TWAS
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About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Blood Platelet Count
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chr12:191,619-1,471,232
Best TWAS P=8.96e-16 · Best GWAS P=1.14e-36 conditioned to 2.75e-10
0.2M
0.4M
0.6M
0.8M
1M
1.2M
1.4M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
NINJ2
0.10
0.01
lasso
6
0.02
1.6e-03
-3.3
8.0
9.0e-16
0.36
0.10
0.51
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
NINJ2
0.09
0.01
blup
114
0.05
2.2e-06
-8.3
-8.0
1.7e-15
-0.40
0.42
0.29
TRUE
1
GTEx
Whole Blood
RP11-218M22.1
0.30
0.22
enet
27
0.22
2.7e-20
4.8
6.4
1.2e-10
0.52
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
NINJ2
0.05
0.04
lasso
3
0.03
3.4e-04
4.6
5.4
5.9e-08
0.54
0.12
0.73
FALSE