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chr16:19,016,966-21,352,507

Best TWAS P=1.53e-11 · Best GWAS P=6.28e-11 conditioned to 0.000544

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	6.5	-6.3	2.6e-10	-0.96	0.00	0.99	FALSE
2	GTEx	Adipose Subcutaneous	AC002550.5	0.41	0.50	enet	17	0.52	7.9e-49	5.0	5.3	8.6e-08	0.73	0.94	0.06	FALSE
3	GTEx	Adipose Visceral Omentum	KNOP1	0.39	0.52	lasso	3	0.53	9.1e-32	5.0	5.3	8.8e-08	0.75	0.95	0.05	FALSE
4	GTEx	Adrenal Gland	KNOP1	0.40	0.34	lasso	4	0.40	1.1e-15	5.8	5.6	2.1e-08	0.79	0.49	0.51	FALSE
5	GTEx	Adrenal Gland	AC002550.5	0.37	0.39	enet	28	0.40	1.6e-15	5.0	5.4	5.8e-08	0.74	0.92	0.08	FALSE
6	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	5.0	5.5	3.9e-08	0.76	0.95	0.05	FALSE
7	GTEx	Artery Aorta	AC002550.5	0.52	0.52	lasso	7	0.49	1.9e-30	5.0	5.2	2.2e-07	0.75	0.95	0.05	FALSE
8	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	5.0	5.6	1.7e-08	0.82	0.11	0.89	FALSE
9	GTEx	Artery Coronary	AC002550.5	0.30	0.34	enet	11	0.37	1.5e-13	5.0	5.6	1.7e-08	0.78	0.50	0.50	FALSE
10	GTEx	Artery Tibial	AC002550.5	0.31	0.36	lasso	8	0.39	6.8e-32	5.0	5.2	2.4e-07	0.72	0.94	0.06	FALSE
11	GTEx	Brain Cerebellum	AC004381.6	0.23	0.09	enet	18	0.12	1.9e-04	4.5	5.6	1.9e-08	-0.07	0.10	0.63	FALSE
12	GTEx	Brain Cortex	KNOP1	0.30	0.21	lasso	4	0.26	1.1e-07	5.0	5.7	1.3e-08	0.70	0.67	0.29	FALSE
13	GTEx	Brain Cortex	AC002550.5	0.50	0.46	lasso	6	0.46	3.9e-14	5.0	5.1	3.1e-07	0.71	0.94	0.06	FALSE
14	GTEx	Brain Frontal Cortex BA9	KNOP1	0.43	0.33	lasso	14	0.30	1.0e-08	5.0	5.3	9.5e-08	0.76	0.89	0.08	FALSE
15	GTEx	Brain Hippocampus	KNOP1	0.25	0.25	lasso	7	0.14	3.2e-04	5.0	5.2	1.7e-07	0.70	0.55	0.12	FALSE
16	GTEx	Brain Hippocampus	AC002550.5	0.25	0.24	lasso	4	0.22	6.9e-06	5.1	5.2	1.9e-07	0.70	0.54	0.15	FALSE
17	GTEx	Brain Hypothalamus	AC002550.5	0.37	0.47	lasso	2	0.46	3.1e-12	5.0	5.2	1.9e-07	0.72	0.59	0.40	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	KNOP1	0.34	0.38	lasso	5	0.37	1.0e-10	5.1	5.3	1.2e-07	0.74	0.86	0.13	FALSE
19	GTEx	Brain Putamen basal ganglia	AC002550.5	0.59	0.48	enet	23	0.58	1.2e-16	5.0	5.7	1.4e-08	0.62	0.93	0.06	FALSE
20	GTEx	Breast Mammary Tissue	AC002550.5	0.37	0.49	enet	13	0.50	3.3e-29	5.0	5.8	5.6e-09	0.80	0.66	0.34	FALSE
21	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	5.3	5.6	2.3e-08	0.89	0.05	0.94	FALSE
22	GTEx	Breast Mammary Tissue (Female)	AC002550.5	0.36	0.26	enet	19	0.33	1.3e-10	5.8	6.4	2.0e-10	0.75	0.32	0.68	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	KNOP1	0.70	0.58	lasso	7	0.59	2.1e-23	5.1	5.2	2.1e-07	0.69	0.93	0.07	FALSE
24	GTEx	Cells Transformed fibroblasts	AC002550.5	0.12	0.10	enet	15	0.10	4.3e-08	5.0	5.3	1.4e-07	0.70	0.93	0.06	FALSE
25	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	5.0	5.6	1.9e-08	0.80	0.14	0.86	FALSE
26	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	5.0	5.6	1.8e-08	0.81	0.51	0.49	FALSE
27	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	5.0	5.8	8.5e-09	0.81	0.86	0.14	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	5.8	5.7	1.4e-08	0.84	0.16	0.84	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	5.1	5.5	3.7e-08	0.76	0.83	0.17	FALSE
30	GTEx	Esophagus Mucosa	KNOP1	0.31	0.43	lasso	5	0.43	5.6e-31	5.0	5.2	2.2e-07	0.73	0.95	0.05	FALSE
31	GTEx	Esophagus Muscularis	KNOP1	0.47	0.51	lasso	10	0.56	1.9e-40	5.0	5.4	6.5e-08	0.74	0.94	0.06	FALSE
32	GTEx	Heart Left Ventricle	KNOP1	0.34	0.48	lasso	2	0.44	2.3e-25	5.0	5.1	3.1e-07	0.73	0.95	0.05	FALSE
33	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	5.1	5.7	1.1e-08	0.81	0.52	0.39	FALSE
34	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	5.1	5.9	4.0e-09	0.85	0.84	0.16	FALSE
35	GTEx	Lung	KNOP1	0.34	0.48	lasso	8	0.49	4.0e-42	5.0	5.5	4.1e-08	0.76	0.95	0.05	FALSE
36	GTEx	Lung	AC002550.5	0.43	0.55	lasso	9	0.54	6.4e-48	5.0	5.1	3.0e-07	0.72	0.95	0.05	FALSE
37	GTEx	Muscle Skeletal	AC002550.5	0.35	0.53	lasso	6	0.52	3.2e-59	5.0	5.2	2.2e-07	0.73	0.95	0.05	FALSE
38	GTEx	Ovary	KNOP1	0.61	0.64	lasso	7	0.57	4.4e-17	5.0	5.4	5.6e-08	0.77	0.69	0.31	FALSE
39	GTEx	Ovary	AC002550.5	0.66	0.56	lasso	4	0.47	3.6e-13	5.0	5.6	2.0e-08	0.72	0.76	0.24	FALSE
40	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	5.1	5.8	5.5e-09	0.84	0.64	0.36	FALSE
41	GTEx	Pancreas	AC002550.5	0.37	0.36	lasso	12	0.36	3.2e-16	5.0	5.4	5.3e-08	0.76	0.86	0.14	FALSE
42	GTEx	Prostate	AC002550.5	0.49	0.25	lasso	8	0.33	5.7e-09	5.0	5.4	5.4e-08	0.74	0.87	0.12	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	KNOP1	0.37	0.43	lasso	3	0.41	5.0e-24	5.1	5.4	6.0e-08	0.74	0.92	0.08	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	AC002550.5	0.44	0.43	enet	24	0.43	1.2e-25	5.1	5.6	2.6e-08	0.79	0.91	0.09	FALSE
45	GTEx	Skin Sun Exposed Lower leg	KNOP1	0.33	0.47	lasso	9	0.48	5.4e-44	5.0	5.5	4.3e-08	0.75	0.95	0.05	FALSE
46	GTEx	Skin Sun Exposed Lower leg	AC002550.5	0.38	0.56	lasso	6	0.57	8.6e-58	5.0	5.3	9.6e-08	0.73	0.95	0.05	FALSE
47	GTEx	Spleen	KNOP1	0.45	0.36	lasso	7	0.41	1.2e-11	5.0	5.4	7.5e-08	0.74	0.40	0.60	FALSE
48	GTEx	Stomach	KNOP1	0.28	0.21	lasso	6	0.21	1.8e-10	5.7	6.4	1.6e-10	0.77	0.12	0.88	TRUE
49	GTEx	Stomach	AC002550.5	0.36	0.26	lasso	7	0.32	4.8e-16	5.0	5.8	6.0e-09	0.72	0.87	0.13	FALSE
50	GTEx	Testis	KNOP1	0.37	0.34	lasso	5	0.30	8.1e-14	5.0	5.2	2.2e-07	0.70	0.93	0.07	FALSE
51	GTEx	Testis	AC002550.5	0.49	0.57	lasso	5	0.56	7.7e-30	5.0	5.6	2.6e-08	0.76	0.94	0.06	FALSE
52	GTEx	Thyroid	KNOP1	0.35	0.41	enet	11	0.43	4.7e-36	5.0	5.2	1.6e-07	0.71	0.95	0.05	FALSE
53	GTEx	Uterus	KNOP1	0.29	0.22	enet	10	0.18	1.7e-04	5.0	5.2	1.8e-07	0.73	0.12	0.62	FALSE
54	GTEx	Uterus	AC002550.5	0.51	0.40	lasso	12	0.36	2.3e-08	5.0	5.4	5.5e-08	0.76	0.37	0.56	FALSE
55	GTEx	Vagina	KNOP1	0.43	0.35	lasso	5	0.36	4.2e-09	5.0	5.4	5.6e-08	0.74	0.45	0.54	FALSE
56	GTEx	Vagina	AC002550.5	0.47	0.24	lasso	4	0.38	1.0e-09	5.0	5.2	2.5e-07	0.71	0.74	0.25	FALSE
57	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	5.0	5.5	3.0e-08	0.86	0.39	0.57	FALSE
58	METSIM	Adipose	KNOP1	0.15	0.23	bslmm	442	0.24	9.4e-35	5.0	5.3	1.4e-07	0.71	0.95	0.05	FALSE
59	YFS	Blood	DCUN1D3	0.01	0.01	blup	353	0.01	1.4e-03	4.5	6.8	1.5e-11	-0.08	0.09	0.83	TRUE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C16orf88	0.08	0.08	lasso	2	0.08	4.9e-07	5.0	5.2	1.6e-07	0.72	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	5.5	5.7	1.4e-08	0.84	0.02	0.92	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf62	0.04	0.02	lasso	3	0.02	6.6e-06	5.0	5.6	1.9e-08	0.68	0.05	0.91	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf88	0.10	0.08	lasso	3	0.08	7.1e-17	5.0	5.4	7.7e-08	0.75	0.05	0.95	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCK	0.03	0.03	blup	73	0.03	1.6e-07	5.1	5.4	5.6e-08	0.80	0.05	0.95	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	C16orf88	0.34	0.07	lasso	3	0.12	1.5e-04	5.8	5.5	3.9e-08	0.78	0.00	0.94	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf88	0.22	0.08	lasso	3	0.08	2.0e-09	5.8	5.6	2.5e-08	0.81	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf88	0.07	0.05	lasso	2	0.05	7.7e-04	5.8	5.8	8.7e-09	0.82	0.00	0.94	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf62	0.05	0.03	blup	114	0.02	9.6e-04	5.0	5.5	4.8e-08	0.61	0.05	0.87	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf62	0.04	0.01	enet	9	0.03	1.4e-04	5.7	5.3	8.6e-08	0.59	0.00	0.96	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	5.8	5.6	2.0e-08	0.79	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	5.2	5.8	7.9e-09	0.93	0.02	0.96	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C16orf88	0.34	0.21	lasso	4	0.17	3.1e-07	5.8	5.7	1.3e-08	0.82	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf88	0.20	0.18	blup	37	0.19	6.3e-18	5.0	5.2	2.5e-07	0.68	0.07	0.93	FALSE