Hub : Genes

KIAA1462

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2270	0.0580	1.8e-05	0.108	NA	0.133	NA	0.139	1.6e-06	NA	8.8e-08	NA	4.4e-08
2	GTEx	Brain Caudate basal ganglia	0.4710	0.1270	4.6e-03	0.153	NA	0.048	NA	0.133	3.7e-05	NA	1.7e-02	NA	1.2e-04
3	GTEx	Cells Transformed fibroblasts	0.3560	0.0540	2.6e-13	0.265	NA	0.231	NA	0.247	5.8e-20	NA	2.5e-17	NA	1.6e-18
4	TCGA	Breast Invasive Carcinoma	0.0458	0.0181	8.0e-05	0.003	0.021	0.005	NA	0.005	6.9e-02	2.5e-05	3.3e-02	NA	2.9e-02
5	TCGA	Pheochromocytoma and Paraganglioma	0.1480	0.0720	6.6e-03	0.016	0.021	-0.004	NA	0.010	7.3e-02	4.8e-02	5.1e-01	NA	1.2e-01
6	TCGA	Thyroid Carcinoma	0.0980	0.0410	1.4e-04	0.057	0.054	0.029	NA	0.057	3.1e-06	5.9e-06	7.4e-04	NA	3.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.5	2.4	3.9	-1.6	1.3	2.0	-1.5	-0.1	2.0
Bipolar Disorder or Schizophrenia	0.9	2.1	10.6	-0.8	0.6	0.5	-0.8	0.6	3.3
Depressed Affect (Nagel 2018)	0.8	1.7	5.5	-1.6	1.3	0.2	-0.4	-0.4	2.4
Depression (Nagel 2018)	0.4	0.6	1.5	-0.9	0.4	0.6	-0.2	-0.9	1.2
Intelligence (Savage-Jansen 2018)	1.4	4.2	10.5	0.8	-2.8	-3.2	-0.4	1.9	-1.4
Neuroticism (Nagel 2018)	0.5	1.1	3.3	-1.1	0.6	0.9	-0.1	-0.9	1.8
Schizophrenia (2018)	0.7	1.4	6.6	0.3	-0.3	-1.0	0.2	0.8	2.6
Schizophrenia vs Biploar Disorder	1.7	2.3	5.7	2.4	-1.2	-1.6	1.4	1.4	-0.3
Worry (Nagel 2018)	0.9	1.9	4.0	-1.1	0.8	2.0	0.4	-1.2	1.9
Alzheimer’s Disease (in mother)	1.1	1.2	2.9	-1.3	1.7	0.8	-1.2	-0.7	0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.3	-0.7	0.6	0.4	-0.4	0.5	1.5
Alzheimer’s Disease (including proxy)	1.5	2.2	3.7	-1.8	1.9	0.9	-1.3	-0.5	1.8
Crohns Disease (2017)	0.2	0.5	0.9	0.9	-0.4	-0.9	-0.3	0.5	0.8
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	1.3	-0.4	-1.5	-1.2	0.6	1.0
Ulcerative Colitis (UC)	0.5	0.8	2.5	1.1	0.3	-0.7	-1.6	0.0	0.9
Major Depression (MDD)	1.0	1.2	2.4	-0.9	0.9	-1.2	-1.5	-0.4	1.4
Reaction Time	0.2	0.4	1.3	1.2	-0.3	-0.6	0.2	0.7	-0.3
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.4	0.7	-2.1	-2.9	-1.0	2.4	-1.0
Breast Cancer	0.4	0.9	2.8	-1.7	-0.4	0.3	-0.8	-1.1	0.4
Ovarian Cancer	0.3	0.4	1.5	1.2	-0.0	-0.3	0.7	0.5	0.2
Prostate Cancer	0.1	0.1	0.4	-0.6	-0.0	0.0	-0.3	0.1	0.6
Age at First Birth	0.6	0.8	2.2	-1.5	-0.7	1.3	-0.1	-0.7	-0.4
Bipolar Disorder (2011)	0.6	0.5	1.0	0.3	-0.8	1.0	0.7	0.9	-0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	0.1	0.5	0.7	0.2	0.5	-0.0
Coronary Artery Disease (CAD)	5.3	6.3	13.3	3.6	-2.6	-2.7	0.8	2.8	-1.3
Crohns Disease (2012)	0.1	0.2	1.0	-0.0	0.2	-0.2	-0.4	-0.1	1.0
Mean Putamen Volume	1.5	1.7	3.3	1.2	-1.8	0.9	1.8	0.1	-1.1
Fasting Glucose	0.6	0.7	1.6	0.7	1.0	-0.0	-1.3	0.9	-0.3
HbA1C	0.4	0.5	2.2	1.5	0.5	0.4	0.4	0.1	-0.2
HDL Cholesterol	0.6	1.0	2.0	-1.4	-1.0	-1.0	-1.2	0.6	0.7
LDL Cholesterol	0.2	0.3	1.0	0.4	0.2	-1.0	-0.4	0.7	-0.1
Lupus	0.4	0.6	1.6	0.1	-0.9	0.0	0.8	1.3	-0.8
Neuroticism (2016)	0.9	1.2	4.1	0.1	0.3	0.7	-0.8	-1.5	2.0
Primary Biliary Cirrhosis	0.8	1.2	3.0	0.9	1.7	0.6	-1.7	0.2	0.1
Rheumatoid Arthritis	3.1	4.3	8.0	-1.9	1.9	1.9	-1.5	-2.8	2.1
Schizophrenia (2014)	1.0	2.2	9.2	0.2	0.6	-1.0	-0.9	1.4	3.0
Triglycerides	0.3	0.5	1.4	0.9	1.0	1.2	-0.0	0.0	0.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	8.4	0.4	1.8	-0.5	-0.7	-0.2	2.9
Ulcerative Colitis	0.4	0.6	1.6	0.7	0.3	-1.3	-0.8	-0.1	1.0
Blood Eosinophil Count	0.4	3.4	10.6	0.6	-1.5	-2.6	0.1	3.2	-0.8
Blood Platelet Count	3.8	43.8	94.7	7.4	-4.1	-9.7	3.8	8.4	-3.5
Blood Red Count	1.2	11.7	19.4	-4.1	4.1	1.5	-4.4	-0.8	3.8
Blood White Count	1.1	8.2	25.0	1.8	-0.2	-5.0	-0.2	4.6	0.2
Heel T-Score	1.2	9.7	17.6	2.1	-4.2	-4.0	2.6	2.6	-2.6
BMI	0.6	3.3	12.2	0.5	2.3	3.5	1.5	-0.3	-0.2
Height	0.6	11.9	44.2	-0.5	-3.8	-6.7	-1.5	3.1	-0.7
Waist Hip Ratio (WHR)	1.5	6.6	13.8	-1.6	2.2	-0.0	-3.3	-2.7	3.7
Systolic Blood Pressure	1.2	5.9	12.2	3.5	-1.4	-3.2	1.9	1.7	-2.2
Smoking Status	1.5	3.7	8.5	2.6	-1.3	-0.4	2.9	1.8	-1.2
Allergy or Eczema	0.6	1.7	5.3	-0.4	1.7	-0.1	-1.1	-0.8	2.3
Cardiovascular Disease	0.4	1.2	3.0	0.5	0.7	-1.2	-0.6	1.7	-1.2
Hypothyroidism (self reported)	1.5	3.4	5.1	-1.6	2.2	2.2	-1.8	-2.0	1.0
Respiratory disease	0.3	0.7	1.6	-0.2	0.9	-1.0	0.7	0.3	1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.8	-0.1	0.9	0.1	0.3	-0.2	-0.5
Lung FEV1/FVC ratio	1.1	5.8	17.8	1.1	-1.5	3.0	-0.1	-2.1	-4.2
Lung FVC	1.1	5.8	15.7	-2.4	0.8	4.0	-0.2	-3.6	0.6
Neuroticism	1.0	2.3	5.9	-1.1	0.4	1.6	0.3	-2.1	2.4
Chronotype (morning person)	0.2	0.4	1.0	0.3	-1.0	-0.6	-1.0	-0.3	0.3
Hair Pigment	0.0	1.1	3.3	0.1	-0.9	1.3	1.8	-0.7	0.8
Tanning	0.1	1.1	3.6	0.1	-0.9	0.4	1.9	0.4	-1.4
Hand grip strength (left)	0.6	1.6	3.8	-1.8	1.9	0.6	-0.7	0.1	1.3
Number of treatments/medications taken	0.3	0.5	1.3	0.4	-0.2	-0.7	-1.1	0.5	-0.9
Average weekly spirits intake	0.5	0.6	1.8	-0.1	1.0	0.5	0.0	-0.6	1.3
Sensitivity / hurt feelings	0.4	0.7	2.4	-1.5	0.0	-0.4	-0.4	-0.3	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.1	-0.7	0.7	1.1	-1.4	-1.3	0.5
Hearing difficulty/problems: Yes	1.0	1.5	6.0	1.1	-0.2	-1.3	0.2	2.4	-0.1
Relative age of first facial hair	0.7	1.4	3.3	-1.4	0.1	1.8	0.0	-1.1	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.7	0.8	-0.1	1.6	0.3	-0.5	-0.6
Ever used hormone-replacement therapy (HRT)	2.3	2.9	9.0	3.0	-0.7	-2.4	0.1	1.5	-0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	0.8	0.2	0.3	0.8	1.1	-0.1
Systolic blood pressure, automated reading	2.0	5.8	16.4	4.0	-1.3	-1.7	2.7	1.2	-2.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.0	-0.5	0.8	1.4	-0.1	0.0	-0.5
Angina	4.0	5.2	10.4	3.2	-1.1	-2.1	0.8	2.1	-3.2
Medication for hormone replacement therapy	1.2	1.3	4.8	2.2	-0.8	-1.0	0.8	0.2	-0.9
Vitamin and mineral supplements	2.0	2.6	6.8	-0.2	-1.3	-2.3	0.2	2.6	-1.3
Supplements: Zinc	0.6	0.7	2.1	-0.4	0.3	0.1	-1.4	-1.1	0.7
Medication: Co-codamol	0.6	0.7	1.6	-1.1	0.9	0.6	-1.3	-0.2	0.3
Medication: Metformin	0.5	0.8	3.1	-0.2	1.8	-0.1	-0.5	1.1	0.0
Diabetes (father)	0.3	0.3	1.6	-1.3	-0.2	0.4	0.1	0.4	-0.4
Diabetes (mother)	1.0	1.3	3.8	-0.4	1.2	1.2	-0.1	-2.0	0.8
Severe depression (siblings)	0.4	0.4	1.2	0.8	-0.1	-0.5	1.1	0.6	-0.3
Pack years adult smoking proportion	0.4	0.7	2.3	-0.8	1.5	0.8	0.4	-0.5	0.1
Impedance of leg (right)	0.8	3.6	7.4	-1.1	1.4	-2.6	-2.2	0.1	2.7
Leg fat-free mass (left)	0.1	0.5	0.9	-0.3	0.1	0.9	0.8	0.8	-1.0
Trunk fat percentage	0.2	1.0	3.7	1.9	1.1	0.4	0.2	0.9	-0.4
Hand grip strength (right)	0.1	0.4	1.2	-0.1	1.1	-0.7	0.6	0.4	0.4
Townsend deprivation index at recruitment	0.6	0.9	1.3	0.9	-0.4	-0.9	1.1	1.1	-1.0
Current tobacco smoking	0.2	0.4	1.2	-0.1	0.9	0.5	0.2	-0.3	1.1
Average weekly fortified wine intake	0.5	0.6	2.4	0.5	-1.1	0.1	-0.1	0.0	-1.5
Maternal smoking around birth	1.6	2.4	6.8	1.0	-0.9	-2.0	2.6	1.2	-0.6
Fed-up feelings	0.8	1.4	3.5	-0.9	1.9	1.0	0.1	-0.7	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	-0.6	1.1	0.4	-0.4	-1.3	0.8
Relative age voice broke	0.6	0.9	2.3	-1.5	0.2	1.1	-0.9	-0.1	1.0
Taking other prescription medications	0.3	0.4	1.6	0.1	0.8	-0.4	-0.2	0.3	-1.3
Age when periods started (menarche)	0.9	2.2	5.8	1.6	1.7	1.0	0.1	-0.9	2.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.9	0.1	1.7	0.8	0.1	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	11.9	0.9	-3.5	-2.1	1.4	1.8	-2.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.9	0.3	-0.1	-0.1	1.7	1.1	0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.5	-0.6	1.1	0.4	1.2	0.0	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.9	0.0	-0.3	0.4	-0.0	-0.4	-0.9
High blood pressure	0.3	0.7	2.2	0.6	-0.2	-0.8	-0.3	1.0	-1.5
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.3	-0.1	1.3	-0.0	-1.8	-1.1	2.5
Multivitamins +/- minerals	0.6	0.8	2.8	0.8	0.3	1.0	0.2	-1.7	0.6
Stomach or abdominal pain in last month	0.7	0.9	2.1	0.3	-1.2	-1.5	0.8	0.7	0.5
Supplements: Glucosamine	0.8	1.1	2.3	-0.8	1.5	0.5	-1.3	-0.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.2	-0.4	1.5	0.8	-0.2	0.6	0.2
Medication: Atenolol	1.4	1.7	3.9	0.1	-1.1	-1.1	0.4	2.0	-1.9
Medication: Levothyroxine sodium	1.0	1.8	3.8	0.0	1.9	0.1	-1.8	-1.5	1.3
Sitting height	0.8	5.8	18.4	-1.9	-1.7	-4.3	-0.7	3.0	0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	-0.1	-0.9	0.8	0.9	0.8	1.2
High blood pressure (mother)	1.1	1.5	3.2	1.3	-0.2	-0.6	1.8	1.2	-1.6
Body mass index (BMI)	0.4	1.7	3.3	1.8	1.1	1.5	1.2	1.0	-1.1
Impedance of leg (left)	0.6	3.0	7.4	-0.7	1.1	-2.7	-2.2	0.2	2.1
Leg predicted mass (left)	0.1	0.5	0.8	-0.3	0.2	0.9	0.8	0.9	-0.9
Trunk fat mass	0.2	0.8	2.5	1.6	0.9	0.3	0.3	1.1	-0.5
Waist circumference	0.3	1.1	3.1	1.6	1.8	0.2	-0.5	0.9	0.2
Number of incorrect matches in round	0.5	0.8	1.8	-1.1	1.3	0.2	-0.9	-0.2	1.0
Past tobacco smoking	2.7	4.9	11.1	-3.3	1.9	0.9	-3.0	-1.4	1.7
Alcohol usually taken with meals	0.8	1.2	2.9	-0.8	-1.7	0.8	1.1	0.8	-1.2
Nervous feelings	0.9	1.7	4.8	-0.5	0.2	2.2	2.0	-1.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.0	0.1	0.3	-0.1	-0.7	-0.2	1.7
Hearing difficulty/problems with background noise	1.2	2.0	4.4	1.4	-1.9	-1.2	-0.5	2.1	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.2	0.2	-0.3	0.5	-0.5	-0.2
Had menopause	0.1	0.2	0.4	0.4	-0.4	0.1	-0.5	-0.3	-0.6
Had other major operations	0.2	0.3	1.0	1.0	-0.1	0.1	0.2	-0.7	0.3
Forced vital capacity (FVC)	0.8	3.0	12.5	-3.5	0.7	0.3	-0.9	-2.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.7	0.6	-2.4	-1.6	1.2	1.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.6	0.6	1.6	0.2	0.9	0.2	-0.4
Qualifications: None of the above	0.8	1.7	3.7	-1.4	1.9	1.1	-0.3	-0.2	1.9
Financial difficulties in last 2 years	1.2	1.7	4.3	-0.1	2.1	1.6	0.3	-1.1	1.4
Mouth/teeth dental problems	0.3	0.5	1.3	-0.4	1.1	-0.5	-0.6	-0.8	0.6
Heart attack	0.7	0.9	3.4	0.8	0.3	-0.8	-0.3	1.8	-0.9
Allergy	0.7	1.6	4.2	0.3	-1.6	0.1	1.5	0.1	-2.0
Pain all over the body in last month	1.0	1.1	4.1	-2.0	0.7	-0.0	0.6	0.1	1.3
Diabetes (self-reported)	0.1	0.2	0.4	0.3	0.5	-0.7	-0.0	-0.2	-0.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.3	-0.6	0.8	-0.6	-1.8	0.6	1.8
Medication: Ramipril	4.0	5.1	11.1	2.1	-2.2	-2.7	0.5	1.4	-3.3
Medication: Simvastatin	3.1	4.6	8.2	1.6	-2.2	-2.6	0.2	2.9	-2.4
Fluid intelligence score	1.1	2.4	4.2	0.3	-1.9	-1.9	0.2	2.1	-1.7
Illnesses of siblings	2.1	3.0	7.4	-1.5	0.2	1.1	-1.4	-2.2	2.7
Neuroticism score	1.0	2.2	6.4	-1.2	0.8	1.1	0.3	-1.8	2.5
Weight	0.1	0.7	2.4	0.8	0.7	0.2	0.5	1.5	-0.7
Impedance of arm (right)	0.2	1.1	3.2	-1.0	-0.6	-1.8	-1.4	-0.4	0.3
Arm fat percentage (right)	0.4	1.4	3.8	1.9	1.1	1.2	0.9	0.6	-0.8
Trunk fat-free mass	0.1	0.5	1.8	-0.9	-0.3	-0.2	0.4	1.3	-0.3
Hip circumference	0.8	3.2	7.2	2.3	-0.0	-1.0	1.4	2.7	-2.0
Time employed in main current job	0.3	0.3	1.0	0.3	-0.2	-0.4	-0.3	1.0	-0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.4	1.2	0.3	0.7	0.3	-1.2	0.4
Father’s age at death	4.0	5.3	12.0	-3.5	0.3	1.8	-2.6	-2.5	2.0
Worrier / anxious feelings	2.8	5.3	9.4	-3.1	1.4	2.4	-1.2	-2.8	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.9	-1.3	1.4	0.1	-1.7	0.4	1.7
Falls in the last year	2.5	3.4	8.2	-2.9	1.8	1.9	-0.9	-1.4	1.6
Hair/balding pattern: Pattern 3	1.1	1.7	4.0	2.0	0.1	-2.0	-0.7	1.3	0.3
Number of live births	2.6	3.7	5.8	-2.4	2.4	2.1	-1.2	-1.3	1.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.4	-2.7	0.2	1.0	-0.8	-2.3	-1.1
Pulse rate	2.1	3.6	6.7	-1.1	2.2	1.4	-0.9	-2.6	2.4
Happiness	0.9	1.1	2.0	1.4	-0.3	0.8	1.3	-0.5	-1.4
Noisy workplace	4.0	4.9	18.1	-4.2	2.2	0.5	-1.7	-1.1	1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.8	0.7	-1.7	-0.2	-0.5	-0.1	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.2	0.6	0.0	-0.8	0.8	1.0
Mouth/teeth dental problems: Dentures	1.0	1.6	2.7	0.7	-1.6	0.2	1.6	1.2	-1.5
Asthma	0.7	1.3	2.7	-1.0	1.6	-0.7	-0.3	1.0	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.0	-1.1	1.4	-0.9	-0.9	0.5	1.2
Medication: Cholesterol lowering	1.4	2.2	4.9	1.9	-1.2	-1.5	0.4	2.2	-1.1
Depression (self-reported)	1.1	1.4	4.6	0.3	1.0	2.1	-0.5	-1.4	-0.6
Medication: Lansoprazole	0.3	0.3	0.7	0.9	0.5	0.5	0.8	-0.3	-0.1
Prospective memory result	0.2	0.2	0.9	1.0	0.3	0.1	0.2	-0.2	-0.3
Lung cancer (father)	0.5	0.6	2.0	0.7	0.6	-0.1	0.3	1.4	0.7
Illnesses of mother	1.1	1.4	3.1	-1.3	0.5	1.2	-0.5	-1.8	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.0	-2.0	-0.3	1.8	0.1	-2.0	-1.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.8	1.7	-0.6	-0.5	0.1	-0.0	-0.4
Impedance of arm (left)	0.3	1.3	2.0	-1.4	-0.2	-1.3	-1.3	-1.2	0.9
Arm fat mass (right)	0.3	1.2	2.9	1.7	0.9	0.7	0.8	1.3	-0.7
Trunk predicted mass	0.1	0.5	2.0	-0.9	-0.3	-0.3	0.4	1.4	-0.3
Standing height	0.3	2.9	7.5	-2.1	-0.8	-2.7	-1.6	1.2	0.8
Length of working week for main job	1.5	1.6	5.4	-1.4	0.9	0.6	-2.3	-0.3	1.0
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.4	0.8	-0.6	0.7	1.3	1.3
Breastfed as a baby	0.9	1.1	4.1	0.3	-2.0	-0.5	0.5	1.3	-0.6
Tense / ‘highly strung’	0.5	0.8	2.5	0.1	0.8	0.1	-0.5	-1.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	0.5	1.1	-0.5	-0.4	1.2	0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	-1.3	-1.0	-0.5	-0.4	0.4	0.1
Birth weight of first child	0.8	1.5	4.2	0.6	0.1	2.0	1.8	-0.9	-0.4
Peak expiratory flow (PEF)	6.4	14.9	52.8	-7.3	2.5	2.9	-2.7	-3.8	0.4
Pulse wave reflection index	0.2	0.3	0.7	0.7	0.5	-0.4	-0.1	-0.4	0.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.7	0.4	-0.7	0.2	0.2	1.6	-1.3
Loud music exposure frequency	0.6	0.6	1.2	0.9	0.0	0.8	1.1	-0.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.0	1.4	-0.7	-0.2	0.1	-0.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.8	-0.4	0.4	0.2	-0.7	-0.4
Blood clot in the leg (DVT)	0.4	0.5	1.7	-0.5	0.5	0.4	-0.9	0.1	-1.3
Medication: Paracetamol	0.5	0.8	2.2	-0.7	1.1	0.9	-0.1	0.6	1.5
Headache pain in last month	0.3	0.5	1.2	-0.8	-0.6	-1.1	-0.1	0.9	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	-1.4	0.8	0.3	-0.4	-1.4	0.4
Glaucoma (self-reported)	1.1	1.3	3.6	-0.1	-1.1	-0.7	0.9	1.1	-1.9
Gout (self-reported)	0.5	0.7	2.5	-0.6	0.3	1.1	0.4	-1.6	-0.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.6	5.9	-1.0	2.1	1.3	-1.7	-2.4	0.5
Medication: Amlodipine	2.4	3.3	6.3	2.5	-1.1	-0.3	2.5	1.3	-2.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	-0.4	0.5	-1.0	-0.5	0.4	0.3
Birth weight	1.0	2.2	7.7	0.2	0.7	2.8	0.9	-2.0	0.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.8	0.1	0.4	-1.9	-0.6	1.5	1.2
High blood pressure (siblings)	1.5	2.2	5.3	1.2	-0.5	-1.2	1.2	1.8	-2.3
Forced vital capacity (FVC), Best measure	0.5	1.8	5.8	-2.4	-0.0	1.2	0.4	-1.8	-0.5
Body fat percentage	0.3	1.3	4.6	2.1	1.4	0.6	0.3	0.7	-0.3
Leg fat percentage (right)	0.4	1.6	4.5	2.1	1.9	0.5	0.3	1.1	0.2
Arm fat-free mass (right)	0.1	0.3	1.5	-0.2	0.2	-0.1	0.5	1.2	-0.4
Exposure to tobacco smoke outside home	0.5	0.7	2.3	0.9	0.2	0.3	1.5	0.4	-0.9
Comparative body size at age 10	0.4	1.2	5.1	-0.2	-2.3	-0.0	-0.7	0.4	-1.1
Number of full brothers	0.5	0.7	1.1	-0.0	1.1	0.7	1.0	0.7	0.9
Worry too long after embarrassment	1.0	1.6	3.6	-1.5	0.1	1.5	-0.0	-1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.3	1.8	-0.5	-1.4	0.2	1.7	-1.1
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	0.4	-0.0	-0.7	0.6	1.4	0.1
Number of children fathered	2.7	3.1	6.4	-1.8	1.4	0.9	-2.5	-0.8	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	4.0	1.2	-1.0	-2.0	1.4	0.8	-0.3
Age at first live birth	0.2	0.4	0.9	-0.6	-0.3	0.5	-0.8	-1.0	-0.3
Pulse wave peak to peak time	0.7	0.8	4.0	-2.0	0.5	0.3	-0.1	0.5	0.4
Health satisfaction	0.5	0.7	1.3	0.9	1.0	1.1	0.8	-0.3	-0.4
Shortness of breath walking on level ground	1.3	1.5	4.6	2.1	-0.1	1.1	1.4	-0.6	-0.9
Qualifications: College or University degree	0.8	2.4	4.4	1.2	-2.1	-2.1	-0.6	0.9	-1.8
Eye problems/disorders: None of the above	1.0	1.1	2.7	-0.2	0.1	0.7	-1.1	-1.6	1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.6	-0.1	0.7	1.1	0.6	-1.0
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.3	0.8	-0.5	0.2	0.8	0.9
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	-0.0	-0.2	-0.1	0.2	-0.4	-0.5
Neck or shoulder pain in last month	1.5	2.2	5.1	-1.4	2.3	0.8	-1.4	-1.0	1.6
Medication: Blood pressure	0.4	0.7	2.0	1.1	-0.2	-0.3	-0.1	1.4	-0.9
Angina (self-reported)	3.3	4.4	9.4	2.8	-1.1	-2.0	0.7	1.9	-3.1
Migraine (self-reported)	0.4	0.4	0.8	-0.9	0.9	0.3	-0.5	-0.7	0.6
Medication: Ibuprofen	1.4	1.7	3.1	-1.7	1.8	-0.2	-1.3	-0.7	1.4
Medication: Allopurinol	0.1	0.1	0.4	-0.1	-0.1	0.2	-0.0	0.6	-0.3
Medication: Omeprazole	0.7	0.8	3.0	-0.5	1.7	1.3	-0.4	-0.0	0.3
Medication: Seretide 50 evohaler	1.5	1.7	3.5	1.6	-1.6	-1.3	0.1	1.9	-0.1
Mean time to correctly identify matches	0.4	0.7	3.0	1.7	-0.3	-0.2	-0.7	0.9	0.3
Heart disease (mother)	5.9	7.2	15.4	3.9	-2.7	-1.4	1.4	2.0	-3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	1.6	0.1	-1.8	0.6	0.7	-1.2
Whole body fat mass	0.2	1.0	2.8	1.7	1.1	0.6	0.4	1.1	-0.6
Leg fat mass (right)	0.3	1.1	2.3	1.5	1.5	0.5	0.4	1.3	-0.2
Arm predicted mass (right)	0.1	0.4	1.8	0.2	0.2	0.0	0.7	1.4	-0.4
Pulse rate, automated reading	1.2	4.0	6.7	-2.2	2.2	0.7	-1.9	-2.0	2.6
Alcohol intake frequency.	2.1	4.8	8.1	-1.9	2.5	2.2	-2.8	-1.1	2.2
Comparative height size at age 10	0.4	2.3	7.0	0.2	-1.3	-2.6	-0.0	2.2	-0.4
Number of full sisters	0.7	0.8	2.6	-0.1	-1.4	0.4	1.6	0.4	-0.3
Suffer from ‘nerves’	0.9	1.5	4.0	-0.1	1.0	2.0	1.1	-0.9	1.3
Overall health rating	0.2	0.5	1.9	-0.2	1.4	-0.0	-0.4	0.9	0.4
Chest pain or discomfort	1.1	1.6	5.1	0.9	-1.1	-0.8	1.1	0.6	-2.3
Had major operations	0.4	0.4	0.9	0.5	-0.7	-0.1	-0.5	0.9	-0.9
Age at last live birth	0.5	0.7	3.4	-0.8	0.2	0.1	-1.8	0.2	0.3
Family relationship satisfaction	1.4	1.7	5.5	2.4	0.1	1.5	1.4	-0.3	-0.6
Leg pain on walking	0.3	0.3	1.2	1.1	0.3	0.4	0.1	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.8	-1.8	1.5	0.8	-0.4	-0.7	1.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.8	-0.3	1.3	-0.6	0.2	0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.3	-1.1	-0.0	0.7	0.4	-1.0
Medication: Aspirin	1.7	2.3	4.8	0.9	-1.9	-2.2	-0.6	1.1	-1.7
Supplements: Vitamin C	1.3	1.5	3.7	-0.3	0.7	1.9	-0.8	-1.9	0.8
Knee pain experienced in last month	0.2	0.3	0.5	0.1	0.6	0.7	0.6	0.6	-0.4
Hypertension (Self-reported)	0.5	1.4	2.9	0.8	-0.5	-1.4	-0.7	1.6	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.5	0.2	0.1	0.9	1.6	-0.9	-0.1
Illnesses of father: Heart disease	6.9	9.5	12.8	3.6	-3.2	-3.3	1.6	2.9	-3.5
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.3	-0.4	-0.5	-0.3	0.8	-0.4
Smoking status: Previous	3.0	4.4	10.3	3.2	-1.6	-1.4	2.4	1.5	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.4	-1.5	-0.3	-0.2	-0.0	-0.2	0.7
Whole body fat-free mass	0.1	0.5	1.6	-0.6	-0.1	0.1	0.6	1.3	-0.6
Leg fat-free mass (right)	0.1	0.6	1.6	-0.2	-0.3	0.7	0.9	0.9	-1.3
Arm fat percentage (left)	0.3	1.3	3.3	1.8	1.2	1.2	0.9	0.1	-0.7
Average weekly red wine intake	1.7	2.5	6.3	1.6	-2.5	0.0	2.3	-0.1	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.3	0.9	0.5	-0.7	-0.4	-0.5
Mood swings	0.9	1.6	3.6	-0.9	1.6	1.3	0.8	-0.8	1.9
Loneliness, isolation	1.1	1.6	5.9	-0.9	-0.2	-0.4	-1.5	-0.1	2.4
Long-standing illness, disability or infirmity	0.6	0.9	4.0	-0.4	2.0	-0.4	-0.6	0.6	-0.5
Ever had bowel cancer screening	0.9	1.0	2.7	1.7	-0.7	0.5	0.0	1.1	-1.2
Diabetes diagnosed by doctor	0.3	0.5	0.8	0.0	0.6	-0.8	-0.5	0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.5	1.2	-0.7	0.1	-0.3	0.3	-0.6
Friendships satisfaction	0.7	0.9	3.0	0.8	-0.4	1.7	0.6	-0.8	-0.7
Qualifications: nursing, teaching	0.6	1.0	3.0	-0.8	-0.5	0.9	-0.5	-1.0	-1.7
Commuting to job workplace: Walk	0.3	0.4	0.7	-0.8	0.5	0.8	0.1	-0.5	0.5
Eye problems/disorders: Cataract	0.8	1.0	2.4	0.9	-0.0	-0.3	0.7	1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.2	-1.0	0.3	0.7	-1.4	0.4	1.5
Medication for cholesterol	2.2	3.3	6.7	-1.8	0.8	2.6	-0.0	-2.5	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.6	-0.9	0.3	1.5	-0.2	-1.9	1.3
Back pain experienced in last month	1.2	1.7	7.7	0.0	2.8	0.4	-1.2	0.8	0.7
Mineral and other dietary supplements	0.5	0.7	1.9	-0.9	-0.5	-0.9	-0.6	1.4	-0.0
Breast cancer (self-reported)	0.8	0.9	2.7	-0.8	-0.4	-1.0	-0.5	1.6	0.9
Asthma (self-reported)	0.7	1.4	3.4	-1.1	1.8	-0.5	-0.2	0.8	1.6
Osteoporosis (self-reported)	0.4	0.5	0.9	0.5	0.4	0.9	-0.4	-0.9	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.1	0.4	0.5	0.4	1.0	-1.2
Medication: Aspirin	1.7	2.2	3.8	1.6	-1.7	-1.8	-0.2	0.9	-1.9
Medication: Gliclazide	0.1	0.2	0.6	-0.1	0.1	0.8	0.6	0.0	0.0
Illnesses of father: None of the above (group 1)	5.0	6.1	10.0	-2.6	3.1	2.0	-0.9	-3.2	2.3
Smoking status: Current	0.3	0.5	1.0	0.0	0.5	1.0	0.8	-0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	15.3	-1.2	-0.7	3.9	0.0	-3.1	-2.1
Whole body water mass	0.1	0.4	1.5	-0.6	-0.1	0.2	0.6	1.2	-0.6
Leg predicted mass (right)	0.1	0.6	1.6	-0.2	-0.3	0.7	0.8	0.9	-1.3
Arm fat mass (left)	0.2	1.0	2.4	1.5	1.1	0.9	0.8	0.7	-0.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	0.2	0.9	0.2	-1.1	0.7	-1.2
Average weekly champagne plus white wine intake	1.6	2.2	5.9	0.9	-1.8	-1.5	-0.3	2.4	-1.1
Miserableness	1.6	2.8	3.9	-1.6	2.0	1.9	-0.9	-1.7	1.7
Guilty feelings	0.2	0.3	0.7	0.2	-0.8	-0.7	0.2	-0.6	-0.0
Wears glasses or contact lenses	2.5	2.9	10.0	0.7	-3.2	-2.0	-0.1	1.4	-1.1
Ever taken oral contraceptive pill	1.5	1.6	4.7	1.6	-1.4	-0.5	2.2	0.1	-0.5
Hearing aid user	1.3	1.5	3.6	-1.4	1.0	-0.8	-1.9	1.1	0.5
Mother’s age at death	3.0	3.8	8.9	-3.0	1.3	2.7	-0.3	-1.7	1.2
Financial situation satisfaction	1.4	1.7	5.7	0.7	2.4	1.9	-0.0	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.5	0.1	0.2	-0.8	0.3	1.9	-0.4
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.7	-0.5	0.3	0.3	-0.8	-0.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.8	-0.4	-0.7	-0.3	0.8	0.8	-1.7
Medication: Blood pressure	1.9	3.6	8.4	1.4	-1.0	-2.6	0.0	2.9	-1.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	-0.3	1.0	0.5	0.1	1.1	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.7	1.3	0.4	1.1	1.7	-1.5	0.6
High cholesterol (Self-reported)	1.8	3.2	7.9	1.4	-1.0	-2.3	0.1	2.8	-1.8
Medication: Bendroflumethiazide	1.4	2.2	5.6	2.0	-0.7	-1.3	-0.8	2.4	-0.8
Medication: Paracetamol	0.5	0.7	2.5	-0.9	0.5	0.8	-0.6	-0.2	1.6
Medication: Lisinopril	0.7	0.8	2.5	-1.1	1.1	-0.5	0.0	1.6	0.1
Medication: Atorvastatin	1.2	1.4	4.0	1.1	1.1	-1.1	-0.0	2.0	-0.9
Illnesses of father: High blood pressure	2.5	3.1	6.1	1.4	-2.5	-0.6	0.9	2.2	-2.2
Alcohol drinker status: Never	5.8	7.0	13.8	-2.8	2.7	1.7	-3.7	-1.5	2.8
Ever smoked	3.0	5.2	13.0	3.6	-2.1	-1.5	2.6	1.3	-1.8
Basal metabolic rate	0.1	0.4	1.9	-0.2	0.1	0.1	0.6	1.4	-0.6
Leg fat percentage (left)	0.5	1.7	5.6	2.4	1.6	0.3	0.4	1.4	-0.4
Arm fat-free mass (left)	0.1	0.7	3.2	0.4	0.4	-0.0	0.5	1.8	-0.4
Number of operations (self-reported)	0.3	0.4	1.2	0.5	0.6	1.1	-0.2	-0.8	-0.2
Average weekly beer plus cider intake	0.4	0.6	1.5	1.2	0.7	0.1	-0.5	0.0	1.1
Irritability	0.3	0.5	1.9	1.4	-0.3	-0.7	0.6	0.0	0.5
Risk taking	0.8	1.2	3.8	1.9	0.7	0.3	1.4	-0.6	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.8	-0.5	-0.3	1.4	-0.1	0.0	0.4
Fractured/broken bones in last 5 years	0.9	1.2	2.2	-0.7	1.5	1.1	-0.8	-1.1	1.2
Age started oral contraceptive pill	2.8	3.5	6.1	1.9	-2.5	-2.2	0.3	1.5	-2.1
Diastolic blood pressure, automated reading	1.3	4.1	14.8	-3.9	1.4	1.5	0.3	-2.0	1.1
Ever depressed for a whole week	0.3	0.4	1.5	1.2	0.5	-0.0	0.4	-0.1	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.4	0.3	0.5	0.2	0.7	0.8
Commuting to job workplace: Cycle	0.9	1.1	2.9	-1.7	-0.9	-0.2	0.8	0.6	-1.3
Myopia	1.8	2.6	8.5	-2.9	-0.1	-0.8	-2.2	1.2	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.8	-1.1	0.1	0.8	0.2	-1.7	1.6
Cholesterol lowering medication	3.0	4.5	10.2	0.9	-1.0	-3.2	-0.5	3.2	-2.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.4	0.2	1.6	0.9	0.6	0.2	0.5
Pain experienced in last month	1.1	1.8	4.6	2.1	-1.8	-0.7	0.9	-0.2	-1.4
Supplements: Calcium	0.7	0.8	1.7	0.5	-0.2	0.7	-1.1	-1.3	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	-0.9	1.4	1.1	-0.9	0.0	0.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.7	0.8	0.3	-0.8	-0.3	1.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.5	-0.6	0.7	0.6	-0.9	-0.1	-1.2
Heart disease (siblings)	1.4	1.7	4.3	2.1	-0.4	-0.5	-0.1	1.4	-1.8
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.0	-0.2	0.7	0.7	-0.8	-0.2
Pack years of smoking	0.4	0.5	1.8	-0.6	1.3	0.9	0.4	-0.4	-0.2
Impedance of whole body	0.4	2.2	5.6	-1.2	0.4	-2.4	-1.9	-0.4	1.5
Leg fat mass (left)	0.3	1.1	2.4	1.5	1.4	0.5	0.2	1.3	-0.5
Arm predicted mass (left)	0.1	0.7	3.1	0.4	0.3	-0.3	0.6	1.8	-0.7