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chr17:77,072,043-78,818,603

Best TWAS P=6.52e-14 · Best GWAS P=2.22e-14 conditioned to 0.276

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Breast Mammary Tissue (Female)	GAA	0.08	0.09	lasso	2	0.05	1.3e-02	-7.5	7.5	6.5e-14	-0.93	0.01	0.79	TRUE
14	GTEx	Nerve Tibial	CBX8	0.16	0.14	lasso	4	0.14	5.3e-10	5.8	-5.8	8.1e-09	0.05	1.00	0.00	TRUE
5	GTEx	Breast Mammary Tissue	GAA	0.24	0.12	lasso	8	0.13	3.3e-07	-7.5	7.2	5.2e-13	-0.88	0.00	1.00	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	GAA	0.46	0.12	enet	38	0.20	8.8e-08	-4.2	6.7	1.7e-11	-0.61	0.03	0.96	FALSE
19	YFS	Blood	EIF4A3	0.07	0.02	bslmm	446	0.03	1.8e-09	-7.6	6.4	1.8e-10	-0.59	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GAA	0.08	0.09	lasso	4	0.10	1.9e-11	-6.0	6.3	2.2e-10	-0.80	0.16	0.84	FALSE
2	GTEx	Adipose Visceral Omentum	GAA	0.32	0.12	lasso	5	0.15	3.3e-08	-4.2	6.2	6.2e-10	-0.79	0.02	0.98	FALSE
11	GTEx	Heart Left Ventricle	GAA	0.12	0.04	enet	13	0.04	5.5e-03	-7.5	6.1	8.3e-10	-0.79	0.01	0.97	FALSE
8	GTEx	Cells Transformed fibroblasts	EIF4A3	0.21	0.15	lasso	3	0.14	7.2e-11	-5.8	5.9	4.4e-09	-0.72	0.75	0.25	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GAA	0.11	0.07	enet	4	0.07	1.7e-03	-5.9	5.8	5.4e-09	-0.76	0.03	0.28	FALSE
17	GTEx	Testis	GAA	0.36	0.24	lasso	6	0.33	3.9e-15	-4.2	5.7	1.0e-08	-0.73	0.67	0.33	FALSE
18	GTEx	Uterus	GAA	0.63	0.07	lasso	12	0.10	5.1e-03	-7.5	5.7	1.4e-08	-0.79	0.02	0.63	FALSE
9	GTEx	Cells Transformed fibroblasts	CBX8	0.21	0.10	lasso	3	0.08	1.4e-06	5.8	-5.6	2.8e-08	0.04	0.96	0.00	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	GAA	0.04	0.03	enet	13	0.03	1.7e-06	-5.8	5.5	3.0e-08	-0.66	0.09	0.91	FALSE
12	GTEx	Lung	CBX8	0.28	0.19	enet	24	0.18	1.4e-13	5.5	-5.5	3.3e-08	0.03	1.00	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Male)	GAA	0.27	0.03	enet	14	0.07	1.1e-02	-4.2	5.5	4.3e-08	-0.63	0.04	0.60	FALSE
1	GTEx	Adipose Subcutaneous	GAA	0.21	0.20	lasso	6	0.20	7.1e-16	-4.2	5.5	4.5e-08	-0.70	0.94	0.06	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC40	0.18	0.08	enet	10	0.14	1.8e-06	2.5	5.4	5.5e-08	-0.72	0.01	0.97	FALSE
3	GTEx	Brain Cerebellum	GAA	0.48	0.44	enet	14	0.45	5.8e-15	-5.9	5.4	5.6e-08	-0.71	0.95	0.05	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	GAA	0.28	0.29	enet	12	0.32	4.6e-19	-4.2	5.3	9.3e-08	-0.70	0.99	0.01	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GAA	0.16	0.13	lasso	2	0.16	4.1e-17	-4.2	5.3	1.0e-07	-0.67	1.00	0.00	FALSE
4	GTEx	Brain Cortex	GAA	0.18	0.17	enet	8	0.22	7.7e-07	-5.9	5.3	1.3e-07	-0.77	0.03	0.89	FALSE
15	GTEx	Nerve Tibial	GAA	0.35	0.32	lasso	6	0.40	2.4e-30	-4.2	5.2	1.5e-07	-0.68	0.99	0.01	FALSE
16	GTEx	Pancreas	GAA	0.20	0.07	lasso	6	0.12	1.0e-05	3.4	5.2	1.9e-07	-0.63	0.07	0.88	FALSE
13	GTEx	Lung	GAA	0.29	0.22	lasso	10	0.23	2.1e-17	-4.2	5.2	2.4e-07	-0.66	0.99	0.01	FALSE
20	YFS	Blood	GAA	0.43	0.38	enet	35	0.56	1.2e-226	2.9	5.2	2.7e-07	-0.64	1.00	0.00	FALSE