Hub : Genes

ZBTB11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1130	0.0510	2.2e-03	0.032	NA	0.031	NA	0.031	0.01400	NA	0.01500	NA	0.01500
2	GTEx	Testis	0.1950	0.0600	1.6e-05	0.086	NA	0.078	NA	0.078	0.00012	NA	0.00025	NA	0.00023
3	TCGA	Brain Lower Grade Glioma	0.0625	0.0385	9.3e-04	0.002	0.003	0.004	NA	0.000	0.16000	0.13	0.11000	NA	0.36000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.1	0.7	-1.0	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.1	-0.7	-0.9
Depressed Affect (Nagel 2018)	0.6	1.4	2.4	0.9	-1.6	1.0
Depression (Nagel 2018)	1.2	1.7	5.1	-2.3	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	-1.2	-0.5	0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.6	-0.1	-0.7	1.3
Schizophrenia (2018)	0.2	0.5	1.0	-0.7	-0.0	-1.0
Schizophrenia vs Biploar Disorder	0.9	1.2	1.3	-1.0	1.1	-1.1
Worry (Nagel 2018)	0.3	0.6	1.3	-0.4	0.5	1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	-0.5	-1.3	-0.6
Alzheimer’s Disease (in father)	1.6	1.7	3.3	-1.2	1.8	-0.6
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	-0.2	0.1	-0.0
Crohns Disease (2017)	2.9	6.5	10.2	2.3	-3.2	-2.0
Irritable Bowel Disease (IBD)	1.5	3.6	4.3	2.1	-2.0	-1.6
Ulcerative Colitis (UC)	0.4	0.8	1.9	1.4	0.1	-0.7
Major Depression (MDD)	1.6	1.9	4.3	-2.1	-1.0	0.7
Reaction Time	0.4	0.8	1.8	-0.8	0.1	-1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.8	-0.3	-0.7
Breast Cancer	0.7	1.7	4.6	-0.5	-2.1	-0.3
Ovarian Cancer	0.3	0.4	1.2	-1.1	0.1	0.2
Prostate Cancer	0.3	0.5	1.4	-0.0	-1.2	0.1
Age at First Birth	0.1	0.1	0.2	-0.1	0.4	0.3
Bipolar Disorder (2011)	1.5	1.4	2.1	0.9	-1.2	1.4
Body Mass Index (BMI) (2010)	1.6	2.2	5.1	-0.8	-0.9	-2.2
Coronary Artery Disease (CAD)	0.6	0.7	1.6	1.3	0.6	-0.0
Crohns Disease (2012)	3.8	6.2	9.5	1.4	-2.7	-3.1
Mean Putamen Volume	0.0	0.1	0.1	0.2	0.2	-0.3
Fasting Glucose	2.0	2.4	4.4	-2.1	0.2	-1.6
HbA1C	0.2	0.2	0.3	-0.5	0.5	0.3
HDL Cholesterol	0.1	0.2	0.5	0.4	-0.7	-0.1
LDL Cholesterol	0.4	0.7	0.9	-0.9	-0.6	-0.9
Lupus	1.9	2.9	7.1	-1.0	0.7	-2.7
Neuroticism (2016)	0.5	0.7	1.3	-1.1	0.7	0.6
Primary Biliary Cirrhosis	0.4	0.6	1.4	-1.2	-0.2	-0.6
Rheumatoid Arthritis	0.5	0.7	1.5	0.7	-0.0	1.2
Schizophrenia (2014)	0.2	0.4	0.8	-0.9	0.5	-0.5
Triglycerides	0.3	0.6	1.4	0.5	1.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.3	-0.5	0.8
Ulcerative Colitis	0.4	0.5	1.1	1.0	-0.4	-0.6
Blood Eosinophil Count	1.2	9.5	24.9	1.0	1.6	-5.0
Blood Platelet Count	1.9	21.6	38.3	6.2	-3.8	3.4
Blood Red Count	1.0	10.0	16.6	2.1	-4.1	-3.0
Blood White Count	0.3	2.1	3.7	1.9	1.4	0.8
Heel T-Score	1.2	9.3	16.2	-2.2	2.6	4.0
BMI	0.9	5.4	8.3	-0.8	-2.9	-2.7
Height	0.5	9.1	13.8	-3.7	3.7	0.0
Waist Hip Ratio (WHR)	0.1	0.5	0.8	-0.9	0.8	-0.0
Systolic Blood Pressure	0.9	4.5	12.1	1.0	3.5	0.6
Smoking Status	0.2	0.4	0.9	0.9	-0.6	-0.4
Allergy or Eczema	0.4	1.1	2.9	1.7	0.3	-0.5
Cardiovascular Disease	0.6	2.0	5.7	-0.4	2.4	-0.4
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.5	-1.1	0.5
Respiratory disease	1.9	4.3	10.7	3.3	-1.4	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.5	0.3	0.8
Lung FEV1/FVC ratio	0.4	2.1	4.9	0.9	0.6	2.2
Lung FVC	1.4	7.3	16.2	-2.4	4.0	-0.3
Neuroticism	0.5	1.3	2.9	0.4	-0.9	1.7
Chronotype (morning person)	0.3	0.6	0.9	1.0	-0.9	0.3
Hair Pigment	0.1	3.0	5.4	0.3	-1.9	-2.3
Tanning	0.2	2.6	4.7	-0.5	1.7	-2.2
Hand grip strength (left)	0.7	1.8	2.6	0.8	-1.6	1.5
Number of treatments/medications taken	0.3	0.5	1.4	1.2	0.4	0.2
Average weekly spirits intake	1.9	2.3	4.5	2.1	-0.2	1.6
Sensitivity / hurt feelings	0.4	0.8	2.2	-0.3	0.1	1.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.9	-2.0	-0.7	-0.3
Hearing difficulty/problems: Yes	2.2	3.3	8.6	2.9	-0.8	0.9
Relative age of first facial hair	0.6	1.2	3.0	0.1	0.8	-1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.2	-0.8	-0.7
Ever used hormone-replacement therapy (HRT)	2.0	2.5	5.8	1.3	-2.4	-0.2
Ever had hysterectomy (womb removed)	1.0	1.1	1.5	1.2	-0.6	-1.2
Systolic blood pressure, automated reading	0.5	1.4	3.8	0.4	2.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.3	-1.5	0.3	0.8
Angina	0.5	0.7	1.7	-0.5	0.1	1.3
Medication for hormone replacement therapy	0.5	0.6	1.6	-0.4	-1.3	-0.1
Vitamin and mineral supplements	0.5	0.6	1.4	-0.7	-1.2	-0.1
Supplements: Zinc	1.1	1.2	2.8	0.6	1.7	0.5
Medication: Co-codamol	0.8	0.9	2.3	-1.5	-0.5	-0.5
Medication: Metformin	0.3	0.5	1.0	0.2	-1.0	0.6
Diabetes (father)	1.0	1.2	3.5	0.1	-1.9	-0.3
Diabetes (mother)	1.5	1.9	5.3	2.3	-0.3	0.4
Severe depression (siblings)	1.6	1.8	4.2	-0.9	2.0	0.5
Pack years adult smoking proportion	0.6	0.9	1.3	1.1	-1.0	-0.6
Impedance of leg (right)	0.7	3.5	6.6	2.6	-2.0	0.1
Leg fat-free mass (left)	0.4	1.9	5.1	-2.2	0.8	-0.3
Trunk fat percentage	1.8	7.1	14.4	1.3	-3.8	-2.3
Hand grip strength (right)	0.3	0.9	1.9	0.5	-1.4	0.8
Townsend deprivation index at recruitment	2.8	3.9	7.4	-1.9	0.7	-2.7
Current tobacco smoking	1.9	3.1	5.3	1.2	-2.3	-1.7
Average weekly fortified wine intake	4.0	4.7	7.9	-2.8	0.8	-2.4
Maternal smoking around birth	0.6	0.8	1.5	1.2	-0.4	0.9
Fed-up feelings	0.4	0.8	1.9	0.4	-0.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	-2.1	-0.1	0.5
Relative age voice broke	1.6	2.4	6.5	0.4	-0.8	-2.5
Taking other prescription medications	0.1	0.2	0.3	0.4	0.6	0.1
Age when periods started (menarche)	0.6	1.5	1.8	1.2	-1.0	1.3
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	4.8	2.2	-2.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.0	19.4	0.2	1.2	4.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.4	-0.5	-1.5	-0.1
Qualifications: CSEs or equivalent	1.6	2.1	3.0	1.7	0.6	1.7
Serious illness, injury or assault to yourself	1.7	2.1	3.2	-1.8	0.7	-1.6
High blood pressure	1.7	4.9	14.4	0.4	3.8	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	1.1	0.6	-0.1
Multivitamins +/- minerals	1.0	1.2	2.0	1.4	-0.4	1.3
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.7	-0.6	-0.4
Supplements: Glucosamine	2.5	3.3	6.4	2.5	-0.6	1.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.8	1.2	-1.3	0.5
Medication: Atenolol	0.4	0.5	0.9	-0.9	0.4	-0.7
Medication: Levothyroxine sodium	0.5	0.8	1.8	-1.4	-0.7	0.2
Sitting height	0.5	3.3	7.4	-2.7	1.4	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.3	0.7	-0.6
High blood pressure (mother)	0.2	0.2	0.4	-0.4	-0.1	0.7
Body mass index (BMI)	0.7	3.0	6.9	0.2	-2.6	-1.4
Impedance of leg (left)	0.8	3.8	6.3	2.5	-2.2	0.2
Leg predicted mass (left)	0.4	1.9	4.8	-2.2	0.9	-0.3
Trunk fat mass	0.8	3.5	7.1	0.4	-2.7	-1.8
Waist circumference	1.1	4.0	7.1	-0.1	-2.7	-2.2
Number of incorrect matches in round	0.3	0.5	0.7	0.8	-0.8	0.6
Past tobacco smoking	1.3	2.3	3.5	-1.5	-1.9	-1.1
Alcohol usually taken with meals	2.1	3.3	6.4	-2.5	0.2	-1.9
Nervous feelings	0.7	1.2	2.9	-0.8	-0.5	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	-0.9	-0.8	0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.3	1.0	0.3	1.1
Hair/balding pattern: Pattern 2	3.4	4.4	8.6	2.1	-2.9	-0.3
Had menopause	0.6	0.7	1.9	-0.5	0.0	-1.4
Had other major operations	0.7	0.9	1.7	-0.8	-1.3	0.6
Forced vital capacity (FVC)	1.3	4.9	10.4	-1.8	3.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.1	17.9	0.0	0.7	4.2
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.2	-0.4	-1.8	1.4
Qualifications: None of the above	0.1	0.2	0.2	0.4	0.4	0.5
Financial difficulties in last 2 years	1.0	1.3	2.4	-1.0	-1.6	-0.8
Mouth/teeth dental problems	0.7	1.1	3.0	-0.5	0.2	1.7
Heart attack	0.7	0.9	1.4	-1.1	0.1	-1.2
Allergy	0.5	1.1	2.6	-1.6	-0.7	0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.5	0.2	0.2
Diabetes (self-reported)	0.5	0.8	1.8	0.5	-1.3	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.3	-0.6	-0.3
Medication: Ramipril	0.9	1.2	3.3	0.3	0.3	-1.8
Medication: Simvastatin	0.3	0.5	1.2	-0.3	1.1	-0.3
Fluid intelligence score	0.0	0.1	0.1	-0.2	-0.3	-0.2
Illnesses of siblings	1.1	1.5	1.7	-1.2	1.3	1.3
Neuroticism score	1.0	2.1	4.1	0.7	-1.3	2.0
Weight	0.3	1.3	1.6	-1.0	-1.3	-1.2
Impedance of arm (right)	0.7	3.3	5.2	1.5	-1.5	-2.3
Arm fat percentage (right)	1.5	6.0	11.8	1.0	-3.4	-2.2
Trunk fat-free mass	0.7	4.2	6.6	-2.6	2.1	1.3
Hip circumference	1.1	4.5	10.3	-0.4	-3.2	-1.8
Time employed in main current job	1.2	1.4	2.1	-0.5	1.4	1.4
Alcohol intake versus 10 years previously	1.3	1.9	5.1	0.7	-2.3	0.1
Father’s age at death	2.5	3.4	8.6	-2.9	1.2	-0.5
Worrier / anxious feelings	0.6	1.1	2.7	0.6	0.6	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.0	0.2	-1.4	-0.2
Falls in the last year	0.5	0.7	1.6	-1.3	0.1	-0.6
Hair/balding pattern: Pattern 3	1.5	2.2	5.5	-0.1	2.4	1.0
Number of live births	0.1	0.1	0.3	-0.2	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	9.3	-1.6	3.0	2.0
Pulse rate	0.3	0.5	0.9	0.4	-1.0	-0.5
Happiness	0.8	1.0	2.8	-0.2	-1.7	0.3
Noisy workplace	0.3	0.3	0.6	0.8	-0.7	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.8	-1.4	0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.7	6.4	-2.2	0.2	-2.5
Mouth/teeth dental problems: Dentures	0.7	1.1	2.2	0.7	-0.7	-1.5
Asthma	2.2	4.3	12.3	3.5	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.9	-1.3	-1.4	-0.8
Medication: Cholesterol lowering	0.9	1.4	2.0	0.9	1.4	1.1
Depression (self-reported)	0.8	1.0	2.5	-0.7	-0.0	-1.6
Medication: Lansoprazole	0.7	0.8	1.3	1.1	-0.3	1.1
Prospective memory result	0.8	1.0	1.8	1.4	-0.3	-1.0
Lung cancer (father)	0.4	0.5	1.1	-0.2	0.6	-1.0
Illnesses of mother	1.3	1.6	4.5	-0.2	0.6	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	7.3	-1.9	2.7	1.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.3	-1.1	-0.4
Impedance of arm (left)	0.8	3.7	5.9	1.2	-1.9	-2.4
Arm fat mass (right)	0.7	3.0	6.8	0.3	-2.6	-1.4
Trunk predicted mass	0.7	4.2	6.9	-2.6	2.1	1.2
Standing height	0.6	5.6	8.5	-2.8	2.9	0.8
Length of working week for main job	0.4	0.4	1.3	-0.0	-1.1	-0.2
Exposure to tobacco smoke at home	1.9	2.2	6.3	0.0	-0.5	-2.5
Breastfed as a baby	2.0	2.5	5.9	-1.3	2.4	-0.1
Tense / ‘highly strung’	0.0	0.1	0.1	-0.1	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	7.3	-0.7	-2.7	-0.4
Hair/balding pattern: Pattern 4	0.7	1.6	3.4	-0.7	1.8	1.0
Birth weight of first child	0.1	0.2	0.7	-0.2	-0.8	0.1
Peak expiratory flow (PEF)	0.9	2.1	6.1	0.5	0.1	2.5
Pulse wave reflection index	0.5	0.7	1.0	-0.7	0.7	1.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	1.0	-1.3	0.3
Loud music exposure frequency	2.6	2.8	7.5	0.5	0.9	2.7
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	5.4	-0.9	-1.9	-2.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.3	-0.6	0.0	-1.1
Blood clot in the leg (DVT)	1.0	1.4	2.4	-1.6	1.2	-0.5
Medication: Paracetamol	0.0	0.0	0.1	-0.0	-0.1	0.3
Headache pain in last month	0.2	0.3	0.6	-0.8	-0.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.7	-1.6	0.3
Glaucoma (self-reported)	0.9	1.0	2.2	-0.9	-1.5	-0.0
Gout (self-reported)	0.5	0.7	1.0	-1.0	-1.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.3	-1.5	-0.6	-0.1
Medication: Amlodipine	0.6	0.9	2.2	0.6	1.5	-0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	-0.8	0.8	-1.6
Birth weight	0.2	0.4	0.9	-0.3	-1.0	0.4
Chronic bronchitis/emphysema (mother)	3.8	4.5	7.2	2.7	-2.3	-0.9
High blood pressure (siblings)	0.4	0.6	1.2	0.3	-1.1	-0.7
Forced vital capacity (FVC), Best measure	1.2	4.5	8.3	-2.2	2.9	0.4
Body fat percentage	1.8	7.2	14.9	1.4	-3.9	-2.2
Leg fat percentage (right)	1.9	6.7	15.8	1.2	-4.0	-1.7
Arm fat-free mass (right)	0.4	2.2	3.9	-2.0	1.0	1.3
Exposure to tobacco smoke outside home	1.1	1.5	2.4	1.1	-0.9	1.6
Comparative body size at age 10	0.6	1.8	3.1	-1.4	-1.8	-0.5
Number of full brothers	1.6	2.1	5.3	2.3	-0.4	-0.8
Worry too long after embarrassment	0.9	1.5	3.9	-0.0	0.8	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-0.9	-0.9	-0.2
Wheeze or whistling in the chest in last year	1.2	2.1	6.0	2.5	-0.6	0.2
Number of children fathered	0.1	0.1	0.3	0.2	-0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	4.4	-1.3	2.1	-0.1
Age at first live birth	0.3	0.6	1.4	-1.2	-0.5	0.3
Pulse wave peak to peak time	0.4	0.5	1.4	-0.1	1.2	0.3
Health satisfaction	0.2	0.2	0.5	0.2	-0.7	0.3
Shortness of breath walking on level ground	0.5	0.6	1.2	0.6	-1.1	0.3
Qualifications: College or University degree	0.5	1.6	2.4	-1.6	-0.3	-1.5
Eye problems/disorders: None of the above	1.2	1.4	2.2	1.5	-0.5	1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.3	-0.9	-0.7
Emphysema/chronic bronchitis	1.5	1.7	3.3	-0.3	-1.3	-1.8
Medication for pain relief, constipation, heartburn	0.6	1.0	2.4	1.6	0.2	0.7
Neck or shoulder pain in last month	0.5	0.8	0.9	-0.9	0.8	-0.9
Medication: Blood pressure	0.9	1.5	2.7	-0.0	1.6	-1.4
Angina (self-reported)	1.0	1.3	3.7	-0.4	0.2	1.9
Migraine (self-reported)	2.0	2.4	4.7	-2.2	-0.2	-1.6
Medication: Ibuprofen	0.7	0.9	1.3	-1.1	-1.2	-0.4
Medication: Allopurinol	0.1	0.1	0.3	0.0	0.6	-0.0
Medication: Omeprazole	0.4	0.5	1.1	-0.6	0.2	1.0
Medication: Seretide 50 evohaler	2.7	3.1	5.0	2.2	-2.1	0.0
Mean time to correctly identify matches	1.1	2.1	4.6	-1.3	-0.1	-2.1
Heart disease (mother)	1.7	2.1	4.8	-0.1	-1.3	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.8	1.7	-1.0	1.2
Whole body fat mass	0.8	3.4	7.1	0.5	-2.7	-1.7
Leg fat mass (right)	0.9	3.6	8.2	0.4	-2.9	-1.6
Arm predicted mass (right)	0.4	1.9	4.4	-2.1	0.7	0.9
Pulse rate, automated reading	0.8	2.5	4.9	2.2	-1.3	-0.8
Alcohol intake frequency.	0.5	1.1	1.5	-0.9	-0.9	-1.2
Comparative height size at age 10	0.4	2.4	4.2	-2.1	1.3	1.1
Number of full sisters	1.2	1.4	3.1	-1.8	0.7	-0.8
Suffer from ‘nerves’	0.9	1.5	4.4	-2.1	-0.0	-0.1
Overall health rating	0.7	1.5	2.7	-0.3	-1.6	-1.4
Chest pain or discomfort	0.6	0.8	1.3	-1.0	-0.3	-1.2
Had major operations	0.3	0.3	0.6	0.8	-0.5	0.4
Age at last live birth	0.5	0.8	1.6	-1.3	-0.6	-0.6
Family relationship satisfaction	1.0	1.3	3.7	-0.2	-0.2	1.9
Leg pain on walking	2.0	2.5	5.0	2.2	-0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.3	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	0.4	-0.8	0.8
Illness, injury, bereavement, stress in last 2 years	3.4	4.2	6.8	1.4	1.9	2.6
Medication: Aspirin	0.4	0.5	1.4	-1.2	0.1	-0.1
Supplements: Vitamin C	0.7	0.9	1.3	-0.8	0.9	-1.1
Knee pain experienced in last month	0.4	0.6	1.3	-0.8	-1.1	-0.2
Hypertension (Self-reported)	1.5	4.3	12.6	0.4	3.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.9	0.6	1.4	1.2
Illnesses of father: Heart disease	0.5	0.7	2.0	1.4	0.4	0.1
Illnesses of siblings: Diabetes	0.9	1.1	2.5	0.8	-1.6	-0.5
Smoking status: Previous	1.2	1.8	3.6	1.0	1.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.8	0.9	1.1	1.3
Whole body fat-free mass	0.6	3.3	7.0	-2.6	1.6	0.6
Leg fat-free mass (right)	0.5	2.6	6.4	-2.5	1.1	-0.2
Arm fat percentage (left)	1.6	6.5	13.7	0.8	-3.7	-2.3
Average weekly red wine intake	0.4	0.6	1.7	0.2	-0.2	-1.3
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.2	-0.6	1.0	-2.0
Mood swings	1.2	2.2	2.4	1.6	-1.4	1.5
Loneliness, isolation	0.6	0.8	1.2	-1.1	-0.5	1.0
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.3	0.4	-0.4
Ever had bowel cancer screening	1.0	1.2	3.5	1.9	-0.0	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.6	-0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.7	-1.0	-1.7	-1.0
Friendships satisfaction	1.8	2.3	4.9	1.4	0.1	2.2
Qualifications: nursing, teaching	0.6	1.0	2.1	0.3	-1.4	0.8
Commuting to job workplace: Walk	2.6	2.8	4.8	-2.2	0.1	-1.9
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.1	0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.6	1.3	0.7	1.6
Medication for cholesterol	0.0	0.1	0.1	-0.4	-0.2	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	0.3	-1.0	-0.4
Back pain experienced in last month	1.8	2.6	7.0	-2.6	0.8	0.6
Mineral and other dietary supplements	1.4	1.9	3.5	-1.4	-0.4	-1.9
Breast cancer (self-reported)	0.6	0.7	1.8	-0.5	0.3	1.4
Asthma (self-reported)	2.1	4.2	12.2	3.5	-0.4	0.6
Osteoporosis (self-reported)	1.0	1.2	3.6	-0.2	0.1	-1.9
Osteoarthritis (self-reported)	0.7	0.9	1.3	1.1	0.7	-0.9
Medication: Aspirin	0.4	0.5	1.2	-1.1	0.4	0.1
Medication: Gliclazide	0.4	0.4	0.6	-0.8	-0.5	-0.6
Illnesses of father: None of the above (group 1)	1.4	1.7	4.2	-0.2	-2.0	1.0
Smoking status: Current	1.8	2.8	5.7	1.2	-2.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.2	-0.1	1.1	0.9
Whole body water mass	0.6	3.3	6.5	-2.6	1.7	0.7
Leg predicted mass (right)	0.5	2.6	6.4	-2.5	1.1	-0.2
Arm fat mass (left)	0.8	3.5	7.8	0.0	-2.8	-1.6
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	-0.2	1.0	-1.3
Average weekly champagne plus white wine intake	1.0	1.4	3.6	0.8	-1.9	-0.2
Miserableness	1.4	2.4	6.2	0.9	-2.5	0.1
Guilty feelings	0.7	1.1	1.6	-1.2	-1.1	0.8
Wears glasses or contact lenses	2.4	2.7	5.7	-1.3	0.9	-2.4
Ever taken oral contraceptive pill	1.4	1.5	3.7	0.8	0.5	1.9
Hearing aid user	1.6	1.8	3.3	1.8	-1.3	0.5
Mother’s age at death	1.5	1.8	3.3	-1.0	1.8	1.1
Financial situation satisfaction	0.7	0.9	2.1	-1.5	-0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	0.2	-0.3	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.4	-1.2	0.3	-0.7
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	-0.5	-1.7	-0.6
Medication: Blood pressure	0.4	0.8	2.5	0.1	1.6	-0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.3	-0.9	0.7
Supplements: Fish oil (including cod liver oil)	1.9	2.4	6.5	0.6	0.7	2.5
High cholesterol (Self-reported)	0.2	0.3	0.6	0.3	0.7	-0.5
Medication: Bendroflumethiazide	0.4	0.5	1.2	0.6	1.1	-0.3
Medication: Paracetamol	0.1	0.2	0.3	-0.6	0.2	0.4
Medication: Lisinopril	0.3	0.4	0.9	-0.5	0.9	-0.4
Medication: Atorvastatin	1.3	1.6	4.8	0.1	0.2	2.2
Illnesses of father: High blood pressure	0.9	1.1	2.5	0.7	1.6	0.5
Alcohol drinker status: Never	0.1	0.1	0.2	-0.5	0.2	-0.1
Ever smoked	0.7	1.3	1.9	1.1	1.4	0.9
Basal metabolic rate	0.4	2.1	5.2	-2.3	0.9	0.3
Leg fat percentage (left)	1.7	6.1	14.7	1.1	-3.8	-1.6
Arm fat-free mass (left)	0.3	1.5	3.5	-1.9	0.7	0.8
Number of operations (self-reported)	0.3	0.4	1.2	0.1	-1.1	-0.0
Average weekly beer plus cider intake	1.4	2.0	4.7	-1.1	2.2	0.3
Irritability	1.4	2.4	3.4	1.9	-1.3	1.4
Risk taking	0.4	0.6	1.2	-0.5	-0.4	-1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	-1.1	-0.5	-0.8
Fractured/broken bones in last 5 years	0.8	1.1	2.0	-0.1	-1.4	-1.1
Age started oral contraceptive pill	0.4	0.5	1.0	-0.0	1.0	-0.7
Diastolic blood pressure, automated reading	0.6	1.8	3.3	0.4	1.8	-1.4
Ever depressed for a whole week	2.0	2.5	6.8	-0.9	-2.6	0.1
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.6	-0.1	-0.0
Commuting to job workplace: Cycle	1.4	1.7	4.9	0.5	-0.1	2.2
Myopia	1.0	1.5	2.0	-0.9	1.2	-1.4
Vascular/heart problems diagnosed by doctor	2.4	6.5	19.3	0.3	-4.4	0.3
Cholesterol lowering medication	0.1	0.1	0.2	0.0	-0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	-0.9	-0.4	0.5
Pain experienced in last month	0.3	0.5	1.1	1.1	0.6	-0.3
Supplements: Calcium	0.0	0.0	0.1	0.2	0.2	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.6	0.1	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	-0.7	-0.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.9	-1.7	1.2	-0.5
Heart disease (siblings)	0.4	0.5	0.8	0.8	-0.2	0.9
Alcohol drinker status: Previous	1.2	1.4	3.6	-0.5	1.9	-0.5
Pack years of smoking	0.5	0.8	1.3	1.1	-0.8	-0.7
Impedance of whole body	0.7	3.8	5.6	2.2	-2.4	-0.9
Leg fat mass (left)	0.8	3.2	7.6	0.3	-2.8	-1.4
Arm predicted mass (left)	0.2	1.3	2.8	-1.7	0.6	0.8