TWAS hub - NINJ2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Prostate	0.4840	0.1260	4.3e-03	-0.003	NA	0.011	NA	-0.011	3.9e-01	NA	1.6e-01	NA	7.7e-01
2	GTEx	Whole Blood	0.1600	0.0430	4.6e-05	0.074	NA	0.065	NA	0.084	2.2e-07	NA	1.2e-06	NA	3.5e-08
3	ROSMAP	Brain Pre-frontal Cortex	0.0955	0.0325	2.8e-03	0.014	0.005	0.004	0.011	0.019	5.9e-03	6.9e-02	9.3e-02	1.2e-02	1.6e-03
4	YFS	Blood	0.2622	0.0288	0.0e+00	0.249	0.242	0.266	0.267	0.271	9.3e-81	2.5e-78	4.4e-87	2.8e-87	8.8e-89
5	TCGA	Breast Invasive Carcinoma	0.0415	0.0156	7.2e-05	0.012	0.013	0.014	NA	0.013	1.1e-03	7.3e-04	6.2e-04	NA	8.4e-04
6	TCGA	Lung Adenocarcinoma	0.0931	0.0273	2.2e-06	0.010	0.049	0.040	NA	0.032	2.3e-02	2.2e-06	1.5e-05	NA	1.0e-04
7	TCGA	Thyroid Carcinoma	0.0480	0.0210	2.9e-03	0.039	0.028	0.028	NA	0.033	1.0e-04	8.5e-04	9.5e-04	NA	3.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Primary Biliary Cirrhosis	3.9	5.5	18.7	-0.2	-1.0	0.7	0.1	3.0	-4.3	3.1
Medication: Aspirin	2.9	3.8	10.0	0.4	3.2	2.6	2.7	0.9	1.1	0.7
Had menopause	2.7	3.3	5.8	-0.2	1.5	2.2	2.4	1.9	-0.8	2.4
Medication: Gliclazide	2.7	3.1	8.4	-1.2	2.0	1.2	0.9	2.2	-0.8	2.9
Medication: Metformin	2.5	3.5	6.1	-2.5	2.0	1.9	2.0	1.4	1.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	5.9	-0.1	1.4	-1.2	2.3	2.4	0.8	2.2
Health satisfaction	2.4	3.1	11.1	-0.2	2.7	3.3	0.9	1.0	-0.2	1.3
Age started oral contraceptive pill	2.4	3.0	8.5	-0.0	1.0	0.1	1.8	2.9	-0.8	2.7
Blood Platelet Count	2.3	26.7	64.6	-2.0	3.4	8.0	-1.3	3.5	-8.0	5.4
Medication: Lansoprazole	2.3	2.7	10.6	-0.8	3.3	1.6	0.8	0.9	1.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	7.2	0.2	2.7	-1.6	1.2	1.5	1.7	1.8
Illnesses of father: None of the above (group 1)	2.2	2.7	6.8	-1.5	-2.6	-0.2	-0.4	-1.9	-0.9	-2.2
Medication: Blood pressure	2.2	4.1	10.6	1.7	3.3	1.4	2.2	2.0	1.4	1.6
Cholesterol lowering medication	2.2	3.3	10.4	-0.2	1.8	1.9	3.2	0.6	2.2	0.8
Age at First Birth	2.1	3.0	9.4	0.4	3.1	0.5	1.8	1.5	0.9	2.3
Medication: Aspirin	2.1	2.7	7.0	-0.0	2.6	2.1	2.4	0.3	1.4	-0.0
Diabetes diagnosed by doctor	2.1	3.4	6.0	-1.2	2.2	2.1	2.5	1.7	0.9	1.8
Type 2 Diabetes (T2D) (2018)	2.0	3.7	7.3	-2.1	1.6	1.9	1.3	2.5	-0.2	2.7
Diabetes (self-reported)	2.0	3.0	7.1	-0.5	1.8	2.7	1.4	1.8	-0.5	2.3
Qualifications: nursing, teaching	2.0	3.2	6.4	1.6	-1.9	-2.5	-1.1	-1.9	1.4	-1.7
Alzheimer’s Disease (in father)	1.9	2.1	4.5	-1.7	1.6	-0.6	2.1	-0.1	2.1	-0.3
Illnesses of mother	1.9	2.4	5.2	1.4	-0.8	-1.2	-0.2	-2.1	2.3	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.0	-1.0	0.7	-1.1	1.7	2.2	0.3	2.2
Blood White Count	1.8	13.2	27.6	-4.3	0.6	1.4	1.5	4.7	-4.5	5.2
Diabetes (mother)	1.8	2.3	4.9	0.1	0.9	1.4	2.2	1.7	-1.5	1.9
Hand grip strength (right)	1.8	4.8	12.0	0.8	-2.6	0.8	-1.4	-3.3	1.0	-3.5
Number of full sisters	1.8	2.1	8.4	0.5	0.8	-0.2	2.9	1.7	1.2	1.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.8	2.2	1.1	0.3	1.2	1.8	-0.4	1.5
Eye problems/disorders: Glaucoma	1.7	2.0	4.8	-0.3	0.9	2.0	-1.9	-0.3	-2.2	0.5
Alzheimer’s Disease (in mother)	1.6	1.9	5.0	-2.2	0.2	0.2	-0.9	1.3	-2.0	1.4
Hypothyroidism (self reported)	1.6	3.7	8.6	0.1	-1.7	-0.7	-2.3	-2.5	-1.6	-2.9
Neuroticism (2016)	1.5	2.1	4.9	1.6	0.2	-1.6	-2.2	-1.5	0.9	-1.3
Medication for pain relief, constipation, heartburn	1.5	2.5	7.4	0.4	-2.5	-2.7	-1.5	-0.7	-0.4	-1.0
Ever taken oral contraceptive pill	1.5	1.7	3.7	-1.1	-1.9	-0.7	-1.4	-1.6	0.5	-1.4
Illnesses of father: High blood pressure	1.5	1.9	4.3	1.5	2.1	-1.3	1.2	1.4	1.1	0.7
Alcohol drinker status: Previous	1.5	1.7	3.9	-0.5	-0.9	0.7	-2.0	-1.7	-0.8	-1.6
Chronic bronchitis/emphysema (father)	1.4	1.6	4.2	1.0	0.1	-1.2	1.2	2.0	-0.4	1.8
Illnesses of siblings: Diabetes	1.4	1.7	3.0	-0.8	1.4	1.5	0.1	-1.7	1.6	-1.1
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.7	1.2	1.5	1.5	0.6	1.3	-1.3	1.6
Smoking Status	1.3	3.1	6.9	-0.3	2.0	2.6	2.3	1.3	0.9	1.7
Chronotype (morning person)	1.3	3.0	8.4	-0.2	-1.6	1.1	-2.9	-1.8	-2.0	-1.3
Ever had hysterectomy (womb removed)	1.3	1.5	4.2	0.9	-0.1	-0.9	0.6	1.6	-2.1	1.2
Medication: Ramipril	1.3	1.6	4.7	-0.0	2.2	1.3	0.9	1.5	-0.4	1.4
Length of working week for main job	1.3	1.5	3.5	0.7	-1.9	-0.8	-1.4	-1.2	-0.5	-1.5
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	6.5	0.3	-1.5	0.1	-1.5	-2.3	-1.2	-2.5
Number of children fathered	1.3	1.5	4.2	0.3	-0.4	1.2	0.0	-2.0	1.5	-1.5
Supplements: Calcium	1.3	1.4	5.4	-0.4	-0.7	0.4	-1.8	-0.2	-2.3	0.2
Crohns Disease (2017)	1.2	2.6	4.3	1.8	-2.0	0.3	-1.6	-1.9	-0.7	-2.1
Crohns Disease (2012)	1.2	1.9	5.2	-0.1	-1.2	0.5	-2.3	-1.7	-0.5	-1.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.6	-0.7	0.8	-0.6	-1.5	-1.6	1.6	-0.8
Hand grip strength (left)	1.2	3.1	7.1	1.5	-2.2	0.0	-1.4	-2.3	0.4	-2.7
Supplements: Zinc	1.2	1.3	4.6	0.1	-0.8	0.3	-1.7	0.2	-2.1	0.7
Stomach or abdominal pain in last month	1.2	1.5	4.8	0.2	-1.1	1.4	-1.5	0.0	-2.2	0.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.1	-2.0	-0.1	-0.8	1.8	1.0	0.8	0.0
Commuting to job workplace: Car/motor vehicle	1.2	1.4	5.4	2.3	0.6	-0.6	-1.4	-0.6	1.0	-0.7
Mood swings	1.2	2.1	4.0	0.6	2.0	1.6	-1.3	1.1	-1.1	1.9
Loneliness, isolation	1.2	1.7	6.0	0.1	1.0	-0.3	2.5	1.1	1.9	0.3
Average weekly champagne plus white wine intake	1.2	1.6	4.2	-0.1	-1.6	0.6	-0.6	-2.1	0.2	-1.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.4	1.0	0.2	-0.5	-1.4	-1.8	0.8	-1.7
Vascular/heart problems diagnosed by doctor	1.2	3.2	10.2	-1.7	-3.2	-1.8	-0.5	-0.6	-2.2	-0.6
Pack years of smoking	1.2	1.7	5.7	0.1	2.4	1.1	1.0	-0.2	2.0	0.1
Schizophrenia (2018)	1.1	2.3	5.6	-1.0	2.2	2.4	-1.9	-0.9	-0.1	0.1
Schizophrenia vs Biploar Disorder	1.1	1.5	4.6	-0.9	0.2	1.3	0.6	1.1	-2.1	1.4
Heel T-Score	1.1	8.7	19.6	2.3	-1.5	2.0	-2.6	-4.4	1.9	-4.4
Medication for hormone replacement therapy	1.1	1.3	5.2	0.2	-1.0	-0.3	-2.3	0.1	-1.6	-0.1
Medication: Levothyroxine sodium	1.1	1.9	2.8	1.1	-1.6	-0.6	-1.4	-1.5	-1.6	-1.7
Qualifications: None of the above	1.1	2.3	5.1	0.8	1.0	-0.7	1.7	2.2	-1.1	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	7.4	1.2	1.4	2.7	-0.7	-0.8	0.3	-0.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.2	-0.5	-1.2	1.1	-0.4	-0.7	-1.8	-1.4
Eye problems/disorders: None of the above	1.1	1.3	4.2	2.0	-0.3	-0.2	1.6	0.8	0.6	0.9
Overall health rating	1.1	2.3	8.3	2.9	1.9	1.6	1.1	0.2	0.6	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.5	0.7	1.5	-1.0	-1.6	-0.6	1.6	-0.2
Illnesses of father: Heart disease	1.1	1.5	4.3	1.8	1.2	2.1	-1.0	-0.4	0.4	0.0
Eye problems/disorders: Cataract	1.1	1.3	3.5	-1.9	-1.8	-0.3	-1.1	-0.7	-0.1	-1.0
Schizophrenia (2014)	1.0	2.2	6.9	-0.6	2.6	2.1	-1.5	-0.1	-0.4	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	-0.8	1.6	0.0	1.2	1.0	0.7	1.2
Pack years adult smoking proportion	1.0	1.6	5.1	0.1	2.3	0.9	1.2	0.0	1.9	0.2
High blood pressure	1.0	2.9	8.5	1.9	2.9	1.7	0.4	0.1	2.3	0.3
Nervous feelings	1.0	1.9	4.8	1.1	-0.5	-2.2	-1.6	-1.2	0.2	-1.6
Worrier / anxious feelings	1.0	1.9	3.4	1.1	-1.3	-0.7	-1.8	-1.5	-1.2	-1.7
Happiness	1.0	1.2	3.9	-1.6	-0.1	-0.0	2.0	0.4	1.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	5.0	-0.9	-0.6	0.1	-2.2	-0.7	-1.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.4	-0.1	1.5	-1.1	1.5	1.2	1.5	0.9
Hair/balding pattern: Pattern 4	1.0	2.5	10.0	0.6	0.5	-0.1	-3.2	-1.2	-2.3	-0.5
Peak expiratory flow (PEF)	1.0	2.3	7.3	-0.5	0.3	1.4	-2.7	-2.3	0.5	-0.8
Gout (self-reported)	1.0	1.3	3.3	0.7	-0.3	-0.1	-0.9	-1.8	1.8	-1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.8	1.4	-0.2	1.5	-1.7	-1.4	-0.2	-0.6
High blood pressure (siblings)	1.0	1.4	4.0	2.0	-0.2	-0.3	0.1	-1.3	1.2	-1.7
Mean time to correctly identify matches	1.0	1.9	3.8	0.2	1.5	1.6	2.0	1.8	-0.4	1.2
Hypertension (Self-reported)	1.0	2.8	7.9	2.1	2.8	1.7	0.4	0.2	2.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.8	2.4	-0.8	1.7	-0.9	0.2	-1.8	0.7
Medication for cholesterol	1.0	1.5	4.6	-1.0	-2.2	-0.9	-0.7	-1.4	-0.5	-1.0
Financial situation satisfaction	1.0	1.2	5.8	-0.9	0.4	2.4	0.7	0.4	-0.8	0.5
Medication: Lisinopril	1.0	1.3	2.5	1.4	0.6	1.5	-1.3	-1.6	0.3	-0.3
Fractured/broken bones in last 5 years	1.0	1.2	3.3	1.3	0.1	-0.7	-0.2	1.7	-0.3	1.8
Bipolar Disorder (2018)	0.9	1.4	3.1	1.8	0.9	-0.8	-1.3	-0.7	1.4	-1.2
Worry (Nagel 2018)	0.9	2.0	4.2	0.7	-0.3	-1.2	-1.9	-1.8	-0.6	-2.1
Alzheimer’s Disease (including proxy)	0.9	1.3	5.5	-2.3	1.0	-0.1	0.6	0.8	0.2	1.1
Average weekly spirits intake	0.9	1.1	2.0	1.2	-1.4	1.2	-0.3	-1.3	0.1	-0.9
Sensitivity / hurt feelings	0.9	1.5	6.5	-1.3	1.0	0.3	-2.5	-1.0	-0.5	0.6
Trunk fat percentage	0.9	3.6	8.1	0.5	2.7	2.9	1.9	1.1	0.2	2.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.0	0.6	0.5	-0.7	1.7	1.5	-0.7	0.3
Had other major operations	0.9	1.1	4.3	-0.6	0.4	-0.1	2.1	1.5	0.1	0.6
Pain all over the body in last month	0.9	0.9	1.6	0.1	1.1	-0.9	-0.6	-1.3	1.2	-1.1
Medication: Simvastatin	0.9	1.3	3.1	-0.1	1.7	1.1	1.3	0.5	1.8	0.5
Prospective memory result	0.9	1.1	4.6	-0.3	-1.0	-0.0	-1.0	0.8	-2.2	-0.1
Lung cancer (father)	0.9	1.1	3.4	-1.8	-0.1	0.2	1.1	1.2	-0.4	1.2
Tense / ‘highly strung’	0.9	1.5	5.5	2.3	0.7	-0.4	-1.2	-1.0	1.0	-1.1
Glaucoma (self-reported)	0.9	1.1	2.3	-0.6	1.5	1.1	-1.0	0.2	-1.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.6	1.2	-1.6	-1.2	-0.2	-0.1	0.5	-1.1
Osteoporosis (self-reported)	0.9	1.2	2.9	-1.5	1.4	1.7	0.6	0.3	-0.5	0.6
Number of operations (self-reported)	0.9	1.3	3.8	0.1	0.3	0.3	1.9	1.7	-1.5	0.6
Ever depressed for a whole week	0.9	1.1	2.7	-1.6	1.3	0.0	0.2	1.3	-0.1	1.1
Unable to work because of sickness or disability	0.9	1.2	3.8	-1.0	1.4	1.9	0.8	-0.4	0.9	0.1
Bipolar Disorder or Schizophrenia	0.8	2.0	5.0	0.3	2.2	1.3	-2.2	-1.1	0.8	-0.6
Fasting Glucose	0.8	1.0	2.3	0.1	-1.3	0.6	-1.5	-1.5	0.2	-0.5
Qualifications: CSEs or equivalent	0.8	1.0	2.7	1.2	-0.1	-0.1	-0.6	-1.6	0.2	-1.6
Trunk fat mass	0.8	3.5	10.5	1.3	2.4	3.2	1.4	0.6	0.0	2.0
Financial difficulties in last 2 years	0.8	1.1	4.1	-0.7	-0.3	2.0	0.4	-0.7	-1.4	-0.7
Mouth/teeth dental problems	0.8	1.2	3.0	-1.4	-0.1	-1.7	0.3	0.0	1.7	-0.4
Arm fat percentage (right)	0.8	3.1	7.8	-0.1	2.7	2.8	1.8	0.8	0.5	1.6
Depression (self-reported)	0.8	0.9	1.8	-1.3	0.1	-0.0	-0.3	1.0	-1.3	1.4
Loud music exposure frequency	0.8	0.9	2.5	-0.2	1.0	-0.3	-0.9	1.0	-0.8	1.6
Headache pain in last month	0.8	1.3	2.4	-0.8	1.3	1.6	0.9	1.5	-0.8	0.9
Medication: Ibuprofen	0.8	1.0	3.6	0.2	0.3	1.9	-0.7	-1.5	-0.3	-0.7
Medication: Seretide 50 evohaler	0.8	0.9	3.9	-0.4	-0.2	2.0	-0.8	-1.1	-0.0	0.5
Supplements: Vitamin C	0.8	1.0	3.8	0.0	-1.2	-0.2	-2.0	-0.5	-1.1	-0.3
Arm fat percentage (left)	0.8	3.3	9.0	-0.2	2.4	3.0	2.1	1.0	0.3	1.8
Long-standing illness, disability or infirmity	0.8	1.3	4.1	-0.9	0.5	1.3	-1.0	0.7	-2.0	0.6
Breast cancer (self-reported)	0.8	0.9	1.9	-0.6	0.5	1.3	1.4	1.3	-0.5	0.7
Asthma (self-reported)	0.8	1.6	6.3	-0.5	-0.6	0.9	-2.5	-0.4	-1.6	-0.5
Mother’s age at death	0.8	1.0	4.5	0.1	0.5	-0.2	0.2	1.5	0.1	2.1
Medication: Bendroflumethiazide	0.8	1.2	5.4	2.3	1.1	0.2	0.8	0.7	0.5	0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.8	-1.7	1.6	0.7	0.2	0.2	1.0	0.3
Mean Putamen Volume	0.7	0.8	2.6	-1.6	-0.9	0.7	-0.7	-0.2	-1.2	0.0
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.3	-1.8	0.2	0.4	1.0	1.1	-0.7	0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.3	1.5	1.3	0.8	0.1	0.6	-0.6	0.6
Relative age voice broke	0.7	1.1	3.2	-0.5	-1.1	0.7	-1.6	-0.3	-1.8	-0.3
Serious illness, injury or assault to yourself	0.7	0.8	3.1	-0.2	-1.0	-0.4	1.8	1.0	0.2	0.5
Multivitamins +/- minerals	0.7	0.9	1.7	-1.1	1.3	0.4	0.8	1.1	-0.4	1.3
Supplements: Glucosamine	0.7	0.9	2.4	0.4	1.5	-0.7	-1.3	0.2	0.5	1.2
Sitting height	0.7	5.3	13.2	3.2	-2.5	1.1	-3.6	-1.1	-2.1	0.8
High blood pressure (mother)	0.7	0.9	3.8	0.4	1.9	0.0	-0.3	0.8	0.4	1.3
Waist circumference	0.7	2.4	8.0	1.1	1.7	2.8	0.7	0.6	-0.9	1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	-1.5	0.7	-0.0	-0.9	0.5	-1.2	0.9
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-1.4	0.6	-0.2	1.3	1.1	0.1	1.6
Noisy workplace	0.7	0.9	2.6	0.3	0.9	1.6	1.2	1.0	-0.2	0.6
Asthma	0.7	1.4	5.6	-0.5	-0.4	0.9	-2.4	-0.3	-1.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	-0.4	-0.5	1.3	-0.7	-1.6	-0.6	-1.0
Pulse wave Arterial Stiffness index	0.7	0.8	3.1	-0.7	0.6	1.8	0.3	0.2	-1.0	0.5
Arm fat mass (right)	0.7	2.8	8.6	0.8	2.2	2.9	1.7	0.7	0.1	1.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.8	0.1	-0.7	-0.1	-2.2	-1.0	-0.7	-1.1
Body fat percentage	0.7	2.8	6.4	0.4	2.2	2.5	2.1	0.9	-0.1	1.8
Number of full brothers	0.7	0.9	4.9	-0.3	0.2	0.1	2.2	0.8	-0.6	-0.1
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	0.8	1.7	1.7	0.3	0.8	-0.7	0.8
Emphysema/chronic bronchitis	0.7	0.8	3.3	1.8	0.0	-0.3	0.2	0.7	-0.3	1.2
Medication: Allopurinol	0.7	0.9	3.5	0.7	0.6	0.6	-0.4	-1.2	1.9	-0.5
Heart disease (mother)	0.7	0.9	2.1	-1.1	1.0	1.4	0.7	0.8	0.3	0.9
Whole body fat mass	0.7	2.8	8.6	1.2	1.9	2.9	1.6	0.6	-0.2	1.8
Suffer from ‘nerves’	0.7	1.1	3.0	0.5	0.9	-0.3	-0.9	-1.4	0.6	-1.7
Age at last live birth	0.7	0.9	2.6	-0.9	-0.4	0.6	0.2	-0.9	1.6	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	4.1	0.1	0.0	2.0	1.1	-0.0	0.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	-0.4	0.5	-1.3	0.6	1.3	0.6	1.2
Ever had bowel cancer screening	0.7	0.8	2.7	-0.1	0.4	-1.6	1.1	-0.2	0.7	-1.1
Friendships satisfaction	0.7	0.8	2.4	0.9	1.1	1.5	0.6	-0.5	0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.6	0.5	1.9	0.4	1.3	-0.3	1.6	0.1
Back pain experienced in last month	0.7	1.1	4.5	-0.6	0.5	-2.1	1.2	0.8	-0.2	-0.1
Arm fat mass (left)	0.7	2.9	8.7	0.8	2.0	2.9	1.8	0.7	0.1	1.6
Medication: Paracetamol	0.7	1.0	3.0	1.3	1.2	1.7	0.1	0.3	-0.9	0.5
Medication: Atorvastatin	0.7	0.8	3.6	-1.4	0.2	0.3	1.9	0.2	0.5	-0.0
Alcohol drinker status: Never	0.7	0.8	4.3	0.2	-0.6	0.1	-0.7	0.8	-2.1	0.2
Reaction Time	0.6	1.1	2.9	0.4	1.1	1.2	1.7	1.2	0.0	0.4
Bipolar Disorder (2011)	0.6	0.6	2.9	-0.0	0.4	-0.1	-1.7	-0.3	-1.1	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.0	-0.7	0.5	-0.6	-1.2	-1.4	1.1	-0.4
Blood Red Count	0.6	6.1	10.8	3.0	1.8	0.3	3.1	3.0	0.6	3.3
Height	0.6	12.0	50.4	7.1	2.6	3.7	-3.0	-0.1	-0.5	2.0
Medication: Co-codamol	0.6	0.7	2.3	-0.4	0.1	-1.1	1.5	0.9	-0.2	-0.1
Current tobacco smoking	0.6	0.9	4.5	-0.6	0.7	2.1	1.0	-0.1	-0.3	-0.1
Taking other prescription medications	0.6	1.0	3.4	0.4	1.1	0.7	-0.3	1.1	-0.5	1.9
Age when periods started (menarche)	0.6	1.4	4.2	2.1	-0.5	-0.9	-0.9	-1.2	1.0	-1.0
Weight	0.6	2.8	10.4	2.2	1.5	3.2	0.4	-0.4	-0.2	1.2
Pulse rate	0.6	1.0	3.1	0.3	0.4	1.5	0.3	1.0	-0.7	1.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.5	0.9	0.1	1.9	-0.2	-0.8	-1.4	0.2
Standing height	0.6	5.7	28.3	5.3	0.8	1.8	-2.3	-0.9	0.2	1.3
Pulse wave reflection index	0.6	0.7	2.2	-0.9	0.4	-0.4	0.5	-0.7	1.0	-1.5
Medication: Paracetamol	0.6	1.0	2.3	0.9	0.6	1.4	-0.7	0.5	-1.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.9	-0.7	-0.8	-1.3	1.4	0.9	-0.8	0.5
Pulse wave peak to peak time	0.6	0.8	2.1	1.0	-0.5	-1.5	-0.4	-0.4	1.2	-0.6
Medication: Blood pressure	0.6	1.0	2.1	1.0	1.3	1.5	-1.1	-0.9	0.4	-0.3
Migraine (self-reported)	0.6	0.8	3.1	-0.4	0.7	1.8	-0.1	-0.8	0.8	-0.6
Had major operations	0.6	0.7	2.1	-0.4	0.5	-0.1	-0.2	1.4	-0.8	1.4
Commuting to job workplace: Walk	0.6	0.7	1.0	-1.0	-1.0	-1.0	0.8	-0.7	0.2	-0.8
Smoking status: Current	0.6	1.0	3.0	-0.6	0.7	1.7	1.7	0.6	-0.1	0.4
Irritability	0.6	1.0	2.2	-1.5	0.3	-0.0	-1.1	-1.3	0.9	-0.8
Risk taking	0.6	0.9	3.8	0.6	-1.9	-0.6	0.2	-0.6	0.3	-1.1
Pain experienced in last month	0.6	1.0	2.4	-0.2	-1.6	-1.4	0.9	0.8	-0.1	0.9
HDL Cholesterol	0.5	0.8	2.6	0.3	-1.6	-0.1	-0.7	0.5	-1.5	0.6
Rheumatoid Arthritis	0.5	0.7	3.1	0.6	-0.5	1.8	0.4	0.0	-1.0	-0.5
Cardiovascular Disease	0.5	1.8	6.3	2.5	0.8	1.2	-0.9	-0.9	1.4	-0.5
Diabetes (father)	0.5	0.7	1.8	0.6	-0.8	0.6	-1.3	-0.2	-1.2	0.2
Severe depression (siblings)	0.5	0.6	2.0	0.4	1.4	1.0	-0.3	0.6	0.2	0.8
Leg fat-free mass (left)	0.5	2.6	9.2	2.6	1.1	3.0	-0.4	-0.6	-0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	0.7	1.1	0.7	-0.0	-0.8	0.4	-1.1
Leg predicted mass (left)	0.5	2.5	9.1	2.5	1.0	3.0	-0.6	-0.7	-0.2	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.7	1.2	-0.6	-1.0	0.1	-0.5	1.6	-1.2
Allergy	0.5	1.1	5.9	0.5	-0.2	-0.8	2.4	0.8	0.6	0.2
Hip circumference	0.5	2.1	8.1	1.0	1.8	2.8	0.7	0.2	-0.4	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	-0.1	0.7	-1.1	0.2	1.3	-0.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.9	0.5	0.6	1.4	-1.4	0.0	-0.4	0.2
Medication: Amlodipine	0.5	0.7	1.5	1.0	1.0	1.2	0.5	0.5	-0.2	1.1
Age at first live birth	0.5	0.9	3.1	-1.1	0.8	-0.1	1.1	-0.0	1.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	-0.4	-0.7	-0.2	0.6	1.1	-1.4	0.2
Pulse rate, automated reading	0.5	1.6	4.4	-0.3	0.3	0.6	0.3	1.9	-1.6	2.1
Comparative height size at age 10	0.5	2.9	14.1	3.8	0.3	0.8	-1.0	-1.9	0.3	-0.9
Family relationship satisfaction	0.5	0.6	1.5	-0.5	-0.1	-0.1	0.9	1.2	-0.7	1.2
Knee pain experienced in last month	0.5	0.7	1.7	0.9	1.3	1.3	0.3	-0.1	0.7	-0.2
Leg fat-free mass (right)	0.5	2.7	9.9	2.2	1.4	3.1	0.0	-0.2	0.2	1.3
Average weekly red wine intake	0.5	0.7	2.1	-0.8	0.2	1.4	-0.5	0.3	-0.6	1.1
Leg predicted mass (right)	0.5	2.7	10.0	2.2	1.5	3.2	0.1	-0.2	0.3	1.3
Wears glasses or contact lenses	0.5	0.6	2.4	-1.6	1.0	-0.0	0.6	0.3	-0.6	0.3
Commuting to job workplace: Public transport	0.5	0.6	3.5	0.3	0.3	1.9	0.1	0.4	-0.4	0.5
Commuting to job workplace: Cycle	0.5	0.6	2.3	0.1	1.2	1.5	-0.3	-0.2	0.1	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	1.2	0.7	0.4	-1.4	-0.6	0.3	-0.0
Leg fat mass (left)	0.5	1.8	6.5	0.8	1.4	2.5	1.4	0.2	-0.5	1.2
Major Depression (MDD)	0.4	0.5	2.3	0.8	0.6	0.1	-0.2	0.0	1.5	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	-1.1	-0.8	-0.6	-0.8	0.4	-1.7	0.4
Lupus	0.4	0.6	1.5	-1.2	0.3	0.3	0.8	1.0	-0.6	0.7
Number of treatments/medications taken	0.4	0.8	2.3	0.6	1.4	1.5	0.5	0.5	-0.5	0.4
Systolic blood pressure, automated reading	0.4	1.2	5.0	0.5	2.2	1.2	-0.5	0.3	0.0	1.2
Impedance of leg (right)	0.4	1.8	6.3	0.8	-1.4	-2.5	-1.4	-0.6	-0.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	1.5	-1.0	-0.7	-0.3	-0.5	0.8	-1.1
Body mass index (BMI)	0.4	1.6	6.9	-0.2	1.2	2.6	1.5	0.0	-0.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.6	1.3	1.1	0.7	-0.7	-0.0	0.3	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	0.4	-0.2	-0.2	1.4	0.4	0.9	-0.3
Fluid intelligence score	0.4	0.8	2.2	0.0	-0.4	-1.2	-0.3	0.7	-1.5	0.9
Illnesses of siblings	0.4	0.6	2.1	-0.1	0.5	-0.5	0.2	1.2	0.3	1.4
Trunk fat-free mass	0.4	2.4	8.6	2.9	-0.4	2.1	-1.4	-1.3	-0.4	0.2
Time employed in main current job	0.4	0.4	1.3	-0.3	-0.1	1.1	-0.7	-0.4	-1.0	0.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.2	-0.6	1.0	-0.1	-1.5	-0.3	-0.6	0.0
Trunk predicted mass	0.4	2.5	8.2	2.9	-0.5	2.1	-1.5	-1.5	-0.4	0.1
Breastfed as a baby	0.4	0.5	1.6	0.4	0.8	0.2	0.5	0.5	1.3	0.6
Arm fat-free mass (right)	0.4	2.3	7.6	2.8	-0.6	2.4	-0.3	-0.6	-1.2	0.7
Qualifications: College or University degree	0.4	1.3	4.1	-0.9	-1.3	-0.3	-2.0	-1.2	-0.7	-0.5
Medication: Omeprazole	0.4	0.4	2.2	-1.5	0.5	0.5	-0.3	0.3	0.5	0.2
Leg fat mass (right)	0.4	1.7	6.0	1.2	1.1	2.5	1.4	0.0	-0.6	0.9
Arm predicted mass (right)	0.4	2.2	7.1	2.7	-0.7	2.3	-0.5	-0.9	-1.1	0.4
Alcohol intake frequency.	0.4	0.9	3.5	0.3	0.6	-0.2	0.0	1.3	-1.9	1.0
Chest pain or discomfort	0.4	0.5	1.3	1.1	0.4	1.1	-0.3	0.1	-0.3	-0.9
Smoking status: Previous	0.4	0.6	1.6	-0.8	0.5	1.3	0.8	0.1	0.7	0.7
Whole body fat-free mass	0.4	2.3	7.6	2.8	0.1	2.5	-1.0	-1.1	-0.3	0.4
Mineral and other dietary supplements	0.4	0.5	1.4	0.6	-0.7	1.2	1.1	0.2	0.0	-0.3
Whole body water mass	0.4	2.4	7.5	2.7	0.2	2.6	-1.0	-1.0	-0.5	0.5
Hearing aid user	0.4	0.5	2.1	-0.1	0.4	-0.7	1.5	0.0	0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	-0.7	1.0	-0.5	0.1	0.8	0.6	1.1
Ever smoked	0.4	0.7	2.7	-0.4	0.6	1.6	0.8	-0.4	1.0	0.0
Basal metabolic rate	0.4	2.4	7.5	2.7	0.5	2.7	-0.7	-0.8	-0.4	0.7
Leg fat percentage (left)	0.4	1.3	3.2	-0.3	1.5	1.7	1.8	0.3	-0.2	1.0
Arm fat-free mass (left)	0.4	1.8	6.4	2.5	-0.3	1.9	-0.9	-1.0	-0.9	0.2
Diastolic blood pressure, automated reading	0.4	1.2	3.8	1.0	0.4	0.4	-1.2	-1.9	1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-1.2	-0.1	-0.1	0.5	-0.5	0.3	-1.3
Arm predicted mass (left)	0.4	1.8	6.6	2.6	-0.3	1.8	-0.9	-1.1	-0.9	0.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	1.1	0.9	0.5	0.1	0.7	-1.2	0.7
Depression (Nagel 2018)	0.3	0.4	1.7	-0.1	1.3	-0.2	0.2	-0.6	0.3	-0.9
Neuroticism (Nagel 2018)	0.3	0.6	1.4	1.0	0.5	-0.8	-1.2	-0.7	-0.3	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.9	1.4	-0.8	-0.5	-1.0	-0.7	-0.6	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	1.8	1.3	-0.9	0.1	0.3	-0.2	0.4	-0.2
Triglycerides	0.3	0.5	1.0	-0.3	-0.9	-0.4	-0.6	-0.6	-1.0	-0.9
Ulcerative Colitis	0.3	0.4	1.9	0.3	0.2	-0.4	-1.4	-0.0	-0.0	0.7
Blood Eosinophil Count	0.3	2.2	4.6	-2.0	0.8	1.2	0.9	1.8	-0.9	2.1
Allergy or Eczema	0.3	0.8	2.0	-1.0	0.8	1.0	-0.7	0.4	-0.4	1.4
Respiratory disease	0.3	0.6	1.9	-1.4	0.4	0.6	-0.8	0.3	-0.5	0.9
Lung FEV1/FVC ratio	0.3	1.5	3.1	-0.7	1.6	-1.3	-1.8	-0.0	1.5	0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.8	-0.3	0.2	0.1	0.5	0.6	-1.3	0.6
Relative age of first facial hair	0.3	0.6	2.1	0.2	-0.5	1.0	-1.5	-0.8	-0.3	-0.1
Angina	0.3	0.4	1.6	-0.6	0.3	1.3	0.2	0.9	-0.3	-0.0
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.6	-0.0	1.1	0.5	0.5	-0.7	0.3
Average weekly fortified wine intake	0.3	0.4	1.3	-0.4	0.0	-1.1	-0.7	-0.6	-0.5	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.7	-0.4	0.3	0.9	-1.6	-0.7	-0.1	0.1
Number of incorrect matches in round	0.3	0.5	1.5	-0.5	-0.8	-0.3	1.2	0.8	0.5	-0.1
Past tobacco smoking	0.3	0.6	2.1	0.9	-0.1	-1.5	-0.9	-0.0	-0.3	-0.5
Alcohol usually taken with meals	0.3	0.6	1.4	-1.2	0.2	-0.4	0.6	1.1	0.1	0.8
Neuroticism score	0.3	0.6	1.6	0.6	0.6	0.1	-1.3	-0.9	-0.4	-0.9
Impedance of arm (right)	0.3	1.2	4.0	0.6	2.0	-0.5	-0.6	0.7	1.6	0.8
Father’s age at death	0.3	0.4	2.3	-1.5	0.3	-0.6	0.1	0.2	-0.1	0.2
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.8	0.6	0.7	0.5	0.6	-0.2	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.6	-0.7	-0.5	-0.2	0.2	-0.5	-0.1	-1.3
Neck or shoulder pain in last month	0.3	0.5	2.1	0.4	0.4	1.5	-0.1	-0.3	-0.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.6	0.3	-0.4	-1.3	0.6	0.1	0.0	-0.4
Leg pain on walking	0.3	0.4	0.9	-1.0	-0.2	0.7	0.3	-0.4	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.1	-1.1	-0.0	0.2	1.5	1.0	-0.1	0.7
Miserableness	0.3	0.5	1.6	1.3	0.9	0.1	0.2	-0.4	0.5	-0.6
Guilty feelings	0.3	0.4	0.8	0.3	0.5	0.9	-0.7	-0.9	0.2	-0.7
High cholesterol (Self-reported)	0.3	0.4	1.5	-1.2	0.1	0.5	0.7	0.2	0.7	0.6
Myopia	0.3	0.4	1.9	1.4	0.9	0.1	0.3	-0.1	0.2	-0.6
Heart disease (siblings)	0.3	0.3	0.7	0.6	0.1	0.8	0.7	-0.1	-0.8	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.6	-1.2	0.1	-1.2	-0.0	-0.6	-0.5	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.7	0.4	-1.2	-0.4	0.4	0.1	0.5
Ovarian Cancer	0.2	0.3	1.0	0.2	-0.1	-0.4	-0.8	-0.1	-0.3	-1.0
HbA1C	0.2	0.2	0.6	-0.8	0.8	-0.1	0.1	0.5	-0.2	0.4
LDL Cholesterol	0.2	0.4	1.3	-1.0	-0.1	0.4	0.1	-0.3	1.1	-0.0
BMI	0.2	1.1	4.0	-0.2	0.8	1.3	2.0	0.3	0.7	0.9
Systolic Blood Pressure	0.2	0.8	2.9	1.0	1.2	1.7	-0.5	-0.3	-0.0	0.2
Maternal smoking around birth	0.2	0.3	1.3	-0.6	-0.1	0.7	-0.3	-0.2	-1.1	0.1
Medication: Atenolol	0.2	0.3	1.2	-0.6	0.4	1.1	0.0	-0.1	0.3	0.0
Impedance of leg (left)	0.2	1.0	5.6	0.3	-0.7	-2.4	-0.6	0.3	-0.3	0.0
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.3	-0.8	-0.8	0.2	0.5	-0.5	-0.3
Heart attack	0.2	0.3	1.0	0.3	1.0	0.6	0.2	0.2	0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.9	-0.6	-0.1	0.4	-0.3	0.1	-0.9	0.3
Falls in the last year	0.2	0.2	0.7	0.8	0.7	-0.3	-0.7	0.0	-0.0	-0.1
Number of live births	0.2	0.3	0.8	0.8	-0.7	-0.1	0.0	0.1	-0.9	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.2	0.8	-0.2	0.6	-1.1	-1.1	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-1.0	0.1	-1.0	-0.7	-0.2	-0.2	-0.0
Impedance of arm (left)	0.2	0.8	2.8	0.4	1.7	0.0	-0.2	0.9	0.9	1.0
Birth weight of first child	0.2	0.4	1.1	1.0	-0.3	-1.0	-0.2	-0.6	-0.1	-0.5
Birth weight	0.2	0.4	2.1	0.1	0.4	0.3	-1.5	-0.2	-0.7	0.4
Leg fat percentage (right)	0.2	0.9	2.5	0.2	1.0	1.6	1.4	-0.1	-0.5	0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.7	1.3	0.3	-0.6	0.2	0.2	0.0	-0.1
Comparative body size at age 10	0.2	0.6	2.4	-0.3	0.8	0.0	1.6	-0.2	0.8	-0.7
Worry too long after embarrassment	0.2	0.4	1.3	0.6	0.2	-1.1	0.2	-0.2	0.7	-0.6
Angina (self-reported)	0.2	0.3	1.2	-0.5	0.2	1.1	0.1	0.8	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.5	0.1	-0.8	0.3	0.4	0.5	0.1
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.1	1.0	0.4	0.4	-0.6	0.2	-0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.4	0.3	1.0	0.4	0.4	-0.9	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.4	0.1	0.1	-0.1	1.2	0.4	0.1	0.3
Average weekly beer plus cider intake	0.2	0.3	1.2	0.3	-0.2	0.3	-0.6	-1.1	-0.0	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.8	0.8	0.5	-0.0	0.3	-0.3	0.6
Waist Hip Ratio (WHR)	0.1	0.6	1.4	1.2	-0.6	-0.5	0.5	0.9	-0.5	0.8
Lung FVC	0.1	0.7	1.6	-0.4	0.5	-0.3	1.3	1.3	-0.7	1.0
Neuroticism	0.1	0.3	0.6	0.4	-0.1	-0.3	-0.8	-0.4	-0.6	-0.7
Hair Pigment	0.1	1.6	4.5	1.1	-0.3	0.8	-0.8	-1.9	0.7	-2.1
Tanning	0.1	1.2	2.4	-1.5	0.2	-0.2	-0.3	1.3	-1.4	1.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.5	-0.4	0.7	-0.2	0.1	-0.1	0.3	-0.2
Vitamin and mineral supplements	0.1	0.1	0.4	-0.4	-0.6	0.0	0.0	-0.2	0.4	-0.3
Fed-up feelings	0.1	0.2	0.5	0.3	0.7	0.3	-0.3	-0.4	-0.2	-0.1
Forced vital capacity (FVC)	0.1	0.5	1.4	1.2	-0.4	1.0	-0.5	-1.0	0.2	-0.1
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.9	0.1	0.1	0.2	0.3	0.6	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.2	0.0	-1.1	-0.3	-0.8	-0.2	-0.6	0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	1.4	0.4	-1.2	0.3	-0.4	-0.3	-0.9	0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	0.2	-0.5	-0.1	-0.4	0.1	0.1	-0.1
Impedance of whole body	0.1	0.4	1.8	0.4	0.4	-1.3	-0.5	0.7	0.2	0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

NINJ2

Models

Trait associations