Best TWAS P=2.32e-34 · Best GWAS P=1.55e-43 conditioned to 6.79e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | RP11-245C23.3 | 0.10 | 0.05 | lasso | 2 | 0.01 | 1.5e-01 | -2.7 | 7.4 | 1.3e-13 | 0.55 | 0.05 | 0.31 | FALSE |
| 2 | GTEx | Esophagus Mucosa | MFN1 | 0.25 | 0.18 | enet | 40 | 0.19 | 5.1e-13 | 3.6 | 6.3 | 3.5e-10 | 0.04 | 1.00 | 0.00 | TRUE |
| 3 | NTR | Blood | ZMAT3 | 0.04 | 0.01 | blup | 398 | 0.02 | 1.6e-06 | -2.4 | -8.0 | 1.9e-15 | -0.44 | 0.93 | 0.03 | FALSE |
| 4 | YFS | Blood | ZMAT3 | 0.21 | 0.05 | bslmm | 397 | 0.11 | 2.6e-33 | -8.6 | -10.4 | 2.1e-25 | -0.28 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZMAT3 | 0.02 | 0.01 | enet | 10 | 0.02 | 1.0e-05 | -8.6 | -12.2 | 2.3e-34 | -0.69 | 0.02 | 0.91 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ZMAT3 | 0.12 | 0.09 | enet | 4 | 0.06 | 1.7e-04 | -8.6 | -9.1 | 1.1e-19 | -0.45 | 0.30 | 0.23 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZMAT3 | 0.06 | 0.02 | lasso | 2 | 0.03 | 5.0e-04 | -8.6 | -11.3 | 1.1e-29 | -0.59 | 0.12 | 0.23 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MFN1 | 0.79 | -0.01 | blup | 41 | 0.02 | 1.0e-01 | 4.0 | 5.8 | 6.3e-09 | 0.06 | 0.00 | 0.01 | FALSE |