TWAS
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Models
Genes
Traits
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Traits
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Blood Platelet Count
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chr10:29,603,847-31,102,564
Best TWAS P=2.14e-22 · Best GWAS P=1.41e-23 conditioned to 1
29.6M
29.8M
30M
30.2M
30.4M
30.6M
30.8M
31M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells Transformed fibroblasts
KIAA1462
0.36
0.26
lasso
6
0.25
1.6e-18
-9.7
-9.7
2.1e-22
0.97
0.04
0.96
TRUE
1
GTEx
Artery Aorta
KIAA1462
0.23
0.11
lasso
5
0.14
4.4e-08
-6.6
7.4
1.5e-13
-0.29
0.88
0.08
TRUE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
KIAA1462
0.15
0.02
blup
112
0.02
4.8e-02
-6.9
8.4
4.5e-17
-0.69
0.01
0.63
FALSE