Best TWAS P=1.52e-11 · Best GWAS P=1.74e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CDH1 | 0.08 | 0.09 | lasso | 6 | 0.09 | 8.9e-11 | 5.8 | 5.8 | 5.9e-09 | 0.65 | 0.05 | 0.95 | FALSE |
2 | GTEx | Brain Cortex | ZFP90 | 0.20 | 0.09 | lasso | 4 | 0.13 | 2.3e-04 | 6.5 | 6.4 | 1.6e-10 | 0.85 | 0.04 | 0.89 | FALSE |
3 | GTEx | Brain Hypothalamus | ZFP90 | 0.17 | 0.13 | lasso | 7 | 0.09 | 5.0e-03 | 6.4 | 6.7 | 2.7e-11 | 0.91 | 0.04 | 0.84 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ZFP90 | 0.12 | 0.05 | enet | 7 | 0.04 | 2.7e-04 | 6.5 | 6.5 | 7.9e-11 | 0.87 | 0.02 | 0.98 | FALSE |
5 | GTEx | Lung | ZFP90 | 0.11 | 0.07 | enet | 21 | 0.06 | 2.4e-05 | 6.3 | -6.0 | 1.9e-09 | -0.72 | 0.06 | 0.93 | FALSE |
6 | GTEx | Muscle Skeletal | ZFP90 | 0.07 | 0.06 | lasso | 10 | 0.04 | 4.6e-05 | 6.3 | -6.4 | 1.6e-10 | -0.91 | 0.05 | 0.95 | FALSE |
7 | GTEx | Nerve Tibial | NOB1 | 0.10 | 0.08 | enet | 8 | 0.08 | 1.9e-06 | 3.1 | -6.2 | 7.2e-10 | -0.04 | 0.03 | 0.94 | TRUE |
8 | GTEx | Nerve Tibial | CTD-2033A16.3 | 0.13 | 0.04 | enet | 16 | 0.07 | 1.7e-05 | 3.1 | -6.1 | 8.2e-10 | -0.07 | 0.01 | 0.98 | FALSE |
9 | GTEx | Spleen | ZFP90 | 0.31 | 0.25 | lasso | 9 | 0.22 | 3.0e-06 | 6.3 | -6.2 | 4.6e-10 | -0.86 | 0.05 | 0.92 | FALSE |
10 | GTEx | Testis | ZFP90 | 0.14 | 0.14 | lasso | 5 | 0.11 | 1.0e-05 | 6.7 | 6.8 | 1.5e-11 | 0.97 | 0.02 | 0.98 | TRUE |
11 | GTEx | Whole Blood | ZFP90 | 0.13 | 0.09 | lasso | 5 | 0.14 | 5.6e-13 | 6.4 | -6.8 | 1.5e-11 | -0.83 | 0.05 | 0.95 | FALSE |
12 | METSIM | Adipose | ZFP90 | 0.09 | 0.06 | lasso | 7 | 0.07 | 3.0e-11 | 6.3 | -6.7 | 1.7e-11 | -0.95 | 0.04 | 0.96 | FALSE |
13 | NTR | Blood | ZFP90 | 0.07 | 0.07 | enet | 14 | 0.07 | 9.4e-22 | 6.5 | -6.7 | 2.7e-11 | -0.94 | 0.03 | 0.97 | FALSE |
14 | YFS | Blood | ZFP90 | 0.43 | 0.46 | enet | 35 | 0.48 | 2.1e-184 | 6.3 | -6.3 | 2.2e-10 | -0.89 | 0.08 | 0.92 | FALSE |
15 | The Cancer Genome Atlas | Glioblastoma Multiforme | ZFP90 | 0.10 | 0.08 | blup | 33 | 0.09 | 8.3e-04 | 5.6 | 6.5 | 6.1e-11 | 0.80 | 0.02 | 0.77 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZFP90 | 0.10 | 0.16 | lasso | 2 | 0.16 | 1.5e-17 | 5.6 | 5.6 | 2.7e-08 | 0.53 | 0.71 | 0.29 | FALSE |