TWAS hub - FAM46C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.2517	0.0613	2.1e-05	0.138	NA	0.166	NA	0.172	8.9e-08	NA	3.5e-09	NA	1.9e-09
2	ROSMAP	Brain Pre-frontal Cortex	0.0357	0.0188	2.8e-02	0.001	0.006	-0.002	0.007	0.000	2.2e-01	4.9e-02	9.9e-01	0.04000	2.9e-01
3	YFS	Blood	0.0363	0.0135	1.1e-03	0.007	0.005	0.005	0.008	0.006	2.3e-03	7.3e-03	8.2e-03	0.00068	3.0e-03
4	TCGA	Cervical Squamous Cell Carcinoma	0.1180	0.0580	4.4e-03	0.003	0.051	0.037	NA	0.022	2.1e-01	1.6e-03	6.2e-03	NA	2.9e-02
5	TCGA	Brain Lower Grade Glioma	0.1246	0.0427	7.3e-09	0.080	0.085	0.094	NA	0.090	2.4e-09	7.6e-10	8.4e-11	NA	2.3e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Platelet Count	6.0	69.2	114.5	7.1	-9.5	-8.5	-10.7	4.3
Breast Cancer	3.8	9.1	14.4	-2.6	3.2	0.7	3.8	-3.7
Medication: Co-codamol	3.4	3.9	9.3	1.4	-1.5	-1.2	-3.0	2.1
Commuting to job workplace: Walk	3.3	3.6	6.7	-2.6	2.1	0.7	1.2	2.2
Medication: Seretide 50 evohaler	3.1	3.5	4.8	-2.2	1.3	-2.1	-1.7	2.0
Knee pain experienced in last month	3.1	4.8	10.7	-1.9	-2.9	-3.3	1.1	-0.4
Mouth/teeth dental problems	3.0	4.7	9.6	-1.7	3.1	2.6	1.5	-1.4
Medication: Atorvastatin	2.8	3.5	7.5	-1.9	1.4	1.8	2.7	-1.2
Neuroticism (2016)	2.5	3.6	10.6	1.9	-3.2	0.7	-1.6	-0.7
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	9.2	3.0	-2.3	-0.1	-1.1	-1.0
Medication: Levothyroxine sodium	2.4	4.1	8.1	-1.8	2.6	0.8	2.8	-1.4
Hypothyroidism/myxoedema (self-reported)	2.4	4.8	9.4	-2.2	2.7	0.6	3.1	-1.5
Primary Biliary Cirrhosis	2.3	3.3	8.8	2.4	-3.0	-0.5	0.3	-1.4
Osteoarthritis (self-reported)	2.3	2.9	7.3	-0.5	-2.2	-2.7	-1.2	1.0
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	9.7	-1.8	1.8	1.3	3.1	-0.3
Birth weight	2.2	4.8	15.0	-0.5	1.2	3.9	2.5	-0.9
Bipolar Disorder (2011)	2.1	2.1	3.3	0.0	-1.6	1.1	1.8	-1.8
Blood Red Count	2.1	20.3	60.4	0.4	-5.6	-7.8	-3.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	5.8	-1.8	-2.4	-2.0	0.3	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.2	1.4	-2.7	-2.0	-0.2	-0.4
Overall health rating	2.1	4.6	16.8	-0.9	-4.1	-2.1	0.2	1.0
Multivitamins +/- minerals	2.0	2.6	3.5	1.6	-1.5	-1.8	-1.2	-1.9
High blood pressure (mother)	2.0	2.7	5.2	-0.4	-2.0	-2.3	-1.2	1.8
Hair/balding pattern: Pattern 4	2.0	4.8	16.6	-2.0	-0.5	4.1	1.8	-0.3
Chest pain or discomfort	2.0	2.9	7.0	-2.2	-2.6	-1.5	0.6	0.6
Back pain experienced in last month	2.0	2.9	6.8	-1.2	-1.7	-1.6	-0.7	2.6
Pain experienced in last month	2.0	3.4	9.0	0.6	3.0	1.8	0.7	-2.0
Vitamin and mineral supplements	1.9	2.6	3.3	-1.8	1.7	1.8	0.5	1.8
Diabetes (mother)	1.9	2.5	5.7	0.4	-2.4	-0.2	1.1	-2.3
Hypothyroidism (self reported)	1.8	4.0	6.9	-1.9	2.6	1.1	2.6	-1.3
Medication: Ibuprofen	1.8	2.2	6.9	1.1	-2.6	-1.7	-0.1	-0.1
Smoking status: Previous	1.8	2.6	4.6	0.9	-1.9	-1.0	-2.1	1.7
Long-standing illness, disability or infirmity	1.8	2.8	9.2	-3.0	-0.5	-1.4	1.4	0.8
Supplements: Glucosamine	1.7	2.2	4.7	2.2	-0.5	-1.5	-1.7	-1.1
High blood pressure (siblings)	1.7	2.5	5.2	-0.0	-1.7	-1.9	-0.7	2.3
Leg pain on walking	1.7	2.1	8.2	-2.9	0.5	-0.4	1.4	-0.0
Number of operations (self-reported)	1.7	2.5	11.0	0.2	-3.3	-0.1	-0.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.4	-1.8	1.8	1.5	0.3	1.2
Past tobacco smoking	1.6	2.9	7.2	-1.4	2.7	1.1	1.8	-0.9
Alcohol usually taken with meals	1.6	2.5	6.0	-0.2	2.5	1.9	1.6	0.6
Illnesses of siblings	1.6	2.3	6.8	0.5	1.9	0.7	0.4	-2.6
Illnesses of mother	1.6	2.0	5.4	0.6	2.3	1.6	-0.1	-1.4
Exposure to tobacco smoke at home	1.6	1.8	5.6	-0.0	-1.3	-2.4	-1.2	-0.5
Neck or shoulder pain in last month	1.6	2.3	6.2	1.1	-2.5	-1.5	-1.1	0.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	5.4	0.7	-1.5	-0.9	0.5	-2.3
Illnesses of father: High blood pressure	1.6	2.0	5.1	-1.9	0.8	0.3	-0.9	2.3
Commuting to job workplace: Cycle	1.6	1.9	5.2	0.5	2.3	-0.1	-1.3	1.5
Alcohol drinker status: Previous	1.6	1.8	6.8	-1.2	0.4	2.6	-0.1	0.8
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.2	0.4	-1.0	1.0	1.8	-1.7
Medication for hormone replacement therapy	1.5	1.7	7.8	0.5	0.5	0.2	-0.5	-2.8
Heart attack	1.5	2.0	4.7	-1.7	1.2	2.2	0.8	0.2
Pain all over the body in last month	1.5	1.6	4.0	0.4	0.8	-0.7	-2.0	1.6
Impedance of arm (right)	1.5	7.2	15.5	-3.4	3.9	0.3	1.0	2.8
Prospective memory result	1.5	1.8	3.9	1.5	-2.0	-0.6	0.4	-1.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.9	0.8	-2.0	1.2	0.8	-1.5
Medication: Paracetamol	1.5	2.4	4.6	0.7	-2.0	-1.6	-2.1	0.5
Medication: Allopurinol	1.5	2.0	4.3	2.0	-0.9	0.5	-2.1	-0.6
Medication: Paracetamol	1.5	2.3	4.3	1.4	-2.1	-1.2	-1.9	0.6
Age at First Birth	1.4	2.0	4.8	-0.7	2.2	1.1	-0.2	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	5.7	-1.1	-2.4	-1.2	0.6	-0.4
Time employed in main current job	1.4	1.6	3.8	1.3	-1.4	-1.9	-1.0	0.0
Qualifications: nursing, teaching	1.4	2.2	3.9	-2.0	1.6	1.2	1.6	0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.0	-1.6	1.2	2.0	0.7	0.4
Depression (Nagel 2018)	1.3	2.0	3.0	-1.7	-1.7	-1.4	1.4	0.4
Schizophrenia vs Biploar Disorder	1.3	1.7	4.1	0.4	2.0	1.6	-0.6	1.2
Verbal and Numeric Reasoning (VNR)	1.3	3.1	6.9	-1.8	2.6	1.9	-0.4	1.3
Coronary Artery Disease (CAD)	1.3	1.5	6.2	-1.0	-0.5	2.5	-0.0	-0.0
LDL Cholesterol	1.3	2.0	5.0	-0.6	0.8	1.2	1.6	-2.2
Rheumatoid Arthritis	1.3	1.8	5.1	-1.3	1.4	0.7	0.1	2.3
Type 2 Diabetes (T2D) (2012)	1.3	1.4	3.5	-1.3	0.6	1.3	1.9	0.4
Blood White Count	1.3	9.7	18.3	4.1	-4.3	-0.9	-1.0	-3.4
BMI	1.3	7.5	21.4	3.0	-4.6	-0.4	-1.9	-1.8
Hair/balding pattern: Pattern 2	1.3	1.6	4.1	-1.3	1.4	-2.0	0.4	0.5
Qualifications: None of the above	1.3	2.7	5.7	2.0	-2.4	-0.6	-1.9	0.1
Falls in the last year	1.3	1.8	4.6	-1.5	-1.0	0.8	0.5	2.1
Impedance of arm (left)	1.3	6.0	12.6	-2.9	3.5	1.2	0.7	2.5
Birth weight of first child	1.3	2.3	6.2	0.5	-0.8	1.5	2.5	-1.5
Emphysema/chronic bronchitis	1.3	1.5	3.7	1.1	-1.9	-1.3	-0.8	0.4
Medication: Omeprazole	1.3	1.5	2.3	-1.1	1.5	1.5	-0.3	1.3
Number of full sisters	1.3	1.6	3.2	0.7	-1.8	-1.2	-1.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	-1.5	1.2	-1.5	-0.4	0.9
Medication: Bendroflumethiazide	1.3	1.9	5.1	-0.5	-1.2	-1.2	-1.2	2.3
Medication: Lisinopril	1.3	1.7	5.8	0.6	-2.4	1.4	0.2	-0.3
Unable to work because of sickness or disability	1.3	1.7	2.8	-1.7	-1.0	-1.6	-1.1	0.8
Pack years of smoking	1.3	1.9	4.7	-2.2	1.8	-0.0	1.1	0.6
Fasting Glucose	1.2	1.4	3.0	1.3	-1.6	-0.0	0.0	-1.7
Townsend deprivation index at recruitment	1.2	1.7	5.6	0.9	-2.4	-1.4	0.2	-0.1
Had menopause	1.2	1.5	4.3	-0.8	1.5	-0.2	-0.7	2.1
Tense / ‘highly strung’	1.2	2.0	5.5	0.7	-1.4	-2.3	-0.8	1.3
Gout (self-reported)	1.2	1.7	3.8	1.9	-1.6	0.3	-1.0	-1.0
Respiratory disease	1.1	2.4	7.3	-1.4	-1.0	-1.3	-0.1	2.7
Hayfever, allergic rhinitis or eczema	1.1	2.3	4.0	-1.6	2.0	1.0	0.6	1.9
Pulse wave peak to peak time	1.1	1.3	5.7	-0.2	2.4	0.4	0.8	-0.0
Leg fat percentage (left)	1.1	4.0	15.7	1.4	-4.0	-1.4	-0.7	-0.5
Impedance of whole body	1.1	5.4	12.0	-2.9	3.5	0.9	1.2	2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.4	0.3	0.5	2.3	0.9	-1.8
Frequency of depressed mood in last 2 weeks	1.0	1.5	4.0	-0.5	-2.0	-1.5	0.6	0.6
Pack years adult smoking proportion	1.0	1.5	3.7	-1.9	1.5	-0.0	1.3	0.1
Maternal smoking around birth	1.0	1.4	3.2	-1.8	0.9	1.1	-1.0	0.9
Age when periods started (menarche)	1.0	2.4	4.1	-1.4	1.7	1.0	2.0	-1.3
Body mass index (BMI)	1.0	4.5	17.1	1.7	-4.1	-0.7	-1.2	-0.7
Diabetes (self-reported)	1.0	1.6	3.9	-0.4	0.8	2.0	0.8	-1.7
Asthma	1.0	1.9	6.3	-0.9	-0.6	-1.0	-1.1	2.5
Headache pain in last month	1.0	1.6	2.6	-1.4	-1.4	-1.1	0.7	1.6
Leg fat percentage (right)	1.0	3.5	14.0	1.2	-3.7	-1.2	-0.7	-0.1
Number of full brothers	1.0	1.3	3.5	-0.1	-0.8	-0.6	1.4	-1.9
Wheeze or whistling in the chest in last year	1.0	1.7	6.8	-0.8	-2.6	-0.5	0.2	1.0
Medication: Aspirin	1.0	1.3	3.7	-1.4	-0.7	1.9	0.1	0.5
Illnesses of father: Heart disease	1.0	1.4	3.4	0.6	-1.3	0.4	1.8	-1.1
Diabetes diagnosed by doctor	1.0	1.7	6.1	-0.2	0.6	2.5	0.9	-1.1
Smoking status: Current	1.0	1.7	2.3	0.1	-1.5	-1.4	1.3	-1.5
Supplements: Calcium	1.0	1.1	2.2	0.2	-1.5	1.1	1.2	-0.9
HbA1C	0.9	1.1	2.9	0.2	-1.1	1.7	0.6	-0.9
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	-1.3	1.4	0.3	0.7	0.9
Relative age voice broke	0.9	1.4	3.7	-1.2	1.2	0.4	0.5	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.3	2.0	0.1	1.1	-2.1	-0.9
Chronic bronchitis/emphysema (father)	0.9	1.1	2.0	-1.4	-0.8	-0.5	0.8	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.1	0.2	-2.5	-1.1	0.0	-0.1
Number of live births	0.9	1.3	5.6	-0.5	-2.4	-0.1	-0.7	0.3
Happiness	0.9	1.1	3.1	-1.8	-0.9	-0.8	1.1	-0.0
Qualifications: A levels/AS levels or equivalent	0.9	2.1	8.2	0.3	0.9	0.7	2.9	-1.0
Mouth/teeth dental problems: Dentures	0.9	1.5	4.6	-0.8	-0.2	-0.2	-1.4	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	4.7	-2.2	-0.1	0.4	0.0	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.9	-1.4	-0.1	-0.7	1.2	1.4
Number of children fathered	0.9	1.0	2.2	0.9	-1.5	-0.5	-0.8	1.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.6	0.2	-1.2	-1.9	-0.4	0.1
Mean time to correctly identify matches	0.9	1.8	3.4	-1.4	1.8	-0.3	1.4	1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.1	1.1	-1.8	-1.3	0.8	0.8
Osteoporosis (self-reported)	0.9	1.2	2.9	1.4	-1.7	0.8	-0.4	-0.4
Medication: Aspirin	0.9	1.2	3.6	-1.5	-0.4	1.9	0.2	0.3
Number of self-reported non-cancer illnesses	0.9	1.6	6.6	-0.8	-2.6	0.4	0.9	-0.0
Alcohol drinker status: Never	0.9	1.0	2.5	0.4	-0.1	1.6	-0.3	1.6
Fractured/broken bones in last 5 years	0.9	1.1	3.8	0.5	-1.0	-0.7	-0.4	-1.9
Diastolic blood pressure, automated reading	0.9	2.9	9.5	-1.9	-0.6	-0.9	-0.5	3.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.8	-1.4	2.2	2.0	0.9	0.5
Had other major operations	0.8	1.0	3.3	0.2	-1.8	0.4	0.3	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.2	-0.7	0.7	1.1	0.2	1.8
Fluid intelligence score	0.8	1.6	2.5	-1.4	1.6	1.4	0.3	1.2
Worrier / anxious feelings	0.8	1.5	5.0	-0.4	-1.3	0.5	2.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.4	-0.8	2.3	1.2	1.1	-2.0
Pulse wave Arterial Stiffness index	0.8	1.0	4.7	-0.1	-2.2	-0.0	-0.4	0.1
Glaucoma (self-reported)	0.8	0.9	1.8	0.5	0.4	0.9	1.3	-1.3
Forced vital capacity (FVC), Best measure	0.8	3.1	7.7	-1.4	2.8	0.9	1.5	-1.7
Age at first live birth	0.8	1.4	5.3	1.0	0.6	0.4	0.6	-2.3
Qualifications: College or University degree	0.8	2.6	6.5	-1.1	2.5	1.3	1.7	-0.8
Angina (self-reported)	0.8	1.0	2.1	0.1	-0.8	0.8	-1.5	-1.3
Age at last live birth	0.8	1.2	4.9	0.7	-0.1	0.8	0.3	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.0	-1.4	0.6	0.2	0.8	1.4
Asthma (self-reported)	0.8	1.5	4.9	-1.1	-0.6	-0.8	-0.8	2.2
Medication: Gliclazide	0.8	0.9	2.6	1.6	-1.2	0.5	-0.3	-0.5
Wears glasses or contact lenses	0.8	1.0	1.3	1.1	1.1	-0.9	-1.0	0.7
Commuting to job workplace: Public transport	0.8	1.0	3.2	0.3	-0.0	-1.2	0.4	1.8
Age started oral contraceptive pill	0.8	1.0	2.9	-0.0	1.7	1.0	-0.9	0.6
Depressed Affect (Nagel 2018)	0.7	1.4	2.7	-1.4	-0.9	-0.5	1.6	-1.0
Schizophrenia (2018)	0.7	1.5	3.0	1.2	0.6	0.4	-1.7	1.6
Ulcerative Colitis (UC)	0.7	1.3	3.0	0.4	-1.1	-0.6	-1.7	1.3
Triglycerides	0.7	1.1	2.6	-0.7	0.4	1.6	0.9	-1.3
Blood Eosinophil Count	0.7	5.1	8.1	2.3	-2.8	-0.9	-2.8	1.9
Height	0.7	14.1	31.0	-5.6	3.9	2.6	2.9	3.0
Smoking Status	0.7	1.6	6.5	0.2	-2.6	-0.9	0.5	-0.4
Lung FVC	0.7	3.7	14.6	-1.2	3.8	0.3	1.0	-1.2
Severe depression (siblings)	0.7	0.8	1.6	-0.8	-1.2	-0.1	1.3	-0.1
Current tobacco smoking	0.7	1.1	2.0	-0.0	-1.2	-0.9	1.4	-1.2
Qualifications: CSEs or equivalent	0.7	1.0	2.1	-1.0	0.2	1.5	0.2	-1.3
Serious illness, injury or assault to yourself	0.7	0.9	3.1	-0.1	-0.1	-1.8	-0.7	0.9
Stomach or abdominal pain in last month	0.7	0.9	2.0	-0.5	-1.4	-1.1	1.0	-0.4
Alcohol intake versus 10 years previously	0.7	1.0	2.0	1.1	-1.4	0.2	-1.4	0.1
Noisy workplace	0.7	0.8	2.9	0.3	-1.7	0.4	0.6	-0.8
Length of working week for main job	0.7	0.8	1.7	-0.1	0.9	-0.8	0.8	-1.3
Loud music exposure frequency	0.7	0.7	1.0	-1.0	1.0	0.9	-0.3	0.9
Medication for pain relief, constipation, heartburn	0.7	1.2	4.2	0.6	2.0	-0.8	0.5	-0.6
Mood swings	0.7	1.3	2.5	0.2	-1.2	-0.0	1.6	-1.6
Breast cancer (self-reported)	0.7	0.9	2.1	0.5	-1.4	0.4	-0.8	1.1
Illnesses of father: None of the above (group 1)	0.7	0.8	2.4	1.5	-0.1	0.3	-1.1	-0.7
Mother’s age at death	0.7	0.9	2.3	1.5	0.6	-0.7	-1.0	0.4
Heart disease (siblings)	0.7	0.9	1.8	-1.3	-1.2	-0.3	0.8	0.5
Leg fat mass (left)	0.7	2.7	11.8	0.8	-3.4	-0.4	-0.5	-0.9
Neuroticism	0.6	1.5	5.2	-0.1	-2.3	-1.3	0.8	-0.3
Diabetes (father)	0.6	0.8	3.3	-0.6	-0.1	0.3	1.8	-0.3
Average weekly fortified wine intake	0.6	0.7	2.9	-0.7	0.2	0.2	1.7	0.1
Fed-up feelings	0.6	1.1	2.7	-0.0	-1.6	-0.6	0.1	-1.6
Forced vital capacity (FVC)	0.6	2.2	7.0	-1.2	2.6	0.3	1.4	-0.8
Allergy	0.6	1.4	4.6	1.1	-1.0	-0.3	0.3	-2.1
Medication: Simvastatin	0.6	0.9	1.7	1.0	-0.8	0.1	-1.1	-1.3
Arm fat percentage (right)	0.6	2.4	9.4	0.4	-3.1	-1.1	-1.0	0.7
Hip circumference	0.6	2.7	8.9	1.4	-3.0	-1.2	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.6	-1.1	2.4	0.4	1.2	-1.4
Breastfed as a baby	0.6	0.7	1.9	0.8	0.7	-1.4	-0.3	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.4	-0.7	-1.6	-0.0	0.6	0.7
Health satisfaction	0.6	0.8	3.1	-0.1	-0.6	-1.8	0.1	0.5
Medication: Blood pressure	0.6	1.1	2.1	-0.5	-1.4	1.1	1.2	-0.8
Migraine (self-reported)	0.6	0.8	3.6	0.6	-1.9	0.2	0.1	0.1
Leg fat mass (right)	0.6	2.5	11.2	0.6	-3.3	-0.2	-0.5	-0.7
Alcohol intake frequency.	0.6	1.4	4.0	-0.3	-2.0	1.7	-0.1	0.3
Had major operations	0.6	0.7	1.4	-0.6	-1.2	0.5	-0.2	-1.2
Arm fat percentage (left)	0.6	2.4	9.9	0.6	-3.1	-0.6	-1.0	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.6	-1.0	1.3	-0.3	-0.8	0.7
Loneliness, isolation	0.6	0.9	2.2	-1.5	-0.1	-1.4	-0.0	0.0
Ever had bowel cancer screening	0.6	0.7	1.5	-0.6	0.1	-1.2	0.1	1.2
Arm fat mass (left)	0.6	2.6	11.4	0.8	-3.4	-0.3	-0.9	0.2
Bipolar Disorder (2018)	0.5	0.8	1.0	-1.0	-1.0	-0.9	1.0	-0.5
Neuroticism (Nagel 2018)	0.5	1.3	2.3	-1.3	-1.1	-1.0	1.5	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.8	-0.6	-0.5	-0.6	-1.3	0.1
Irritable Bowel Disease (IBD)	0.5	1.1	3.6	-0.1	-0.4	0.3	-1.2	1.9
Major Depression (MDD)	0.5	0.7	1.5	-0.8	-0.9	0.5	-0.4	1.2
Ulcerative Colitis	0.5	0.8	2.0	0.4	-0.4	-0.2	-1.4	1.2
Allergy or Eczema	0.5	1.3	4.2	-0.7	1.4	0.1	-0.1	2.0
Hand grip strength (left)	0.5	1.3	3.7	-0.5	1.9	0.5	0.5	-1.5
Number of treatments/medications taken	0.5	1.0	4.3	-0.4	-2.1	0.0	0.4	0.6
Sensitivity / hurt feelings	0.5	0.9	2.7	0.3	-1.1	0.1	0.6	-1.6
Hearing difficulty/problems: Yes	0.5	0.8	1.3	-0.2	-1.1	-1.1	-1.0	0.7
Relative age of first facial hair	0.5	0.9	3.8	-0.2	0.1	-0.1	-0.9	2.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	1.4	0.6	0.5	-0.1	-0.8
Systolic blood pressure, automated reading	0.5	1.4	4.4	-2.1	-0.7	-0.7	0.3	1.3
Angina	0.5	0.6	1.4	-0.3	-0.7	0.5	-1.0	-1.2
Supplements: Zinc	0.5	0.6	0.8	0.8	0.9	-0.7	-0.2	-0.9
Impedance of leg (right)	0.5	2.6	7.1	-1.8	2.7	0.3	1.1	1.1
Taking other prescription medications	0.5	0.8	1.4	-1.1	-0.8	-0.8	1.2	-0.5
High blood pressure	0.5	1.4	2.7	-1.3	-1.5	-0.4	0.1	1.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.4	-0.3	-0.6	1.2	0.8	-0.4
Waist circumference	0.5	2.0	7.1	1.0	-2.7	-0.5	-0.7	0.9
Nervous feelings	0.5	1.0	4.4	0.3	-2.1	-0.2	-0.1	0.5
Hearing difficulty/problems with background noise	0.5	0.8	2.2	-0.7	-1.5	-0.9	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.0	1.2	0.7	1.1	-1.7	-0.3
Financial difficulties in last 2 years	0.5	0.7	1.4	-0.9	-0.4	0.7	0.9	-1.2
Neuroticism score	0.5	1.1	2.8	0.2	-1.7	-1.0	0.8	-0.9
Father’s age at death	0.5	0.7	1.7	1.3	0.1	0.7	-0.8	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-1.3	1.0	0.2	0.5	-0.6
Medication: Cholesterol lowering	0.5	0.7	2.5	-0.5	0.1	0.9	-0.3	-1.6
Depression (self-reported)	0.5	0.6	1.0	-0.6	-1.0	0.1	1.0	-0.9
Lung cancer (father)	0.5	0.6	1.2	-1.1	0.5	-0.8	0.0	1.0
Arm fat mass (right)	0.5	2.1	9.3	0.5	-3.1	-0.6	-0.9	0.3
Standing height	0.5	4.8	9.2	-3.0	2.4	2.1	1.7	1.4
Pulse wave reflection index	0.5	0.6	2.2	0.5	-1.5	0.1	-0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.7	0.6	1.0	-0.6	-0.7	1.3
Body fat percentage	0.5	1.8	8.7	0.3	-3.0	-0.4	-0.3	0.3
Worry too long after embarrassment	0.5	0.8	1.7	-1.3	-0.8	0.1	-0.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.3	-0.1	-1.5	-0.6	0.0	0.5
Supplements: Vitamin C	0.5	0.6	1.6	1.3	-0.2	-1.0	-0.2	0.6
Illnesses of siblings: Diabetes	0.5	0.7	1.5	-0.7	-0.1	1.2	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.9	-1.3	1.4	1.1	0.6	-0.4
Eye problems/disorders: Cataract	0.5	0.6	1.6	-0.1	-1.3	0.4	-0.7	0.8
Mineral and other dietary supplements	0.5	0.6	1.2	-0.8	0.8	1.1	-0.5	0.7
Average weekly champagne plus white wine intake	0.5	0.7	2.6	-0.1	1.6	0.8	-0.2	0.2
Guilty feelings	0.5	0.7	2.1	0.7	-1.4	-0.7	-0.2	0.8
Ever taken oral contraceptive pill	0.5	0.5	1.3	1.1	-0.2	-0.1	-0.2	-1.1
Hearing aid user	0.5	0.6	1.7	0.2	-1.3	-1.0	0.2	-0.1
Financial situation satisfaction	0.5	0.6	2.1	-0.8	0.0	-1.4	-0.1	-0.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	0.7	0.1	1.5	0.6	-0.1
Ever smoked	0.5	0.9	3.3	0.8	-1.8	-0.4	-0.0	0.5
Average weekly beer plus cider intake	0.5	0.7	1.7	0.6	-1.3	-0.0	-0.9	-1.0
Irritability	0.5	0.8	3.1	0.2	0.1	-1.8	-0.1	-0.9
Ever depressed for a whole week	0.5	0.7	1.8	-1.4	-0.5	-0.6	0.9	0.3
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	-1.4	0.5	-0.0	-0.2	0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	0.4	-0.9	1.0	-0.0	-0.8
Schizophrenia (2014)	0.4	1.0	2.4	0.9	0.2	0.6	-1.1	1.6
Heel T-Score	0.4	3.2	7.8	2.3	-1.1	0.8	-1.1	-2.8
Waist Hip Ratio (WHR)	0.4	1.7	7.6	-0.5	0.5	0.2	-0.2	2.8
Systolic Blood Pressure	0.4	2.0	3.2	-1.5	-1.4	-1.8	-0.6	1.5
Chronotype (morning person)	0.4	0.8	1.6	0.2	0.9	1.3	0.4	-1.3
Average weekly spirits intake	0.4	0.5	0.8	0.6	0.8	0.6	-0.9	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	-1.0	-0.7	0.4	1.0	-0.2
Medication: Metformin	0.4	0.5	1.0	-1.0	0.0	1.0	0.7	0.5
Trunk fat percentage	0.4	1.5	7.1	-0.2	-2.7	0.0	0.0	0.6
Sitting height	0.4	3.1	6.2	-2.5	1.7	1.1	2.3	-0.3
Impedance of leg (left)	0.4	1.7	5.0	-1.4	2.2	-0.0	1.0	0.7
Trunk fat mass	0.4	1.6	7.8	-0.0	-2.8	0.1	-0.1	0.2
Number of incorrect matches in round	0.4	0.6	2.7	0.6	0.2	1.6	0.3	0.2
Weight	0.4	1.8	8.6	0.3	-2.9	0.2	-0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.3	0.1	-1.5	-0.2	0.4	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.1	-0.1	-0.4	-1.1	-0.1	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.1	-1.0	0.7	-0.9	0.5
Arm fat-free mass (right)	0.4	2.1	6.4	1.0	-2.5	0.8	0.2	-1.6
Comparative body size at age 10	0.4	1.2	3.4	0.8	-0.6	-1.3	-0.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.5	0.2	1.2	0.6	-0.2	-0.4
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.2	0.4	-1.0	-1.0	0.3
Whole body fat mass	0.4	1.8	8.7	0.3	-3.0	-0.2	-0.3	-0.2
Arm predicted mass (right)	0.4	1.8	6.1	0.8	-2.5	1.1	-0.3	-1.1
Suffer from ‘nerves’	0.4	0.7	2.7	-0.4	-0.5	-1.6	0.3	-0.2
Family relationship satisfaction	0.4	0.5	1.4	-0.2	1.2	0.4	0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.6	0.9	1.1	0.4	-0.3
Hypertension (Self-reported)	0.4	1.0	2.2	-1.5	-1.4	0.1	0.3	0.8
Miserableness	0.4	0.7	1.5	-1.2	-0.1	-0.4	1.2	-0.5
Medication: Blood pressure	0.4	0.7	2.1	0.1	-0.4	-0.2	-1.1	1.4
Worry (Nagel 2018)	0.3	0.5	1.3	-0.2	-0.9	-0.6	1.2	-0.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	-1.1	0.2	0.3	0.6	0.4
Crohns Disease (2017)	0.3	0.7	2.1	0.2	-0.3	0.9	-0.8	1.4
Reaction Time	0.3	0.5	1.0	-0.9	1.0	-0.1	0.8	0.3
HDL Cholesterol	0.3	0.6	1.2	-0.4	1.1	-0.2	0.9	-0.8
Lupus	0.3	0.4	1.0	0.6	-1.0	0.6	-0.1	-0.5
Cardiovascular Disease	0.3	1.0	4.2	-0.3	-2.1	-0.6	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.1	0.5	0.9	0.0	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.7	0.5	-0.8	-0.1	-0.3
Medication: Atenolol	0.3	0.4	1.3	-0.0	-0.7	1.1	-0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.5	-0.1	-0.8	0.4	1.0
Pulse rate	0.3	0.5	0.9	-0.9	0.5	-0.9	0.6	-0.0
Medication: Lansoprazole	0.3	0.3	0.7	-0.6	-0.7	0.1	0.8	-0.4
Medication: Amlodipine	0.3	0.5	0.9	-0.9	-0.1	-0.7	0.4	1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.7	0.4	-0.2	-0.7	0.7
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.1	-0.7	-0.9	0.8	0.4
Heart disease (mother)	0.3	0.4	1.2	-0.3	-0.4	0.6	1.1	-0.1
Pulse rate, automated reading	0.3	0.9	1.7	-0.6	-0.5	-1.3	1.0	1.0
Average weekly red wine intake	0.3	0.4	0.9	0.6	0.2	-0.8	-0.4	0.9
Friendships satisfaction	0.3	0.4	1.3	0.3	0.1	-0.1	0.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.5	0.0	0.8	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	1.2	1.1	0.2	-0.2	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.5	-0.9	-0.5	0.9	0.3
High cholesterol (Self-reported)	0.3	0.5	1.3	0.4	-0.2	0.6	-0.8	-1.1
Risk taking	0.3	0.4	1.7	0.3	0.3	-0.1	-1.3	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	1.3	1.5	-0.3	-0.1	-0.8
Cholesterol lowering medication	0.3	0.5	1.6	-0.0	-0.5	0.8	1.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	0.1	-0.4	-1.0	0.1	-1.0
Arm predicted mass (left)	0.3	1.3	6.1	0.6	-2.5	0.2	-0.1	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	0.4	-0.2	-0.3	-0.9	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	1.4	-1.2	0.1	-0.3	-0.0	0.3
Ovarian Cancer	0.2	0.2	0.6	-0.1	0.5	-0.8	0.4	0.1
Prostate Cancer	0.2	0.3	0.6	-0.5	-0.8	-0.1	0.7	-0.5
Crohns Disease (2012)	0.2	0.4	0.8	-0.0	-0.4	0.6	-0.7	0.9
Mean Putamen Volume	0.2	0.2	0.3	-0.5	0.5	0.3	-0.6	0.1
Tanning	0.2	1.8	6.1	-0.1	2.5	0.4	-0.3	1.7
Leg fat-free mass (left)	0.2	1.0	3.4	-0.3	-1.9	1.2	0.0	-0.4
Hand grip strength (right)	0.2	0.5	1.2	0.7	0.8	0.3	0.2	-1.1
Leg predicted mass (left)	0.2	1.0	3.6	-0.3	-1.9	1.1	-0.0	-0.4
Medication: Ramipril	0.2	0.2	0.8	-0.9	-0.5	0.0	-0.3	-0.3
Peak expiratory flow (PEF)	0.2	0.4	1.2	-0.6	0.2	0.5	0.2	-1.1
Whole body fat-free mass	0.2	0.9	2.9	0.0	-1.7	1.0	0.3	-0.8
Leg fat-free mass (right)	0.2	1.2	4.2	0.0	-2.1	1.1	0.0	-0.7
Medication for cholesterol	0.2	0.3	0.8	-0.3	0.0	-0.6	-0.1	0.9
Whole body water mass	0.2	0.9	3.4	0.2	-1.8	0.8	-0.0	-0.7
Leg predicted mass (right)	0.2	1.1	3.8	-0.0	-2.0	1.1	0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.9	0.0	0.4	0.3	0.1	1.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.0	-0.2	0.3	-0.1	1.0	-0.3
Basal metabolic rate	0.2	1.2	5.0	0.2	-2.2	0.7	-0.0	-0.6
Arm fat-free mass (left)	0.2	1.1	5.3	0.5	-2.3	0.2	-0.0	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.2	0.7	0.7	-0.5	0.3
Myopia	0.2	0.3	0.6	-0.1	0.7	0.2	-0.7	0.5
Lung FEV1/FVC ratio	0.1	0.3	0.8	-0.5	0.5	-0.3	-0.0	-0.9
Hair Pigment	0.1	2.0	4.8	1.6	-2.2	-0.8	-0.5	-1.4
Trunk fat-free mass	0.1	0.6	2.0	0.3	-1.4	0.7	0.1	-0.7
Trunk predicted mass	0.1	0.6	1.8	0.3	-1.3	0.7	0.1	-0.6
Comparative height size at age 10	0.1	0.7	1.5	-1.2	0.1	0.5	1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.2	0.1	0.1	0.1	-0.5

Hub : Genes

FAM46C

Models

Trait associations