Best TWAS P=2.23e-12 · Best GWAS P=1.15e-09 conditioned to 0.631
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PHF11 | 0.06 | 0.00 | enet | 19 | 0.01 | 4.4e-02 | -5.0 | 7.0 | 2.2e-12 | 0.43 | 0.05 | 0.36 | TRUE |
2 | GTEx | Colon Transverse | SETDB2 | 0.15 | 0.02 | lasso | 7 | 0.05 | 3.0e-03 | 5.9 | -5.2 | 1.9e-07 | -0.77 | 0.02 | 0.93 | FALSE |
3 | GTEx | Muscle Skeletal | PHF11 | 0.11 | 0.14 | lasso | 6 | 0.13 | 9.4e-13 | -5.7 | 5.7 | 1.6e-08 | 0.93 | 0.06 | 0.94 | FALSE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | RCBTB1 | 0.17 | 0.03 | lasso | 8 | 0.02 | 1.9e-02 | -5.1 | 5.5 | 4.8e-08 | 0.52 | 0.16 | 0.50 | FALSE |
5 | METSIM | Adipose | PHF11 | 0.16 | 0.14 | lasso | 9 | 0.14 | 8.7e-20 | -5.7 | 5.8 | 5.7e-09 | 0.93 | 0.06 | 0.94 | FALSE |
6 | METSIM | Adipose | SETDB2 | 0.06 | 0.03 | enet | 17 | 0.05 | 5.1e-08 | -4.9 | -5.3 | 1.1e-07 | -0.80 | 0.01 | 0.99 | FALSE |
7 | NTR | Blood | PHF11 | 0.04 | 0.03 | bslmm | 406 | 0.04 | 3.1e-12 | -5.2 | 5.6 | 2.5e-08 | 0.77 | 0.18 | 0.82 | FALSE |
8 | NTR | Blood | RCBTB1 | 0.07 | 0.05 | lasso | 13 | 0.08 | 9.6e-24 | -5.2 | 5.6 | 1.9e-08 | 0.69 | 0.20 | 0.80 | FALSE |
9 | YFS | Blood | PHF11 | 0.16 | 0.16 | lasso | 19 | 0.16 | 5.0e-49 | -5.2 | 5.3 | 1.0e-07 | 0.91 | 0.31 | 0.68 | FALSE |
10 | YFS | Blood | RCBTB1 | 0.07 | 0.03 | enet | 36 | 0.09 | 5.7e-28 | -2.6 | 5.2 | 2.4e-07 | 0.61 | 0.92 | 0.08 | FALSE |
11 | YFS | Blood | SETDB2 | 0.12 | 0.13 | enet | 22 | 0.15 | 5.3e-46 | 5.8 | -5.5 | 4.6e-08 | -0.89 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CAB39L | 0.09 | 0.02 | blup | 88 | 0.06 | 4.1e-04 | -3.7 | -5.4 | 6.9e-08 | -0.66 | 0.02 | 0.62 | FALSE |
13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PHF11 | 0.13 | 0.13 | blup | 92 | 0.12 | 4.3e-06 | -5.2 | -6.5 | 1.0e-10 | -0.86 | 0.06 | 0.94 | TRUE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CAB39L | 0.12 | 0.12 | lasso | 3 | 0.11 | 2.3e-05 | -5.5 | -5.4 | 5.7e-08 | -0.80 | 0.02 | 0.93 | FALSE |