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chr2:108,372,251-110,102,339

Best TWAS P=4.27e-17 · Best GWAS P=2.12e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GCC2	0.12	0.17	enet	30	0.18	5.1e-21	-6.2	-6.7	2.4e-11	-0.82	0.99	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RANBP2	0.04	0.01	blup	395	0.03	4.2e-04	7.1	-7.3	3.2e-13	-0.85	0.04	0.88	FALSE
3	GTEx	Adipose Subcutaneous	GCC2	0.36	0.46	enet	23	0.45	5.8e-40	7.8	-8.0	1.5e-15	-0.99	0.02	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	GCC2	0.25	0.27	lasso	11	0.22	9.8e-12	8.1	-7.9	2.7e-15	-0.99	0.01	0.99	FALSE
5	GTEx	Artery Aorta	GCC2	0.09	0.03	lasso	11	0.02	3.3e-02	7.8	-8.4	4.3e-17	-0.97	0.02	0.94	TRUE
6	GTEx	Artery Aorta	LIMS1	0.17	0.11	lasso	4	0.10	5.0e-06	8.2	-8.3	1.5e-16	-0.98	0.01	0.98	FALSE
7	GTEx	Artery Coronary	GCC2	0.31	0.26	lasso	4	0.18	8.8e-07	7.8	-8.0	1.3e-15	-0.97	0.02	0.98	FALSE
8	GTEx	Artery Tibial	GCC2	0.21	0.16	lasso	4	0.18	5.7e-14	7.8	-8.2	1.9e-16	-0.95	0.03	0.97	FALSE
9	GTEx	Artery Tibial	AC012487.2	0.06	0.03	enet	21	0.01	2.5e-02	-5.6	-5.4	8.5e-08	-0.62	0.11	0.54	FALSE
10	GTEx	Brain Cerebellar Hemisphere	GCC2	0.22	-0.01	lasso	7	-0.01	8.2e-01	-6.3	7.2	8.1e-13	0.89	0.11	0.16	FALSE
11	GTEx	Brain Cerebellum	GCC2	0.17	0.10	enet	16	0.08	2.4e-03	-5.6	-6.2	5.7e-10	-0.67	0.28	0.35	FALSE
12	GTEx	Brain Cortex	CCDC138	0.16	-0.01	lasso	3	0.00	3.4e-01	3.9	-6.0	2.1e-09	-0.63	0.05	0.54	FALSE
13	GTEx	Breast Mammary Tissue	GCC2	0.31	0.32	lasso	8	0.31	1.6e-16	8.1	-8.1	5.4e-16	-1.00	0.01	0.99	FALSE
14	GTEx	Breast Mammary Tissue (Male)	GCC2	0.37	0.22	lasso	9	0.16	1.8e-04	7.5	-7.5	4.9e-14	-0.91	0.02	0.95	FALSE
15	GTEx	Breast Mammary Tissue (Female)	GCC2	0.28	0.31	lasso	10	0.28	6.4e-09	8.1	-8.1	8.0e-16	-0.99	0.02	0.98	FALSE
16	GTEx	Cells Transformed fibroblasts	GCC2	0.19	0.16	enet	14	0.18	3.4e-13	8.1	-8.0	8.9e-16	-0.99	0.02	0.98	FALSE
17	GTEx	Colon Sigmoid	GCC2	0.17	0.10	lasso	3	0.09	3.7e-04	8.2	-7.8	6.2e-15	-0.97	0.02	0.95	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	GCC2	0.16	0.14	lasso	9	0.12	5.8e-05	8.1	-7.8	4.8e-15	-0.98	0.02	0.98	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	AC012487.2	0.14	0.01	enet	14	0.07	1.7e-03	-6.4	-5.6	1.9e-08	-0.55	0.04	0.67	FALSE
20	GTEx	Esophagus Mucosa	GCC2	0.24	0.28	enet	22	0.28	3.0e-19	8.2	-8.0	1.9e-15	-0.97	0.01	0.99	FALSE
21	GTEx	Esophagus Muscularis	GCC2	0.18	0.18	lasso	3	0.20	3.8e-12	7.8	-7.9	3.1e-15	-0.96	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	LIMS1	0.10	0.00	lasso	3	0.00	2.4e-01	-5.5	-5.5	3.8e-08	-0.61	0.08	0.73	FALSE
23	GTEx	Heart Atrial Appendage	GCC2	0.14	0.14	lasso	1	0.11	1.5e-05	7.8	-7.8	5.6e-15	-0.99	0.02	0.97	FALSE
24	GTEx	Heart Left Ventricle	GCC2	0.11	0.09	lasso	4	0.08	7.2e-05	8.1	-7.4	1.9e-13	-0.94	0.02	0.96	FALSE
25	GTEx	Lung	GCC2	0.21	0.29	lasso	3	0.29	3.7e-22	8.2	-8.0	9.7e-16	-0.99	0.02	0.98	FALSE
26	GTEx	Muscle Skeletal	GCC2	0.05	0.04	lasso	9	0.03	1.2e-03	7.8	-8.0	1.8e-15	-0.97	0.02	0.97	FALSE
27	GTEx	Nerve Tibial	GCC2	0.27	0.28	lasso	10	0.27	2.8e-19	7.5	-7.6	3.4e-14	-0.91	0.16	0.84	FALSE
28	GTEx	Pancreas	GCC2	0.29	0.17	lasso	9	0.19	2.2e-08	8.1	-7.8	8.0e-15	-0.97	0.02	0.98	FALSE
29	GTEx	Prostate	GCC2	0.27	-0.01	lasso	12	-0.01	7.0e-01	8.1	-6.7	1.8e-11	-0.86	0.03	0.58	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	GCC2	0.21	0.30	lasso	4	0.28	8.8e-16	7.8	-7.5	6.7e-14	-0.98	0.02	0.98	FALSE
31	GTEx	Skin Sun Exposed Lower leg	GCC2	0.30	0.29	lasso	10	0.32	3.2e-27	7.8	-7.8	5.3e-15	-0.98	0.02	0.98	FALSE
32	GTEx	Spleen	GCC2	0.41	0.33	lasso	7	0.31	9.9e-09	8.1	-8.1	4.4e-16	-1.00	0.01	0.98	FALSE
33	GTEx	Stomach	GCC2	0.17	0.21	lasso	11	0.22	5.6e-11	8.1	-8.1	5.1e-16	-0.98	0.01	0.99	FALSE
34	GTEx	Stomach	AC012487.2	0.08	0.02	enet	19	0.05	2.2e-03	8.2	-7.5	6.0e-14	-0.89	0.02	0.96	FALSE
35	GTEx	Thyroid	GCC2	0.24	0.19	enet	27	0.19	3.1e-14	8.1	-7.8	9.3e-15	-0.96	0.01	0.99	FALSE
36	GTEx	Uterus	GCC2	0.37	0.06	lasso	5	0.10	4.4e-03	7.8	-5.3	1.4e-07	-0.79	0.02	0.79	FALSE
37	GTEx	Whole Blood	GCC2	0.08	0.09	enet	17	0.09	1.3e-08	7.8	-7.8	6.0e-15	-0.97	0.02	0.98	FALSE
38	METSIM	Adipose	GCC2	0.15	0.17	bslmm	384	0.17	9.6e-25	7.8	-6.9	4.5e-12	-0.95	0.02	0.98	FALSE
39	NTR	Blood	GCC2	0.03	0.04	lasso	2	0.03	2.0e-10	7.5	-7.5	6.2e-14	-0.91	0.04	0.96	FALSE
40	YFS	Blood	GCC2	0.05	0.05	enet	19	0.05	8.7e-16	8.1	-8.3	1.4e-16	-0.98	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	GCC2	0.05	0.03	enet	19	0.04	5.5e-08	7.5	-6.2	4.2e-10	-0.78	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GCC2	0.03	0.02	blup	43	0.02	1.2e-03	8.1	-8.0	1.1e-15	-0.94	0.01	0.93	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LIMS1	0.02	0.01	blup	54	0.02	4.1e-03	8.2	7.7	1.4e-14	0.93	0.02	0.85	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GCC2	0.07	0.04	enet	9	0.08	2.8e-09	8.1	-7.2	7.4e-13	-0.84	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GCC2	0.05	0.01	blup	43	0.03	2.8e-03	-2.6	-6.3	2.5e-10	-0.76	0.02	0.36	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	GCC2	0.07	0.04	blup	43	0.07	8.3e-08	7.8	-6.7	1.9e-11	-0.85	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	LIMS1	0.03	0.01	blup	54	0.03	4.4e-04	-5.9	-7.1	1.4e-12	-0.89	0.04	0.87	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	GCC2	0.19	0.20	blup	43	0.22	9.5e-21	7.8	-7.6	3.6e-14	-0.91	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	LIMS1	0.07	0.04	blup	53	0.03	3.7e-04	8.2	6.8	1.5e-11	0.86	0.01	0.96	FALSE