TWAS hub - CBX8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.209	0.0580	1.8e-04	0.095	NA	0.073	NA	0.080	1.3e-07	NA	4.1e-06	NA	1.4e-06
2	GTEx	Lung	0.283	0.0586	5.2e-07	0.188	NA	0.178	NA	0.059	2.3e-14	NA	1.4e-13	NA	2.8e-05
3	GTEx	Nerve Tibial	0.158	0.0507	2.1e-03	0.135	NA	0.083	NA	0.138	8.5e-10	NA	1.8e-06	NA	5.3e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Breast Cancer	15.7	37.7	39.3	-6.3	-6.1	-6.0
Smoking status: Previous	13.9	20.8	21.8	4.7	4.5	4.5
Past tobacco smoking	11.8	21.6	22.0	-4.6	-4.7	-4.6
Nervous feelings	11.6	21.7	23.2	-4.8	-4.4	-4.8
Impedance of arm (left)	8.9	41.0	42.2	-6.3	-6.5	-6.4
Ever smoked	8.9	15.6	16.7	3.8	4.1	3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.7	18.3	18.9	4.3	4.2	4.3
Hand grip strength (right)	8.6	23.4	25.4	5.0	4.7	4.7
Smoking Status	8.4	20.1	20.7	4.3	4.5	4.6
Hand grip strength (left)	8.3	21.8	23.3	4.7	4.8	4.4
Impedance of arm (right)	8.3	38.6	39.4	-6.2	-6.2	-6.3
Birth weight	8.3	17.9	19.8	4.1	4.5	4.2
Impedance of whole body	7.8	39.8	41.3	-6.1	-6.4	-6.4
Worry too long after embarrassment	7.7	12.9	14.2	-3.8	-3.3	-3.7
Number of children fathered	7.5	8.4	9.3	3.0	3.0	2.7
Alcohol drinker status: Previous	7.2	8.2	8.9	3.0	2.8	2.8
Happiness	7.1	8.6	9.4	-3.0	-2.8	-3.1
Peak expiratory flow (PEF)	7.1	16.6	16.7	4.1	4.1	4.0
Worry (Nagel 2018)	6.5	13.8	14.2	-3.8	-3.6	-3.7
Prospective memory result	6.4	7.9	8.1	2.8	2.8	2.8
Friendships satisfaction	6.4	7.9	9.1	-2.8	-2.7	-3.0
Arm predicted mass (left)	6.4	32.4	34.5	5.5	5.9	5.7
Arm fat-free mass (right)	6.1	31.5	32.0	5.5	5.7	5.7
Arm fat-free mass (left)	6.1	30.8	33.1	5.4	5.8	5.5
Arm predicted mass (right)	5.9	30.1	30.9	5.4	5.5	5.6
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.4	19.7	4.2	4.4	4.2
Commuting to job workplace: Car/motor vehicle	5.8	6.6	7.3	2.7	2.5	2.5
Body mass index (BMI)	5.7	24.4	27.0	4.7	5.2	4.9
Medication: Simvastatin	5.7	8.3	9.5	-3.1	-2.7	-2.8
Serious illness, injury or assault of a close relative in last 2 years	5.1	5.9	6.3	-2.5	-2.4	-2.4
Forced expiratory volume in 1-second (FEV1)	5.0	17.0	17.6	4.2	4.1	4.0
Sensitivity / hurt feelings	4.9	8.3	10.6	-3.2	-2.4	-2.9
Average weekly spirits intake	4.8	6.0	6.8	2.6	2.3	2.5
Trunk fat-free mass	4.8	27.4	28.3	5.1	5.3	5.2
Trunk predicted mass	4.8	27.3	28.3	5.1	5.3	5.2
Hair/balding pattern: Pattern 4	4.8	11.5	14.1	-3.2	-3.8	-3.2
Whole body water mass	4.8	27.3	28.5	5.1	5.3	5.2
Eye problems/disorders: Glaucoma	4.8	5.7	5.9	-2.4	-2.4	-2.3
Fractured/broken bones in last 5 years	4.8	6.2	6.7	2.5	2.6	2.4
Stomach or abdominal pain in last month	4.7	5.9	6.4	2.5	2.3	2.4
Whole body fat-free mass	4.7	27.1	28.1	5.1	5.3	5.2
Back pain experienced in last month	4.7	6.8	8.0	2.4	2.8	2.5
Basal metabolic rate	4.7	25.9	27.1	5.0	5.2	5.1
Neuroticism (2016)	4.6	6.6	7.0	-2.5	-2.6	-2.5
Impedance of leg (right)	4.6	22.2	23.3	-4.5	-4.8	-4.8
Breast cancer (self-reported)	4.6	5.5	6.2	2.3	2.2	2.5
Waist circumference	4.5	16.6	19.5	3.8	4.4	4.0
Risk taking	4.5	6.5	8.7	2.4	3.0	2.3
Number of incorrect matches in round	4.4	7.3	8.2	-2.9	-2.7	-2.5
Weight	4.4	21.4	23.5	4.4	4.8	4.6
Tense / ‘highly strung’	4.4	7.2	7.9	-2.6	-2.8	-2.6
Leg fat mass (left)	4.4	17.3	20.5	3.8	4.5	4.1
Age when periods started (menarche)	4.3	10.4	13.2	2.8	3.6	3.2
Neuroticism score	4.3	9.0	10.0	-3.2	-2.7	-3.0
Leg fat mass (right)	4.3	16.8	19.7	3.7	4.4	4.1
Diastolic blood pressure, automated reading	4.3	13.3	14.3	3.6	3.8	3.5
Medication: Cholesterol lowering	4.2	6.5	7.3	-2.7	-2.3	-2.6
Neuroticism (Nagel 2018)	4.1	9.6	9.8	-3.1	-3.1	-3.1
Allergy	4.1	9.5	10.0	3.2	3.0	3.1
Forced vital capacity (FVC), Best measure	4.1	15.0	15.1	3.9	3.9	3.9
Neck or shoulder pain in last month	4.1	5.8	6.4	2.4	2.5	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	5.9	2.4	2.0	2.1
High cholesterol (Self-reported)	4.0	7.2	7.5	-2.7	-2.6	-2.7
Impedance of leg (left)	3.9	19.0	20.2	-4.2	-4.4	-4.5
Lung FVC	3.8	19.4	20.4	4.4	4.3	4.5
Forced vital capacity (FVC)	3.8	14.7	15.6	4.0	3.8	3.8
Average weekly champagne plus white wine intake	3.8	5.2	5.8	2.2	2.3	2.4
Number of operations (self-reported)	3.8	5.6	6.2	2.3	2.5	2.3
Heart attack	3.7	4.7	5.4	-2.3	-2.1	-2.1
Medication: Ventolin 100micrograms inhaler	3.7	4.8	5.7	-2.1	-2.4	-2.0
Osteoporosis (self-reported)	3.7	4.6	5.1	2.1	2.3	2.0
Leg predicted mass (right)	3.7	19.7	20.8	4.3	4.6	4.5
Leg fat-free mass (left)	3.6	19.0	19.7	4.2	4.4	4.4
Leg fat-free mass (right)	3.6	19.5	21.0	4.2	4.6	4.4
Heart attack/myocardial infarction (self-reported)	3.6	4.7	5.3	-2.3	-2.0	-2.1
BMI	3.5	20.4	21.2	4.4	4.6	4.5
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.4	4.6	2.0	2.1	2.1
Basal cell carcinoma (self-reported)	3.4	4.1	5.5	2.3	1.6	2.0
Leg predicted mass (left)	3.3	17.5	18.3	4.0	4.3	4.2
Comparative body size at age 10	3.3	9.1	10.0	3.2	2.9	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	4.4	2.1	1.8	2.0
Suffer from ‘nerves’	3.3	5.2	5.7	-2.3	-2.1	-2.4
Severe depression (siblings)	3.2	3.6	4.7	-2.2	-1.5	-2.0
Arm fat mass (right)	3.2	13.3	15.8	3.3	4.0	3.6
Medication for cholesterol, blood pressure or diabetes	3.1	5.1	5.2	2.3	2.3	2.2
Arm fat mass (left)	3.1	12.8	14.7	3.3	3.8	3.6
LDL Cholesterol	3.0	4.8	5.6	-1.9	-2.4	-2.2
Ever highly irritable/argumentative for 2 days	3.0	3.6	3.8	-1.9	-1.9	-1.9
High blood pressure (siblings)	3.0	4.3	4.8	2.2	1.8	2.2
Leg pain on walking	3.0	3.7	4.5	2.1	1.7	1.9
Mean time to correctly identify matches	2.9	5.5	7.1	-2.7	-1.9	-2.4
Allergy or Eczema	2.8	7.4	8.6	-2.5	-2.6	-2.9
Depression (self-reported)	2.8	3.4	4.0	-1.8	-1.7	-2.0
Blood Platelet Count	2.7	31.6	33.3	-5.6	-5.5	-5.8
Body Mass Index (BMI) (2010)	2.6	3.6	4.1	1.9	2.0	1.8
HbA1C	2.6	2.9	4.8	-1.4	-2.2	-1.4
Mineral and other dietary supplements	2.6	3.5	3.9	-2.0	-1.7	-2.0
Leg fat percentage (left)	2.6	9.5	12.3	2.7	3.5	3.0
Pulse wave reflection index	2.5	3.1	4.1	2.0	1.6	1.6
Whole body fat mass	2.5	10.6	12.8	2.9	3.6	3.2
Systolic blood pressure, automated reading	2.4	7.1	7.6	2.6	2.8	2.6
High blood pressure (mother)	2.4	3.4	3.5	1.9	1.8	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	2.9	1.7	1.7	1.6
Lupus	2.2	3.3	4.0	-2.0	-1.4	-2.0
Emphysema/chronic bronchitis	2.2	2.4	2.7	-1.6	-1.6	-1.5
Medication: Aspirin	2.2	2.8	3.4	-1.9	-1.5	-1.6
Supplements: Zinc	2.1	2.3	2.9	-1.6	-1.1	-1.7
Hayfever, allergic rhinitis or eczema	2.1	4.5	5.4	-2.1	-1.9	-2.3
Glaucoma (self-reported)	2.1	2.5	3.3	-1.5	-1.8	-1.5
Leg fat percentage (right)	2.1	7.8	10.0	2.4	3.2	2.8
Medication: Aspirin	2.1	2.8	3.5	-1.9	-1.5	-1.6
Osteoarthritis (self-reported)	2.1	2.8	3.9	1.8	1.0	2.0
Pulse wave Arterial Stiffness index	1.9	2.2	3.1	1.8	1.1	1.5
Medication: Paracetamol	1.9	3.2	4.1	2.0	1.2	2.0
Medication: Ibuprofen	1.9	2.3	2.5	1.5	1.5	1.6
Medication: Seretide 50 evohaler	1.9	2.2	2.6	-1.4	-1.6	-1.5
Hearing aid user	1.9	2.1	2.5	1.6	1.2	1.6
Alzheimer’s Disease (including proxy)	1.8	2.7	4.1	-2.0	-1.0	-1.7
Reaction Time	1.8	3.5	4.8	-2.2	-1.5	-1.9
Neuroticism	1.8	4.4	4.8	-2.1	-1.9	-2.2
Frequency of depressed mood in last 2 weeks	1.8	2.5	2.9	1.7	1.4	1.6
Father’s age at death	1.8	2.4	3.6	1.3	1.9	1.4
Mouth/teeth dental problems: Dentures	1.8	3.1	3.5	1.6	1.9	1.8
Breastfed as a baby	1.8	2.3	4.2	1.1	2.0	1.2
Pulse wave peak to peak time	1.8	2.2	3.1	-1.7	-1.1	-1.5
Medication: Blood pressure	1.8	3.5	3.9	1.7	1.9	2.0
Supplements: Calcium	1.8	2.0	3.1	1.2	1.8	1.2
Hip circumference	1.7	7.2	8.3	2.4	2.9	2.7
Pulse rate	1.7	2.9	3.5	-1.6	-1.6	-1.9
Medication: Paracetamol	1.7	2.7	3.0	1.7	1.5	1.7
Supplements: Glucosamine	1.6	2.1	2.9	1.7	1.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	2.3	-1.4	-1.5	-1.4
Family relationship satisfaction	1.6	2.0	2.4	-1.4	-1.3	-1.5
Wears glasses or contact lenses	1.6	1.8	2.3	-1.4	-1.1	-1.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.9	0.9	1.7	1.2
Trunk fat mass	1.5	6.5	8.2	2.2	2.9	2.5
Financial difficulties in last 2 years	1.5	2.1	2.9	1.6	0.8	1.7
Illnesses of siblings	1.5	2.1	2.4	-1.5	-1.4	-1.5
Length of working week for main job	1.4	1.5	2.7	1.0	1.6	0.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	3.4	1.8	0.9	1.6
Knee pain experienced in last month	1.4	2.2	2.5	1.4	1.4	1.6
Arm fat percentage (left)	1.4	5.7	7.1	2.0	2.7	2.4
Hearing difficulty/problems: Yes	1.3	2.1	2.5	1.4	1.6	1.3
Hair/balding pattern: Pattern 2	1.3	1.7	1.8	1.2	1.3	1.4
Diabetes (self-reported)	1.3	2.0	2.1	-1.5	-1.4	-1.4
Arm fat percentage (right)	1.3	5.2	6.9	1.9	2.6	2.3
Alcohol intake versus 10 years previously	1.3	1.9	2.1	1.5	1.2	1.4
Worrier / anxious feelings	1.3	2.5	3.0	-1.7	-1.4	-1.6
Alzheimer’s Disease (in father)	1.2	1.3	1.8	-1.3	-0.9	-1.1
Ovarian Cancer	1.2	1.5	1.8	-1.3	-1.1	-1.3
Hearing difficulty/problems with background noise	1.2	1.9	3.1	1.1	1.8	1.2
Heart disease (mother)	1.2	1.5	1.8	-1.1	-1.3	-1.2
Asthma (self-reported)	1.2	2.4	3.6	-1.3	-1.9	-1.4
Medication: Gliclazide	1.2	1.4	1.6	-1.1	-1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	2.7	-1.6	-1.4	-1.6
Had other major operations	1.1	1.3	1.5	1.1	1.2	1.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.0	-1.1	-1.1	-1.4
Time employed in main current job	1.1	1.3	1.8	1.3	1.1	1.0
Exposure to tobacco smoke at home	1.1	1.2	1.6	1.1	0.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	1.8	-1.3	-1.4	-1.2
Commuting to job workplace: Walk	1.1	1.2	1.7	-1.0	-1.3	-0.9
Ever taken oral contraceptive pill	1.1	1.2	1.9	-0.9	-1.4	-0.9
Irritability	1.1	1.9	2.1	-1.2	-1.5	-1.4
Diabetes (father)	1.0	1.3	2.0	-0.9	-1.4	-1.0
Medication: Blood pressure	1.0	1.8	2.3	-1.5	-1.2	-1.3
Medication: Allopurinol	1.0	1.3	1.8	-1.3	-0.7	-1.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.4	1.1	1.1	1.2
Pain experienced in last month	1.0	1.7	1.9	-1.1	-1.4	-1.4
Chronotype (morning person)	0.9	2.0	2.6	1.6	1.0	1.5
Falls in the last year	0.9	1.2	1.5	1.0	1.0	1.2
Asthma	0.9	1.9	2.5	-1.2	-1.6	-1.3
Had major operations	0.9	1.1	1.8	0.8	1.4	0.9
Diabetes diagnosed by doctor	0.9	1.5	1.6	-1.2	-1.3	-1.2
Medication: Atorvastatin	0.9	1.1	1.3	-1.1	-1.0	-1.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.2	1.1	0.9	1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.1	1.1	0.9	0.9
Medication: Co-codamol	0.8	0.9	1.4	1.0	0.6	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.1	-1.1	-0.7	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.1	-1.0	-1.0	-1.0
Body fat percentage	0.8	3.1	4.5	1.3	2.1	1.7
Qualifications: College or University degree	0.8	2.6	3.0	-1.7	-1.4	-1.7
Cholesterol lowering medication	0.8	1.1	1.4	-1.2	-1.0	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.6	1.7	-1.2	-1.3	-1.3
Lung FEV1/FVC ratio	0.7	3.7	4.8	1.8	2.2	1.7
Relative age of first facial hair	0.7	1.5	1.6	1.1	1.2	1.2
Relative age voice broke	0.7	1.1	1.3	-1.1	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	1.6	-1.3	-1.2	-1.3
Number of live births	0.7	1.0	1.4	1.2	0.7	1.1
Gout (self-reported)	0.7	0.9	1.1	-1.0	-1.0	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.3	1.7	-1.1	-1.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.0	-0.7	-0.9	-1.0
Blood White Count	0.6	4.7	5.2	-2.2	-2.0	-2.3
Systolic Blood Pressure	0.6	3.0	3.5	1.7	1.9	1.7
Fed-up feelings	0.6	1.1	1.4	-1.1	-1.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.1	-0.9	-1.1	-0.7
Medication: Lansoprazole	0.6	0.7	0.7	0.8	0.8	0.9
Age at last live birth	0.6	0.9	1.5	1.2	0.9	0.7
Illnesses of father: High blood pressure	0.6	0.7	1.0	0.7	1.0	0.9
Bipolar Disorder (2018)	0.5	0.8	1.0	-1.0	-0.8	-0.9
Primary Biliary Cirrhosis	0.5	0.8	0.9	-0.9	-1.0	-0.8
Blood Eosinophil Count	0.5	4.0	4.6	-1.9	-1.9	-2.1
Hypothyroidism (self reported)	0.5	1.2	1.8	-0.9	-1.4	-1.0
Tanning	0.5	6.1	6.8	2.6	2.2	2.6
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	0.4	1.1	0.5
Sitting height	0.5	3.7	4.2	-1.8	-2.0	-1.9
Pain all over the body in last month	0.5	0.5	0.9	-0.9	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.1	1.1	0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.3	1.1	0.8	1.1
Long-standing illness, disability or infirmity	0.5	0.7	1.0	-0.8	-1.0	-0.7
Miserableness	0.5	0.8	0.8	-0.9	-0.9	-0.9
Age started oral contraceptive pill	0.5	0.6	0.7	-0.9	-0.7	-0.7
Unable to work because of sickness or disability	0.5	0.7	1.2	-1.1	-0.5	-0.8
Commuting to job workplace: Cycle	0.5	0.6	0.8	-0.8	-0.9	-0.7
Schizophrenia (2018)	0.4	0.9	1.2	-0.8	-1.1	-0.9
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	-0.6	-0.8	-0.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.4	-1.1	-0.6	-1.2
Angina	0.4	0.5	0.9	0.7	0.5	1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.9	-0.2	0.8
Loud music exposure frequency	0.4	0.4	0.9	0.4	1.0	0.5
Medication: Amlodipine	0.4	0.6	0.8	-0.8	-0.9	-0.7
Illnesses of siblings: Diabetes	0.4	0.4	0.5	0.6	0.7	0.7
Average weekly red wine intake	0.4	0.6	1.2	0.5	1.1	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.6	0.6	0.8	0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.8	-0.9	-0.7	-0.9
Mother’s age at death	0.4	0.5	0.8	-0.9	-0.5	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-0.5	-1.0	-0.7
Ulcerative Colitis (UC)	0.3	0.6	1.0	-0.8	-0.4	-1.0
Prostate Cancer	0.3	0.5	0.7	-0.7	-0.4	-0.9
Ulcerative Colitis	0.3	0.5	0.8	-0.7	-0.3	-0.9
Waist Hip Ratio (WHR)	0.3	1.4	1.9	1.1	1.4	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.5	-0.7	-0.2	-0.7
Medication for hormone replacement therapy	0.3	0.3	0.7	0.3	0.8	0.3
Diabetes (mother)	0.3	0.4	0.6	0.7	0.4	0.6
Trunk fat percentage	0.3	1.1	1.7	0.7	1.3	1.0
Average weekly fortified wine intake	0.3	0.4	0.6	0.8	0.6	0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.6	0.6	0.4	0.8
High blood pressure	0.3	1.0	1.2	0.8	1.1	1.1
Qualifications: None of the above	0.3	0.7	0.8	0.8	0.9	0.8
Mouth/teeth dental problems	0.3	0.4	0.6	0.8	0.6	0.6
Lung cancer (father)	0.3	0.3	0.5	0.5	0.5	0.7
Angina (self-reported)	0.3	0.3	0.6	0.5	0.3	0.8
Number of full sisters	0.3	0.3	0.5	0.5	0.4	0.7
Hypertension (Self-reported)	0.3	0.8	1.1	0.7	0.9	1.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	-0.9	-0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	0.5	0.6	0.7
Commuting to job workplace: Public transport	0.3	0.4	0.9	0.3	1.0	0.4
Alcohol drinker status: Never	0.3	0.3	0.8	-0.2	-0.9	-0.3
Average weekly beer plus cider intake	0.3	0.4	0.7	0.7	0.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.6	0.4	0.7
Crohns Disease (2017)	0.2	0.4	0.5	-0.7	-0.4	-0.6
Fasting Glucose	0.2	0.2	0.4	-0.4	-0.7	-0.3
HDL Cholesterol	0.2	0.3	0.8	-0.4	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	-0.0	0.3
Heel T-Score	0.2	1.8	2.0	-1.4	-1.2	-1.4
Height	0.2	4.1	4.6	2.1	2.1	1.9
Respiratory disease	0.2	0.5	0.6	-0.5	-0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.4	-0.9	-0.5
Vitamin and mineral supplements	0.2	0.2	0.3	0.6	0.1	0.5
Multivitamins +/- minerals	0.2	0.2	0.4	-0.6	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	-0.4	-0.5	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.3	-1.0	-0.4
Noisy workplace	0.2	0.2	0.3	0.5	0.5	0.5
Illnesses of mother	0.2	0.2	0.3	0.4	0.5	0.4
Birth weight of first child	0.2	0.4	0.6	0.8	0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.4	0.5	0.5	0.6
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.6	0.3	0.3
Medication: Omeprazole	0.2	0.2	0.3	0.4	0.4	0.6
Mood swings	0.2	0.4	0.6	-0.5	-0.6	-0.8
Ever had bowel cancer screening	0.2	0.2	0.4	0.3	0.6	0.4
Guilty feelings	0.2	0.4	0.4	-0.7	-0.6	-0.6
Financial situation satisfaction	0.2	0.2	0.3	-0.5	-0.5	-0.4
Depression (Nagel 2018)	0.1	0.2	0.3	0.6	0.1	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.4	-0.6	-0.6	-0.6
Age at First Birth	0.1	0.1	0.3	0.2	0.5	-0.1
Crohns Disease (2012)	0.1	0.2	0.4	0.2	0.6	0.3
Mean Putamen Volume	0.1	0.1	0.4	0.1	-0.6	-0.0
Schizophrenia (2014)	0.1	0.2	0.3	-0.4	-0.6	-0.5
Pack years adult smoking proportion	0.1	0.2	0.4	0.3	0.3	0.6
Maternal smoking around birth	0.1	0.2	0.3	0.3	0.5	0.3
Medication: Atenolol	0.1	0.2	0.3	-0.3	0.6	0.3
Alcohol usually taken with meals	0.1	0.1	0.3	-0.0	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.0	-0.6	-0.0
Had menopause	0.1	0.1	0.2	-0.3	0.5	-0.2
Fluid intelligence score	0.1	0.2	0.3	0.5	0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.3	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	-0.5	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.4	0.2	-0.1
Headache pain in last month	0.1	0.1	0.2	-0.4	-0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	0.1	-0.6	-0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	0.2	0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.2	-0.1	-0.4
Number of full brothers	0.1	0.1	0.3	-0.5	0.2	-0.1
Health satisfaction	0.1	0.1	0.3	0.4	0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	-0.4	0.1
Pulse rate, automated reading	0.1	0.4	0.7	-0.6	-0.8	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.2	0.3	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.3	0.5	-0.1	0.5
Eye problems/disorders: Cataract	0.1	0.2	0.3	0.3	0.2	0.6
Smoking status: Current	0.1	0.1	0.2	0.2	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.0	-0.5	0.2
Medication: Lisinopril	0.1	0.1	0.1	-0.3	-0.4	-0.3
Ever depressed for a whole week	0.1	0.1	0.2	0.4	-0.4	0.3
Myopia	0.1	0.1	0.2	0.3	-0.4	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.3	-0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.0	0.5	0.3
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.5	0.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	0.0	-0.5	0.0
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.4	0.0	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.1	-0.0	-0.3	0.1
Triglycerides	0.0	0.1	0.2	-0.0	0.4	0.2
Blood Red Count	0.0	0.1	0.3	-0.1	0.1	-0.5
Cardiovascular Disease	0.0	0.1	0.2	0.4	0.2	0.4
Hair Pigment	0.0	1.0	1.4	0.9	1.2	1.0
Number of treatments/medications taken	0.0	0.1	0.2	0.1	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	-0.0	0.4	-0.0
Medication: Metformin	0.0	0.0	0.0	0.1	0.2	0.2
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.3	0.2	0.0
Current tobacco smoking	0.0	0.0	0.1	0.0	0.3	0.2
Taking other prescription medications	0.0	0.0	0.0	-0.1	0.1	0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.0	-0.3	0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	-0.2	0.1
Medication: Ramipril	0.0	0.0	0.1	-0.2	-0.3	0.2
Standing height	0.0	0.1	0.1	0.4	0.2	0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.1	-0.1	0.1
Age at first live birth	0.0	0.0	0.1	0.2	-0.3	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.1	0.0	-0.3	0.0
Migraine (self-reported)	0.0	0.0	0.0	0.0	-0.1	-0.0
Alcohol intake frequency.	0.0	0.1	0.2	0.4	-0.1	0.4
Comparative height size at age 10	0.0	0.0	0.1	0.0	0.0	-0.3
Overall health rating	0.0	0.0	0.1	-0.2	-0.1	0.3
Chest pain or discomfort	0.0	0.0	0.0	0.1	0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.2	0.2	-0.0
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	-0.1	-0.4
Illnesses of father: Heart disease	0.0	0.0	0.1	0.1	-0.3	0.0
Loneliness, isolation	0.0	0.1	0.1	0.3	0.2	0.2
Medication for cholesterol	0.0	0.0	0.1	-0.1	-0.3	-0.1
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.1	-0.2	-0.1
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.2	0.2	-0.0
Pack years of smoking	0.0	0.0	0.1	-0.3	-0.1	0.1

Hub : Genes

CBX8

Models

Trait associations