Hub : Genes

RANBP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.038 0.0170 0.0018 0.014 0.025 0.005 0.024 0.012 0.0075 0.00042 0.06400 0.00056 0.0120
2 GTEx Cells EBV-transformed lymphocytes 0.169 0.0760 0.0037 0.025 NA 0.013 NA 0.031 0.0510 NA 0.12000 NA 0.0340
3 GTEx Nerve Tibial 0.100 0.0376 0.0011 0.027 NA 0.041 NA 0.027 0.0047 NA 0.00063 NA 0.0052

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.8 2.8 6.3 -0.3 1.4 2.5
Bipolar Disorder or Schizophrenia 0.6 1.6 4.1 0.6 0.5 2.0
Depressed Affect (Nagel 2018) 1.0 2.2 5.9 0.7 0.3 2.4
Depression (Nagel 2018) 0.9 1.3 2.6 -0.1 1.2 1.6
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.2 1.1 -0.8 0.3
Neuroticism (Nagel 2018) 1.3 3.1 8.4 0.4 0.8 2.9
Schizophrenia (2018) 0.2 0.5 0.9 1.0 -0.5 0.6
Schizophrenia vs Biploar Disorder 0.8 1.1 2.6 0.8 -1.6 0.3
Worry (Nagel 2018) 1.1 2.3 4.8 -0.3 1.4 2.2
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.2 0.1 -0.0
Alzheimer’s Disease (in father) 1.4 1.5 3.5 -0.6 0.9 -1.9
Alzheimer’s Disease (including proxy) 1.6 2.3 3.9 -1.2 1.2 -2.0
Crohns Disease (2017) 1.1 2.5 5.9 -1.2 2.4 0.1
Irritable Bowel Disease (IBD) 0.3 0.6 1.1 0.4 1.0 0.8
Ulcerative Colitis (UC) 0.8 1.5 2.7 1.6 0.1 1.3
Major Depression (MDD) 0.7 0.8 1.4 -0.1 1.1 1.2
Reaction Time 0.6 1.2 2.2 -1.2 1.5 -0.3
Verbal and Numeric Reasoning (VNR) 0.6 1.3 2.9 1.7 -1.0 0.4
Breast Cancer 1.5 3.6 4.2 1.6 -2.0 2.1
Ovarian Cancer 0.6 0.8 1.1 -0.4 1.1 1.0
Prostate Cancer 0.1 0.2 0.5 -0.1 -0.0 -0.7
Age at First Birth 0.9 1.3 3.3 0.2 -0.8 -1.8
Bipolar Disorder (2011) 0.5 0.5 1.1 1.1 -0.1 0.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.6 -0.3 0.7 0.8
Coronary Artery Disease (CAD) 0.4 0.5 0.8 -0.5 0.9 -0.7
Crohns Disease (2012) 2.0 3.3 5.2 -2.0 2.3 -0.9
Mean Putamen Volume 0.7 0.8 1.3 -0.7 1.1 -0.8
Fasting Glucose 1.3 1.6 4.0 -0.7 -0.5 -2.0
HbA1C 0.7 0.8 2.4 0.2 0.0 1.6
HDL Cholesterol 0.1 0.2 0.5 0.3 0.2 -0.7
LDL Cholesterol 0.1 0.2 0.4 -0.0 -0.7 -0.4
Lupus 0.1 0.1 0.3 -0.1 -0.2 -0.5
Neuroticism (2016) 3.5 5.0 11.9 0.1 1.8 3.4
Primary Biliary Cirrhosis 0.0 0.1 0.2 -0.0 0.4 0.0
Rheumatoid Arthritis 3.2 4.4 8.1 -2.8 2.2 -0.6
Schizophrenia (2014) 0.7 1.5 2.1 1.4 -0.7 1.4
Triglycerides 0.1 0.2 0.5 -0.2 -0.2 -0.7
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 -0.1 -0.3 -0.2
Ulcerative Colitis 1.8 2.6 4.2 2.0 -1.3 1.4
Blood Eosinophil Count 0.2 1.8 2.3 -1.5 1.0 -1.4
Blood Platelet Count 2.8 32.6 53.0 -7.3 4.7 -4.7
Blood Red Count 0.8 8.1 9.9 -3.1 3.0 -2.3
Blood White Count 0.0 0.3 0.8 -0.3 0.0 0.9
Heel T-Score 0.6 4.9 6.2 -1.8 2.5 -2.3
BMI 1.3 7.7 14.0 -2.5 3.7 -1.7
Height 0.9 16.8 22.6 4.8 -3.4 4.0
Waist Hip Ratio (WHR) 0.3 1.1 2.1 -0.6 0.9 -1.5
Systolic Blood Pressure 0.0 0.2 0.4 0.7 -0.2 0.5
Smoking Status 0.1 0.3 0.7 -0.3 0.9 -0.1
Allergy or Eczema 0.9 2.4 5.8 -1.1 0.5 -2.4
Cardiovascular Disease 0.1 0.3 0.8 0.9 0.3 0.3
Hypothyroidism (self reported) 1.4 3.3 7.1 1.4 -2.7 -0.9
Respiratory disease 0.5 1.1 1.6 -1.2 1.3 -0.3
Type 2 Diabetes (T2D) (2018) 2.2 4.1 6.0 -2.3 2.4 -0.9
Lung FEV1/FVC ratio 0.3 1.7 4.2 2.0 -1.0 0.3
Lung FVC 0.3 1.4 2.2 -1.5 0.7 -1.2
Neuroticism 1.5 3.6 5.4 -1.6 2.3 1.7
Chronotype (morning person) 1.4 3.2 6.0 -1.6 2.4 -1.0
Hair Pigment 0.1 4.3 8.0 -2.0 0.9 -2.8
Tanning 0.1 0.9 1.1 -0.9 1.1 -0.8
Hand grip strength (left) 0.2 0.4 0.9 0.5 -0.3 0.9
Number of treatments/medications taken 2.1 3.8 5.6 2.4 -1.2 2.1
Average weekly spirits intake 0.6 0.8 1.9 -0.6 0.3 -1.4
Sensitivity / hurt feelings 1.5 2.6 6.9 0.9 0.2 2.6
Frequency of depressed mood in last 2 weeks 1.3 1.9 4.2 0.5 1.1 2.0
Hearing difficulty/problems: Yes 0.5 0.7 1.6 -0.7 1.3 -0.3
Relative age of first facial hair 1.0 2.0 4.2 2.0 -1.3 -0.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.2 0.8 -1.5 0.1
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.7 0.5 -1.2 -1.6
Ever had hysterectomy (womb removed) 3.2 3.6 8.1 -1.6 2.8 0.2
Systolic blood pressure, automated reading 0.2 0.5 1.2 -0.5 -0.2 -1.1
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 4.3 -0.5 0.4 2.1
Angina 1.5 1.9 2.5 1.5 -1.0 1.6
Medication for hormone replacement therapy 0.1 0.1 0.4 0.2 -0.6 0.1
Vitamin and mineral supplements 0.8 1.1 1.9 -1.0 0.7 -1.4
Supplements: Zinc 0.9 1.0 2.0 -1.0 0.3 -1.4
Medication: Co-codamol 0.1 0.1 0.2 0.5 -0.1 -0.0
Medication: Metformin 0.3 0.5 0.7 -0.6 0.9 -0.5
Diabetes (father) 1.1 1.4 2.2 0.8 1.2 1.5
Diabetes (mother) 1.4 1.8 3.3 1.4 -0.4 1.8
Severe depression (siblings) 0.8 0.9 2.2 0.7 -0.0 1.5
Pack years adult smoking proportion 0.3 0.4 0.7 -0.1 0.9 0.7
Impedance of leg (right) 2.5 12.3 20.0 3.9 -4.5 1.5
Leg fat-free mass (left) 0.5 2.8 6.2 -1.4 2.5 0.1
Trunk fat percentage 0.1 0.3 0.5 -0.2 0.7 -0.6
Hand grip strength (right) 0.6 1.7 3.8 1.1 -0.4 1.9
Townsend deprivation index at recruitment 2.3 3.2 5.9 -0.4 1.9 2.4
Current tobacco smoking 0.2 0.3 0.9 0.9 -0.3 0.2
Average weekly fortified wine intake 1.5 1.8 2.9 -1.3 1.7 -0.9
Maternal smoking around birth 1.0 1.5 4.2 0.0 0.5 2.1
Fed-up feelings 2.9 5.2 14.9 0.8 0.5 3.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.4 0.1 1.2 1.0
Relative age voice broke 0.1 0.1 0.2 0.2 -0.1 -0.5
Taking other prescription medications 0.6 1.0 2.3 1.5 -0.5 0.7
Age when periods started (menarche) 0.3 0.7 1.1 1.0 -0.3 1.1
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 -0.1 0.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 3.9 -2.0 1.1 -1.8
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.3 -0.3 1.1 1.1
Qualifications: CSEs or equivalent 2.3 3.0 4.6 -2.1 1.5 -1.4
Serious illness, injury or assault to yourself 0.4 0.4 0.9 -0.0 0.7 0.9
High blood pressure 0.1 0.2 0.5 0.3 -0.0 0.7
Hayfever, allergic rhinitis or eczema 1.1 2.5 5.2 -1.3 0.7 -2.3
Multivitamins +/- minerals 0.2 0.3 0.7 0.8 -0.1 0.5
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.4 0.4 0.8
Supplements: Glucosamine 0.0 0.1 0.2 0.1 -0.0 -0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.1 1.1 -0.3 0.9
Medication: Atenolol 2.8 3.5 4.0 1.8 -2.0 1.8
Medication: Levothyroxine sodium 0.4 0.7 1.5 -0.1 -1.2 -0.8
Sitting height 0.5 3.8 5.9 1.9 -1.4 2.4
Chronic bronchitis/emphysema (father) 0.1 0.2 0.3 -0.1 -0.5 0.4
High blood pressure (mother) 0.4 0.5 1.0 -1.0 0.8 -0.2
Body mass index (BMI) 1.0 4.4 8.5 -1.8 2.9 -1.2
Impedance of leg (left) 1.6 7.9 12.7 3.1 -3.6 1.1
Leg predicted mass (left) 0.5 2.5 5.6 -1.4 2.4 0.1
Trunk fat mass 0.1 0.6 1.4 -0.4 1.2 -0.3
Waist circumference 0.6 2.2 5.2 -1.1 2.3 -0.7
Number of incorrect matches in round 1.4 2.3 4.0 -2.0 1.7 0.1
Past tobacco smoking 0.8 1.5 2.1 0.6 -1.5 1.4
Alcohol usually taken with meals 1.3 2.0 2.7 1.6 -0.9 1.7
Nervous feelings 0.5 0.9 2.0 -0.6 0.6 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.8 -0.7 1.4 0.4
Hearing difficulty/problems with background noise 0.5 0.8 1.3 -0.7 1.1 0.8
Hair/balding pattern: Pattern 2 0.9 1.1 3.3 0.2 -0.0 -1.8
Had menopause 1.0 1.2 3.1 -0.7 0.3 -1.8
Had other major operations 2.0 2.4 4.6 2.1 -0.6 1.6
Forced vital capacity (FVC) 0.0 0.2 0.4 -0.1 0.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 2.5 -1.6 1.1 -1.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.7 0.5 -0.8 -0.0
Qualifications: None of the above 0.5 1.0 2.3 0.2 0.7 1.5
Financial difficulties in last 2 years 0.8 1.1 1.2 -0.9 1.1 1.1
Mouth/teeth dental problems 0.5 0.8 1.5 -0.8 1.2 0.3
Heart attack 0.8 1.0 2.0 1.4 -0.7 0.7
Allergy 0.6 1.4 2.0 1.2 -0.8 1.4
Pain all over the body in last month 2.0 2.1 3.0 -1.6 0.9 -1.7
Diabetes (self-reported) 1.2 1.9 3.4 -1.8 1.5 -0.4
Hayfever/allergic rhinitis (self-reported) 1.5 1.9 3.7 0.8 -1.9 -1.2
Medication: Ramipril 0.9 1.1 2.0 1.4 -1.1 0.3
Medication: Simvastatin 3.1 4.5 6.4 2.5 -2.3 1.4
Fluid intelligence score 0.3 0.7 1.0 0.6 -1.0 -0.8
Illnesses of siblings 1.5 2.1 2.4 -1.4 1.3 -1.5
Neuroticism score 1.5 3.2 6.7 -0.4 1.6 2.6
Weight 0.4 1.8 4.7 -0.8 2.2 -0.0
Impedance of arm (right) 1.5 6.8 10.8 2.7 -3.3 1.6
Arm fat percentage (right) 0.2 0.7 1.7 -0.6 1.3 -0.3
Trunk fat-free mass 0.2 0.9 1.8 -0.3 1.4 0.9
Hip circumference 0.5 2.1 5.1 -1.1 2.3 -0.2
Time employed in main current job 0.4 0.5 0.7 0.4 0.8 0.7
Alcohol intake versus 10 years previously 2.0 3.0 5.0 -1.9 2.2 0.5
Father’s age at death 0.1 0.2 0.4 -0.6 0.2 -0.1
Worrier / anxious feelings 0.7 1.2 3.3 0.3 0.6 1.8
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 5.8 1.0 0.0 2.4
Falls in the last year 1.4 1.9 2.4 -1.6 1.3 -1.3
Hair/balding pattern: Pattern 3 1.1 1.6 4.6 -0.0 -0.6 2.1
Number of live births 0.5 0.8 1.2 1.1 -0.3 1.0
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.3 -0.1 0.5 0.3
Pulse rate 0.1 0.2 0.3 0.4 -0.5 0.3
Happiness 0.5 0.6 1.6 0.4 -0.0 1.3
Noisy workplace 0.2 0.2 0.6 -0.8 0.1 -0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.2 0.9 -1.1 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 0.3 -1.0 0.6
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.7 0.4 -0.2
Asthma 0.6 1.2 1.4 -1.2 1.0 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.6 1.4 -0.4 1.9
Medication: Cholesterol lowering 1.6 2.5 4.3 1.7 -2.1 0.6
Depression (self-reported) 2.3 2.8 7.8 0.5 -0.5 2.8
Medication: Lansoprazole 0.4 0.5 0.8 0.9 -0.5 0.5
Prospective memory result 0.2 0.3 0.8 -0.3 -0.2 -0.9
Lung cancer (father) 1.2 1.4 2.6 -1.1 0.6 -1.6
Illnesses of mother 0.2 0.2 0.5 -0.3 0.7 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.2 0.5 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.1 0.1 -0.0 -1.1
Impedance of arm (left) 1.4 6.4 9.6 2.7 -3.1 1.6
Arm fat mass (right) 0.3 1.3 2.9 -0.8 1.7 -0.6
Trunk predicted mass 0.2 0.9 1.7 -0.2 1.3 0.9
Standing height 0.4 4.1 6.1 2.1 -1.4 2.5
Length of working week for main job 0.4 0.4 0.6 -0.8 0.6 0.6
Exposure to tobacco smoke at home 1.5 1.7 4.6 0.7 -0.1 2.1
Breastfed as a baby 0.6 0.7 1.7 1.3 -0.7 0.3
Tense / ‘highly strung’ 0.4 0.6 1.3 0.0 0.7 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.0 -0.1 1.1 1.4
Hair/balding pattern: Pattern 4 1.6 3.8 4.2 -2.1 1.7 -2.1
Birth weight of first child 0.9 1.7 2.7 -1.5 0.2 -1.6
Peak expiratory flow (PEF) 0.0 0.1 0.2 0.2 -0.5 -0.0
Pulse wave reflection index 0.2 0.2 0.7 -0.0 -0.1 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 -0.5 -0.1 -0.8
Loud music exposure frequency 0.6 0.7 1.1 1.1 -0.2 0.9
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 4.7 1.6 -2.2 0.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.9 0.4 -1.4 -0.6
Blood clot in the leg (DVT) 0.9 1.2 2.7 -0.9 1.6 0.2
Medication: Paracetamol 1.8 3.0 3.8 1.8 -1.4 2.0
Headache pain in last month 0.3 0.5 0.9 0.5 -1.0 0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 2.3 -1.5 1.1 -1.4
Glaucoma (self-reported) 1.0 1.2 2.3 -1.1 0.3 -1.5
Gout (self-reported) 0.3 0.4 0.7 -0.3 -0.5 -0.9
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.9 0.0 -1.4 -0.6
Medication: Amlodipine 1.0 1.4 2.3 0.9 -1.5 1.1
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.6 -1.2 0.5 -1.6
Birth weight 4.4 9.6 14.3 -3.8 3.0 -2.4
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.6 0.4 0.6 1.3
High blood pressure (siblings) 0.6 0.9 1.9 0.9 -0.3 1.4
Forced vital capacity (FVC), Best measure 0.1 0.3 0.5 -0.4 0.7 0.5
Body fat percentage 0.1 0.4 0.9 -0.3 1.0 -0.4
Leg fat percentage (right) 0.1 0.5 0.8 -0.5 0.9 -0.7
Arm fat-free mass (right) 0.3 1.6 3.9 -0.9 2.0 -0.1
Exposure to tobacco smoke outside home 0.6 0.7 2.2 0.3 0.0 1.5
Comparative body size at age 10 2.5 6.9 11.0 -3.1 3.3 -0.5
Number of full brothers 0.6 0.8 1.8 -1.3 0.8 -0.1
Worry too long after embarrassment 0.7 1.1 2.7 -0.2 0.8 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.6 0.5 0.4 1.9
Wheeze or whistling in the chest in last year 1.8 3.3 3.6 -1.9 1.8 -1.8
Number of children fathered 1.5 1.7 2.8 1.7 -1.4 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.4 1.2 -1.1 0.2
Age at first live birth 0.7 1.2 1.9 0.3 -1.3 -1.4
Pulse wave peak to peak time 0.4 0.5 1.5 0.0 0.0 1.2
Health satisfaction 1.1 1.4 3.1 1.8 -0.5 1.0
Shortness of breath walking on level ground 0.7 0.8 1.5 1.2 -0.0 1.0
Qualifications: College or University degree 0.1 0.4 0.5 0.5 -0.7 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.1 0.0 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.6 0.8 0.4 -0.5
Emphysema/chronic bronchitis 1.6 1.8 4.0 -1.1 2.0 0.4
Medication for pain relief, constipation, heartburn 3.7 6.4 8.4 -2.9 2.6 -2.0
Neck or shoulder pain in last month 0.9 1.3 2.0 1.4 -0.8 1.1
Medication: Blood pressure 1.4 2.5 5.3 1.3 -0.7 2.3
Angina (self-reported) 1.2 1.6 2.2 1.5 -0.7 1.4
Migraine (self-reported) 0.2 0.2 0.3 0.6 -0.2 0.5
Medication: Ibuprofen 1.2 1.5 3.5 0.9 0.1 1.9
Medication: Allopurinol 0.2 0.3 0.4 0.6 -0.5 0.6
Medication: Omeprazole 2.2 2.6 2.9 1.7 -1.7 1.5
Medication: Seretide 50 evohaler 3.7 4.3 6.1 2.3 -1.3 2.5
Mean time to correctly identify matches 0.4 0.8 1.5 -0.9 1.2 -0.1
Heart disease (mother) 0.4 0.5 0.9 0.5 -0.6 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 0.9 -0.3 -0.0
Whole body fat mass 0.2 0.9 2.1 -0.6 1.5 -0.4
Leg fat mass (right) 0.4 1.4 3.1 -0.9 1.8 -0.5
Arm predicted mass (right) 0.3 1.6 3.9 -0.9 2.0 -0.3
Pulse rate, automated reading 0.1 0.5 0.9 -0.9 0.7 0.0
Alcohol intake frequency. 0.9 2.1 3.3 -1.6 1.8 0.4
Comparative height size at age 10 0.2 1.0 1.3 1.1 -0.9 1.0
Number of full sisters 1.1 1.3 2.4 1.3 -0.0 1.5
Suffer from ‘nerves’ 0.7 1.0 1.5 -0.7 1.2 1.1
Overall health rating 4.2 9.0 11.2 3.3 -2.2 3.3
Chest pain or discomfort 0.2 0.3 0.7 -0.0 -0.5 -0.8
Had major operations 1.1 1.3 2.4 1.1 -0.6 1.6
Age at last live birth 0.8 1.2 3.5 -0.1 -0.3 -1.9
Family relationship satisfaction 1.4 1.8 5.2 0.3 -0.1 2.3
Leg pain on walking 0.7 0.9 1.6 0.5 -0.9 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 -0.4 -0.0 -0.6
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.6 1.2 -1.2 0.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.5 0.3 -0.7 -1.6
Medication: Aspirin 0.6 0.8 1.3 1.0 -1.1 -0.2
Supplements: Vitamin C 1.4 1.6 2.8 0.5 -1.7 1.4
Knee pain experienced in last month 0.1 0.2 0.4 -0.1 0.6 0.2
Hypertension (Self-reported) 0.2 0.6 1.0 0.8 -0.2 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.2 0.1 -1.2 -1.5
Illnesses of father: Heart disease 4.3 5.9 9.1 2.9 -3.0 0.0
Illnesses of siblings: Diabetes 1.4 1.8 1.9 -1.3 1.3 -1.4
Smoking status: Previous 0.5 0.8 1.2 -0.4 1.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.0 0.8 0.2 2.0
Whole body fat-free mass 0.3 1.6 3.8 -0.8 1.9 0.5
Leg fat-free mass (right) 0.8 4.3 9.1 -1.9 3.0 0.1
Arm fat percentage (left) 0.3 1.2 2.7 -0.8 1.6 -0.3
Average weekly red wine intake 0.7 1.0 1.7 -0.8 0.7 -1.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.9 0.8 -0.6 -0.9
Mood swings 0.8 1.5 3.2 0.3 1.1 1.8
Loneliness, isolation 3.8 5.3 11.9 1.9 -0.3 3.5
Long-standing illness, disability or infirmity 1.7 2.6 5.0 1.4 -1.0 2.2
Ever had bowel cancer screening 0.7 0.8 1.1 -0.6 0.9 1.0
Diabetes diagnosed by doctor 1.1 1.7 2.7 -1.5 1.6 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 2.1 1.5 -1.0 0.8
Friendships satisfaction 0.3 0.3 0.6 0.6 -0.4 0.8
Qualifications: nursing, teaching 1.7 2.7 4.8 1.7 -2.2 -0.6
Commuting to job workplace: Walk 0.4 0.4 0.8 0.6 -0.9 -0.4
Eye problems/disorders: Cataract 0.2 0.3 0.4 0.5 -0.4 0.6
Mouth/teeth dental problems: Mouth ulcers 3.3 5.3 8.8 2.7 -3.0 0.1
Medication for cholesterol 1.0 1.5 3.4 -1.8 0.5 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.6 0.4 -0.8 0.4
Back pain experienced in last month 0.2 0.3 0.6 0.8 0.1 0.4
Mineral and other dietary supplements 1.8 2.5 4.1 -1.5 2.0 -1.1
Breast cancer (self-reported) 2.0 2.4 3.7 1.9 -1.6 0.8
Asthma (self-reported) 0.6 1.2 1.7 -1.2 0.7 -1.3
Osteoporosis (self-reported) 1.3 1.6 4.4 0.3 0.6 2.1
Osteoarthritis (self-reported) 1.1 1.5 2.4 1.4 -1.5 0.2
Medication: Aspirin 0.4 0.5 0.8 0.9 -0.8 -0.0
Medication: Gliclazide 1.6 1.8 2.7 -1.6 1.0 -1.3
Illnesses of father: None of the above (group 1) 1.5 1.8 2.6 -1.1 1.3 -1.6
Smoking status: Current 0.1 0.2 0.6 0.8 -0.2 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 -0.4 0.5 0.9
Whole body water mass 0.3 1.7 3.9 -0.9 2.0 0.5
Leg predicted mass (right) 0.8 4.3 9.3 -1.9 3.0 0.1
Arm fat mass (left) 0.5 2.0 4.8 -1.0 2.2 -0.4
Number of self-reported non-cancer illnesses 1.8 3.2 5.1 2.0 -2.3 0.7
Average weekly champagne plus white wine intake 1.0 1.3 2.1 1.4 -1.4 0.2
Miserableness 0.6 1.0 2.6 0.4 -0.3 1.6
Guilty feelings 0.3 0.4 0.9 0.5 -0.3 1.0
Wears glasses or contact lenses 2.7 3.2 4.7 2.0 -1.0 2.2
Ever taken oral contraceptive pill 1.3 1.5 3.2 0.9 -0.5 1.8
Hearing aid user 2.2 2.5 5.3 1.4 -2.3 -0.2
Mother’s age at death 0.2 0.3 0.9 -0.1 -0.1 1.0
Financial situation satisfaction 1.0 1.2 3.5 0.2 0.4 1.9
Tinnitus: Yes, now most or all of the time 1.6 1.8 3.2 -1.5 1.8 0.1
Commuting to job workplace: Public transport 0.4 0.5 1.2 -0.2 -0.5 -1.1
Eye problems/disorders: Glaucoma 0.9 1.0 1.8 -1.1 0.4 -1.3
Medication: Blood pressure 0.1 0.1 0.2 0.3 0.5 -0.3
Pain type(s) experienced in last month: Hip pain 1.6 2.1 5.2 -1.0 2.3 0.0
Supplements: Fish oil (including cod liver oil) 1.8 2.3 3.6 1.4 -1.9 1.2
High cholesterol (Self-reported) 0.4 0.6 1.6 1.3 -0.2 -0.5
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.5 0.4 0.1
Medication: Paracetamol 1.4 2.1 2.6 1.6 -1.3 1.4
Medication: Lisinopril 0.2 0.3 0.4 -0.6 0.6 -0.3
Medication: Atorvastatin 0.4 0.4 1.3 -0.1 -0.1 -1.2
Illnesses of father: High blood pressure 1.2 1.5 1.7 -1.2 1.3 1.2
Alcohol drinker status: Never 0.3 0.4 0.9 0.6 0.1 0.9
Ever smoked 1.0 1.7 2.9 -0.5 1.7 -1.4
Basal metabolic rate 0.3 1.8 4.4 -0.9 2.1 0.3
Leg fat percentage (left) 0.3 1.0 1.8 -0.7 1.4 -0.7
Arm fat-free mass (left) 0.2 1.1 3.1 -0.4 1.8 0.2
Number of operations (self-reported) 3.6 5.4 8.3 2.9 -2.3 1.6
Average weekly beer plus cider intake 4.2 6.1 13.4 -2.1 0.8 -3.7
Irritability 0.2 0.3 0.5 -0.5 0.7 -0.1
Risk taking 0.8 1.2 2.5 -1.6 1.1 0.0
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 0.4 -0.9 -0.1
Fractured/broken bones in last 5 years 0.8 1.0 2.6 0.5 -0.4 1.6
Age started oral contraceptive pill 2.6 3.3 6.5 0.5 -1.8 -2.5
Diastolic blood pressure, automated reading 0.3 1.0 1.7 -1.3 0.5 -1.1
Ever depressed for a whole week 0.3 0.3 0.5 -0.7 0.7 -0.2
Unable to work because of sickness or disability 0.8 1.1 1.4 -0.9 1.2 -1.0
Commuting to job workplace: Cycle 1.9 2.4 5.5 -1.2 0.4 -2.3
Myopia 0.0 0.0 0.1 0.3 0.0 -0.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.5 -0.2 -0.1 -0.7
Cholesterol lowering medication 2.3 3.3 6.2 2.5 -1.4 1.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.6 0.7 -0.8 0.7
Pain experienced in last month 0.0 0.1 0.2 0.1 -0.4 -0.0
Supplements: Calcium 1.0 1.1 1.8 1.3 -0.8 0.9
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 0.3 -1.0 -0.1
Heart attack/myocardial infarction (self-reported) 0.7 1.0 1.9 1.4 -0.6 0.7
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.3 -1.0 1.8 0.1
Heart disease (siblings) 1.5 1.8 3.5 0.9 -1.9 -1.0
Alcohol drinker status: Previous 0.6 0.7 0.8 -0.9 -0.8 -0.9
Pack years of smoking 0.1 0.2 0.4 0.1 0.6 0.5
Impedance of whole body 1.8 9.2 15.3 3.3 -3.9 1.3
Leg fat mass (left) 0.5 1.8 4.2 -1.0 2.0 -0.5
Arm predicted mass (left) 0.3 1.3 3.4 -0.7 1.8 0.2