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chr16:49,403,920-50,831,256

Best TWAS P=3.17e-13 · Best GWAS P=3.28e-11 conditioned to 0.735

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HEATR3	0.15	0.18	lasso	6	0.20	3.0e-23	-5.8	5.5	3.6e-08	-0.58	0.43	0.57	FALSE
2	GTEx	Adipose Subcutaneous	HEATR3	0.17	0.19	lasso	8	0.20	2.3e-16	-5.8	5.6	2.5e-08	-0.76	0.45	0.55	FALSE
3	GTEx	Adrenal Gland	HEATR3	0.33	0.30	lasso	9	0.31	1.3e-11	-5.7	5.7	9.3e-09	-0.74	0.35	0.65	FALSE
4	GTEx	Artery Aorta	HEATR3	0.41	0.41	enet	62	0.42	5.4e-25	-5.7	5.8	7.6e-09	-0.67	0.43	0.57	FALSE
5	GTEx	Artery Aorta	RP11-429P3.3	0.15	0.15	lasso	4	0.14	5.6e-08	-5.7	5.3	1.0e-07	-0.74	0.24	0.76	FALSE
6	GTEx	Artery Coronary	HEATR3	0.30	0.25	lasso	5	0.25	6.0e-09	-5.7	5.7	9.9e-09	-0.76	0.07	0.92	FALSE
7	GTEx	Artery Tibial	HEATR3	0.27	0.31	enet	17	0.32	2.1e-25	-5.8	6.0	1.6e-09	-0.74	0.42	0.58	FALSE
8	GTEx	Brain Caudate basal ganglia	HEATR3	0.36	0.14	lasso	12	0.20	2.6e-06	-5.8	6.0	1.5e-09	-0.72	0.11	0.85	FALSE
9	GTEx	Brain Cerebellar Hemisphere	HEATR3	0.67	0.49	enet	36	0.52	1.4e-15	-5.7	5.7	1.2e-08	-0.70	0.20	0.79	FALSE
10	GTEx	Brain Cerebellum	HEATR3	0.70	0.66	lasso	7	0.69	1.4e-27	-5.7	6.3	2.6e-10	-0.78	0.43	0.57	FALSE
11	GTEx	Brain Cerebellum	RP11-429P3.3	0.40	0.22	enet	11	0.26	1.9e-08	-5.7	7.3	3.2e-13	-0.89	0.02	0.98	TRUE
12	GTEx	Brain Cortex	HEATR3	0.51	0.46	lasso	11	0.47	8.5e-15	-5.7	6.0	2.5e-09	-0.73	0.40	0.60	FALSE
13	GTEx	Brain Frontal Cortex BA9	HEATR3	0.30	0.20	lasso	10	0.16	5.6e-05	-5.8	6.0	2.2e-09	-0.73	0.05	0.86	FALSE
14	GTEx	Brain Hippocampus	HEATR3	0.27	0.23	enet	9	0.19	3.9e-05	-5.7	6.0	2.7e-09	-0.77	0.07	0.78	FALSE
15	GTEx	Brain Hypothalamus	HEATR3	0.26	0.01	lasso	6	0.01	1.9e-01	-5.7	6.3	2.4e-10	-0.83	0.03	0.75	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	HEATR3	0.36	0.20	enet	18	0.24	3.8e-07	-5.8	6.2	5.6e-10	-0.77	0.18	0.80	FALSE
17	GTEx	Breast Mammary Tissue	HEATR3	0.33	0.26	lasso	6	0.25	2.6e-13	-5.8	5.9	4.4e-09	-0.72	0.43	0.57	FALSE
18	GTEx	Breast Mammary Tissue (Female)	HEATR3	0.27	0.07	lasso	5	0.13	1.3e-04	-5.8	5.4	6.2e-08	-0.60	0.06	0.30	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	HEATR3	0.22	0.25	lasso	5	0.25	1.1e-08	-5.2	5.4	6.0e-08	-0.75	0.27	0.71	FALSE
20	GTEx	Colon Sigmoid	HEATR3	0.27	0.32	lasso	5	0.28	1.6e-10	-5.8	5.7	1.5e-08	-0.75	0.39	0.61	FALSE
21	GTEx	Colon Transverse	HEATR3	0.36	0.36	lasso	7	0.36	9.1e-18	-5.8	5.7	9.2e-09	-0.75	0.41	0.59	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	HEATR3	0.36	0.26	lasso	6	0.25	1.7e-09	-5.7	6.0	2.2e-09	-0.79	0.38	0.62	FALSE
23	GTEx	Esophagus Mucosa	HEATR3	0.18	0.16	lasso	11	0.15	2.6e-10	-5.8	5.7	1.6e-08	-0.76	0.32	0.68	FALSE
24	GTEx	Esophagus Muscularis	HEATR3	0.40	0.38	lasso	8	0.39	6.1e-25	-5.8	5.6	2.6e-08	-0.72	0.42	0.58	FALSE
25	GTEx	Heart Atrial Appendage	HEATR3	0.30	0.30	lasso	8	0.27	1.1e-12	-5.7	5.7	1.2e-08	-0.76	0.40	0.60	FALSE
26	GTEx	Heart Left Ventricle	HEATR3	0.29	0.14	enet	25	0.22	8.4e-12	-5.8	6.7	2.8e-11	-0.65	0.42	0.58	FALSE
27	GTEx	Lung	HEATR3	0.34	0.40	enet	19	0.41	6.4e-34	-5.7	5.7	1.6e-08	-0.74	0.44	0.56	FALSE
28	GTEx	Muscle Skeletal	HEATR3	0.17	0.17	lasso	8	0.15	1.1e-14	-5.2	5.4	7.4e-08	-0.76	0.53	0.47	FALSE
29	GTEx	Nerve Tibial	HEATR3	0.38	0.39	lasso	9	0.38	6.5e-28	-5.2	5.6	1.9e-08	-0.77	0.50	0.50	FALSE
30	GTEx	Nerve Tibial	RP11-429P3.3	0.18	0.12	enet	13	0.12	1.7e-08	-5.8	5.7	1.2e-08	-0.67	0.37	0.63	FALSE
31	GTEx	Ovary	HEATR3	0.30	0.14	lasso	11	0.16	1.2e-04	-5.8	5.2	1.6e-07	-0.70	0.15	0.44	FALSE
32	GTEx	Pituitary	HEATR3	0.55	0.36	lasso	7	0.48	1.3e-13	-5.7	6.7	2.0e-11	-0.92	0.01	0.99	FALSE
33	GTEx	Prostate	HEATR3	0.23	0.25	lasso	4	0.22	4.2e-06	-5.1	5.6	2.1e-08	-0.69	0.04	0.88	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	HEATR3	0.22	0.18	lasso	9	0.18	5.0e-10	-5.8	5.7	1.2e-08	-0.75	0.43	0.57	FALSE
35	GTEx	Skin Sun Exposed Lower leg	HEATR3	0.28	0.20	enet	47	0.23	7.4e-19	-5.8	5.4	5.9e-08	-0.67	0.43	0.57	FALSE
36	GTEx	Spleen	HEATR3	0.43	0.13	lasso	9	0.13	2.7e-04	-5.8	5.8	4.8e-09	-0.73	0.11	0.82	FALSE
37	GTEx	Stomach	HEATR3	0.36	0.27	enet	14	0.28	1.6e-13	-5.2	6.1	1.1e-09	-0.85	0.11	0.89	FALSE
38	GTEx	Testis	HEATR3	0.47	0.37	enet	33	0.38	4.5e-18	-5.8	6.6	3.2e-11	-0.77	0.43	0.57	FALSE
39	GTEx	Testis	RP11-429P3.3	0.21	0.03	lasso	5	0.03	1.6e-02	-5.8	5.6	1.7e-08	-0.75	0.10	0.26	FALSE
40	GTEx	Thyroid	HEATR3	0.34	0.37	enet	19	0.37	6.6e-30	-5.7	6.1	9.4e-10	-0.77	0.45	0.55	FALSE
41	GTEx	Whole Blood	HEATR3	0.12	0.09	lasso	6	0.08	1.3e-07	-5.2	5.4	6.8e-08	-0.71	0.49	0.51	FALSE
42	GTEx	Whole Blood	RP11-429P3.3	0.08	0.01	enet	12	0.01	2.6e-02	4.0	5.6	2.7e-08	-0.51	0.12	0.53	FALSE
43	METSIM	Adipose	HEATR3	0.18	0.23	lasso	7	0.23	1.9e-33	-5.8	6.0	2.3e-09	-0.76	0.43	0.57	FALSE
44	NTR	Blood	HEATR3	0.02	0.00	blup	386	0.01	1.4e-04	-4.1	5.4	8.3e-08	-0.53	0.36	0.60	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	HEATR3	0.13	0.07	blup	39	0.10	5.1e-04	-6.1	5.7	9.9e-09	-0.79	0.04	0.71	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEATR3	0.02	0.01	enet	4	0.01	1.3e-02	-5.7	5.3	9.4e-08	-0.68	0.06	0.28	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEATR3	0.14	0.04	blup	39	0.08	3.2e-04	-5.2	6.5	1.1e-10	-0.63	0.04	0.38	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	HEATR3	0.16	0.20	blup	39	0.21	6.4e-20	-5.7	6.6	3.0e-11	-0.80	0.41	0.59	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	PAPD5	0.02	0.03	lasso	1	0.02	1.8e-03	-5.7	5.7	1.6e-08	-0.56	0.08	0.30	FALSE