3 0.9
Qualifications: O levels/GCSEs or equivalent 2.2 3.5 9.7 -1.8 1.8 1.3 3.1 -0.3
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 9.2 3.0 -2.3 -0.1 -1.1 -1.0
Blood clot in the leg (DVT) 0.4 0.5 1.1 -0.1 -0.4 -1.1 -0.1 -1.0
Medication: Paracetamol 1.5 2.4 4.6 0.7 -2.0 -1.6 -2.1 0.5
Headache pain in last month 1.0 1.6 2.6 -1.4 -1.4 -1.1 0.7 1.6
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.7 0.6 1.0 -0.6 -0.7 1.3
Glaucoma (self-reported) 0.8 0.9 1.8 0.5 0.4 0.9 1.3 -1.3
Gout (self-reported) 1.2 1.7 3.8 1.9 -1.6 0.3 -1.0 -1.0
Hypothyroidism/myxoedema (self-reported) 2.4 4.8 9.4 -2.2 2.7 0.6 3.1 -1.5
Medication: Amlodipine 0.3 0.5 0.9 -0.9 -0.1 -0.7 0.4 1.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 -0.1 -1.0 0.7 -0.9 0.5
Birth weight 2.2 4.8 15.0 -0.5 1.2 3.9 2.5 -0.9
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.4 -0.7 -1.6 -0.0 0.6 0.7
High blood pressure (siblings) 1.7 2.5 5.2 -0.0 -1.7 -1.9 -0.7 2.3
Forced vital capacity (FVC), Best measure 0.8 3.1 7.7 -1.4 2.8 0.9 1.5 -1.7
Body fat percentage 0.5 1.8 8.7 0.3 -3.0 -0.4 -0.3 0.3
Leg fat percentage (right) 1.0 3.5 14.0 1.2 -3.7 -1.2 -0.7 -0.1
Arm fat-free mass (right) 0.4 2.1 6.4 1.0 -2.5 0.8 0.2 -1.6
Exposure to tobacco smoke outside home 0.3 0.4 0.6 -0.7 0.4 -0.2 -0.7 0.7
Comparative body size at age 10 0.4 1.2 3.4 0.8 -0.6 -1.3 -0.3 -1.9
Number of full brothers 1.0 1.3 3.5 -0.1 -0.8 -0.6 1.4 -1.9
Worry too long after embarrassment 0.5 0.8 1.7 -1.3 -0.8 0.1 -0.1 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 1.9 -1.4 -0.1 -0.7 1.2 1.4
Wheeze or whistling in the chest in last year 1.0 1.7 6.8 -0.8 -2.6 -0.5 0.2 1.0
Number of children fathered 0.9 1.0 2.2 0.9 -1.5 -0.5 -0.8 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.5 0.2 1.2 0.6 -0.2 -0.4
Age at first live birth 0.8 1.4 5.3 1.0 0.6 0.4 0.6 -2.3
Pulse wave peak to peak time 1.1 1.3 5.7 -0.2 2.4 0.4 0.8 -0.0
Health satisfaction 0.6 0.8 3.1 -0.1 -0.6 -1.8 0.1 0.5
Shortness of breath walking on level ground 0.3 0.4 0.8 -0.1 -0.7 -0.9 0.8 0.4
Qualifications: College or University degree 0.8 2.6 6.5 -1.1 2.5 1.3 1.7 -0.8
Eye problems/disorders: None of the above 0.4 0.5 1.0 -0.2 0.4 -1.0 -1.0 0.3
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.6 0.2 -1.2 -1.9 -0.4 0.1
Emphysema/chronic bronchitis 1.3 1.5 3.7 1.1 -1.9 -1.3 -0.8 0.4
Medication for pain relief, constipation, heartburn 0.7 1.2 4.2 0.6 2.0 -0.8 0.5 -0.6
Neck or shoulder pain in last month 1.6 2.3 6.2 1.1 -2.5 -1.5 -1.1 0.7
Medication: Blood pressure 0.6 1.1 2.1 -0.5 -1.4 1.1 1.2 -0.8
Angina (self-reported) 0.8 1.0 2.1 0.1 -0.8 0.8 -1.5 -1.3
Migraine (self-reported) 0.6 0.8 3.6 0.6 -1.9 0.2 0.1 0.1
Medication: Ibuprofen 1.8 2.2 6.9 1.1 -2.6 -1.7 -0.1 -0.1
Medication: Allopurinol 1.5 2.0 4.3 2.0 -0.9 0.5 -2.1 -0.6
Medication: Omeprazole 1.3 1.5 2.3 -1.1 1.5 1.5 -0.3 1.3
Medication: Seretide 50 evohaler 3.1 3.5 4.8 -2.2 1.3 -2.1 -1.7 2.0
Mean time to correctly identify matches 0.9 1.8 3.4 -1.4 1.8 -0.3 1.4 1.3
Heart disease (mother) 0.3 0.4 1.2 -0.3 -0.4 0.6 1.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.3 -0.1 -1.5 -0.6 0.0 0.5
Whole body fat mass 0.4 1.8 8.7 0.3 -3.0 -0.2 -0.3 -0.2
Leg fat mass (right) 0.6 2.5 11.2 0.6 -3.3 -0.2 -0.5 -0.7
Arm predicted mass (right) 0.4 1.8 6.1 0.8 -2.5 1.1 -0.3 -1.1
Pulse rate, automated reading 0.3 0.9 1.7 -0.6 -0.5 -1.3 1.0 1.0
Alcohol intake frequency. 0.6 1.4 4.0 -0.3 -2.0 1.7 -0.1 0.3
Comparative height size at age 10 0.1 0.7 1.5 -1.2 0.1 0.5 1.1 0.7
Number of full sisters 1.3 1.6 3.2 0.7 -1.8 -1.2 -1.6 0.5
Suffer from ‘nerves’ 0.4 0.7 2.7 -0.4 -0.5 -1.6 0.3 -0.2
Overall health rating 2.1 4.6 16.8 -0.9 -4.1 -2.1 0.2 1.0
Chest pain or discomfort 2.0 2.9 7.0 -2.2 -2.6 -1.5 0.6 0.6
Had major operations 0.6 0.7 1.4 -0.6 -1.2 0.5 -0.2 -1.2
Age at last live birth 0.8 1.2 4.9 0.7 -0.1 0.8 0.3 -2.2
Family relationship satisfaction 0.4 0.5 1.4 -0.2 1.2 0.4 0.5 -0.8
Leg pain on walking 1.7 2.1 8.2 -2.9 0.5 -0.4 1.4 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.2 0.1 0.1 0.1 -0.5
Commuting to job workplace: Car/motor vehicle 1.6 1.8 5.4 0.7 -1.5 -0.9 0.5 -2.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.3 -0.6 0.9 1.1 0.4 -0.3
Medication: Aspirin 1.0 1.3 3.7 -1.4 -0.7 1.9 0.1 0.5
Supplements: Vitamin C 0.5 0.6 1.6 1.3 -0.2 -1.0 -0.2 0.6
Knee pain experienced in last month 3.1 4.8 10.7 -1.9 -2.9 -3.3 1.1 -0.4
Hypertension (Self-reported) 0.4 1.0 2.2 -1.5 -1.4 0.1 0.3 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.0 -1.4 0.6 0.2 0.8 1.4
Illnesses of father: Heart disease 1.0 1.4 3.4 0.6 -1.3 0.4 1.8 -1.1
Illnesses of siblings: Diabetes 0.5 0.7 1.5 -0.7 -0.1 1.2 0.9 -0.6
Smoking status: Previous 1.8 2.6 4.6 0.9 -1.9 -1.0 -2.1 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.9 -1.3 1.4 1.1 0.6 -0.4
Whole body fat-free mass 0.2 0.9 2.9 0.0 -1.7 1.0 0.3 -0.8
Leg fat-free mass (right) 0.2 1.2 4.2 0.0 -2.1 1.1 0.0 -0.7
Arm fat percentage (left) 0.6 2.4 9.9 0.6 -3.1 -0.6 -1.0 0.4
Average weekly red wine intake 0.3 0.4 0.9 0.6 0.2 -0.8 -0.4 0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.6 -1.0 1.3 -0.3 -0.8 0.7
Mood swings 0.7 1.3 2.5 0.2 -1.2 -0.0 1.6 -1.6
Loneliness, isolation 0.6 0.9 2.2 -1.5 -0.1 -1.4 -0.0 0.0
Long-standing illness, disability or infirmity 1.8 2.8 9.2 -3.0 -0.5 -1.4 1.4 0.8
Ever had bowel cancer screening 0.6 0.7 1.5 -0.6 0.1 -1.2 0.1 1.2
Diabetes diagnosed by doctor 1.0 1.7 6.1 -0.2 0.6 2.5 0.9 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.3 -1.5 1.2 -1.5 -0.4 0.9
Friendships satisfaction 0.3 0.4 1.3 0.3 0.1 -0.1 0.6 -1.2
Qualifications: nursing, teaching 1.4 2.2 3.9 -2.0 1.6 1.2 1.6 0.7
Commuting to job workplace: Walk 3.3 3.6 6.7 -2.6 2.1 0.7 1.2 2.2
Eye problems/disorders: Cataract 0.5 0.6 1.6 -0.1 -1.3 0.4 -0.7 0.8
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.1 1.1 -1.8 -1.3 0.8 0.8
Medication for cholesterol 0.2 0.3 0.8 -0.3 0.0 -0.6 -0.1 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.5 0.0 0.8 -0.4 -0.8
Back pain experienced in last month 2.0 2.9 6.8 -1.2 -1.7 -1.6 -0.7 2.6
Mineral and other dietary supplements 0.5 0.6 1.2 -0.8 0.8 1.1 -0.5 0.7
Breast cancer (self-reported) 0.7 0.9 2.1 0.5 -1.4 0.4 -0.8 1.1
Asthma (self-reported) 0.8 1.5 4.9 -1.1 -0.6 -0.8 -0.8 2.2
Osteoporosis (self-reported) 0.9 1.2 2.9 1.4 -1.7 0.8 -0.4 -0.4
Osteoarthritis (self-reported) 2.3 2.9 7.3 -0.5 -2.2 -2.7 -1.2 1.0
Medication: Aspirin 0.9 1.2 3.6 -1.5 -0.4 1.9 0.2 0.3
Medication: Gliclazide 0.8 0.9 2.6 1.6 -1.2 0.5 -0.3 -0.5
Illnesses of father: None of the above (group 1) 0.7 0.8 2.4 1.5 -0.1 0.3 -1.1 -0.7
Smoking status: Current 1.0 1.7 2.3 0.1 -1.5 -1.4 1.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.4 1.2 1.1 0.2 -0.2 -1.0
Whole body water mass 0.2 0.9 3.4 0.2 -1.8 0.8 -0.0 -0.7
Leg predicted mass (right) 0.2 1.1 3.8 -0.0 -2.0 1.1 0.0 -0.6
Arm fat mass (left) 0.6 2.6 11.4 0.8 -3.4 -0.3 -0.9 0.2
Number of self-reported non-cancer illnesses 0.9 1.6 6.6 -0.8 -2.6 0.4 0.9 -0.0
Average weekly champagne plus white wine intake 0.5 0.7 2.6 -0.1 1.6 0.8 -0.2 0.2
Miserableness 0.4 0.7 1.5 -1.2 -0.1 -0.4 1.2 -0.5
Guilty feelings 0.5 0.7 2.1 0.7 -1.4 -0.7 -0.2 0.8
Wears glasses or contact lenses 0.8 1.0 1.3 1.1 1.1 -0.9 -1.0 0.7
Ever taken oral contraceptive pill 0.5 0.5 1.3 1.1 -0.2 -0.1 -0.2 -1.1
Hearing aid user 0.5 0.6 1.7 0.2 -1.3 -1.0 0.2 -0.1
Mother’s age at death 0.7 0.9 2.3 1.5 0.6 -0.7 -1.0 0.4
Financial situation satisfaction 0.5 0.6 2.1 -0.8 0.0 -1.4 -0.1 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.9 0.0 0.4 0.3 0.1 1.0
Commuting to job workplace: Public transport 0.8 1.0 3.2 0.3 -0.0 -1.2 0.4 1.8
Eye problems/disorders: Glaucoma 0.5 0.6 2.2 0.7 0.1 1.5 0.6 -0.1
Medication: Blood pressure 0.4 0.7 2.1 0.1 -0.4 -0.2 -1.1 1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.5 -0.9 -0.5 0.9 0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.0 -0.2 0.3 -0.1 1.0 -0.3
High cholesterol (Self-reported) 0.3 0.5 1.3 0.4 -0.2 0.6 -0.8 -1.1
Medication: Bendroflumethiazide 1.3 1.9 5.1 -0.5 -1.2 -1.2 -1.2 2.3
Medication: Paracetamol 1.5 2.3 4.3 1.4 -2.1 -1.2 -1.9 0.6
Medication: Lisinopril 1.3 1.7 5.8 0.6 -2.4 1.4 0.2 -0.3
Medication: Atorvastatin 2.8 3.5 7.5 -1.9 1.4 1.8 2.7 -1.2
Illnesses of father: High blood pressure 1.6 2.0 5.1 -1.9 0.8 0.3 -0.9 2.3
Alcohol drinker status: Never 0.9 1.0 2.5 0.4 -0.1 1.6 -0.3 1.6
Ever smoked 0.5 0.9 3.3 0.8 -1.8 -0.4 -0.0 0.5
Basal metabolic rate 0.2 1.2 5.0 0.2 -2.2 0.7 -0.0 -0.6
Leg fat percentage (left) 1.1 4.0 15.7 1.4 -4.0 -1.4 -0.7 -0.5
Arm fat-free mass (left) 0.2 1.1 5.3 0.5 -2.3 0.2 -0.0 -0.3
Number of operations (self-reported) 1.7 2.5 11.0 0.2 -3.3 -0.1 -0.2 -1.2
Average weekly beer plus cider intake 0.5 0.7 1.7 0.6 -1.3 -0.0 -0.9 -1.0
Irritability 0.5 0.8 3.1 0.2 0.1 -1.8 -0.1 -0.9
Risk taking 0.3 0.4 1.7 0.3 0.3 -0.1 -1.3 -0.1
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 0.2 0.7 0.7 -0.5 0.3
Fractured/broken bones in last 5 years 0.9 1.1 3.8 0.5 -1.0 -0.7 -0.4 -1.9
Age started oral contraceptive pill 0.8 1.0 2.9 -0.0 1.7 1.0 -0.9 0.6
Diastolic blood pressure, automated reading 0.9 2.9 9.5 -1.9 -0.6 -0.9 -0.5 3.1
Ever depressed for a whole week 0.5 0.7 1.8 -1.4 -0.5 -0.6 0.9 0.3
Unable to work because of sickness or disability 1.3 1.7 2.8 -1.7 -1.0 -1.6 -1.1 0.8
Commuting to job workplace: Cycle 1.6 1.9 5.2 0.5 2.3 -0.1 -1.3 1.5
Myopia 0.2 0.3 0.6 -0.1 0.7 0.2 -0.7 0.5
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.2 1.3 1.5 -0.3 -0.1 -0.8
Cholesterol lowering medication 0.3 0.5 1.6 -0.0 -0.5 0.8 1.3 0.0
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 3.4 -1.8 1.8 1.5 0.3 1.2
Pain experienced in last month 2.0 3.4 9.0 0.6 3.0 1.8 0.7 -2.0
Supplements: Calcium 1.0 1.1 2.2 0.2 -1.5 1.1 1.2 -0.9
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 -1.4 0.5 -0.0 -0.2 0.9
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.0 -1.6 1.2 2.0 0.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 0.1 -0.4 -1.0 0.1 -1.0
Heart disease (siblings) 0.7 0.9 1.8 -1.3 -1.2 -0.3 0.8 0.5
Alcohol drinker status: Previous 1.6 1.8 6.8 -1.2 0.4 2.6 -0.1 0.8
Pack years of smoking 1.3 1.9 4.7 -2.2 1.8 -0.0 1.1 0.6
Impedance of whole body 1.1 5.4 12.0 -2.9 3.5 0.9 1.2 2.0
Leg fat mass (left) 0.7 2.7 11.8 0.8 -3.4 -0.4 -0.5 -0.9
Arm predicted mass (left) 0.3 1.3 6.1 0.6 -2.5 0.2 -0.1 -0.4