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chr12:5,365,243-11,287,271

Best TWAS P=6.01e-156 · Best GWAS P=4.93e-188 conditioned to 2.48e-42

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	NTR	Blood	CD9	0.03	0.02	bslmm	503	0.02	3.7e-06	22.495	26.6	6.0e-156	-0.53	1.00	0.00	TRUE
13	METSIM	Adipose	RP1-102E24.8	0.08	0.06	enet	18	0.06	9.5e-10	10.600	8.8	2.1e-18	-0.03	0.99	0.00	TRUE
22	YFS	Blood	TNFRSF1A	0.06	0.05	lasso	3	0.05	5.5e-15	8.371	8.4	6.0e-17	0.09	1.00	0.00	TRUE
9	GTEx	Testis	CD27-AS1	0.29	0.06	enet	18	0.13	2.0e-06	-1.839	-7.8	4.3e-15	0.17	0.16	0.29	TRUE
12	METSIM	Adipose	LPAR5	0.06	0.00	blup	297	0.02	1.1e-03	2.864	7.8	8.2e-15	-0.25	0.09	0.05	TRUE
14	METSIM	Adipose	ZNF384	0.08	0.02	bslmm	286	0.04	2.6e-07	-1.287	-7.0	2.1e-12	0.10	0.85	0.00	TRUE
5	GTEx	Brain Cerebellum	CD9	0.25	-0.01	enet	25	0.00	3.2e-01	-8.060	6.9	3.8e-12	-0.08	0.07	0.05	TRUE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRC4	0.05	0.04	lasso	2	0.04	2.9e-05	6.657	6.7	1.9e-11	0.07	0.00	0.99	TRUE
4	CommonMind	Brain Pre-frontal Cortex	NCAPD2	0.06	0.01	blup	377	0.02	8.2e-04	-0.052	-6.5	9.2e-11	0.23	0.76	0.04	TRUE
6	GTEx	Brain Nucleus accumbens basal ganglia	MRPL51	0.51	0.01	enet	35	0.00	3.0e-01	2.977	6.1	1.1e-09	0.00	0.05	0.08	TRUE
7	GTEx	Esophagus Mucosa	RP1-102E24.8	0.08	0.01	lasso	7	0.01	5.9e-02	-5.463	5.8	5.4e-09	-0.10	0.12	0.03	TRUE
8	GTEx	Testis	LTBR	0.57	0.46	enet	14	0.49	1.2e-24	4.721	5.8	6.5e-09	-0.04	1.00	0.00	TRUE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CLEC12A	0.21	0.18	lasso	4	0.16	8.7e-08	-5.256	-5.8	7.5e-09	-0.08	0.05	0.95	TRUE
21	YFS	Blood	CD9	0.21	0.16	bslmm	480	0.16	1.1e-51	23.781	19.9	2.4e-88	-0.41	1.00	0.00	FALSE
23	YFS	Blood	VWF	0.32	0.08	bslmm	646	0.22	2.0e-69	23.410	11.4	3.7e-30	-0.29	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	KLRC1	0.05	0.03	blup	31	0.05	2.2e-11	6.660	6.7	2.2e-11	0.06	0.02	0.98	FALSE
11	METSIM	Adipose	KLRK1	0.09	0.06	bslmm	512	0.06	1.6e-09	6.448	6.6	3.5e-11	0.08	0.04	0.96	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KLRC1	0.05	0.08	blup	31	0.08	6.2e-09	6.657	6.5	6.7e-11	0.08	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	KLRC1	0.03	0.01	blup	31	0.04	2.8e-05	6.657	6.3	3.0e-10	0.08	0.01	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KLRC3	0.19	0.16	lasso	7	0.14	4.8e-17	5.873	6.1	8.3e-10	0.07	0.35	0.65	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KLRC4	0.06	0.01	blup	41	0.02	6.1e-03	4.468	-6.0	2.1e-09	-0.04	0.02	0.37	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KLRC2	0.60	0.51	enet	19	0.66	5.4e-107	6.955	5.8	6.4e-09	0.04	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRK1	0.04	0.02	lasso	4	0.03	8.2e-05	3.922	5.8	7.3e-09	0.08	0.02	0.94	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KLRC1	0.15	0.08	enet	12	0.12	1.9e-10	5.873	5.7	1.2e-08	0.03	0.01	0.99	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	KLRC2	0.62	0.47	bslmm	439	0.63	1.8e-104	6.955	5.7	1.5e-08	0.04	0.00	1.00	FALSE
19	NTR	Blood	KLRC3	0.13	0.15	lasso	6	0.16	3.7e-50	4.468	5.6	2.1e-08	0.08	1.00	0.00	FALSE
10	METSIM	Adipose	CLEC12A	0.29	0.28	bslmm	339	0.28	2.7e-42	-5.256	-5.4	7.0e-08	-0.07	0.99	0.01	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	KLRC1	0.08	0.09	enet	8	0.10	2.9e-10	4.339	5.4	8.4e-08	0.07	0.71	0.29	FALSE
18	NTR	Blood	KLRC1	0.03	0.01	lasso	5	0.02	4.8e-08	7.061	5.3	1.0e-07	0.06	0.00	1.00	FALSE
16	NTR	Blood	CLEC12A	0.54	0.60	lasso	2	0.60	1.4e-252	-5.256	-5.3	1.4e-07	-0.07	0.98	0.02	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLEC12B	0.17	0.19	lasso	1	0.18	1.8e-10	-5.256	-5.3	1.5e-07	-0.07	0.05	0.95	FALSE
36	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLEC12B	0.12	0.08	lasso	1	0.06	1.2e-04	-5.256	-5.3	1.5e-07	-0.07	0.04	0.56	FALSE
17	NTR	Blood	CLEC12B	0.16	0.16	lasso	4	0.15	3.2e-47	-5.256	-5.2	1.7e-07	-0.07	0.99	0.01	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	CLEC12A	0.17	0.18	lasso	3	0.17	5.4e-19	-5.256	-5.2	1.9e-07	-0.07	0.05	0.95	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LTBR	0.16	0.07	lasso	5	0.07	8.7e-09	4.209	5.2	2.6e-07	-0.01	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	CLEC12A	0.14	0.12	lasso	3	0.12	2.1e-07	-4.645	-5.1	2.8e-07	-0.06	0.10	0.89	FALSE