TWAS hub - LRCH1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0700	0.0260	0.00130	-0.002	0.015	0.001	0.013	-0.001	9.2e-01	0.0056	2.1e-01	0.00980	5.1e-01
2	GTEx	Adipose Subcutaneous	0.0750	0.0270	0.00130	0.049	NA	0.050	NA	0.053	7.0e-05	NA	6.3e-05	NA	3.9e-05
3	GTEx	Cells EBV-transformed lymphocytes	0.3880	0.1270	0.00680	-0.008	NA	-0.009	NA	-0.007	7.5e-01	NA	9.7e-01	NA	6.6e-01
4	GTEx	Cells Transformed fibroblasts	0.1120	0.0430	0.00190	0.002	NA	0.017	NA	0.005	2.3e-01	NA	1.9e-02	NA	1.2e-01
5	GTEx	Heart Left Ventricle	0.1376	0.0480	0.00170	0.039	NA	0.023	NA	0.027	3.7e-03	NA	2.2e-02	NA	1.3e-02
6	GTEx	Nerve Tibial	0.1214	0.0416	0.00067	0.029	NA	0.022	NA	0.011	3.6e-03	NA	1.0e-02	NA	5.1e-02
7	METSIM	Adipose	0.0429	0.0169	0.00089	0.033	0.017	0.030	0.030	0.032	9.1e-06	0.0010	2.2e-05	0.00002	1.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Headache pain in last month	7.8	13.4	23.5	4.0	4.8	-3.4	3.3	3.3	1.8	4.2
Medication: Ibuprofen	4.6	5.5	9.1	1.1	2.8	-3.0	2.3	2.9	0.6	2.6
Medication: Lansoprazole	4.5	5.2	12.9	-1.2	-2.2	3.6	-1.5	-1.8	-2.4	-2.4
Guilty feelings	4.3	6.5	17.0	1.6	3.1	-4.1	2.2	0.9	1.8	2.7
Mood swings	4.1	7.4	12.5	2.8	2.7	-3.5	2.9	2.2	2.0	2.8
Medication: Aspirin	4.1	5.3	17.6	-0.6	-3.0	4.2	-1.5	-0.5	-1.1	-2.6
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.0	8.6	0.7	2.6	-2.8	2.3	2.9	0.5	2.5
Alzheimer’s Disease (in father)	3.1	3.4	9.6	3.1	1.0	-2.0	-0.5	2.2	1.4	1.4
Type 2 Diabetes (T2D) (2012)	3.1	3.6	8.9	-0.5	-2.8	3.0	-1.0	-0.6	-1.2	-2.3
Risk taking	3.1	4.5	8.3	2.9	2.6	-0.9	1.6	1.8	1.4	2.9
Neuroticism	3.0	7.2	10.5	2.3	3.2	-2.3	2.7	2.6	2.4	3.2
Alcohol intake versus 10 years previously	3.0	4.5	8.1	1.9	2.2	-1.8	2.0	2.9	1.4	2.3
Medication: Aspirin	3.0	4.0	14.8	-0.4	-2.5	3.8	-1.1	-0.1	-0.6	-2.2
Depressed Affect (Nagel 2018)	2.9	6.0	11.4	2.5	2.4	-2.7	3.4	2.2	1.1	2.4
Medication: Levothyroxine sodium	2.9	5.0	7.8	2.7	2.5	-1.9	0.7	2.8	1.9	2.4
Illnesses of father: None of the above (group 1)	2.9	3.6	5.1	1.6	2.3	-0.8	2.1	2.2	2.0	1.9
Illnesses of father: High blood pressure	2.7	3.4	7.0	-1.0	-2.3	-0.3	-1.5	-2.6	-1.6	-2.3
Qualifications: CSEs or equivalent	2.6	3.4	10.8	-0.2	-1.7	0.1	-1.6	-3.3	-2.2	-1.5
Gout (self-reported)	2.5	3.4	5.3	1.0	-2.0	1.9	-1.6	-2.3	-1.8	-2.0
Medication for pain relief, constipation, heartburn	2.5	4.2	9.5	-1.8	-2.0	-0.0	-3.1	-2.8	-0.9	-1.8
Loneliness, isolation	2.5	3.5	10.0	1.3	2.1	-0.4	3.2	1.1	1.4	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	6.2	2.5	2.5	-0.5	0.9	1.6	1.2	1.8
Medication: Bendroflumethiazide	2.5	3.9	7.3	-0.4	-2.1	0.5	-2.7	-2.2	-1.7	-2.6
Blood Platelet Count	2.4	27.3	51.9	-3.3	-5.6	4.1	-4.7	-5.4	-7.2	-5.3
Sensitivity / hurt feelings	2.4	4.1	6.9	-0.1	2.4	-2.4	2.6	1.4	2.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	9.8	1.4	1.1	-0.5	3.1	1.5	1.3	1.1
High cholesterol (Self-reported)	2.4	4.2	16.4	0.1	-2.0	4.0	-0.9	-1.8	-0.9	-2.0
Ever had hysterectomy (womb removed)	2.3	2.6	6.5	-0.1	-2.5	2.2	0.1	0.1	0.5	-2.5
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	5.5	0.1	-2.1	0.9	-1.9	-1.7	-1.0	-2.3
Falls in the last year	2.3	3.2	6.8	1.4	2.3	-0.9	2.6	1.1	1.8	1.6
Comparative height size at age 10	2.3	12.9	21.5	-3.6	-3.3	3.2	-4.3	-2.0	-4.6	-3.4
Basal cell carcinoma (self-reported)	2.3	2.7	5.7	-2.1	-1.3	2.4	-1.2	-1.2	-1.6	-1.4
Neuroticism (Nagel 2018)	2.2	5.2	9.1	2.1	2.3	-3.0	2.4	2.0	1.7	2.2
Worrier / anxious feelings	2.2	4.1	9.8	2.1	2.3	-3.1	0.3	1.5	1.7	1.8
Medication: Cholesterol lowering	2.2	3.4	6.5	-0.2	-1.8	2.5	-2.5	-1.5	-1.5	-1.8
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	7.3	0.9	2.1	-2.2	2.7	1.5	1.1	2.1
Illnesses of siblings: Diabetes	2.2	2.7	6.5	1.8	1.8	-0.6	1.5	1.0	2.5	1.7
Friendships satisfaction	2.2	2.8	4.6	0.6	1.7	-0.7	2.1	2.1	2.1	1.4
Osteoarthritis (self-reported)	2.2	2.9	8.0	2.1	0.4	-0.4	1.7	2.2	2.8	0.3
Medication: Paracetamol	2.2	3.5	8.6	1.0	2.0	-0.7	2.9	2.2	1.1	2.0
Cholesterol lowering medication	2.2	3.2	14.7	0.4	-2.1	3.8	0.1	-0.3	-0.5	-1.7
Systolic Blood Pressure	2.1	10.6	19.2	-2.5	-4.4	2.0	-4.2	-2.5	-2.2	-4.0
Sitting height	2.1	15.1	31.8	-5.6	-3.4	3.0	-4.4	-2.2	-4.1	-3.4
Medication: Paracetamol	2.1	3.5	9.5	0.6	2.0	-0.6	3.1	2.1	1.4	2.0
Medication: Blood pressure	2.1	3.8	11.6	-0.0	-2.2	1.3	-3.4	-1.6	-1.1	-2.1
Medication: Atenolol	2.0	2.5	4.4	-0.9	-1.8	1.1	-1.5	-1.0	-2.0	-2.1
Financial difficulties in last 2 years	2.0	2.6	4.2	2.0	2.0	-1.5	1.2	1.5	0.7	2.0
Medication: Ramipril	2.0	2.5	4.5	1.7	-2.1	1.3	-1.6	-0.7	-1.0	-2.1
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.2	1.4	-1.9	2.5	-1.1	-0.9	-0.2	-2.1
Ovarian Cancer	1.9	2.5	7.0	-0.1	-2.2	0.1	-1.2	-1.5	-1.4	-2.6
Systolic blood pressure, automated reading	1.9	5.5	15.3	-0.4	-3.9	1.9	-2.3	-0.8	-1.1	-3.5
Standing height	1.9	18.8	31.5	-5.6	-4.4	2.9	-4.7	-2.2	-5.1	-4.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.6	1.8	2.1	-1.2	2.1	1.4	0.6	2.0
Leg pain on walking	1.9	2.3	4.1	1.5	1.4	-2.0	1.7	1.7	0.9	1.3
Ever smoked	1.9	3.3	8.8	0.4	2.8	-0.5	0.9	2.1	0.9	3.0
Primary Biliary Cirrhosis	1.8	2.6	5.1	0.3	2.1	0.5	1.5	1.1	2.3	2.2
Height	1.8	35.3	46.2	-6.2	-6.8	5.7	-6.1	-2.9	-6.2	-6.8
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.6	-1.0	1.9	0.4	0.7	1.9	1.1	1.9
Stomach or abdominal pain in last month	1.8	2.3	7.5	0.1	-0.5	-0.5	-2.3	-1.2	-2.7	-1.1
Heart attack	1.8	2.3	5.2	1.2	-1.8	2.3	-1.3	-0.7	-0.5	-2.0
Prospective memory result	1.8	2.2	6.9	2.1	0.9	-2.6	1.3	0.8	-0.7	0.9
Glaucoma (self-reported)	1.8	2.2	6.0	0.4	-1.5	2.4	-1.6	-1.0	-1.2	-1.3
Angina (self-reported)	1.8	2.4	6.6	0.9	-0.8	2.6	-0.9	-2.1	-1.4	-1.2
Taking other prescription medications	1.7	2.7	13.7	0.1	-1.3	3.7	0.2	0.1	-0.8	-1.6
Hair/balding pattern: Pattern 2	1.7	2.2	6.5	-2.6	-1.2	1.2	-0.7	-1.7	-0.5	-1.5
Neuroticism score	1.7	3.6	5.4	1.3	2.3	-2.1	2.3	1.3	1.0	2.3
Pulse wave reflection index	1.7	2.1	4.5	2.0	-0.3	-2.0	-1.0	-0.2	-2.1	-0.9
Pain experienced in last month	1.7	2.8	5.0	-2.2	-1.6	2.0	-0.6	-2.0	-1.4	-1.2
Intelligence (Savage-Jansen 2018)	1.6	4.9	12.6	-1.3	-2.1	3.6	-1.7	-2.8	-1.1	-1.8
Ever used hormone-replacement therapy (HRT)	1.6	2.1	5.2	-1.3	-2.3	1.2	-0.6	-0.9	-1.1	-1.9
Medication: Simvastatin	1.6	2.4	6.7	0.4	-2.2	2.6	0.1	-1.1	-0.4	-1.9
Illnesses of siblings	1.6	2.3	7.2	-2.7	-0.9	0.6	-0.3	-2.1	-1.8	-0.5
Medication: Allopurinol	1.6	2.2	3.0	0.8	-1.5	1.7	-1.2	-1.7	-1.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	6.6	-2.6	-2.2	0.7	-1.5	-1.4	-1.7	-2.0
Relative age voice broke	1.5	2.2	4.7	1.0	2.0	-0.5	1.5	1.6	1.1	2.2
Exposure to tobacco smoke outside home	1.5	2.0	4.2	-0.9	-1.1	0.1	-2.0	-1.4	-2.0	-1.3
Comparative body size at age 10	1.5	4.3	10.6	-0.8	-2.1	0.2	-2.0	-3.3	-2.0	-2.4
Medication: Atorvastatin	1.5	1.8	7.1	0.1	-0.6	1.4	-2.7	-0.4	-1.7	-0.7
Chronotype (morning person)	1.4	3.2	6.5	0.7	-2.5	1.0	-0.9	-2.0	-1.7	-2.5
Alcohol usually taken with meals	1.4	2.3	5.5	0.1	2.0	-0.7	-0.0	2.2	1.0	2.3
Tense / ‘highly strung’	1.4	2.3	4.5	2.1	1.9	-1.0	0.6	1.6	0.6	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.2	0.3	1.5	-2.0	0.3	1.6	0.5	1.6
Illnesses of father: Heart disease	1.4	2.0	3.6	-1.9	-0.9	1.9	-1.8	-0.4	-1.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.3	2.3	1.1	-1.2	0.4	1.0	1.1	1.0
Fasting Glucose	1.3	1.6	8.4	0.8	0.9	-2.9	0.4	-0.0	-0.6	1.0
Triglycerides	1.3	2.1	5.6	2.4	1.1	-0.4	1.7	1.2	1.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	7.1	-1.6	-2.2	1.3	-1.0	-1.4	-0.9	-2.7
Breast cancer (self-reported)	1.3	1.6	3.0	-1.4	0.9	-0.7	0.6	1.7	1.7	1.2
Hearing aid user	1.3	1.5	2.9	-0.2	-1.7	1.7	-1.3	0.0	-1.0	-1.3
Alcohol drinker status: Previous	1.3	1.5	4.5	1.4	1.1	-0.4	1.3	0.5	2.1	1.0
HDL Cholesterol	1.2	2.0	5.0	-2.2	-0.8	1.4	-1.7	-0.1	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	6.0	2.5	1.0	1.0	1.2	0.3	1.0	0.6
Angina	1.2	1.6	3.8	0.7	-0.5	2.0	-0.8	-1.8	-1.3	-1.0
Supplements: Glucosamine	1.2	1.5	6.5	2.5	0.2	-1.0	0.8	0.9	1.3	0.3
Noisy workplace	1.2	1.4	3.6	-1.9	-1.2	1.6	0.0	0.5	-0.5	-1.3
Pulse wave peak to peak time	1.2	1.4	3.7	-1.9	-0.9	1.0	-1.0	-1.6	0.2	-0.7
Fractured/broken bones in last 5 years	1.2	1.6	2.9	1.7	1.4	-0.1	1.3	1.7	0.4	1.3
Heel T-Score	1.1	8.5	15.2	-2.7	-3.9	1.9	-2.6	-2.7	-2.0	-3.9
Impedance of leg (left)	1.1	5.4	8.5	-1.2	-2.5	2.6	-1.1	-2.9	-2.8	-2.4
Number of children fathered	1.1	1.2	4.2	-0.5	-1.8	0.8	-0.2	0.5	-0.1	-2.1
Migraine (self-reported)	1.1	1.4	2.8	1.7	1.1	-1.5	0.7	1.2	0.5	1.1
Average weekly champagne plus white wine intake	1.1	1.5	3.0	-0.2	1.5	-1.2	0.4	1.0	1.6	1.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	-0.5	-1.7	1.6	-1.2	0.3	-0.5	-1.5
Age started oral contraceptive pill	1.1	1.4	2.6	1.2	1.2	-0.4	0.8	1.6	1.5	1.2
Major Depression (MDD)	1.0	1.2	2.7	1.6	1.5	0.4	1.1	-0.8	0.9	1.0
Age at First Birth	1.0	1.5	3.0	-1.3	-1.5	0.7	-0.6	-0.9	-1.3	-1.7
Cardiovascular Disease	1.0	3.2	11.9	-0.8	-2.1	3.5	-1.4	-0.5	0.1	-1.8
Impedance of leg (right)	1.0	4.9	8.3	-1.5	-2.4	2.0	-1.0	-2.9	-2.8	-2.3
Average weekly fortified wine intake	1.0	1.2	3.1	-0.3	1.8	-0.6	-0.3	1.2	1.4	1.1
Age when periods started (menarche)	1.0	2.4	4.1	0.3	1.7	-1.7	2.0	2.0	1.2	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	-1.5	-0.6	1.7	-1.1	-1.2	0.3	-0.8
Loud music exposure frequency	1.0	1.1	2.0	0.7	1.4	-1.0	0.7	1.2	1.0	1.3
Medication: Omeprazole	1.0	1.1	4.9	2.2	0.7	-1.0	-0.5	0.4	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.8	-1.9	-0.1	0.7	-1.4	-0.9	-1.2	-0.2
Hypertension (Self-reported)	1.0	2.7	5.5	-0.3	-2.3	2.3	-1.7	-0.7	-0.3	-2.0
Mineral and other dietary supplements	1.0	1.4	3.4	-1.9	-0.8	0.2	-1.6	-0.6	-1.5	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	8.3	0.6	-0.8	2.9	0.3	-0.1	1.1	-1.2
Ever taken oral contraceptive pill	1.0	1.1	3.0	1.7	0.8	1.3	0.8	-0.7	0.1	1.0
Impedance of whole body	1.0	4.9	7.9	-1.4	-2.2	2.5	-1.2	-2.7	-2.8	-2.1
Number of treatments/medications taken	0.9	1.6	6.9	1.3	-0.9	2.6	0.4	0.3	0.0	-1.1
Hearing difficulty/problems: Yes	0.9	1.3	2.5	0.4	1.6	0.5	1.3	1.3	0.8	1.6
Trunk fat percentage	0.9	3.5	8.2	1.9	-2.7	1.6	-1.8	-0.2	-0.4	-2.9
High blood pressure	0.9	2.6	5.8	-0.1	-2.4	2.3	-1.7	-0.4	-0.1	-2.1
Trunk fat mass	0.9	4.0	9.7	1.1	-3.0	1.5	-2.4	-0.2	-0.8	-3.1
Time employed in main current job	0.9	1.0	2.4	-0.8	-1.2	-1.1	-0.5	-1.6	-0.1	-1.1
Hair/balding pattern: Pattern 3	0.9	1.3	4.3	1.5	0.8	-2.1	-0.3	0.7	0.7	1.0
Pulse rate	0.9	1.6	3.0	-0.6	0.6	1.7	1.3	1.0	1.7	1.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	8.9	-3.0	0.7	0.7	-0.7	-1.7	0.1	0.8
Impedance of arm (left)	0.9	4.3	7.2	-1.2	-2.1	2.4	-1.1	-2.6	-2.7	-2.0
Length of working week for main job	0.9	1.0	4.7	-0.2	0.6	-2.2	0.8	-0.5	0.7	0.8
Breastfed as a baby	0.9	1.1	2.5	-1.1	-1.5	0.5	-1.6	-0.6	0.3	-1.2
Hair/balding pattern: Pattern 4	0.9	2.2	7.2	-0.9	-1.9	2.7	-0.3	-0.3	-0.9	-1.6
Peak expiratory flow (PEF)	0.9	2.1	4.3	-1.1	-1.5	0.4	-2.1	-1.3	-1.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.5	-0.7	-1.1	-0.2	-0.9	-1.3	-0.5	-1.6
Shortness of breath walking on level ground	0.9	1.1	2.9	0.3	-0.9	1.3	-0.7	-1.7	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	4.8	-1.1	-0.6	2.2	-0.2	0.5	0.7	-0.7
Average weekly red wine intake	0.9	1.3	3.4	-0.1	1.5	-0.1	0.9	0.4	1.4	1.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.2	0.5	1.1	-1.5	0.4	-1.0	-1.3	1.0
Long-standing illness, disability or infirmity	0.9	1.4	4.4	2.1	-1.0	1.4	-0.2	-0.7	0.5	-1.3
Eye problems/disorders: Cataract	0.9	1.0	3.3	0.1	-0.9	1.8	-1.0	0.4	-0.4	-1.2
Medication for cholesterol	0.9	1.3	3.9	0.3	2.0	-1.1	-0.2	0.8	0.2	1.8
Mother’s age at death	0.9	1.1	3.5	0.1	0.9	-0.8	1.0	0.7	1.9	1.2
Medication: Blood pressure	0.9	1.7	4.2	0.3	-1.9	2.0	0.5	-0.7	0.3	-1.7
Diastolic blood pressure, automated reading	0.9	2.6	10.0	0.6	-3.2	-0.6	-0.8	-0.3	-0.8	-2.6
Commuting to job workplace: Cycle	0.9	1.1	2.2	-0.8	1.3	0.3	1.5	0.5	1.1	1.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.1	-0.0	2.2	-2.5	1.4	0.5	-0.1	2.0
Schizophrenia (2018)	0.8	1.7	3.5	1.0	1.9	-0.6	1.0	1.0	1.6	1.6
Crohns Disease (2012)	0.8	1.2	4.8	0.3	-0.3	2.2	-0.5	-0.1	-1.7	-0.7
Ulcerative Colitis	0.8	1.1	2.0	-0.7	-1.2	1.0	-0.8	-0.8	-1.4	-1.3
Medication: Metformin	0.8	1.1	2.9	0.5	-1.1	1.4	-1.7	-0.1	0.0	-1.2
Impedance of arm (right)	0.8	3.7	8.7	-1.1	-1.7	2.9	-0.7	-2.3	-2.3	-1.6
Mouth/teeth dental problems: Dentures	0.8	1.4	2.6	0.8	-1.5	1.5	-0.6	-0.3	-1.3	-1.6
Illnesses of mother	0.8	0.9	5.2	0.5	0.8	-2.3	0.3	0.1	0.3	0.3
Body fat percentage	0.8	3.0	6.6	2.1	-2.4	1.3	-1.6	-0.0	0.0	-2.6
Wheeze or whistling in the chest in last year	0.8	1.5	2.6	1.1	1.4	-0.4	1.3	1.4	1.6	0.8
Qualifications: College or University degree	0.8	2.5	15.0	-3.9	0.5	1.2	-0.1	0.3	0.6	0.8
Eye problems/disorders: None of the above	0.8	0.9	3.3	-0.8	0.6	-0.3	0.8	-1.8	-0.8	0.7
Supplements: Vitamin C	0.8	0.9	4.7	-2.2	0.4	-0.0	0.1	0.9	-0.7	0.2
Smoking status: Previous	0.8	1.2	2.3	0.9	1.5	0.9	-0.0	1.3	0.8	1.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.7	-0.2	-0.5	1.3	-1.6	0.1	-1.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.2	1.2	-0.4	-1.3	-1.5	-0.8	-0.4	-0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.6	0.9	0.7	-1.2	-0.2	1.3	1.2	0.9
Irritable Bowel Disease (IBD)	0.7	1.7	4.0	-0.6	0.0	1.6	1.1	-1.8	-2.0	-0.2
Ulcerative Colitis (UC)	0.7	1.3	3.3	-1.2	-0.1	1.2	0.6	-1.5	-1.8	-0.1
Bipolar Disorder (2011)	0.7	0.7	2.9	0.0	-0.8	1.7	-0.5	-0.5	0.5	-0.6
LDL Cholesterol	0.7	1.1	2.9	1.7	0.2	-1.7	0.8	1.2	-0.1	0.0
Average weekly spirits intake	0.7	0.8	3.7	-1.9	-0.2	-0.4	-0.3	1.0	0.3	-0.9
Maternal smoking around birth	0.7	1.0	4.6	2.2	-0.2	-1.1	-0.6	0.0	-0.7	-0.5
Fed-up feelings	0.7	1.3	4.0	2.0	1.1	-0.5	1.3	0.9	-0.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.0	1.0	1.0	-1.4	1.3	-0.0	0.8	0.9
High blood pressure (mother)	0.7	0.9	4.1	-0.7	-0.5	2.0	-0.8	-0.4	-0.9	0.0
Past tobacco smoking	0.7	1.3	3.7	-0.4	-1.8	-0.6	0.1	-1.3	-0.4	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.7	1.9	0.8	-0.8	1.3	0.4	-0.1	0.5
Forced vital capacity (FVC)	0.7	2.8	5.3	-2.3	-1.9	0.3	-1.0	-1.7	-1.6	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.8	-1.9	-1.3	1.2	-0.8	-0.7	-0.3	-1.6
Father’s age at death	0.7	1.0	2.3	-0.0	1.2	-0.9	1.0	0.8	0.7	1.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.0	-2.0	-0.3	0.3	-1.3	-1.5	0.5	0.1
Blood clot in the leg (DVT)	0.7	0.9	2.2	0.9	-0.5	-1.4	-1.5	-0.7	-0.5	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.3	1.2	-1.1	0.9	0.1	-1.1	-0.3	-0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	8.1	-2.9	-1.7	-0.1	-0.5	-1.1	-1.3	-1.8
Number of full brothers	0.7	0.8	2.2	0.9	-0.3	0.7	0.5	1.5	1.2	-0.6
Worry too long after embarrassment	0.7	1.2	3.3	0.4	0.4	-1.8	1.6	-0.2	1.4	-0.1
Emphysema/chronic bronchitis	0.7	0.8	3.8	0.6	-0.3	1.9	-0.4	-1.2	-0.0	-0.3
Whole body fat mass	0.7	3.1	7.0	1.3	-2.5	1.2	-2.2	0.1	-0.4	-2.6
Age at last live birth	0.7	1.0	2.0	-1.4	-0.7	1.2	-0.8	-0.6	-1.4	-0.2
Eye problems/disorders: Glaucoma	0.7	0.8	1.9	0.1	-1.0	0.8	-1.4	-0.3	-0.9	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.5	1.2	-0.0	0.1	1.6	0.7	1.5	-0.1
Number of operations (self-reported)	0.7	1.0	2.7	1.4	-0.1	1.6	-1.3	-0.4	0.5	-0.3
Crohns Disease (2017)	0.6	1.2	3.2	0.7	0.7	1.6	1.8	-0.8	-0.9	0.5
Prostate Cancer	0.6	0.9	3.3	-0.3	-0.5	-0.3	-0.6	-1.8	-1.2	-0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.0	-0.2	-1.4	0.7	-0.8	0.3	-0.6	-1.2
Schizophrenia (2014)	0.6	1.4	3.0	0.8	1.5	-1.0	0.7	0.7	1.7	1.4
Lung FEV1/FVC ratio	0.6	3.1	11.9	1.3	1.5	-0.3	1.1	3.5	1.7	1.4
Hand grip strength (left)	0.6	1.5	3.4	-1.8	-1.0	-0.1	-1.0	-0.9	-1.7	-1.0
Number of incorrect matches in round	0.6	1.0	3.1	1.8	1.3	-0.6	-0.5	0.0	0.1	1.3
Had other major operations	0.6	0.7	2.7	1.7	0.7	-0.5	-0.7	0.6	0.5	0.7
Diabetes (self-reported)	0.6	0.9	2.6	1.2	-0.7	1.3	-1.6	0.1	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.8	-2.0	-1.6	0.6	-1.1	-1.0	-1.3	-1.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	1.4	0.5	-0.7	0.5	1.3	-0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.7	0.9	1.3	-1.2	1.0	1.1	1.3	0.9
Leg fat percentage (right)	0.6	2.1	4.5	2.1	-2.0	0.7	-0.8	0.6	1.0	-2.0
Mean time to correctly identify matches	0.6	1.2	3.8	-0.3	0.5	-0.4	1.9	1.8	0.8	0.5
Leg fat mass (right)	0.6	2.3	5.1	1.5	-2.2	0.8	-1.6	0.5	0.4	-2.3
Ever had bowel cancer screening	0.6	0.7	3.2	1.8	-0.3	1.1	0.4	-0.1	-0.5	-0.2
Qualifications: nursing, teaching	0.6	1.0	3.5	-1.3	0.8	-0.2	-0.5	-1.9	-0.5	0.6
Back pain experienced in last month	0.6	0.9	2.0	1.0	-0.5	-0.5	-1.4	-1.0	-0.9	-0.9
Smoking status: Current	0.6	0.9	1.8	-1.1	-0.6	-0.4	-0.9	-1.4	-1.3	-0.5
Miserableness	0.6	1.1	2.4	-0.8	0.7	-1.6	1.5	1.0	-0.5	0.7
Wears glasses or contact lenses	0.6	0.7	2.8	0.4	-0.2	0.9	-1.7	0.4	-0.8	-0.1
Leg fat percentage (left)	0.6	2.3	5.8	2.4	-1.9	0.9	-0.8	0.6	1.0	-2.0
Unable to work because of sickness or disability	0.6	0.7	1.7	0.6	-1.0	1.3	-1.0	-0.2	-0.3	-1.1
Myopia	0.6	0.8	2.2	-0.0	-0.8	-0.4	-1.5	-1.2	-1.2	-0.2
Supplements: Calcium	0.6	0.6	2.4	0.2	1.5	0.7	-0.0	0.4	0.4	1.1
Leg fat mass (left)	0.6	2.2	4.9	1.7	-2.1	0.8	-1.5	0.6	0.5	-2.2
HbA1C	0.5	0.6	1.4	1.0	0.3	-0.7	1.1	0.0	1.2	-0.2
Lupus	0.5	0.7	1.3	0.6	0.8	-1.2	1.1	0.3	0.7	0.8
Blood Red Count	0.5	4.4	9.2	-0.5	-3.0	2.8	-1.4	-2.1	-1.0	-2.5
Medication: Co-codamol	0.5	0.5	1.7	0.5	0.9	-1.3	0.6	0.6	0.4	0.3
Current tobacco smoking	0.5	0.9	1.6	-0.9	-0.5	-0.6	-1.2	-1.2	-1.3	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.2	1.1	0.5	0.9	-0.3	0.7	1.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.8	0.2	0.7	-1.7	0.2	0.8	0.3	0.6
Body mass index (BMI)	0.5	2.0	6.6	2.6	-0.1	-0.6	-0.0	1.5	2.1	-0.3
Qualifications: None of the above	0.5	1.0	2.3	1.5	-0.6	1.4	-0.2	0.9	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.7	-2.2	-1.5	0.1	-0.8	-0.9	-1.2	-1.6
Birth weight of first child	0.5	0.9	3.4	0.6	0.2	-1.8	-0.4	0.6	1.4	-0.0
Medication: Amlodipine	0.5	0.7	3.2	0.2	-0.9	0.3	-1.8	-0.5	0.0	-0.7
Health satisfaction	0.5	0.6	2.7	0.6	0.6	-0.7	0.5	0.3	1.6	0.4
Diabetes diagnosed by doctor	0.5	0.8	2.2	1.2	-0.6	1.2	-1.5	0.2	-0.4	-0.6
Commuting to job workplace: Walk	0.5	0.5	1.2	-0.9	-0.0	0.2	-0.9	-1.1	-0.9	0.2
Commuting to job workplace: Public transport	0.5	0.6	2.4	-0.6	0.1	0.7	-1.1	-0.2	-1.5	0.2
Ever depressed for a whole week	0.5	0.6	2.6	-0.1	0.4	-1.6	0.4	0.8	0.5	0.2
Bipolar Disorder or Schizophrenia	0.4	1.1	4.3	0.5	1.0	-0.2	0.8	0.7	2.1	0.9
Vitamin and mineral supplements	0.4	0.5	1.4	1.1	-0.8	-0.2	-1.2	0.2	-0.0	-0.5
Hand grip strength (right)	0.4	1.1	2.6	-1.0	-1.1	-0.3	-1.0	0.1	-1.6	-1.4
Townsend deprivation index at recruitment	0.4	0.6	1.3	-0.4	0.8	0.4	-1.0	-0.3	-0.7	1.1
Waist circumference	0.4	1.3	2.9	1.7	-0.9	0.4	-1.2	0.9	1.3	-1.2
Had menopause	0.4	0.5	1.8	0.1	-0.6	1.4	0.7	0.3	0.7	-0.6
Weight	0.4	2.0	4.7	-0.0	-2.0	0.7	-2.0	0.4	-0.2	-2.2
Arm fat percentage (right)	0.4	1.8	7.2	2.7	-0.8	0.7	-0.5	1.1	1.3	-0.9
Hip circumference	0.4	1.7	4.2	0.2	-2.0	0.5	-1.8	0.2	0.1	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	1.4	-0.4	1.3	-0.8	0.1	-0.3	-0.4
Number of live births	0.4	0.5	2.9	1.7	0.6	-0.0	0.6	0.4	-0.1	0.3
Lung cancer (father)	0.4	0.5	1.3	-0.9	-0.7	0.8	-0.2	0.5	-1.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	0.9	0.1	0.2	-0.1	-0.4	1.4	0.3
Birth weight	0.4	0.9	2.7	0.4	-0.6	0.1	-1.6	-1.6	-0.5	-0.6
Arm fat-free mass (right)	0.4	1.8	4.6	-1.4	-1.6	-0.4	-2.1	0.3	-0.8	-1.7
Age at first live birth	0.4	0.8	1.6	-1.3	-1.0	1.1	-0.7	-0.8	-0.3	-0.6
Heart disease (mother)	0.4	0.5	1.6	0.3	-0.2	1.2	-0.2	0.2	-1.3	-0.2
Arm predicted mass (right)	0.4	2.1	5.4	-1.3	-1.8	-0.2	-2.3	0.2	-1.0	-1.9
Pulse rate, automated reading	0.4	1.3	2.7	-0.3	-1.2	1.6	-1.1	-1.2	-0.6	-1.2
Suffer from ‘nerves’	0.4	0.7	1.7	-0.9	0.2	1.2	-0.2	-1.3	-0.7	0.4
Knee pain experienced in last month	0.4	0.6	1.7	1.3	0.1	-0.3	-0.8	1.1	0.9	-0.0
Arm fat percentage (left)	0.4	1.7	6.2	2.5	-1.2	0.4	-0.8	0.7	1.0	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	1.4	1.1	-0.8	0.7	0.3	-0.1	0.6
Arm fat mass (left)	0.4	1.6	3.1	1.7	-1.6	0.6	-1.4	0.7	0.6	-1.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	-0.9	-0.4	1.2	0.8	0.5	-0.3	-0.4
Medication: Lisinopril	0.4	0.6	2.2	-1.1	-0.4	1.5	-0.3	0.1	0.6	-0.2
Heart disease (siblings)	0.4	0.4	1.5	0.8	-0.2	0.2	-0.8	1.2	0.3	-0.3
Bipolar Disorder (2018)	0.3	0.5	2.0	-0.4	-0.7	0.4	-0.1	-0.2	1.4	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.9	1.0	0.4	-0.1	-0.2	0.4	1.0
Worry (Nagel 2018)	0.3	0.6	1.0	1.0	0.9	-0.6	-0.0	0.9	0.7	1.0
Reaction Time	0.3	0.6	2.1	-0.0	0.2	0.0	1.4	1.0	0.8	0.2
Breast Cancer	0.3	0.8	3.0	-0.2	-0.6	-0.3	1.7	-0.0	-1.0	-1.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	1.4	-0.4	-0.6	-0.2	0.1	-0.6	-0.5
Rheumatoid Arthritis	0.3	0.4	1.1	0.1	-1.0	0.6	-0.6	-0.3	-0.4	-1.1
BMI	0.3	1.8	5.5	2.4	0.5	-0.5	-1.2	1.4	1.7	0.5
Respiratory disease	0.3	0.6	2.7	-0.1	0.4	1.6	-0.6	-0.6	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.1	0.0	-0.7	0.5	-1.5	-0.4	-0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.2	-0.0	0.8	-0.9	-0.3	-0.7	0.5
Medication for hormone replacement therapy	0.3	0.4	2.6	0.0	0.0	-1.6	-0.2	0.0	0.1	0.0
Severe depression (siblings)	0.3	0.3	1.5	1.2	0.1	-0.5	-0.4	0.5	0.2	0.1
Multivitamins +/- minerals	0.3	0.4	0.8	-0.5	0.6	0.9	0.6	-0.3	0.4	0.6
Pain all over the body in last month	0.3	0.3	1.2	0.7	0.3	0.1	1.1	-0.1	0.6	0.1
Trunk fat-free mass	0.3	1.8	3.8	-1.9	-1.3	-0.1	-1.9	0.5	-1.0	-1.4
Happiness	0.3	0.4	1.3	0.9	0.2	-1.2	0.3	-0.2	0.5	0.0
Arm fat mass (right)	0.3	1.4	2.9	1.7	-1.3	0.8	-1.1	0.8	0.8	-1.4
Trunk predicted mass	0.3	1.9	4.0	-1.9	-1.4	0.0	-2.0	0.4	-1.0	-1.4
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.5	0.6	-0.2	1.0	0.5	0.2	0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	1.2	0.6	0.3	0.1	0.5	0.3	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-0.2	0.3	0.4	-0.1	-1.0	-1.1	0.0
High blood pressure (siblings)	0.3	0.4	0.8	0.8	-0.7	0.4	-0.9	0.2	0.0	-0.9
Neck or shoulder pain in last month	0.3	0.4	0.9	0.6	1.0	-0.5	1.0	0.5	0.4	0.5
Number of full sisters	0.3	0.4	0.8	-0.6	0.8	0.1	-0.9	-0.2	-0.4	0.9
Overall health rating	0.3	0.6	1.7	1.2	-0.6	1.3	-0.6	-0.5	0.2	-0.5
Chest pain or discomfort	0.3	0.5	1.0	0.7	0.5	0.4	0.4	-0.9	-1.0	0.7
Had major operations	0.3	0.4	0.7	0.8	0.8	0.5	0.1	-0.3	0.8	0.4
Family relationship satisfaction	0.3	0.3	1.9	1.4	0.1	0.3	0.4	0.2	0.1	0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	0.3	-0.6	0.0	0.0	0.8	1.0	-0.5
Whole body fat-free mass	0.3	1.5	4.2	-1.3	-1.3	-0.0	-2.0	0.6	-0.8	-1.4
Medication: Gliclazide	0.3	0.3	1.0	-0.2	0.1	0.8	-1.0	0.2	-0.5	0.3
Alcohol drinker status: Never	0.3	0.4	1.6	0.2	0.7	-0.5	-0.2	-1.3	-0.3	0.6
Basal metabolic rate	0.3	1.5	4.0	-1.0	-1.5	0.1	-2.0	0.5	-0.7	-1.6
Average weekly beer plus cider intake	0.3	0.4	1.2	0.1	0.9	-1.1	0.0	0.2	0.4	0.7
Irritability	0.3	0.5	2.1	0.5	0.3	-1.4	0.7	-0.0	0.3	0.9
Arm predicted mass (left)	0.3	1.3	3.0	-1.0	-1.5	0.2	-1.7	0.5	-0.5	-1.5
Depression (Nagel 2018)	0.2	0.2	0.5	0.7	0.5	-0.4	0.7	0.0	0.4	0.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.7	0.4	0.2	-0.3	0.7	0.7	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.4	-0.5	0.1	1.2	-0.7	-0.1	0.8	0.3
Mean Putamen Volume	0.2	0.3	0.8	0.9	-0.6	0.3	0.5	-0.5	0.1	-0.3
Neuroticism (2016)	0.2	0.3	1.7	1.3	0.2	0.2	-0.1	0.2	0.2	0.3
Waist Hip Ratio (WHR)	0.2	0.7	1.6	1.0	0.9	1.3	0.2	0.3	1.1	0.6
Smoking Status	0.2	0.5	1.1	0.7	1.1	0.4	0.7	0.0	-0.0	1.1
Hypothyroidism (self reported)	0.2	0.5	1.2	1.1	0.9	-0.8	0.5	0.2	0.7	0.6
Relative age of first facial hair	0.2	0.4	1.1	-0.0	1.0	-0.2	1.0	0.2	-0.2	0.9
Diabetes (mother)	0.2	0.2	0.6	-0.8	-0.4	-0.2	0.0	0.3	0.1	-0.8
Pack years adult smoking proportion	0.2	0.3	0.8	0.1	-0.5	0.8	0.1	-0.3	-0.9	-0.5
Leg fat-free mass (left)	0.2	1.1	3.8	-0.6	-1.2	-0.1	-1.9	0.4	-0.5	-1.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	-0.1	0.5	0.3	1.0	0.3	1.1	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.9	0.9	-0.3	-0.0	0.5	0.2	0.6	-0.1
Leg predicted mass (left)	0.2	1.1	3.5	-0.6	-1.2	-0.1	-1.9	0.5	-0.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.8	-0.1	-0.8	0.4	0.1	0.2	-0.1
Mouth/teeth dental problems	0.2	0.4	0.9	-0.8	-0.3	-0.5	-0.8	0.4	0.9	-0.0
Fluid intelligence score	0.2	0.4	1.0	-0.2	0.6	0.7	0.1	-0.8	0.3	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	0.7	0.6	0.5	0.1	-0.4	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.4	-0.1	0.7	-0.4	-0.7	0.4	-0.4
Alcohol intake frequency.	0.2	0.5	2.5	1.6	0.3	-0.2	0.6	-0.5	0.1	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.9	-0.1	0.6	0.2	-0.8	0.3	0.1
Leg fat-free mass (right)	0.2	1.0	3.5	-0.6	-1.1	0.2	-1.9	0.5	-0.5	-1.1
Osteoporosis (self-reported)	0.2	0.3	0.9	-1.0	-0.1	0.8	0.0	0.0	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.6	-1.6	0.0	-0.7	0.1	0.7	0.1	0.1
Whole body water mass	0.2	1.3	3.8	-1.2	-1.2	-0.1	-1.9	0.6	-0.7	-1.3
Leg predicted mass (right)	0.2	0.9	3.3	-0.5	-1.0	0.1	-1.8	0.5	-0.4	-1.1
Financial situation satisfaction	0.2	0.3	1.0	0.3	-0.1	-0.6	1.0	-0.6	0.5	-0.2
Arm fat-free mass (left)	0.2	1.1	2.9	-1.0	-1.2	-0.2	-1.7	0.8	-0.3	-1.3
Blood White Count	0.1	0.5	3.1	0.0	-0.3	-0.4	-1.8	-0.5	-0.4	-0.1
Allergy or Eczema	0.1	0.3	0.9	-0.1	-0.3	0.9	0.5	0.2	0.7	-0.3
Lung FVC	0.1	0.7	2.7	0.1	0.6	-1.7	0.6	0.5	0.8	0.4
Hair Pigment	0.1	4.0	7.9	-2.6	-1.2	0.5	-1.8	-2.8	-2.6	-1.4
Tanning	0.1	0.9	3.9	2.0	-0.0	-1.3	0.0	-0.8	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.4	0.3	-0.8	0.7	-0.1	0.1	0.3
Supplements: Zinc	0.1	0.1	0.5	-0.7	-0.2	-0.2	0.1	0.4	-0.1	0.1
Diabetes (father)	0.1	0.2	0.5	0.5	0.1	-0.7	0.2	-0.4	-0.5	0.2
Nervous feelings	0.1	0.1	0.4	0.2	-0.2	-0.5	-0.2	0.6	-0.0	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.4	0.4	0.4	-0.1	-0.7	-0.2	0.5
Allergy	0.1	0.3	0.7	0.5	-0.9	0.1	-0.6	-0.0	-0.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.1	0.5	-0.5	0.0	0.0	-0.5	0.3
Asthma	0.1	0.2	0.8	-0.9	0.3	-0.0	0.1	-0.2	0.6	-0.2
Depression (self-reported)	0.1	0.2	0.9	-0.0	0.2	-0.1	1.0	-0.4	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	-0.1	0.3	0.1	0.7	0.4	0.2	0.4
Asthma (self-reported)	0.1	0.3	0.9	-0.9	0.5	0.3	-0.2	-0.1	0.9	0.1
Pack years of smoking	0.1	0.2	0.5	0.7	-0.3	0.6	0.3	-0.1	-0.6	-0.4
Blood Eosinophil Count	0.0	0.2	0.6	-0.5	0.5	0.1	-0.1	0.4	0.8	0.5

Hub : Genes

LRCH1

Models

Trait associations