[Hub]/) : Traits : Blood Platelet Count :

chr16:10,646,170-12,138,068

Best TWAS P=4.23e-17 · Best GWAS P=6.87e-24 conditioned to 5.24e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RMI2 0.49 0.43 bslmm 534 0.57 4.4e-84 6.0 6.1 1.2e-09 0.63 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous RMI2 0.10 0.06 lasso 5 0.07 1.9e-06 6.8 6.6 3.2e-11 0.58 0.95 0.01 FALSE
3 GTEx Artery Aorta RMI2 0.30 0.11 lasso 5 0.17 1.3e-09 6.7 6.6 3.1e-11 0.67 0.96 0.04 FALSE
4 GTEx Artery Coronary RMI2 0.32 0.14 lasso 6 0.12 9.9e-05 6.8 6.9 5.0e-12 0.59 0.66 0.19 FALSE
5 GTEx Artery Tibial RMI2 0.27 0.11 enet 27 0.21 1.4e-16 6.8 6.2 5.1e-10 0.65 1.00 0.00 FALSE
6 GTEx Brain Caudate basal ganglia RMI2 0.46 0.22 enet 19 0.24 1.2e-07 6.0 7.2 6.0e-13 0.77 0.21 0.74 FALSE
7 GTEx Brain Cortex RMI2 0.55 0.15 enet 10 0.17 2.3e-05 6.0 5.8 7.1e-09 0.74 0.41 0.45 FALSE
8 GTEx Breast Mammary Tissue RMI2 0.37 0.25 lasso 7 0.21 3.5e-11 6.0 6.0 1.8e-09 0.75 1.00 0.00 FALSE
9 GTEx Breast Mammary Tissue (Male) RMI2 0.32 0.15 enet 25 0.10 2.9e-03 6.3 6.6 5.5e-11 0.49 0.06 0.27 FALSE
10 GTEx Cells EBV-transformed lymphocytes RMI2 0.50 0.06 enet 11 0.35 4.3e-12 5.3 -8.1 3.9e-16 -0.77 0.01 0.98 FALSE
11 GTEx Cells Transformed fibroblasts RMI2 0.17 0.04 lasso 7 0.07 9.0e-06 -4.7 -6.8 1.0e-11 -0.61 0.87 0.06 FALSE
12 GTEx Colon Sigmoid RMI2 0.30 0.09 enet 11 0.12 6.2e-05 6.0 5.9 2.8e-09 0.75 0.28 0.66 FALSE
13 GTEx Esophagus Gastroesophageal Junction RMI2 0.21 0.02 lasso 6 0.01 1.0e-01 6.0 5.4 6.6e-08 0.68 0.29 0.20 FALSE
14 GTEx Esophagus Mucosa RMI2 0.17 0.10 lasso 4 0.18 6.8e-12 5.3 -6.8 1.0e-11 -0.60 0.99 0.01 TRUE
15 GTEx Esophagus Muscularis RMI2 0.35 0.20 enet 71 0.23 7.4e-14 6.0 5.6 1.7e-08 0.48 0.99 0.01 FALSE
16 GTEx Heart Left Ventricle RMI2 0.24 0.09 lasso 6 0.12 6.2e-07 7.0 6.8 9.5e-12 0.63 0.58 0.33 FALSE
17 GTEx Muscle Skeletal RMI2 0.28 0.12 lasso 11 0.20 2.1e-19 6.8 8.4 4.2e-17 0.80 0.26 0.74 TRUE
18 GTEx Ovary RMI2 0.48 0.26 lasso 9 0.20 1.2e-05 6.3 6.6 4.1e-11 0.75 0.11 0.69 FALSE
19 GTEx Pituitary RMI2 0.52 0.18 enet 6 0.32 6.6e-09 6.0 6.3 3.3e-10 0.76 0.13 0.72 FALSE
20 GTEx Prostate RMI2 0.35 0.09 lasso 2 0.16 1.1e-04 7.0 6.2 5.7e-10 0.58 0.10 0.24 FALSE
21 GTEx Thyroid RMI2 0.44 0.31 enet 37 0.40 2.2e-32 6.0 5.6 1.8e-08 0.67 1.00 0.00 FALSE
22 METSIM Adipose RMI2 0.20 0.18 lasso 8 0.26 3.0e-38 6.0 5.2 1.8e-07 0.59 1.00 0.00 FALSE
23 NTR Blood C16orf75 0.03 0.01 enet 10 0.02 6.4e-08 6.8 5.3 1.4e-07 0.47 0.18 0.81 FALSE
24 ROSMAP Brain Pre-frontal Cortex RMI2 0.46 0.49 bslmm 510 0.58 1.5e-92 6.0 6.4 1.7e-10 0.65 1.00 0.00 FALSE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma C16orf75 0.23 0.13 blup 114 0.15 6.6e-13 5.3 -6.8 1.1e-11 -0.67 0.34 0.66 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma C16orf75 0.13 0.07 lasso 8 0.13 6.8e-25 1.1 -5.4 6.3e-08 -0.48 1.00 0.00 FALSE
27 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C16orf75 0.32 0.14 enet 10 0.27 8.2e-14 5.3 -7.6 3.2e-14 -0.78 0.02 0.98 FALSE
28 The Cancer Genome Atlas Colon Adenocarcinoma C16orf75 0.43 0.11 enet 17 0.18 1.5e-10 5.3 -7.5 4.2e-14 -0.68 0.77 0.22 FALSE
29 The Cancer Genome Atlas Glioblastoma Multiforme C16orf75 0.12 0.02 blup 112 0.04 1.9e-02 6.0 -6.7 2.4e-11 -0.75 0.03 0.38 FALSE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C16orf75 0.10 0.05 lasso 6 0.08 2.2e-09 5.3 -7.1 1.5e-12 -0.67 0.46 0.54 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C16orf75 0.08 0.08 lasso 5 0.08 2.0e-09 -6.1 -5.4 6.0e-08 -0.40 1.00 0.00 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SOCS1 0.08 0.01 enet 7 0.03 8.4e-05 10.1 6.1 9.2e-10 0.63 0.00 0.90 FALSE
33 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C16orf75 0.11 0.02 enet 15 0.07 8.6e-09 5.3 -7.5 6.0e-14 -0.63 0.68 0.18 FALSE
34 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C16orf75 0.14 0.01 blup 114 0.02 1.4e-02 -4.8 -6.2 7.2e-10 -0.45 0.12 0.09 FALSE
35 The Cancer Genome Atlas Stomach Adenocarcinoma C16orf75 0.21 0.10 lasso 6 0.18 9.8e-13 7.4 -8.1 8.1e-16 -0.73 0.12 0.88 FALSE
36 The Cancer Genome Atlas Testicular Germ Cell Tumors C16orf75 0.27 0.14 lasso 4 0.20 1.4e-07 7.4 -8.3 1.2e-16 -0.72 0.30 0.61 FALSE