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chr11:15,946,803-18,822,037

Best TWAS P=6.82e-15 · Best GWAS P=1e-13 conditioned to 0.864

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KCNJ11	0.04	0.03	lasso	3	0.03	2.6e-04	-5.1	-6.1	1.4e-09	-0.59	0.21	0.68	FALSE
2	GTEx	Adipose Subcutaneous	OR7E14P	0.10	0.09	lasso	5	0.10	1.2e-08	7.4	7.2	7.2e-13	0.94	0.03	0.97	FALSE
3	GTEx	Artery Tibial	OR7E14P	0.10	0.07	lasso	8	0.04	3.4e-04	6.3	6.1	1.2e-09	0.94	0.03	0.97	FALSE
4	GTEx	Brain Cortex	NUCB2	0.21	0.12	lasso	4	0.10	1.1e-03	4.1	-5.2	1.6e-07	-0.70	0.06	0.84	FALSE
5	GTEx	Brain Cortex	KCNJ11	0.17	0.01	enet	24	0.06	7.7e-03	6.0	-5.6	2.3e-08	-0.68	0.04	0.76	FALSE
6	GTEx	Breast Mammary Tissue	OR7E14P	0.21	0.06	enet	23	0.08	7.7e-05	-7.3	6.3	3.3e-10	0.75	0.02	0.98	FALSE
7	GTEx	Breast Mammary Tissue (Female)	OR7E14P	0.19	0.07	lasso	6	0.07	3.4e-03	-7.4	6.9	4.1e-12	0.80	0.03	0.82	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	NUCB2	0.36	0.23	lasso	6	0.24	2.6e-08	6.1	6.0	2.0e-09	0.81	0.06	0.94	FALSE
9	GTEx	Cells Transformed fibroblasts	PIK3C2A	0.10	0.08	lasso	4	0.08	1.3e-06	-5.5	6.8	1.5e-11	0.74	0.07	0.92	FALSE
10	GTEx	Cells Transformed fibroblasts	NUCB2	0.13	0.11	lasso	2	0.09	1.7e-07	6.2	6.6	3.9e-11	0.88	0.09	0.91	FALSE
11	GTEx	Cells Transformed fibroblasts	C11orf58	0.13	0.01	enet	25	0.01	3.5e-02	-3.4	-6.2	6.5e-10	-0.09	0.05	0.04	TRUE
12	GTEx	Colon Transverse	NUCB2	0.13	0.09	lasso	6	0.06	9.6e-04	7.4	7.2	6.7e-13	0.95	0.03	0.97	FALSE
13	GTEx	Colon Transverse	OR7E14P	0.21	0.21	enet	21	0.26	7.3e-13	-7.4	6.7	3.0e-11	0.86	0.02	0.97	FALSE
14	GTEx	Esophagus Mucosa	NUCB2	0.08	0.03	lasso	4	0.04	8.8e-04	-7.4	7.2	4.5e-13	0.97	0.03	0.96	FALSE
15	GTEx	Esophagus Mucosa	OR7E14P	0.33	0.32	enet	31	0.41	1.6e-29	6.0	6.9	4.1e-12	0.93	0.03	0.97	FALSE
16	GTEx	Esophagus Mucosa	NCR3LG1	0.38	0.38	enet	39	0.42	3.7e-30	4.1	5.1	2.8e-07	0.71	1.00	0.00	FALSE
17	GTEx	Esophagus Mucosa	RP1-239B22.5	0.28	0.28	enet	47	0.32	2.9e-22	4.0	5.5	4.9e-08	0.73	0.91	0.09	FALSE
18	GTEx	Esophagus Muscularis	RP1-239B22.5	0.06	0.08	enet	8	0.08	1.3e-05	7.4	7.0	1.9e-12	0.94	0.02	0.97	FALSE
19	GTEx	Heart Atrial Appendage	OR7E14P	0.14	0.02	lasso	1	0.03	1.7e-02	7.4	7.4	1.1e-13	1.00	0.03	0.83	FALSE
20	GTEx	Heart Left Ventricle	OR7E14P	0.08	0.06	enet	18	0.07	1.2e-04	6.3	5.8	5.4e-09	0.74	0.04	0.87	FALSE
21	GTEx	Muscle Skeletal	OR7E14P	0.05	0.04	enet	13	0.03	7.5e-04	7.2	7.3	3.7e-13	0.99	0.02	0.97	FALSE
22	GTEx	Nerve Tibial	OR7E14P	0.18	0.28	lasso	3	0.28	9.5e-20	-7.4	7.4	1.5e-13	0.98	0.02	0.98	FALSE
23	GTEx	Nerve Tibial	RP1-239B22.5	0.11	0.08	lasso	2	0.08	2.9e-06	4.4	5.5	3.5e-08	0.55	0.24	0.34	FALSE
24	GTEx	Ovary	NUCB2	0.31	-0.01	enet	35	0.01	2.0e-01	7.4	5.9	2.9e-09	0.72	0.04	0.67	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	KCNJ11	0.18	0.07	lasso	6	0.12	7.0e-07	-5.1	5.2	1.9e-07	0.64	0.87	0.08	FALSE
26	GTEx	Skin Sun Exposed Lower leg	RP1-239B22.5	0.06	0.06	lasso	2	0.07	8.6e-07	4.5	5.3	1.4e-07	0.61	0.80	0.06	FALSE
27	GTEx	Spleen	NUCB2	0.20	0.21	lasso	2	0.17	4.2e-05	6.1	6.1	8.6e-10	0.83	0.06	0.81	FALSE
28	GTEx	Stomach	OR7E14P	0.23	0.07	enet	25	0.01	7.5e-02	7.4	5.9	3.2e-09	0.83	0.04	0.95	FALSE
29	GTEx	Testis	NUCB2	0.28	0.13	lasso	9	0.10	2.5e-05	6.2	-5.9	4.5e-09	-0.81	0.40	0.35	FALSE
30	GTEx	Testis	OR7E14P	0.38	0.33	lasso	6	0.32	7.1e-15	-7.4	7.4	1.6e-13	0.99	0.02	0.98	FALSE
31	GTEx	Thyroid	RP1-239B22.5	0.08	0.07	enet	16	0.08	1.8e-06	-4.9	5.5	4.2e-08	0.48	0.50	0.20	FALSE
32	METSIM	Adipose	NUCB2	0.05	0.07	enet	10	0.05	4.0e-08	6.2	7.0	3.2e-12	0.94	0.06	0.94	FALSE
33	METSIM	Adipose	SAAL1	0.07	0.03	enet	28	0.06	8.2e-09	4.1	-5.2	1.8e-07	-0.10	0.40	0.60	TRUE
34	ROSMAP	Brain Pre-frontal Cortex	OR7E14P	0.04	0.04	lasso	4	0.04	9.1e-06	7.2	7.3	3.2e-13	0.96	0.02	0.98	FALSE
35	YFS	Blood	NUCB2	0.12	0.13	lasso	4	0.14	2.7e-44	6.0	6.0	2.0e-09	0.83	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DKFZp686O24166	0.04	0.00	blup	71	0.02	7.1e-03	4.5	5.9	3.3e-09	0.56	0.01	0.76	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DKFZp686O24166	0.08	0.04	blup	72	0.01	1.4e-01	5.1	5.8	7.0e-09	0.62	0.01	0.46	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PIK3C2A	0.04	0.00	blup	52	0.01	1.4e-01	7.4	6.4	2.0e-10	0.95	0.02	0.71	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DKFZp686O24166	0.03	0.01	blup	72	0.03	2.4e-04	-5.2	5.5	4.3e-08	0.61	0.01	0.94	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUCB2	0.10	0.04	enet	8	0.05	2.6e-06	7.2	6.9	4.1e-12	0.81	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DKFZp686O24166	0.08	0.07	lasso	4	0.05	1.2e-03	5.1	5.5	3.1e-08	0.60	0.02	0.95	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PIK3C2A	0.05	0.01	blup	52	0.03	7.2e-03	-6.8	7.8	6.8e-15	0.83	0.03	0.57	TRUE
43	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PIK3C2A	0.10	0.09	lasso	7	0.09	2.7e-03	7.4	7.4	1.4e-13	0.96	0.02	0.70	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	PIK3C2A	0.08	0.05	lasso	3	0.05	9.6e-06	-6.8	6.5	9.7e-11	0.56	0.50	0.35	FALSE