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chr3:182,510,867-185,786,406

Best TWAS P=1.67e-59 · Best GWAS P=7.05e-222 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABCF3	0.05	0.00	blup	494	0.01	1.6e-02	-8.311	16.3	1.7e-59	-0.27	0.14	0.03	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ECE2	0.24	0.20	bslmm	542	0.19	1.6e-22	-10.334	-9.3	1.2e-20	0.27	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	YEATS2-AS1	0.08	0.02	lasso	10	0.01	3.3e-02	-11.567	10.5	8.3e-26	-0.15	0.44	0.03	TRUE
4	GTEx	Adrenal Gland	EIF2B5	0.14	-0.01	enet	36	0.02	5.3e-02	-12.940	-9.7	3.1e-22	0.20	0.10	0.17	TRUE
5	GTEx	Artery Aorta	ABCF3	0.17	0.18	lasso	3	0.15	2.0e-08	-8.516	-8.3	1.2e-16	0.13	1.00	0.00	TRUE
6	GTEx	Artery Tibial	AP2M1	0.12	0.06	lasso	6	0.05	1.5e-04	-8.457	-8.4	3.8e-17	0.08	0.83	0.02	FALSE
7	GTEx	Artery Tibial	MAP6D1	0.13	0.07	enet	15	0.07	5.1e-06	8.874	-11.4	4.4e-30	0.19	1.00	0.00	FALSE
8	GTEx	Brain Caudate basal ganglia	YEATS2-AS1	0.20	0.05	lasso	3	0.02	1.1e-01	11.259	12.9	2.5e-38	-0.16	0.13	0.14	FALSE
9	GTEx	Brain Cerebellar Hemisphere	MAP6D1	0.20	0.03	lasso	6	0.06	1.0e-02	9.965	-9.3	1.9e-20	0.18	0.21	0.05	FALSE
10	GTEx	Brain Cerebellar Hemisphere	YEATS2-AS1	0.20	0.16	lasso	5	0.16	6.2e-05	8.583	8.6	8.8e-18	-0.18	0.52	0.08	TRUE
11	GTEx	Brain Cerebellum	ABCC5	0.18	0.18	lasso	5	0.13	1.4e-04	11.384	11.9	1.2e-32	-0.10	0.34	0.05	FALSE
12	GTEx	Brain Cerebellum	MAP6D1	0.38	0.27	enet	38	0.34	1.0e-10	9.912	-7.3	3.3e-13	0.03	0.98	0.00	FALSE
13	GTEx	Brain Cerebellum	YEATS2-AS1	0.48	0.48	lasso	10	0.47	8.0e-16	9.912	10.0	1.6e-23	-0.14	1.00	0.00	FALSE
14	GTEx	Brain Cortex	VPS8	0.29	0.07	enet	54	0.02	1.1e-01	-1.776	9.5	1.7e-21	-0.28	0.08	0.13	TRUE
15	GTEx	Brain Putamen basal ganglia	ECE2	0.38	0.03	enet	22	0.11	1.4e-03	-10.386	-5.3	1.1e-07	-0.03	0.09	0.05	TRUE
16	GTEx	Cells Transformed fibroblasts	MAP6D1	0.09	0.03	lasso	6	0.03	2.0e-03	9.157	6.5	6.1e-11	-0.10	0.74	0.02	TRUE
17	GTEx	Colon Transverse	YEATS2	0.27	0.02	lasso	6	0.04	7.5e-03	1.827	-6.8	9.3e-12	0.08	0.07	0.07	FALSE
18	GTEx	Colon Transverse	YEATS2-AS1	0.24	0.01	lasso	6	0.01	6.7e-02	9.912	7.3	2.0e-13	-0.13	0.13	0.04	FALSE
19	GTEx	Esophagus Mucosa	ABCC5	0.13	0.10	lasso	5	0.09	1.8e-06	-12.977	-13.1	3.5e-39	0.12	1.00	0.00	FALSE
20	GTEx	Esophagus Mucosa	MAP6D1	0.08	0.07	lasso	11	0.07	3.4e-05	9.979	9.8	1.2e-22	-0.14	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	YEATS2-AS1	0.09	0.02	enet	25	0.06	1.4e-04	8.782	12.5	6.5e-36	-0.16	0.89	0.01	FALSE
22	GTEx	Heart Left Ventricle	AP2M1	0.10	0.06	enet	15	0.03	9.7e-03	-9.199	-10.3	6.6e-25	0.06	0.65	0.03	FALSE
23	GTEx	Lung	MAGEF1	0.14	0.07	lasso	6	0.07	2.7e-06	-1.994	8.1	5.1e-16	-0.26	0.60	0.37	TRUE
24	GTEx	Lung	YEATS2-AS1	0.13	0.03	enet	27	0.07	3.3e-06	-11.064	7.2	7.5e-13	-0.14	0.60	0.04	FALSE
25	GTEx	Muscle Skeletal	ABCF3	0.10	0.07	lasso	4	0.09	3.7e-09	-7.407	-6.0	2.0e-09	0.00	1.00	0.00	FALSE
26	GTEx	Muscle Skeletal	YEATS2-AS1	0.07	0.08	lasso	7	0.06	1.6e-06	9.912	9.9	3.6e-23	-0.14	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	ABCF3	0.13	0.11	lasso	4	0.09	6.1e-07	-8.516	-8.8	1.3e-18	0.14	0.96	0.00	FALSE
28	GTEx	Nerve Tibial	YEATS2-AS1	0.08	0.07	lasso	4	0.04	5.3e-04	9.912	10.0	2.4e-23	-0.14	0.84	0.01	FALSE
29	GTEx	Pancreas	ECE2	0.26	0.04	enet	24	0.09	1.2e-04	-10.368	-14.5	6.8e-48	0.25	0.16	0.05	TRUE
30	GTEx	Pituitary	ECE2	0.52	0.30	lasso	7	0.23	1.5e-06	-10.386	-7.7	1.4e-14	0.32	0.49	0.04	TRUE
31	GTEx	Skin Not Sun Exposed Suprapubic	ABCC5	0.12	0.01	lasso	3	0.01	8.4e-02	9.919	7.5	4.3e-14	-0.12	0.12	0.04	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	MAP6D1	0.16	0.08	enet	30	0.06	4.8e-04	9.982	8.4	2.8e-17	-0.12	0.98	0.00	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	YEATS2-AS1	0.21	0.21	enet	18	0.21	1.2e-11	9.979	9.7	2.1e-22	-0.15	1.00	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	ABCF3	0.13	0.08	lasso	4	0.11	1.6e-09	-1.632	-5.3	1.4e-07	-0.01	0.99	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	MAP6D1	0.07	0.02	lasso	5	0.03	2.7e-03	9.997	8.1	7.4e-16	-0.10	0.40	0.03	FALSE
36	GTEx	Skin Sun Exposed Lower leg	YEATS2-AS1	0.14	0.16	lasso	2	0.16	7.8e-13	8.782	9.1	9.5e-20	-0.14	1.00	0.00	FALSE
37	GTEx	Testis	CLCN2	0.15	-0.01	enet	18	0.02	4.3e-02	1.020	10.8	2.3e-27	-0.35	0.03	0.70	FALSE
38	GTEx	Testis	YEATS2-AS1	0.15	-0.01	enet	20	0.04	5.8e-03	-12.077	7.1	1.5e-12	-0.12	0.12	0.05	TRUE
39	GTEx	Whole Blood	ABCC5	0.10	0.08	lasso	4	0.08	9.9e-08	14.805	-14.7	6.6e-49	0.14	1.00	0.00	FALSE
40	GTEx	Whole Blood	PARL	0.15	0.12	enet	5	0.12	1.4e-11	-10.031	9.0	1.5e-19	-0.16	1.00	0.00	FALSE
41	METSIM	Adipose	ABCF3	0.19	0.14	enet	20	0.16	1.8e-22	-7.884	-9.2	2.2e-20	0.11	1.00	0.00	FALSE
42	METSIM	Adipose	KLHL6	0.06	0.00	bslmm	480	0.02	1.4e-03	-5.562	-10.3	1.1e-24	0.07	0.09	0.08	FALSE
43	METSIM	Adipose	MAP6D1	0.06	0.05	bslmm	473	0.06	2.3e-09	-11.265	-13.3	3.5e-40	0.20	1.00	0.00	FALSE
44	NTR	Blood	ABCC5	0.08	0.11	enet	26	0.11	6.8e-33	14.805	-15.0	1.4e-50	0.14	1.00	0.00	FALSE
45	YFS	Blood	ABCC5	0.25	0.37	enet	48	0.42	8.9e-154	14.805	-14.3	2.3e-46	0.15	1.00	0.00	FALSE
46	YFS	Blood	AP2M1	0.09	0.06	lasso	5	0.10	6.3e-31	7.502	-10.3	1.0e-24	0.14	1.00	0.00	FALSE
47	YFS	Blood	DVL3	0.04	0.00	bslmm	487	0.02	2.7e-07	-13.421	-10.5	7.4e-26	0.15	0.55	0.01	FALSE
48	YFS	Blood	KLHL6	0.06	0.04	enet	23	0.04	1.3e-13	7.785	-12.6	3.7e-36	0.17	1.00	0.00	FALSE
49	YFS	Blood	MAP6D1	0.25	0.23	enet	42	0.32	5.3e-107	8.234	-6.6	3.1e-11	0.06	1.00	0.00	TRUE
50	YFS	Blood	PARL	0.13	0.08	lasso	4	0.08	2.3e-25	-8.051	6.1	1.1e-09	-0.12	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABCC5	0.05	0.04	enet	8	0.03	7.0e-04	-13.097	-7.6	2.7e-14	0.03	0.44	0.12	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABCF3	0.04	0.00	enet	10	0.02	1.2e-04	-1.695	-8.2	3.5e-16	0.00	0.26	0.31	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MAP6D1	0.07	0.06	blup	55	0.06	9.4e-04	10.021	10.0	1.8e-23	-0.14	0.57	0.10	FALSE
54	The Cancer Genome Atlas	Glioblastoma Multiforme	MAP6D1	0.20	0.05	enet	27	0.05	1.0e-02	9.993	5.7	1.1e-08	-0.08	0.06	0.16	TRUE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MAP6D1	0.04	0.01	blup	55	0.04	4.0e-05	9.025	9.8	1.5e-22	-0.15	0.71	0.06	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLCN2	0.06	0.03	blup	55	0.04	5.0e-05	1.015	6.2	6.4e-10	-0.34	0.61	0.15	TRUE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	ECE2	0.04	0.02	blup	61	0.03	3.5e-04	-10.386	-13.0	2.1e-38	0.40	0.32	0.43	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLHL6	0.06	0.05	enet	7	0.05	4.3e-06	7.608	8.0	1.6e-15	-0.07	0.56	0.38	TRUE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAP6D1	0.03	0.04	enet	17	0.05	1.8e-06	10.384	11.2	3.8e-29	-0.09	0.77	0.19	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	IGF2BP2	0.03	0.02	lasso	1	0.01	5.5e-02	-10.049	10.0	9.3e-24	0.00	0.04	0.28	TRUE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AP2M1	0.04	0.01	blup	53	0.02	3.3e-03	-11.296	-11.0	5.0e-28	0.21	0.05	0.07	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CAMK2N2	0.04	0.01	enet	8	0.03	3.9e-04	-0.069	-5.6	2.0e-08	0.09	0.10	0.33	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABCC5	0.04	0.03	enet	9	0.03	5.5e-04	9.709	-12.4	4.1e-35	0.13	0.54	0.14	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMD2	0.07	0.03	blup	51	0.04	7.5e-05	6.838	5.8	4.8e-09	-0.45	0.95	0.00	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	VWA5B2	0.10	0.04	blup	51	0.04	1.8e-02	-1.815	6.7	2.3e-11	-0.12	0.04	0.09	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	ABCF3	0.05	0.02	lasso	9	0.01	1.4e-02	-7.407	-5.4	7.1e-08	0.02	0.35	0.29	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	MAP6D1	0.14	0.03	enet	10	0.07	2.6e-07	-10.430	9.8	7.0e-23	-0.06	0.79	0.14	FALSE