Best TWAS P=5.97e-13 · Best GWAS P=4.55e-19 conditioned to 1.33e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LRCH1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 3.9e-05 | -4.6 | -5.6 | 1.6e-08 | 0.59 | 0.39 | 0.60 | FALSE |
| 2 | GTEx | Heart Left Ventricle | LRCH1 | 0.14 | 0.04 | lasso | 6 | 0.03 | 1.3e-02 | -5.3 | -5.4 | 6.3e-08 | 0.65 | 0.03 | 0.93 | FALSE |
| 3 | GTEx | Nerve Tibial | LRCH1 | 0.12 | 0.03 | enet | 12 | 0.02 | 1.0e-02 | -8.2 | -7.2 | 6.0e-13 | 0.82 | 0.17 | 0.73 | TRUE |
| 4 | METSIM | Adipose | LRCH1 | 0.04 | 0.03 | lasso | 4 | 0.03 | 1.2e-05 | -4.9 | -5.3 | 9.1e-08 | 0.60 | 0.90 | 0.10 | FALSE |