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chr16:10,646,170-12,138,068

Best TWAS P=4.23e-17 · Best GWAS P=6.87e-24 conditioned to 5.24e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Muscle Skeletal	RMI2	0.28	0.12	lasso	11	0.20	2.1e-19	6.8	8.4	4.2e-17	0.80	0.26	0.74	TRUE
14	GTEx	Esophagus Mucosa	RMI2	0.17	0.10	lasso	4	0.18	6.8e-12	5.3	-6.8	1.0e-11	-0.60	0.99	0.01	TRUE
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C16orf75	0.27	0.14	lasso	4	0.20	1.4e-07	7.4	-8.3	1.2e-16	-0.72	0.30	0.61	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	RMI2	0.50	0.06	enet	11	0.35	4.3e-12	5.3	-8.1	3.9e-16	-0.77	0.01	0.98	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	C16orf75	0.21	0.10	lasso	6	0.18	9.8e-13	7.4	-8.1	8.1e-16	-0.73	0.12	0.88	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C16orf75	0.32	0.14	enet	10	0.27	8.2e-14	5.3	-7.6	3.2e-14	-0.78	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	C16orf75	0.43	0.11	enet	17	0.18	1.5e-10	5.3	-7.5	4.2e-14	-0.68	0.77	0.22	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf75	0.11	0.02	enet	15	0.07	8.6e-09	5.3	-7.5	6.0e-14	-0.63	0.68	0.18	FALSE
6	GTEx	Brain Caudate basal ganglia	RMI2	0.46	0.22	enet	19	0.24	1.2e-07	6.0	7.2	6.0e-13	0.77	0.21	0.74	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf75	0.10	0.05	lasso	6	0.08	2.2e-09	5.3	-7.1	1.5e-12	-0.67	0.46	0.54	FALSE
4	GTEx	Artery Coronary	RMI2	0.32	0.14	lasso	6	0.12	9.9e-05	6.8	6.9	5.0e-12	0.59	0.66	0.19	FALSE
16	GTEx	Heart Left Ventricle	RMI2	0.24	0.09	lasso	6	0.12	6.2e-07	7.0	6.8	9.5e-12	0.63	0.58	0.33	FALSE
11	GTEx	Cells Transformed fibroblasts	RMI2	0.17	0.04	lasso	7	0.07	9.0e-06	-4.7	-6.8	1.0e-11	-0.61	0.87	0.06	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C16orf75	0.23	0.13	blup	114	0.15	6.6e-13	5.3	-6.8	1.1e-11	-0.67	0.34	0.66	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	C16orf75	0.12	0.02	blup	112	0.04	1.9e-02	6.0	-6.7	2.4e-11	-0.75	0.03	0.38	FALSE
3	GTEx	Artery Aorta	RMI2	0.30	0.11	lasso	5	0.17	1.3e-09	6.7	6.6	3.1e-11	0.67	0.96	0.04	FALSE
2	GTEx	Adipose Subcutaneous	RMI2	0.10	0.06	lasso	5	0.07	1.9e-06	6.8	6.6	3.2e-11	0.58	0.95	0.01	FALSE
18	GTEx	Ovary	RMI2	0.48	0.26	lasso	9	0.20	1.2e-05	6.3	6.6	4.1e-11	0.75	0.11	0.69	FALSE
9	GTEx	Breast Mammary Tissue (Male)	RMI2	0.32	0.15	enet	25	0.10	2.9e-03	6.3	6.6	5.5e-11	0.49	0.06	0.27	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	RMI2	0.46	0.49	bslmm	510	0.58	1.5e-92	6.0	6.4	1.7e-10	0.65	1.00	0.00	FALSE
19	GTEx	Pituitary	RMI2	0.52	0.18	enet	6	0.32	6.6e-09	6.0	6.3	3.3e-10	0.76	0.13	0.72	FALSE
5	GTEx	Artery Tibial	RMI2	0.27	0.11	enet	27	0.21	1.4e-16	6.8	6.2	5.1e-10	0.65	1.00	0.00	FALSE
20	GTEx	Prostate	RMI2	0.35	0.09	lasso	2	0.16	1.1e-04	7.0	6.2	5.7e-10	0.58	0.10	0.24	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C16orf75	0.14	0.01	blup	114	0.02	1.4e-02	-4.8	-6.2	7.2e-10	-0.45	0.12	0.09	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SOCS1	0.08	0.01	enet	7	0.03	8.4e-05	10.1	6.1	9.2e-10	0.63	0.00	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RMI2	0.49	0.43	bslmm	534	0.57	4.4e-84	6.0	6.1	1.2e-09	0.63	1.00	0.00	FALSE
8	GTEx	Breast Mammary Tissue	RMI2	0.37	0.25	lasso	7	0.21	3.5e-11	6.0	6.0	1.8e-09	0.75	1.00	0.00	FALSE
12	GTEx	Colon Sigmoid	RMI2	0.30	0.09	enet	11	0.12	6.2e-05	6.0	5.9	2.8e-09	0.75	0.28	0.66	FALSE
7	GTEx	Brain Cortex	RMI2	0.55	0.15	enet	10	0.17	2.3e-05	6.0	5.8	7.1e-09	0.74	0.41	0.45	FALSE
15	GTEx	Esophagus Muscularis	RMI2	0.35	0.20	enet	71	0.23	7.4e-14	6.0	5.6	1.7e-08	0.48	0.99	0.01	FALSE
21	GTEx	Thyroid	RMI2	0.44	0.31	enet	37	0.40	2.2e-32	6.0	5.6	1.8e-08	0.67	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf75	0.08	0.08	lasso	5	0.08	2.0e-09	-6.1	-5.4	6.0e-08	-0.40	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf75	0.13	0.07	lasso	8	0.13	6.8e-25	1.1	-5.4	6.3e-08	-0.48	1.00	0.00	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	RMI2	0.21	0.02	lasso	6	0.01	1.0e-01	6.0	5.4	6.6e-08	0.68	0.29	0.20	FALSE
23	NTR	Blood	C16orf75	0.03	0.01	enet	10	0.02	6.4e-08	6.8	5.3	1.4e-07	0.47	0.18	0.81	FALSE
22	METSIM	Adipose	RMI2	0.20	0.18	lasso	8	0.26	3.0e-38	6.0	5.2	1.8e-07	0.59	1.00	0.00	FALSE