Best TWAS P=1.4e-10 · Best GWAS P=5.99e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | -6.4 | -6.4 | 1.4e-10 | 0.99 | 0.01 | 0.99 | TRUE |
| 1 | GTEx | Cells Transformed fibroblasts | C11orf1 | 0.13 | 0.01 | enet | 25 | 0.03 | 2.3e-03 | -3.9 | 6.0 | 1.5e-09 | -0.67 | 0.22 | 0.11 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | -5.6 | -6.0 | 2.1e-09 | 0.90 | 0.09 | 0.72 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | -6.5 | -5.7 | 1.2e-08 | 0.95 | 0.01 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LAYN | 0.13 | 0.07 | enet | 8 | 0.07 | 9.9e-04 | -3.7 | -5.5 | 3.6e-08 | 0.68 | 0.02 | 0.73 | FALSE |