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chr11:107,181,776-109,156,782

Best TWAS P=5.57e-29 · Best GWAS P=5.91e-29 conditioned to 0.000494

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Nerve Tibial	ACAT1	0.05	0.02	lasso	5	0.00	9.0e-01	-10.64	-11.2	5.6e-29	-0.82	0.08	0.86	TRUE
6	GTEx	Cells Transformed fibroblasts	ATM	0.07	0.06	lasso	2	0.05	2.2e-04	-10.50	-10.6	2.6e-26	-0.74	0.45	0.46	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATM	0.05	0.10	lasso	4	0.10	6.6e-12	-10.50	-10.6	2.8e-26	-0.74	0.72	0.28	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATM	0.05	0.03	blup	72	0.03	2.9e-04	-10.62	-10.6	3.3e-26	-0.67	0.46	0.48	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	ATM	0.04	0.03	lasso	2	0.03	5.7e-03	-10.58	-10.6	4.2e-26	-0.74	0.08	0.16	FALSE
4	GTEx	Artery Tibial	NPAT	0.06	0.06	lasso	4	0.05	5.6e-05	-10.56	10.6	4.3e-26	0.73	0.64	0.24	FALSE
8	GTEx	Esophagus Muscularis	ATM	0.07	0.07	lasso	4	0.04	1.6e-03	-10.46	-10.5	1.2e-25	-0.74	0.35	0.38	FALSE
7	GTEx	Esophagus Mucosa	ACAT1	0.10	0.12	lasso	5	0.13	4.9e-09	7.17	-9.6	9.1e-22	-0.83	0.31	0.69	FALSE
25	YFS	Blood	NPAT	0.06	0.08	lasso	8	0.09	3.2e-28	-10.57	9.6	1.2e-21	0.52	0.74	0.26	FALSE
24	YFS	Blood	ACAT1	0.20	0.21	enet	32	0.34	1.3e-114	-10.53	-9.4	7.5e-21	-0.78	0.84	0.16	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf65	0.03	0.01	blup	75	0.02	4.3e-03	-10.60	9.4	7.7e-21	0.53	0.10	0.15	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	ATM	0.08	0.05	lasso	4	0.05	6.5e-06	-10.62	-9.2	5.4e-20	-0.52	0.43	0.44	FALSE
5	GTEx	Cells Transformed fibroblasts	ACAT1	0.18	0.15	lasso	8	0.21	1.7e-15	-8.07	-9.1	1.0e-19	-0.66	0.83	0.17	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C11orf65	0.02	0.01	blup	75	0.02	7.4e-03	-10.52	9.0	3.1e-19	0.52	0.06	0.09	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	ATM	0.05	0.05	blup	370	0.05	5.8e-07	-10.53	-8.7	3.0e-18	-0.72	0.54	0.46	FALSE
9	GTEx	Esophagus Muscularis	RP11-144G7.2	0.06	0.04	lasso	2	0.03	3.5e-03	7.17	-8.4	3.9e-17	-0.75	0.05	0.81	FALSE
22	NTR	Blood	NPAT	0.02	0.01	blup	380	0.01	8.8e-05	-10.56	8.1	4.7e-16	0.52	0.66	0.28	FALSE
3	GTEx	Artery Tibial	ACAT1	0.12	0.08	lasso	7	0.11	3.9e-09	7.17	-7.9	2.5e-15	-0.84	0.03	0.97	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	ACAT1	0.11	0.12	lasso	5	0.08	2.6e-05	7.17	-7.8	6.3e-15	-0.79	0.07	0.91	FALSE
16	GTEx	Pituitary	ACAT1	0.16	0.09	lasso	10	0.08	5.3e-03	7.14	7.8	9.3e-15	0.88	0.03	0.88	FALSE
10	GTEx	Heart Left Ventricle	KDELC2	0.07	0.05	lasso	4	0.06	3.8e-04	3.86	-7.4	1.3e-13	-0.65	0.03	0.85	FALSE
2	GTEx	Adipose Visceral Omentum	KDELC2	0.14	0.11	lasso	3	0.08	4.5e-05	4.03	-7.3	2.5e-13	-0.64	0.10	0.88	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ACAT1	0.13	0.15	lasso	2	0.14	1.0e-11	7.17	-7.0	2.3e-12	-0.74	1.00	0.00	FALSE
20	GTEx	Thyroid	NPAT	0.08	0.01	enet	32	0.04	8.1e-04	-2.24	7.0	2.5e-12	0.63	0.05	0.87	FALSE
14	GTEx	Muscle Skeletal	RP11-144G7.2	0.22	0.19	lasso	5	0.17	1.2e-16	-7.33	-6.9	3.8e-12	-0.41	1.00	0.00	FALSE
12	GTEx	Muscle Skeletal	ATM	0.10	0.00	enet	24	0.01	1.4e-02	-7.33	-6.5	7.0e-11	-0.35	0.11	0.04	FALSE
11	GTEx	Muscle Skeletal	ACAT1	0.28	0.16	lasso	4	0.17	1.1e-16	-7.33	-5.8	6.0e-09	-0.27	1.00	0.00	FALSE
13	GTEx	Muscle Skeletal	CUL5	0.08	0.01	lasso	5	0.03	8.8e-04	-7.33	-5.7	1.6e-08	-0.24	0.31	0.05	FALSE
21	METSIM	Adipose	EXPH5	0.04	0.02	bslmm	364	0.02	3.9e-04	-0.91	-5.1	2.8e-07	-0.54	0.20	0.54	FALSE
19	GTEx	Testis	ACAT1	0.17	0.04	lasso	6	0.08	3.0e-04	7.17	5.1	2.9e-07	0.63	0.08	0.72	FALSE