Hub : Genes

VIM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0260	7.8e-05	0.002	0.029	0.005	0.003	0.004	1.5e-01	1.6e-04	7.4e-02	1.2e-01	9.2e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.0907	0.0246	3.2e-07	0.077	0.062	0.068	0.068	0.070	3.6e-10	2.0e-08	3.6e-09	4.7e-09	2.7e-09
3	YFS	Blood	0.0639	0.0149	7.5e-12	0.033	0.048	0.042	0.048	0.042	3.9e-11	2.1e-15	1.5e-13	2.6e-15	1.0e-13
4	TCGA	Stomach Adenocarcinoma	0.1260	0.0600	7.0e-04	0.019	0.003	0.003	NA	0.000	1.5e-02	1.8e-01	1.9e-01	NA	3.0e-01
5	TCGA	Thyroid Carcinoma	0.0360	0.0210	6.7e-03	0.040	0.017	0.033	NA	0.037	8.2e-05	7.5e-03	3.6e-04	NA	1.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.9	2.9	5.9	-1.9	-1.8	0.5	2.4	-1.4
Bipolar Disorder or Schizophrenia	0.8	1.9	5.4	-1.1	-0.5	1.1	1.3	-2.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	0.0	-1.2	-1.5	-0.4	1.7
Depression (Nagel 2018)	0.6	0.8	2.2	0.7	0.2	-1.2	0.0	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	-0.3	0.3	0.2	-1.4	-1.2
Neuroticism (Nagel 2018)	0.4	1.0	2.9	0.2	-0.4	-1.7	-0.1	1.4
Schizophrenia (2018)	0.5	1.0	3.4	0.1	0.8	1.0	-0.3	-1.8
Schizophrenia vs Biploar Disorder	0.8	1.1	4.6	-0.1	0.4	-0.4	-2.1	-0.8
Worry (Nagel 2018)	0.3	0.6	1.6	0.4	-0.3	-0.9	0.6	1.3
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	0.8	-0.5	-1.4	0.1	1.2
Alzheimer’s Disease (in father)	1.6	1.8	4.5	-1.4	-2.1	-0.9	0.6	-1.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.1	-0.7	-1.4	0.5	0.5
Crohns Disease (2017)	1.8	3.9	6.6	-2.6	-1.4	-1.4	2.4	-1.8
Irritable Bowel Disease (IBD)	0.8	1.8	5.5	-2.3	-0.8	-1.0	0.8	-1.2
Ulcerative Colitis (UC)	0.4	0.7	1.9	-1.4	-0.4	-0.1	-1.1	-0.3
Major Depression (MDD)	1.9	2.3	4.5	1.8	1.8	2.1	0.3	0.7
Reaction Time	0.3	0.5	1.0	-0.6	-1.0	-0.9	0.5	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	0.2	0.7	0.7	-0.9	-1.1
Breast Cancer	0.2	0.5	1.0	0.5	0.9	0.4	0.6	1.0
Ovarian Cancer	0.5	0.7	1.3	0.7	0.1	-0.5	-1.1	1.1
Prostate Cancer	0.6	0.9	2.6	0.5	0.4	1.0	-0.7	1.6
Age at First Birth	0.8	1.1	2.9	0.8	-1.7	-0.0	-1.2	0.8
Bipolar Disorder (2011)	1.2	1.1	3.5	-0.5	-0.2	0.2	1.3	-1.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	0.3	1.1	0.1	0.6	0.5
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.0	0.8	0.1	0.5	-0.7
Crohns Disease (2012)	3.2	5.1	8.1	-2.6	-1.4	-2.5	2.8	-1.5
Mean Putamen Volume	0.2	0.3	1.0	1.0	-0.3	-0.1	0.1	-0.4
Fasting Glucose	0.8	0.9	2.8	-1.1	-0.2	-0.3	1.7	0.8
HbA1C	1.1	1.2	3.2	1.4	-0.0	-0.4	-0.9	1.8
HDL Cholesterol	1.4	2.3	5.3	2.3	0.0	1.1	-2.0	0.8
LDL Cholesterol	3.8	6.1	13.4	2.4	1.0	2.2	-3.7	2.3
Lupus	1.3	1.9	6.8	-1.3	-2.6	-0.5	-0.0	-0.9
Neuroticism (2016)	0.2	0.3	0.5	0.4	0.7	0.1	-0.7	0.5
Primary Biliary Cirrhosis	0.7	0.9	2.4	-1.6	-0.7	-0.4	0.7	-1.1
Rheumatoid Arthritis	0.2	0.3	0.8	0.7	0.3	-0.9	-0.2	-0.5
Schizophrenia (2014)	0.6	1.3	5.0	-0.3	0.2	1.0	0.4	-2.2
Triglycerides	1.0	1.7	3.2	0.7	1.4	0.8	-1.8	1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.7	-0.4	-1.9	-0.4	-0.7	-0.1
Ulcerative Colitis	0.6	0.8	2.2	-1.5	-0.3	-0.9	-0.6	-0.7
Blood Eosinophil Count	0.4	3.1	7.2	-0.6	-1.7	-2.2	2.7	-0.2
Blood Platelet Count	1.7	19.3	58.1	4.3	-1.5	-0.3	-4.2	7.6
Blood Red Count	0.1	0.7	2.1	0.8	0.0	0.9	-1.4	0.5
Blood White Count	0.3	2.2	4.5	-0.8	-1.5	-1.9	2.1	0.7
Heel T-Score	0.3	2.2	4.2	2.0	1.8	1.0	-0.7	-1.4
BMI	0.7	3.8	8.1	2.8	2.4	-0.5	-0.8	2.1
Height	0.2	2.9	7.0	-0.2	-0.3	-2.6	-2.5	-1.0
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-0.0	-0.6	-1.0	-0.1	-0.3
Systolic Blood Pressure	1.4	6.8	11.5	-0.1	3.0	3.4	3.1	-1.9
Smoking Status	0.3	0.7	2.2	-0.3	1.5	0.5	1.0	-0.3
Allergy or Eczema	0.6	1.6	5.3	-2.3	-0.4	-0.2	1.1	-1.1
Cardiovascular Disease	0.8	2.7	10.0	0.4	1.6	0.6	3.2	-0.6
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	0.2	0.0	0.3	-0.5
Respiratory disease	1.3	2.9	5.3	2.1	0.1	-1.1	-2.3	1.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	0.3	0.7	0.1	1.4	-0.5
Lung FEV1/FVC ratio	0.1	0.3	1.1	-1.0	0.0	-0.1	-0.6	0.4
Lung FVC	1.8	9.2	17.0	-3.8	-4.1	-0.3	2.5	-2.8
Neuroticism	0.5	1.3	2.1	-1.2	-0.6	-1.4	1.5	0.6
Chronotype (morning person)	0.1	0.2	0.4	0.6	-0.5	0.7	0.0	-0.0
Hair Pigment	0.0	1.3	2.9	0.3	-1.7	-0.4	-0.9	1.5
Tanning	0.1	1.3	2.1	1.0	1.4	1.3	-1.1	-0.9
Hand grip strength (left)	0.5	1.4	4.5	0.2	1.4	2.1	0.4	-0.3
Number of treatments/medications taken	1.5	2.7	4.8	2.2	0.2	-1.7	0.8	2.2
Average weekly spirits intake	0.3	0.3	0.8	0.3	0.9	-0.5	-0.2	0.8
Sensitivity / hurt feelings	1.0	1.8	3.5	-1.0	-1.9	-1.9	0.6	0.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.3	1.0	-0.4	-0.6	-0.9	1.5
Hearing difficulty/problems: Yes	2.6	4.0	9.2	3.0	1.0	2.0	-1.1	2.1
Relative age of first facial hair	0.4	0.8	2.4	-1.2	-0.1	-0.0	1.6	0.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.1	0.9	0.2	-2.0	-1.2	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	-0.2	-1.2	-0.5	-0.4	-0.7
Ever had hysterectomy (womb removed)	1.0	1.1	4.5	0.6	-0.7	2.1	-0.1	0.1
Systolic blood pressure, automated reading	0.7	1.9	4.5	0.0	2.1	1.3	1.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.5	1.2	0.6	1.0	-0.0	0.1
Angina	0.4	0.6	1.0	0.5	0.9	0.6	0.8	-1.0
Medication for hormone replacement therapy	0.5	0.5	0.9	0.9	-0.5	0.8	-1.0	0.0
Vitamin and mineral supplements	0.2	0.3	1.2	0.5	0.2	1.1	0.2	0.4
Supplements: Zinc	0.2	0.2	0.4	-0.7	-0.3	0.6	0.2	-0.3
Medication: Co-codamol	2.1	2.4	5.6	2.4	1.5	-0.0	-1.3	1.7
Medication: Metformin	0.4	0.6	2.5	0.3	-0.1	-0.5	1.6	-0.5
Diabetes (father)	1.5	1.8	2.6	1.6	1.6	1.4	-0.9	1.1
Diabetes (mother)	0.6	0.8	2.2	1.5	0.5	1.0	-0.6	-0.1
Severe depression (siblings)	0.2	0.2	0.6	0.1	-0.4	0.4	0.5	-0.8
Pack years adult smoking proportion	4.0	6.0	11.9	3.5	2.1	1.3	-1.3	3.2
Impedance of leg (right)	0.3	1.6	3.3	-1.6	-1.3	0.4	0.4	-1.8
Leg fat-free mass (left)	0.6	3.0	6.1	1.5	0.9	-2.0	-2.5	1.2
Trunk fat percentage	1.0	4.0	6.2	2.5	2.0	-1.9	-2.1	1.4
Hand grip strength (right)	0.4	1.2	2.7	-0.1	1.2	1.0	1.6	-0.8
Townsend deprivation index at recruitment	0.6	0.9	1.9	0.7	-0.1	-1.0	-1.4	1.0
Current tobacco smoking	0.6	0.9	3.0	0.5	1.0	0.7	-0.1	1.7
Average weekly fortified wine intake	0.9	1.1	1.8	-0.4	1.1	-1.1	1.3	-1.1
Maternal smoking around birth	0.3	0.5	0.9	0.7	0.5	0.5	-0.9	-0.6
Fed-up feelings	0.7	1.2	3.8	0.4	-1.2	-0.8	0.3	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	0.3	0.1	-1.0	-0.6	1.3
Relative age voice broke	0.5	0.7	2.2	0.1	0.5	0.3	1.5	1.0
Taking other prescription medications	1.8	2.7	5.9	0.9	0.3	-2.4	2.1	1.4
Age when periods started (menarche)	0.5	1.1	3.7	-0.4	0.6	-1.0	1.9	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.5	0.9	-0.0	0.3	1.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.6	0.5	2.2	1.2	-1.7	-0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.8	0.6	0.1	-1.7	-0.1	1.9
Qualifications: CSEs or equivalent	1.0	1.3	2.7	-1.7	-0.8	0.5	0.9	-1.3
Serious illness, injury or assault to yourself	0.5	0.5	1.1	1.1	0.9	-0.7	0.2	0.4
High blood pressure	1.0	2.7	7.3	-1.8	0.9	-0.7	2.7	-1.3
Hayfever, allergic rhinitis or eczema	1.2	2.6	6.3	-2.5	-1.3	-0.9	1.4	-1.5
Multivitamins +/- minerals	0.5	0.6	2.1	-0.4	-0.3	-1.4	-0.7	-0.3
Stomach or abdominal pain in last month	0.7	0.9	1.9	-0.1	-0.9	1.2	1.4	0.5
Supplements: Glucosamine	0.5	0.7	1.3	0.6	-0.1	-1.1	-0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-0.6	-0.7	0.4	0.1	-1.1
Medication: Atenolol	1.3	1.6	4.4	-1.2	0.2	-0.8	2.1	-1.2
Medication: Levothyroxine sodium	0.8	1.4	4.2	-1.2	-0.4	-0.9	2.1	-0.5
Sitting height	0.1	0.8	2.6	-0.7	0.9	0.1	-0.3	-1.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.6	0.7	-0.5	0.4	0.1
High blood pressure (mother)	0.1	0.2	0.5	-0.2	-0.1	-0.2	0.7	0.6
Body mass index (BMI)	1.3	5.7	10.4	3.2	2.4	-1.1	-2.1	2.6
Impedance of leg (left)	0.3	1.2	2.4	-1.2	-1.6	0.5	0.7	-1.3
Leg predicted mass (left)	0.6	3.0	6.2	1.6	0.9	-2.0	-2.5	1.3
Trunk fat mass	1.1	4.7	6.6	2.6	1.9	-2.2	-2.4	1.6
Waist circumference	1.6	5.9	9.3	3.0	1.8	-2.2	-2.3	2.7
Number of incorrect matches in round	0.2	0.4	0.7	-0.9	-0.8	-0.6	0.1	-0.3
Past tobacco smoking	1.2	2.3	4.3	1.7	-0.7	0.5	-1.9	2.1
Alcohol usually taken with meals	0.4	0.6	1.9	-0.4	-1.4	0.8	0.4	0.4
Nervous feelings	0.7	1.4	2.8	-1.3	-0.9	-1.7	1.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	-0.4	-1.1	-1.5	-1.0	-0.9
Hearing difficulty/problems with background noise	1.0	1.7	4.2	2.1	1.0	0.2	-0.4	1.7
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	0.5	0.7	-0.8	-0.8	1.0
Had menopause	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2	0.3
Had other major operations	0.9	1.0	2.5	-0.9	-1.2	0.3	-0.6	-1.6
Forced vital capacity (FVC)	1.1	4.1	9.2	-2.3	-3.0	0.7	1.1	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.3	0.5	2.1	0.6	-1.4	-1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	0.9	-0.1	-0.5	0.1	0.4
Qualifications: None of the above	0.5	1.1	2.4	1.2	1.5	-1.4	-0.1	0.0
Financial difficulties in last 2 years	1.8	2.4	9.3	-1.1	-3.0	-1.0	-0.7	-0.0
Mouth/teeth dental problems	0.1	0.2	0.4	0.7	0.4	0.4	0.4	-0.3
Heart attack	0.3	0.3	0.8	0.8	0.3	-0.1	-0.9	-0.2
Allergy	0.2	0.6	2.2	-0.3	0.1	1.5	0.6	-0.4
Pain all over the body in last month	0.7	0.8	2.9	0.1	1.7	0.2	-0.3	-1.0
Diabetes (self-reported)	0.3	0.5	2.0	0.2	0.2	-0.2	1.4	-0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.1	-1.2	-0.4	-1.6	0.5	-2.0
Medication: Ramipril	0.5	0.6	3.0	0.2	-0.2	0.3	1.7	-0.4
Medication: Simvastatin	1.5	2.2	4.0	2.0	1.5	0.8	0.9	1.8
Fluid intelligence score	0.3	0.7	1.8	-1.3	0.0	-0.1	-0.2	-1.3
Illnesses of siblings	0.8	1.1	2.9	0.3	1.3	1.7	0.0	-1.0
Neuroticism score	0.5	0.9	2.1	-0.9	-1.5	-0.8	0.5	1.0
Weight	1.1	5.3	8.2	2.8	1.8	-1.8	-2.9	2.1
Impedance of arm (right)	0.1	0.6	1.4	-0.6	-1.2	-0.8	-0.2	-0.9
Arm fat percentage (right)	1.4	5.4	9.9	3.1	2.1	-1.6	-2.3	2.2
Trunk fat-free mass	0.2	1.3	4.0	0.6	0.0	-1.0	-2.0	1.0
Hip circumference	1.7	7.5	10.8	3.3	1.9	-1.7	-3.1	3.3
Time employed in main current job	2.5	2.9	5.5	2.3	1.8	-0.0	-1.4	1.9
Alcohol intake versus 10 years previously	0.6	1.0	2.6	-0.3	-1.6	-0.7	-1.2	0.3
Father’s age at death	1.1	1.5	3.5	-1.9	0.4	-1.7	-0.3	-0.9
Worrier / anxious feelings	0.6	1.2	2.2	-1.4	-1.5	-0.9	1.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.7	1.0	-1.3	-1.9	-0.2	1.8
Falls in the last year	1.9	2.6	4.3	2.0	-0.7	-1.2	-2.1	1.7
Hair/balding pattern: Pattern 3	2.0	2.9	12.7	-0.6	0.8	0.6	0.7	-3.6
Number of live births	0.5	0.7	2.7	0.1	0.0	0.3	-0.9	-1.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.6	-1.9	-2.6	0.9	0.6	-1.8
Pulse rate	0.5	0.8	2.5	0.6	0.9	-1.6	-0.7	-0.1
Happiness	0.6	0.8	2.5	0.1	-0.8	-0.8	-1.6	-0.0
Noisy workplace	0.6	0.7	2.0	0.3	1.4	0.5	-1.0	-0.0
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.6	-2.4	-2.0	0.1	1.1	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.5	0.3	-0.8	-1.6	0.1	1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	0.1	1.3	-0.8	0.4	1.0
Asthma	0.6	1.2	2.1	1.0	-0.7	-1.3	-1.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.1	2.2	0.5	-0.7	-1.5	1.5
Medication: Cholesterol lowering	1.7	2.7	4.6	2.1	1.7	1.6	0.4	1.8
Depression (self-reported)	1.4	1.7	5.3	-0.6	-1.7	-2.3	0.1	-0.0
Medication: Lansoprazole	0.5	0.6	2.8	-0.2	0.0	-1.7	0.1	0.3
Prospective memory result	1.3	1.6	2.7	1.3	1.5	1.6	0.7	1.0
Lung cancer (father)	0.5	0.6	1.3	0.8	0.5	0.9	0.1	-1.1
Illnesses of mother	0.4	0.5	1.1	-0.5	-0.4	-1.1	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	11.0	-2.5	-3.3	1.0	1.1	-1.6
Pulse wave Arterial Stiffness index	0.5	0.5	2.0	0.3	-1.4	0.6	0.4	-0.3
Impedance of arm (left)	0.2	1.1	1.9	-1.1	-1.4	-1.0	0.3	-1.2
Arm fat mass (right)	1.3	5.2	8.7	2.9	2.2	-1.5	-2.4	2.1
Trunk predicted mass	0.2	1.3	3.9	0.6	0.1	-1.1	-2.0	0.9
Standing height	0.2	2.0	3.2	-1.1	-1.1	-1.6	-1.8	-1.3
Length of working week for main job	1.4	1.6	2.4	1.5	1.5	1.3	-1.0	0.8
Exposure to tobacco smoke at home	1.0	1.1	2.5	1.5	0.6	-0.3	-1.6	0.7
Breastfed as a baby	1.7	2.2	5.3	-2.3	-1.6	-0.1	1.5	-0.8
Tense / ‘highly strung’	0.2	0.3	0.7	0.8	0.5	0.7	0.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.0	-0.8	-0.4	0.5	0.7
Hair/balding pattern: Pattern 4	1.7	4.0	8.7	-3.0	-1.8	0.4	0.6	-2.8
Birth weight of first child	0.4	0.7	2.1	-0.1	0.0	-0.8	-1.5	-0.8
Peak expiratory flow (PEF)	0.4	0.9	3.2	0.1	-0.1	1.8	0.1	-1.0
Pulse wave reflection index	0.8	1.0	2.2	0.2	-1.4	1.5	0.8	0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	1.0	-0.2	-0.4	-0.8	0.0
Loud music exposure frequency	0.5	0.6	1.8	0.6	1.3	0.1	0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.8	-1.6	-1.9	-0.4	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.2	-2.0	-1.7	-1.8	-0.2	-1.1
Blood clot in the leg (DVT)	0.3	0.4	1.1	1.0	-0.2	-0.3	-0.1	0.9
Medication: Paracetamol	3.4	5.6	16.3	2.5	-0.1	-0.6	-2.2	4.0
Headache pain in last month	2.3	3.9	10.4	1.9	-0.4	-1.2	-1.9	3.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.6	-1.0	-1.3	-0.1	-1.0	-1.2
Glaucoma (self-reported)	0.9	1.0	2.6	0.1	1.1	1.6	1.0	-0.7
Gout (self-reported)	0.4	0.6	2.5	-0.3	-0.5	1.6	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.5	0.2	-0.7	1.1	-0.1
Medication: Amlodipine	1.7	2.4	6.0	0.8	2.4	0.8	2.2	0.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.5	-0.9	-1.2	-1.6	0.2	-0.6
Birth weight	2.0	4.3	17.5	-0.4	-0.7	-4.2	-1.8	-0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.3	0.4	1.8	0.0	-0.9	-0.7
High blood pressure (siblings)	0.7	1.1	2.3	-1.1	-0.8	-1.5	0.0	1.1
Forced vital capacity (FVC), Best measure	1.5	5.5	13.6	-2.7	-3.7	0.4	1.5	-2.1
Body fat percentage	1.2	4.7	8.0	2.8	2.1	-1.9	-2.2	1.7
Leg fat percentage (right)	1.0	3.6	6.9	2.6	1.6	-1.1	-2.3	1.4
Arm fat-free mass (right)	0.2	1.3	3.0	1.0	0.8	-0.9	-1.7	0.9
Exposure to tobacco smoke outside home	0.7	1.0	2.5	-1.2	-1.6	-0.7	0.4	-0.6
Comparative body size at age 10	0.5	1.3	2.9	1.7	0.8	-0.8	-1.6	0.3
Number of full brothers	0.4	0.4	1.1	-0.9	0.1	-0.5	-0.1	-1.0
Worry too long after embarrassment	1.0	1.6	6.5	0.7	0.0	-0.3	-1.0	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.0	-1.0	-1.4	-1.0	1.1	-1.0
Wheeze or whistling in the chest in last year	0.9	1.7	3.2	1.5	-0.4	-1.8	0.0	1.6
Number of children fathered	0.8	0.9	3.6	-0.4	0.6	0.5	1.9	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.9	-1.0	0.5	2.2	0.7	-0.9
Age at first live birth	0.2	0.4	0.9	0.6	-0.7	0.2	-0.2	1.0
Pulse wave peak to peak time	0.5	0.5	1.5	-0.5	1.2	-0.8	-0.5	0.2
Health satisfaction	2.2	2.9	11.0	1.0	-0.6	-3.3	-1.4	0.2
Shortness of breath walking on level ground	1.4	1.7	4.2	0.7	0.3	-2.1	0.3	1.8
Qualifications: College or University degree	0.1	0.4	1.5	-0.1	0.2	0.4	-1.2	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.7	-0.3	-0.0	-1.3	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.1	1.4	1.1	-0.3	-0.5	-0.3
Emphysema/chronic bronchitis	1.8	2.0	5.2	2.3	0.5	-1.3	-1.5	1.0
Medication for pain relief, constipation, heartburn	2.2	3.7	6.8	-2.6	-0.7	2.3	0.9	-2.3
Neck or shoulder pain in last month	1.0	1.4	3.4	1.4	-0.2	-1.1	-1.8	0.4
Medication: Blood pressure	0.8	1.4	3.6	0.4	1.9	0.1	1.5	1.2
Angina (self-reported)	0.4	0.5	1.0	0.4	0.8	0.5	1.0	-0.9
Migraine (self-reported)	0.8	1.0	2.0	0.1	-1.4	-0.5	-1.3	1.0
Medication: Ibuprofen	1.8	2.2	5.4	2.3	1.0	-1.0	-1.3	1.3
Medication: Allopurinol	0.7	0.9	2.7	0.5	-0.6	1.6	0.0	1.1
Medication: Omeprazole	0.2	0.3	0.9	-0.5	0.0	-0.3	-1.0	0.1
Medication: Seretide 50 evohaler	0.7	0.8	1.9	1.0	-0.1	0.1	-1.1	1.4
Mean time to correctly identify matches	0.2	0.5	0.9	-0.6	-1.0	-0.9	0.5	-0.2
Heart disease (mother)	0.7	0.8	3.1	0.3	-0.5	1.8	0.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.3	0.6	0.9	1.8	1.4	-0.3
Whole body fat mass	1.2	5.2	7.3	2.7	1.8	-2.1	-2.7	1.9
Leg fat mass (right)	1.2	4.5	7.3	2.7	1.7	-2.0	-2.4	1.6
Arm predicted mass (right)	0.3	1.7	4.5	1.0	0.8	-1.1	-2.1	1.0
Pulse rate, automated reading	0.3	1.1	1.6	0.1	1.2	-1.1	-1.2	-0.9
Alcohol intake frequency.	0.4	1.0	2.2	1.5	1.0	0.6	-1.1	0.7
Comparative height size at age 10	0.3	1.4	5.2	0.5	-0.8	-1.0	-2.3	-0.2
Number of full sisters	0.9	1.1	2.6	1.6	1.3	0.6	-0.6	0.7
Suffer from ‘nerves’	1.0	1.5	2.5	-0.1	-1.5	-1.6	0.7	1.6
Overall health rating	0.9	2.0	4.0	1.5	-0.3	-2.0	-1.3	1.4
Chest pain or discomfort	1.3	1.9	4.2	2.1	1.5	-0.5	0.2	1.7
Had major operations	0.8	1.0	1.9	-1.2	-1.4	-1.2	-0.3	-0.3
Age at last live birth	0.6	0.9	1.8	1.0	-0.9	-0.0	-0.9	1.4
Family relationship satisfaction	0.2	0.3	0.6	0.0	-0.8	-0.7	0.4	-0.4
Leg pain on walking	1.1	1.4	2.3	1.5	0.4	-1.5	-1.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.6	9.4	0.6	1.2	3.1	0.5	-1.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.3	1.3	1.4	0.5	1.8	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.8	0.2	0.9	1.3	-0.1	-1.2
Medication: Aspirin	1.4	1.9	4.7	2.2	1.5	-1.4	0.6	0.3
Supplements: Vitamin C	0.5	0.6	0.9	-0.9	-0.8	0.7	-0.0	-0.9
Knee pain experienced in last month	1.1	1.8	4.3	2.1	0.4	0.3	-0.6	2.0
Hypertension (Self-reported)	1.0	2.9	10.0	-1.3	1.2	-0.6	3.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.5	-1.6	-0.9	-1.4	0.3	0.4
Illnesses of father: Heart disease	0.5	0.7	1.6	0.3	1.3	0.8	1.0	-0.6
Illnesses of siblings: Diabetes	0.9	1.2	2.3	-1.0	-1.5	-0.9	-0.9	-1.0
Smoking status: Previous	2.1	3.2	6.8	-2.0	-0.1	-0.4	2.2	-2.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.6	0.1	-1.6	0.6	0.6	0.9
Whole body fat-free mass	0.4	2.1	5.2	1.2	0.5	-1.4	-2.3	1.3
Leg fat-free mass (right)	0.5	2.9	5.0	1.7	0.7	-1.9	-2.2	1.6
Arm fat percentage (left)	1.2	4.8	8.7	3.0	2.0	-1.7	-2.1	2.0
Average weekly red wine intake	0.6	0.9	3.1	-1.8	0.1	0.3	0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.1	1.5	0.3	0.3	0.9	1.4
Mood swings	0.5	0.9	2.7	0.2	-0.6	-0.9	-1.6	0.8
Loneliness, isolation	0.6	0.8	1.8	0.6	-0.7	-1.1	-1.4	0.1
Long-standing illness, disability or infirmity	0.6	0.9	3.6	0.8	-0.1	-1.9	0.8	-0.0
Ever had bowel cancer screening	3.1	3.6	8.3	-2.9	-2.3	-0.9	1.0	-1.6
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.0	-0.0	-0.6	1.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.8	-0.3	0.1	1.7	0.3	0.7
Friendships satisfaction	0.5	0.6	1.9	-0.6	-1.4	-0.7	0.2	-0.5
Qualifications: nursing, teaching	0.8	1.3	2.5	-1.2	-1.0	-0.5	1.6	-1.0
Commuting to job workplace: Walk	1.0	1.1	2.6	-0.6	-0.8	-1.1	-1.6	-0.8
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.1	-0.0	0.3	0.8	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.5	-0.9	-1.9	0.4	-0.4	0.0
Medication for cholesterol	0.8	1.2	3.3	0.7	-0.3	-0.4	-1.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	6.4	1.1	-0.6	-0.8	-2.5	-0.5
Back pain experienced in last month	1.4	2.1	4.6	-0.3	-2.1	-2.0	0.8	1.0
Mineral and other dietary supplements	1.0	1.4	2.8	0.5	1.3	1.7	1.5	0.2
Breast cancer (self-reported)	0.1	0.2	0.4	0.2	0.5	-0.3	-0.1	0.6
Asthma (self-reported)	0.6	1.2	2.0	1.0	-0.8	-1.3	-1.4	0.8
Osteoporosis (self-reported)	1.0	1.3	3.8	1.9	0.5	-0.9	-0.3	1.2
Osteoarthritis (self-reported)	0.7	0.8	2.0	-0.3	-1.4	-1.4	-0.4	0.1
Medication: Aspirin	1.7	2.2	5.5	2.4	1.8	-1.3	0.7	0.3
Medication: Gliclazide	1.0	1.1	2.7	-1.6	-0.5	0.6	0.0	-1.4
Illnesses of father: None of the above (group 1)	0.4	0.4	1.9	-0.3	-0.4	0.1	-0.1	-1.4
Smoking status: Current	0.5	0.9	2.3	0.4	0.9	0.5	-0.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	10.9	-3.3	-3.1	-0.4	0.2	-1.8
Whole body water mass	0.4	2.0	4.7	1.2	0.6	-1.4	-2.2	1.4
Leg predicted mass (right)	0.6	2.9	5.4	1.7	0.7	-1.8	-2.3	1.7
Arm fat mass (left)	1.2	5.0	8.6	2.9	1.9	-1.4	-2.4	2.2
Number of self-reported non-cancer illnesses	0.8	1.4	6.5	0.1	-0.6	-2.5	0.2	0.4
Average weekly champagne plus white wine intake	0.5	0.7	1.3	-0.2	-0.6	0.8	1.1	-1.1
Miserableness	0.7	1.2	3.2	-0.7	-1.1	-1.0	0.0	1.8
Guilty feelings	0.2	0.3	0.7	0.3	-0.3	-0.8	-0.9	0.1
Wears glasses or contact lenses	0.7	0.8	2.7	-0.4	0.1	0.1	-1.1	-1.6
Ever taken oral contraceptive pill	0.3	0.3	1.0	0.1	0.7	-0.2	1.0	-0.0
Hearing aid user	1.7	2.0	4.0	1.7	0.4	0.6	-1.5	2.0
Mother’s age at death	0.8	1.0	2.9	-1.7	-0.5	-0.8	-0.3	-1.1
Financial situation satisfaction	0.6	0.7	1.7	0.8	-0.3	-0.8	-1.3	0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	1.0	-0.0	0.5	0.2	1.4
Commuting to job workplace: Public transport	0.9	1.1	2.4	-1.5	-1.4	-1.0	-0.0	-0.1
Eye problems/disorders: Glaucoma	1.3	1.5	4.3	-0.4	0.1	2.1	1.7	-0.4
Medication: Blood pressure	1.6	3.1	7.1	-2.0	0.8	0.1	2.7	-2.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.8	-0.6	-1.3	-0.7	-0.8	-0.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.6	-1.0	-0.5	-1.2	-1.0	-1.2
High cholesterol (Self-reported)	1.1	1.9	5.3	1.5	1.3	2.3	0.4	0.6
Medication: Bendroflumethiazide	1.9	2.8	8.2	-2.9	-0.5	-1.6	1.3	-1.3
Medication: Paracetamol	3.0	4.6	14.3	2.6	0.3	-0.9	-1.1	3.8
Medication: Lisinopril	1.5	1.9	5.7	-1.5	-0.5	-0.2	2.4	-1.2
Medication: Atorvastatin	0.2	0.3	0.6	-0.4	-0.8	0.6	-0.2	-0.5
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.7	0.6	0.1	-0.0	-0.3
Alcohol drinker status: Never	2.2	2.6	4.9	2.1	1.4	1.2	-2.2	0.4
Ever smoked	1.0	1.8	3.5	-0.8	1.6	1.2	1.9	-0.7
Basal metabolic rate	0.5	2.7	6.2	1.5	0.7	-1.5	-2.5	1.4
Leg fat percentage (left)	1.0	3.8	8.0	2.8	1.4	-1.1	-2.2	1.7
Arm fat-free mass (left)	0.5	2.4	5.7	1.5	0.7	-1.3	-2.4	1.4
Number of operations (self-reported)	0.3	0.4	1.1	-0.1	0.2	0.5	-0.7	-1.1
Average weekly beer plus cider intake	0.1	0.2	0.7	0.3	-0.4	0.8	-0.3	-0.0
Irritability	0.7	1.2	2.0	-1.4	0.0	-1.4	1.4	-0.6
Risk taking	0.1	0.2	0.6	-0.1	0.7	0.0	0.4	0.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.5	-0.0	-0.5	-1.5	1.6	-0.9
Fractured/broken bones in last 5 years	0.9	1.2	2.5	0.8	1.6	-0.7	-1.3	0.8
Age started oral contraceptive pill	2.3	2.9	5.0	-1.9	-1.3	-2.2	1.3	-1.5
Diastolic blood pressure, automated reading	0.9	2.7	7.3	0.5	2.7	1.1	1.3	-1.7
Ever depressed for a whole week	0.4	0.5	1.7	0.8	1.3	-0.3	-0.4	0.3
Unable to work because of sickness or disability	2.1	2.7	6.6	2.5	0.2	-0.0	-2.6	0.8
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.2	0.8	0.9	0.3	1.0
Myopia	0.2	0.2	0.7	-0.2	-0.4	0.2	-0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.9	1.2	-1.5	0.9	-2.2	1.1
Cholesterol lowering medication	0.3	0.5	1.1	0.2	0.6	1.1	0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.6	1.2	1.6	0.3	-1.2	0.8
Pain experienced in last month	1.1	1.9	4.4	-1.2	0.9	1.4	2.1	-0.7
Supplements: Calcium	0.7	0.7	1.4	-0.6	-1.2	-0.6	0.9	-0.8
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	0.8	1.6	1.4	1.0	0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.9	0.3	0.2	-0.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	1.1	-0.1	-0.4	-0.5	0.9
Heart disease (siblings)	0.5	0.6	2.0	0.1	-0.7	0.3	1.4	0.5
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.1	0.6	-0.8	0.5	-0.6
Pack years of smoking	3.5	5.2	10.3	3.2	2.1	1.2	-1.3	2.8
Impedance of whole body	0.3	1.3	2.5	-1.3	-1.4	-0.3	0.5	-1.6
Leg fat mass (left)	1.3	5.0	8.1	2.9	1.8	-2.0	-2.5	1.9
Arm predicted mass (left)	0.4	2.2	5.3	1.4	0.7	-1.0	-2.3	1.5