Best TWAS P=4.24e-13 · Best GWAS P=1.01e-12 conditioned to 0.59
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | QSER1 | 0.12 | 0.05 | bslmm | 366 | 0.06 | 2.9e-08 | 7.1 | -6.8 | 1.1e-11 | -0.76 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adrenal Gland | QSER1 | 0.27 | 0.00 | lasso | 5 | -0.01 | 5.7e-01 | 5.8 | -7.2 | 4.2e-13 | -0.49 | 0.05 | 0.15 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | QSER1 | 0.08 | 0.02 | enet | 12 | 0.06 | 1.8e-05 | -6.5 | -7.0 | 2.8e-12 | -0.13 | 0.19 | 0.48 | TRUE |
| 4 | GTEx | Nerve Tibial | QSER1 | 0.16 | 0.13 | lasso | 4 | 0.12 | 4.4e-09 | 5.7 | -7.1 | 1.0e-12 | -0.80 | 0.09 | 0.91 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | QSER1 | 0.10 | 0.05 | lasso | 7 | 0.04 | 4.7e-06 | 5.8 | -6.2 | 5.1e-10 | -0.88 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WIT1 | 0.02 | 0.01 | lasso | 2 | 0.01 | 2.5e-03 | -5.1 | -5.3 | 1.2e-07 | 0.03 | 0.01 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WT1 | 0.05 | 0.01 | blup | 79 | 0.02 | 9.3e-05 | -3.1 | -5.6 | 2.7e-08 | 0.01 | 0.04 | 0.84 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | QSER1 | 0.07 | 0.09 | lasso | 2 | 0.07 | 4.6e-05 | 5.8 | -5.9 | 4.1e-09 | -0.88 | 0.02 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRRG4 | 0.03 | 0.03 | blup | 42 | 0.01 | 4.6e-02 | 4.8 | 5.8 | 4.8e-09 | 0.78 | 0.02 | 0.53 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | QSER1 | 0.05 | 0.04 | enet | 17 | 0.05 | 7.9e-06 | 7.1 | -6.8 | 1.2e-11 | -0.95 | 0.01 | 0.99 | TRUE |