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chr13:40,440,805-42,465,713

Best TWAS P=7.45e-34 · Best GWAS P=4.69e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Nerve Tibial	CYCSP34	0.05	0.01	lasso	4	0.02	2.8e-02	-10.7	12.1	7.4e-34	0.16	0.28	0.06	TRUE
4	GTEx	Brain Cerebellar Hemisphere	TPTE2P5	0.39	0.27	lasso	4	0.19	1.6e-05	-10.7	10.3	5.6e-25	0.16	0.68	0.04	TRUE
23	YFS	Blood	MRPS31	0.05	0.02	blup	387	0.03	6.5e-11	8.8	-10.2	1.2e-24	-0.74	0.26	0.74	TRUE
20	METSIM	Adipose	ELF1	0.04	0.02	bslmm	386	0.02	1.1e-03	0.9	9.7	1.9e-22	0.31	0.16	0.04	TRUE
11	GTEx	Brain Nucleus accumbens basal ganglia	CYCSP34	0.20	0.03	lasso	6	0.11	5.6e-04	-10.9	9.7	4.4e-22	0.10	0.13	0.06	TRUE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WBP4	0.05	0.02	lasso	2	0.04	4.0e-03	-6.3	-8.3	1.2e-16	-0.06	0.07	0.05	TRUE
18	GTEx	Testis	CYCSP34	0.09	0.05	lasso	3	0.05	2.0e-03	-11.1	8.2	2.1e-16	-0.07	0.33	0.05	TRUE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	SUGT1L1	0.12	0.02	blup	58	0.05	1.4e-06	8.8	7.9	1.9e-15	0.63	0.76	0.01	TRUE
17	GTEx	Testis	KBTBD7	0.18	0.11	lasso	4	0.07	3.2e-04	-6.1	7.1	8.7e-13	0.09	0.20	0.32	TRUE
7	GTEx	Brain Cortex	CYCSP34	0.35	0.06	enet	34	0.10	1.1e-03	-10.7	6.0	1.5e-09	0.10	0.15	0.06	TRUE
19	GTEx	Thyroid	TPTE2P5	0.17	0.00	enet	36	0.01	3.4e-02	9.4	-5.7	9.3e-09	-0.39	0.11	0.14	TRUE
6	GTEx	Brain Cerebellum	CYCSP34	0.39	0.27	lasso	9	0.29	3.1e-09	-10.7	11.5	9.4e-31	0.22	0.94	0.04	FALSE
16	GTEx	Spleen	CYCSP34	0.32	0.07	lasso	4	0.06	1.2e-02	-10.1	11.3	1.6e-29	0.27	0.08	0.18	FALSE
3	GTEx	Brain Caudate basal ganglia	CYCSP34	0.21	0.11	lasso	2	0.13	1.2e-04	-11.1	11.2	6.0e-29	0.25	0.28	0.20	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SUGT1L1	0.06	0.01	blup	58	0.03	1.9e-04	9.5	10.9	7.2e-28	0.67	0.06	0.18	FALSE
14	GTEx	Pituitary	TPTE2P5	0.28	0.10	lasso	13	0.10	1.8e-03	-11.1	10.8	5.1e-27	0.16	0.23	0.06	FALSE
5	GTEx	Brain Cerebellar Hemisphere	CYCSP34	0.37	0.29	lasso	6	0.25	4.8e-07	-10.7	10.7	6.1e-27	0.16	0.79	0.12	FALSE
8	GTEx	Brain Frontal Cortex BA9	TPTE2P5	0.22	-0.01	lasso	3	-0.01	5.4e-01	-9.9	10.6	3.3e-26	0.21	0.04	0.31	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SUGT1L1	0.10	0.00	blup	58	0.04	3.9e-04	-11.1	10.4	2.1e-25	0.56	0.01	0.40	FALSE
2	GTEx	Artery Tibial	CYCSP34	0.09	0.02	lasso	7	0.04	4.6e-04	-9.6	10.3	9.8e-25	0.03	0.75	0.02	FALSE
21	YFS	Blood	FOXO1	0.02	0.02	lasso	4	0.02	3.3e-08	-5.0	10.2	1.3e-24	0.39	0.44	0.48	FALSE
1	GTEx	Adipose Subcutaneous	CYCSP34	0.08	0.03	lasso	7	0.02	1.0e-02	-9.8	10.0	2.5e-23	0.11	0.26	0.08	FALSE
9	GTEx	Brain Hippocampus	CYCSP34	0.16	0.25	lasso	2	0.22	6.1e-06	-9.8	9.8	8.7e-23	0.15	0.39	0.05	FALSE
15	GTEx	Small Intestine Terminal Ileum	CYCSP34	0.25	0.07	lasso	3	0.05	3.0e-02	-9.7	9.3	1.3e-20	-0.01	0.09	0.06	FALSE
12	GTEx	Brain Putamen basal ganglia	CYCSP34	0.40	0.04	enet	17	0.22	6.9e-06	-10.7	8.8	1.1e-18	0.16	0.14	0.07	FALSE
10	GTEx	Brain Hypothalamus	CYCSP34	0.25	0.10	lasso	15	0.11	1.4e-03	1.2	7.4	1.3e-13	-0.16	0.15	0.09	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUGT1L1	0.09	0.06	blup	59	0.06	5.4e-05	9.5	6.7	2.4e-11	0.71	0.56	0.02	FALSE
22	YFS	Blood	KBTBD7	0.13	0.12	lasso	5	0.12	5.6e-36	-6.2	-6.0	1.5e-09	-0.04	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUGT1L1	0.09	0.06	lasso	7	0.09	8.4e-18	1.1	5.8	6.4e-09	0.66	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUGT1L1	0.32	0.22	blup	59	0.27	1.3e-30	1.2	5.5	3.2e-08	0.61	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	SLC25A15	0.06	0.05	blup	28	0.07	4.6e-05	1.2	5.2	1.6e-07	-0.22	0.02	0.94	FALSE