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chr10:15,787,971-18,453,209

Best TWAS P=3.62e-19 · Best GWAS P=8.33e-15 conditioned to 0.0754

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRDMT1	0.07	0.04	blup	92	0.05	1.0e-03	-7.66	8.9	3.6e-19	-0.89	0.02	0.94	TRUE
36	NTR	Blood	RSU1	0.24	0.24	enet	16	0.26	1.4e-82	-7.64	-7.9	2.2e-15	0.08	0.03	0.97	TRUE
12	GTEx	Artery Tibial	RSU1	0.43	0.20	enet	14	0.30	3.9e-24	-7.32	-7.9	2.8e-15	0.04	0.11	0.89	FALSE
19	GTEx	Esophagus Muscularis	RSU1	0.30	0.09	enet	12	0.16	8.5e-10	-7.32	-7.8	5.0e-15	0.05	0.15	0.85	FALSE
35	METSIM	Adipose	RSU1	0.21	0.06	enet	11	0.15	4.1e-22	-6.90	-7.8	7.8e-15	0.04	0.82	0.18	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	TRDMT1	0.19	0.17	lasso	3	0.22	6.6e-21	-7.70	7.7	9.7e-15	-0.98	0.01	0.99	FALSE
27	GTEx	Skin Sun Exposed Lower leg	TRDMT1	0.10	0.02	lasso	4	0.04	3.0e-04	-7.70	7.7	1.3e-14	-0.98	0.01	0.98	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRDMT1	0.07	0.05	enet	11	0.05	2.0e-06	7.62	7.7	1.3e-14	-0.96	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRDMT1	0.08	0.10	blup	92	0.10	5.4e-12	-7.66	7.7	1.6e-14	-0.88	0.01	0.99	FALSE
31	GTEx	Thyroid	TRDMT1	0.21	0.22	lasso	3	0.22	4.8e-17	-7.66	7.6	2.3e-14	-0.97	0.02	0.98	FALSE
9	GTEx	Artery Coronary	TRDMT1	0.31	0.13	enet	10	0.07	3.0e-03	-7.67	7.6	2.5e-14	-0.96	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRDMT1	0.08	0.12	lasso	3	0.12	1.8e-13	-7.66	7.6	2.6e-14	-0.97	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	VIM	0.04	0.04	lasso	1	0.04	1.4e-04	7.62	7.6	2.6e-14	-0.96	0.00	0.95	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRDMT1	0.10	0.01	blup	91	0.03	3.2e-02	6.35	7.6	2.8e-14	-0.88	0.02	0.75	FALSE
8	GTEx	Artery Aorta	RSU1	0.40	0.16	enet	21	0.33	5.5e-19	-5.01	-7.6	3.3e-14	0.03	0.19	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RSU1	0.13	0.08	enet	12	0.14	3.6e-16	-5.47	-7.6	4.1e-14	0.06	0.10	0.90	FALSE
3	GTEx	Adipose Subcutaneous	TRDMT1	0.37	0.21	enet	26	0.24	1.5e-19	-6.02	7.5	5.6e-14	-0.86	0.31	0.69	FALSE
21	GTEx	Muscle Skeletal	RSU1	0.17	0.13	enet	14	0.15	9.7e-15	-5.01	-7.4	1.2e-13	0.04	1.00	0.00	FALSE
20	GTEx	Lung	RSU1	0.30	0.22	enet	16	0.25	3.4e-19	-5.01	-7.4	1.6e-13	0.03	1.00	0.00	FALSE
29	GTEx	Stomach	STAM	0.12	0.08	lasso	5	0.06	1.2e-03	7.75	-7.3	2.0e-13	0.93	0.02	0.92	FALSE
17	GTEx	Colon Transverse	RSU1	0.29	0.21	enet	15	0.26	8.5e-13	-5.01	-7.2	5.8e-13	0.06	0.98	0.01	FALSE
7	GTEx	Artery Aorta	TRDMT1	0.23	0.08	enet	9	0.08	5.5e-05	-7.67	7.2	6.2e-13	-0.96	0.02	0.98	FALSE
18	GTEx	Esophagus Mucosa	RSU1	0.38	0.27	enet	11	0.30	2.4e-20	-5.01	-7.2	6.7e-13	0.04	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	RSU1	0.32	0.21	lasso	5	0.25	3.0e-26	-5.01	-7.1	1.1e-12	0.04	1.00	0.00	FALSE
15	GTEx	Breast Mammary Tissue	TRDMT1	0.20	0.14	lasso	7	0.13	3.2e-07	-6.05	6.9	4.0e-12	-0.81	0.08	0.92	FALSE
23	GTEx	Nerve Tibial	RSU1	0.66	0.45	lasso	7	0.47	5.4e-37	-5.01	-6.8	1.0e-11	0.04	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRDMT1	0.02	0.01	blup	92	0.01	7.4e-04	-6.02	6.8	1.0e-11	-0.82	0.06	0.91	FALSE
16	GTEx	Cells Transformed fibroblasts	RSU1	0.51	0.34	lasso	7	0.36	2.4e-28	-5.92	-6.8	1.1e-11	0.05	1.00	0.00	FALSE
22	GTEx	Nerve Tibial	TRDMT1	0.27	0.10	lasso	2	0.12	8.9e-09	-6.05	6.8	1.2e-11	-0.84	0.15	0.85	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	TRDMT1	0.22	0.11	lasso	5	0.10	4.6e-06	-6.09	6.7	1.7e-11	-0.83	0.06	0.93	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RSU1	0.28	0.22	lasso	4	0.24	7.7e-27	-5.01	-6.7	1.7e-11	0.04	1.00	0.00	FALSE
32	GTEx	Thyroid	RSU1	0.26	0.10	enet	18	0.16	6.0e-12	-7.04	-6.7	2.0e-11	0.06	0.12	0.88	FALSE
33	GTEx	Whole Blood	RSU1	0.15	0.08	enet	30	0.08	8.8e-08	-7.46	-6.5	5.6e-11	0.00	0.07	0.93	FALSE
4	GTEx	Adipose Subcutaneous	RSU1	0.21	0.09	lasso	6	0.09	1.7e-07	-5.64	-6.5	5.9e-11	0.03	0.94	0.05	FALSE
11	GTEx	Artery Tibial	TRDMT1	0.26	0.26	lasso	6	0.26	7.6e-21	-6.05	6.5	7.9e-11	-0.80	0.97	0.03	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	RSU1	0.09	0.04	blup	180	0.04	4.4e-05	-6.79	-6.4	1.4e-10	0.06	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	RSU1	0.39	0.20	lasso	5	0.24	7.8e-23	-4.93	-6.4	1.6e-10	0.04	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSU1	0.06	0.04	lasso	3	0.05	1.7e-06	-4.93	-6.2	6.6e-10	0.04	0.29	0.54	FALSE
14	GTEx	Brain Cerebellar Hemisphere	TRDMT1	0.31	0.20	lasso	4	0.16	5.9e-05	-6.09	6.1	9.4e-10	-0.73	0.25	0.25	FALSE
5	GTEx	Adipose Visceral Omentum	TRDMT1	0.28	0.22	lasso	4	0.18	2.0e-09	-6.05	6.1	1.2e-09	-0.73	0.64	0.36	FALSE
24	GTEx	Pancreas	TRDMT1	0.25	0.17	lasso	3	0.17	9.6e-08	-6.05	6.1	1.2e-09	-0.74	0.52	0.46	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	CUBN	0.08	0.07	lasso	3	0.07	7.6e-09	-6.05	-6.1	1.3e-09	0.74	0.80	0.20	FALSE
10	GTEx	Artery Tibial	CUBN	0.09	0.09	lasso	1	0.06	1.1e-05	-6.05	-6.0	1.4e-09	0.73	0.59	0.39	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	CUBN	0.23	0.11	lasso	2	0.07	9.7e-05	-6.05	-6.1	1.4e-09	0.73	0.26	0.72	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	CUBN	0.05	0.00	enet	14	0.02	1.9e-05	3.76	6.0	1.8e-09	0.14	0.14	0.09	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CUBN	0.15	0.12	lasso	8	0.10	3.4e-12	-6.05	-6.0	1.9e-09	0.74	0.99	0.01	FALSE
6	GTEx	Artery Aorta	CUBN	0.28	0.16	lasso	5	0.12	2.2e-07	-6.05	-5.8	5.1e-09	0.74	0.95	0.04	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSU1	0.09	0.06	lasso	4	0.06	3.9e-12	-5.01	-5.8	5.5e-09	0.03	1.00	0.00	FALSE
13	GTEx	Artery Tibial	RP11-124N14.3	0.11	0.10	lasso	3	0.09	1.3e-07	-5.75	-5.8	5.8e-09	0.30	0.90	0.06	FALSE
28	GTEx	Skin Sun Exposed Lower leg	RSU1	0.50	0.36	lasso	7	0.37	1.2e-31	-5.01	-5.8	5.9e-09	0.04	1.00	0.00	FALSE
38	YFS	Blood	RSU1	0.20	0.09	lasso	8	0.16	1.4e-49	0.75	-5.8	7.3e-09	-0.04	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RSU1	0.17	0.08	enet	4	0.08	5.6e-06	-5.01	-5.5	3.1e-08	0.05	0.73	0.15	FALSE
30	GTEx	Testis	TRDMT1	0.18	0.08	lasso	4	0.10	2.2e-05	2.02	5.4	5.7e-08	-0.64	0.03	0.88	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRDMT1	0.24	0.01	blup	92	0.06	1.2e-03	-7.75	5.2	2.2e-07	-0.78	0.01	0.78	FALSE
34	METSIM	Adipose	CUBN	0.13	0.09	enet	25	0.12	6.4e-17	-6.09	-5.2	2.5e-07	0.51	1.00	0.00	FALSE