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chr3:100,350,244-102,240,698

Best TWAS P=1.25e-19 · Best GWAS P=1.79e-15 conditioned to 0.000242

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	GTEx	Nerve Tibial	PDCL3P4	0.16	0.06	enet	32	0.09	5.9e-07	-7.0	-9.1	1.3e-19	0.54	0.36	0.61	TRUE
38	GTEx	Skin Not Sun Exposed Suprapubic	SENP7	0.14	0.08	lasso	6	0.11	8.0e-07	-7.0	8.7	3.7e-18	-0.78	0.07	0.92	FALSE
45	GTEx	Thyroid	SENP7	0.07	0.02	lasso	4	0.02	1.3e-02	-7.9	8.6	5.8e-18	-0.87	0.03	0.96	FALSE
4	GTEx	Artery Coronary	SENP7	0.11	0.02	enet	40	0.01	1.8e-01	-7.1	8.5	1.3e-17	-0.79	0.06	0.84	FALSE
6	GTEx	Artery Tibial	RP11-49I4.3	0.07	0.03	lasso	5	0.05	4.6e-05	-7.9	8.5	1.5e-17	-0.87	0.04	0.95	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SENP7	0.04	0.03	lasso	2	0.03	1.3e-04	-7.8	8.2	2.3e-16	-0.94	0.03	0.96	FALSE
29	GTEx	Heart Left Ventricle	PDCL3P4	0.11	0.03	enet	14	0.02	2.2e-02	-6.8	-8.2	3.2e-16	0.51	0.32	0.29	FALSE
27	GTEx	Heart Atrial Appendage	SENP7	0.18	0.19	lasso	7	0.23	1.6e-10	-6.8	8.0	8.6e-16	-0.93	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	SENP7	0.10	0.11	enet	30	0.10	1.9e-08	-7.9	8.0	1.4e-15	-0.96	0.03	0.97	FALSE
41	GTEx	Stomach	SENP7	0.10	0.09	lasso	4	0.04	6.3e-03	-7.9	7.9	3.1e-15	-0.93	0.03	0.95	FALSE
22	GTEx	Esophagus Mucosa	SENP7	0.11	0.04	lasso	2	0.06	7.4e-05	-7.8	7.8	4.9e-15	-1.00	0.03	0.96	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	SENP7	0.02	0.03	blup	84	0.02	3.4e-03	-7.9	7.8	7.5e-15	-0.99	0.03	0.94	FALSE
61	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SENP7	0.07	0.09	lasso	5	0.08	2.6e-06	-7.8	7.8	7.7e-15	-1.00	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SENP7	0.04	0.04	lasso	5	0.04	2.1e-05	-7.9	7.7	1.0e-14	-0.99	0.03	0.97	FALSE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SENP7	0.07	0.04	enet	20	0.08	5.6e-05	-7.9	7.7	1.2e-14	-0.85	0.03	0.88	FALSE
5	GTEx	Artery Tibial	SENP7	0.17	0.15	enet	43	0.20	9.6e-16	-6.8	7.6	3.5e-14	-0.89	0.04	0.96	FALSE
12	GTEx	Brain Frontal Cortex BA9	PDCL3P4	0.28	0.20	lasso	10	0.14	1.6e-04	-6.8	-7.5	5.7e-14	0.47	0.28	0.57	FALSE
43	GTEx	Testis	PDCL3P4	0.28	0.27	enet	24	0.28	1.2e-12	-6.8	-7.5	9.4e-14	0.47	0.98	0.02	FALSE
36	GTEx	Pituitary	SENP7	0.14	0.15	lasso	2	0.15	1.3e-04	-6.8	7.4	1.7e-13	-0.62	0.12	0.73	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC285359	0.21	0.04	enet	18	0.08	6.4e-04	5.3	-7.3	2.1e-13	0.42	0.02	0.85	FALSE
34	GTEx	Nerve Tibial	NXPE3	0.13	0.02	lasso	6	0.04	4.6e-04	5.3	-7.3	3.5e-13	0.33	0.61	0.08	FALSE
19	GTEx	Colon Sigmoid	SENP7	0.10	0.09	lasso	3	0.13	2.2e-05	-6.8	7.2	5.8e-13	-0.69	0.13	0.68	FALSE
32	GTEx	Muscle Skeletal	PDCL3P4	0.07	0.08	enet	21	0.07	2.5e-07	-6.8	-7.2	8.0e-13	0.64	0.93	0.07	FALSE
9	GTEx	Brain Cerebellum	PDCL3P4	0.28	0.40	enet	21	0.41	3.2e-13	-6.8	-7.2	8.1e-13	0.49	0.97	0.03	FALSE
30	GTEx	Lung	SENP7	0.11	0.09	lasso	6	0.09	2.8e-07	-6.8	7.2	8.5e-13	-0.88	0.04	0.96	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	PDCL3P4	0.22	0.29	lasso	7	0.29	1.9e-08	-6.8	-7.2	8.8e-13	0.49	0.81	0.13	FALSE
8	GTEx	Brain Cerebellar Hemisphere	PDCL3P4	0.30	0.37	enet	21	0.38	1.3e-10	-6.8	-7.1	9.9e-13	0.50	0.96	0.04	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	RP11-49I4.3	0.16	0.01	enet	8	0.03	2.5e-02	-6.9	7.1	1.7e-12	-0.54	0.11	0.27	FALSE
14	GTEx	Brain Hypothalamus	PDCL3P4	0.45	0.24	lasso	4	0.21	1.1e-05	-7.0	-7.0	2.1e-12	0.60	0.09	0.72	FALSE
7	GTEx	Brain Caudate basal ganglia	PDCL3P4	0.34	0.32	lasso	6	0.34	1.7e-10	-6.8	-7.0	2.4e-12	0.47	0.94	0.06	FALSE
33	GTEx	Nerve Tibial	SENP7	0.20	0.17	lasso	5	0.18	2.0e-12	-7.0	7.0	3.4e-12	-0.81	0.09	0.91	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SENP7	0.04	0.02	blup	84	0.03	4.6e-03	-6.8	7.0	3.7e-12	-0.96	0.03	0.78	FALSE
23	GTEx	Esophagus Muscularis	SENP7	0.10	0.07	enet	13	0.08	2.1e-05	-6.8	6.9	3.9e-12	-0.58	0.91	0.07	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	SENP7	0.10	0.10	lasso	14	0.10	7.6e-11	-7.8	6.9	5.4e-12	-0.92	0.03	0.97	FALSE
16	GTEx	Brain Putamen basal ganglia	PDCL3P4	0.25	0.42	enet	13	0.42	3.5e-11	-6.8	-6.9	6.0e-12	0.47	0.95	0.04	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	SENP7	0.17	0.14	lasso	8	0.14	1.4e-05	-6.8	6.8	8.6e-12	-0.49	0.53	0.31	FALSE
46	GTEx	Thyroid	PDCL3P4	0.05	0.03	lasso	1	0.02	8.3e-03	-6.8	-6.8	8.8e-12	0.48	0.34	0.22	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC285359	0.11	0.21	lasso	8	0.22	2.6e-24	-6.8	-6.8	8.9e-12	0.48	0.02	0.98	FALSE
13	GTEx	Brain Hippocampus	PDCL3P4	0.27	0.24	lasso	5	0.28	2.7e-07	-6.8	-6.8	1.1e-11	0.43	0.44	0.38	FALSE
40	GTEx	Spleen	SENP7	0.25	0.09	enet	43	0.09	3.3e-03	6.7	6.8	1.1e-11	-0.79	0.05	0.88	FALSE
28	GTEx	Heart Atrial Appendage	PDCL3P4	0.14	0.19	lasso	2	0.18	2.3e-08	-6.7	-6.8	1.5e-11	0.46	0.98	0.02	FALSE
10	GTEx	Brain Cortex	PDCL3P4	0.26	0.18	lasso	10	0.17	2.4e-05	-6.8	-6.7	1.6e-11	0.45	0.74	0.05	FALSE
3	GTEx	Adrenal Gland	SENP7	0.11	0.06	lasso	5	0.03	4.0e-02	-7.8	6.7	1.7e-11	-0.95	0.04	0.79	FALSE
48	METSIM	Adipose	SENP7	0.05	0.05	blup	478	0.07	2.5e-10	-7.8	6.7	1.8e-11	-0.81	0.04	0.96	FALSE
42	GTEx	Testis	CEP97	0.20	0.15	lasso	6	0.17	4.3e-08	-6.8	-6.6	3.0e-11	0.61	0.94	0.06	FALSE
39	GTEx	Skin Sun Exposed Lower leg	SENP7	0.07	0.03	lasso	3	0.05	5.6e-05	-6.8	6.6	4.6e-11	-0.77	0.05	0.94	FALSE
25	GTEx	Esophagus Muscularis	RP11-49I4.3	0.09	0.12	lasso	2	0.09	5.9e-06	-6.9	6.5	5.9e-11	-0.45	0.96	0.02	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC285359	0.12	0.06	blup	24	0.06	3.5e-03	-7.0	-6.5	8.2e-11	0.39	0.01	0.70	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC285359	0.17	0.12	blup	24	0.07	3.0e-03	-6.8	-6.5	9.4e-11	0.43	0.02	0.94	FALSE
47	GTEx	Uterus	RP11-49I4.3	0.22	0.01	lasso	21	0.04	5.7e-02	-7.8	6.4	1.9e-10	-0.79	0.04	0.54	FALSE
37	GTEx	Pituitary	PDCL3P4	0.23	0.17	lasso	13	0.12	8.2e-04	-6.8	-6.2	4.3e-10	0.40	0.20	0.50	FALSE
26	GTEx	Heart Atrial Appendage	ZBTB11	0.11	0.03	enet	25	0.03	1.5e-02	5.7	6.2	6.1e-10	-0.39	0.14	0.24	FALSE
66	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SENP7	0.07	0.01	blup	84	0.04	2.1e-02	-7.8	6.1	9.3e-10	-0.93	0.03	0.70	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	SENP7	0.18	0.15	enet	24	0.18	1.0e-10	-7.8	6.0	1.5e-09	-0.88	0.03	0.97	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SENP7	0.04	0.02	blup	84	0.02	8.1e-04	-7.8	6.0	1.7e-09	-0.92	0.03	0.95	FALSE
31	GTEx	Muscle Skeletal	SENP7	0.10	0.03	enet	22	0.03	1.1e-03	1.2	6.0	2.2e-09	-0.45	0.23	0.67	FALSE
64	The Cancer Genome Atlas	Rectum Adenocarcinoma	SENP7	0.15	0.07	blup	84	0.09	4.5e-03	-6.8	6.0	2.6e-09	-0.92	0.03	0.58	FALSE
18	GTEx	Cells Transformed fibroblasts	SENP7	0.16	0.05	lasso	6	0.08	2.4e-06	1.5	5.9	4.2e-09	-0.71	0.05	0.94	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	SENP7	0.04	0.05	enet	10	0.06	1.0e-11	-7.9	5.8	7.6e-09	-0.88	0.03	0.97	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	SENP7	0.30	0.08	enet	40	0.22	9.2e-08	-7.9	5.8	7.8e-09	-0.87	0.04	0.96	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	SENP7	0.04	0.05	enet	15	0.05	1.1e-06	-7.9	5.8	8.3e-09	-0.88	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SENP7	0.22	0.10	enet	45	0.16	1.2e-19	-7.9	5.7	1.2e-08	-0.70	0.03	0.97	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	SENP7	0.14	0.12	blup	84	0.15	1.6e-14	-7.9	5.7	1.3e-08	-0.86	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC285359	0.02	0.01	lasso	8	0.01	2.6e-02	-6.8	-5.6	2.6e-08	0.41	0.01	0.75	FALSE
24	GTEx	Esophagus Muscularis	NXPE3	0.13	0.12	lasso	4	0.11	2.7e-07	-6.8	5.5	2.8e-08	-0.42	0.98	0.02	FALSE
11	GTEx	Brain Cortex	RP11-49I4.3	0.30	0.00	lasso	7	0.04	3.7e-02	-6.8	5.5	2.9e-08	-0.47	0.05	0.15	FALSE
44	GTEx	Testis	ZBTB11-AS1	0.26	0.27	enet	27	0.25	1.8e-11	-6.8	-5.4	5.6e-08	0.46	0.99	0.01	FALSE